{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:35:55Z","timestamp":1779910555926,"version":"3.53.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.cbpc.2022.109500","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T03:14:25Z","timestamp":1667618065000},"page":"109500","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["An assessment of the ameliorative role of hesperidin in Drosophila melanogaster model of cadmium chloride-induced toxicity"],"prefix":"10.1016","volume":"263","author":[{"given":"Folake Olubukola","family":"Asejeje","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olalekan Bukunmi","family":"Ogunro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gbolahan Iyiola","family":"Asejeje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumuyiwa Sunday","family":"Adewumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos Olalekan","family":"Abolaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2022.109500_bb0005","first-page":"33","article-title":"Drosophila melanogaster as a promising model organism in toxicological studies: a mini review neurotoxicity of methylmercury in insects view project science education view project","volume":"1","author":"Abolaji","year":"2013","journal-title":"Arch. Basic Appl. Med."},{"key":"10.1016\/j.cbpc.2022.109500_bb0010","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.redox.2015.06.001","article-title":"Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster","volume":"5","author":"Abolaji","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0015","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.etap.2017.08.038","article-title":"Hesperidin, a citrus bioflavonoid, alleviates trichloroethylene-induced oxidative stress in Drosophila melanogaster","volume":"55","author":"Abolaji","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0020","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bbrc.2018.06.114","article-title":"Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster","volume":"503","author":"Abolaji","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2022.109500_bb0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.toxrep.2020.01.015","article-title":"Curcumin attenuates copper-induced oxidative stress and neurotoxicity in Drosophila melanogaster","volume":"7","author":"Abolaji","year":"2020","journal-title":"Toxicol. Reports"},{"key":"10.1016\/j.cbpc.2022.109500_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0111212","article-title":"Hesperidin produces cardioprotective activity via PPAR-\u03b3 pathway in ischemic heart disease model in diabetic rats","volume":"9","author":"Agrawal","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2022.109500_bb0040","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.nut.2014.03.024","article-title":"Protective effect of hesperidin in a model of Parkinson\u2019s disease induced by 6-hydroxydopamine in aged mice","volume":"30","author":"Antunes","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.cbpc.2022.109500_bb0045","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ejphar.2016.07.042","article-title":"Hesperidin reverses cognitive and depressive disturbances induced by olfactory bulbectomy in mice by modulating hippocampal neurotrophins and cytokine levels and acetylcholinesterase activity","volume":"789","author":"Antunes","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/394652","article-title":"Cadmium toxicity and treatment","volume":"2013","author":"Bernhoft","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.cbpc.2022.109500_bb0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/pest.2001.2549","article-title":"Levels of total acetylcholinesterase in Drosophila melanogaster in relation to insecticide resistance","volume":"70","author":"Charpentier","year":"2001","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0065","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1530\/JOE-14-0662","article-title":"The role of Nrf2 in oxidative stress-induced endothelial injuries","volume":"225","author":"Chen","year":"2015","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0070","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s11064-015-1571-8","article-title":"Hesperidin, a citrus flavonoid, has the ameliorative effects against experimental autoimmune encephalomyelitis (EAE) in a C57BL\/J6 mouse model","volume":"40","author":"Ciftci","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41390-019-0464-y","article-title":"Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity","volume":"87","author":"Elkabany","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0080","series-title":"Tissue Sulfhydryl Groups","first-page":"70","author":"Ellman","year":"1959"},{"key":"10.1016\/j.cbpc.2022.109500_bb0085","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0090","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1139\/cjpp-2014-0281","article-title":"Anti-depressant effect of hesperidin in diabetic rats","volume":"92","author":"El-Marasy","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0095","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuint.2012.12.006","article-title":"Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury","volume":"62","author":"Farina","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.cbpc.2022.109500_bb0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pestbp.2018.01.002","article-title":"Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone-induced toxicity in Drosophila melanogaster","volume":"145","author":"Farombi","year":"2018","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0105","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A drosophila model of Parkinson\u2019s disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2022.109500_bb0110","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and pharmacology of the citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phyther. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1734-1140(10)70321-2","article-title":"Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction","volume":"62","author":"Gaur","year":"2010","journal-title":"Pharmacol. Reports"},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2022.109500_bb0120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mce.2008.02.009","article-title":"Drosophila is an inclusive model for human diseases, growth and development","volume":"293","author":"Gilbert","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2022.109500_bb0130","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione S-transferases","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jneuroim.2016.11.009","article-title":"Hesperidin ameliorates immunological outcome and reduces neuroinflammation in the mouse model of multiple sclerosis","volume":"302","author":"Haghmorad","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24030648","article-title":"Hesperidin as a neuroprotective agent: a review of animal and clinical evidence","volume":"24","author":"Hajialyani","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.cbpc.2022.109500_bb0145","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/ptr.6046","article-title":"Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial","volume":"32","author":"Homayouni","year":"2018","journal-title":"Phyther. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.cbpc.2022.109500_bb0155","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/jmf.2017.4078","article-title":"Beneficial effects of flavonoids against Parkinson\u2019s disease","volume":"21","author":"Jung","year":"2018","journal-title":"J. Med. Food"},{"key":"10.1016\/j.cbpc.2022.109500_bb0160","doi-asserted-by":"crossref","first-page":"369","DOI":"10.5115\/acb.19.119","article-title":"Benefits of hesperidin in central nervous system disorders: a review","volume":"52","author":"Kim","year":"2019","journal-title":"Anat. Cell Biol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0192623309356453","article-title":"Oxidative stress and oxidative damage in carcinogenesis","volume":"38","author":"Klaunig","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.lfs.2018.10.040","article-title":"Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury","volume":"213","author":"Kosari-Nasab","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.cbpc.2022.109500_bb0175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.08.028","article-title":"Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington\u2019s like symptoms in rats: possible role of nitric oxide","volume":"206","author":"Kumar","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0185","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"49","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2022.109500_bb0195","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1091\/mbc.e07-11-1173","article-title":"Gcn4 is required for the response to peroxide stress in the yeast Saccharomyces cerevisiae","volume":"19","author":"Mascarenhas","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cbpc.2022.109500_bb0200","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.neuro.2012.07.007","article-title":"Potential neuroprotective effects of hesperidin on 3-nitropropionic acid-induced neurotoxicity in rats","volume":"33","author":"Menze","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbpc.2022.109500_bb0205","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ptr.5256","article-title":"Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models","volume":"29","author":"Parhiz","year":"2015","journal-title":"Phyther. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0215","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1080\/13880200902950793","article-title":"Protective effect of hesperidin against \u03b3-radiation induced oxidative stress in Sprague-Dawley rats","volume":"47","author":"Park","year":"2009","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0220","first-page":"1","article-title":"Effects of Hg(II) Exposure on MAPK Phosphorylation and Antioxidant System in D. melanogaster","author":"Paula","year":"2012","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0225","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11064-004-2445-7","article-title":"Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro","volume":"30","author":"Puntel","year":"2005","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbpc.2022.109500_bb0230","first-page":"927","article-title":"Atherosclerosis: process, indicators, risk factors and new hopes","volume":"5","author":"Rafieian-Kopaei","year":"2014","journal-title":"Int. J. Prev. Med."},{"key":"10.1016\/j.cbpc.2022.109500_bb0235","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.12.030","article-title":"Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases","volume":"124","author":"Roohbakhsh","year":"2015","journal-title":"Life Sci."},{"issue":"68","key":"10.1016\/j.cbpc.2022.109500_bb0240","first-page":"68","article-title":"Drosophila melanogaster as a model for lead neurotoxicology and toxicogenomics research","volume":"3","author":"Ruden","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbpc.2022.109500_bb0245","series-title":"Advances in Protein Chemistry and Structural Biology","doi-asserted-by":"crossref","DOI":"10.1016\/bs.apcsb.2017.02.001","article-title":"Neuroinflammation in Alzheimer's disease: the preventive and therapeutic potential of polyphenolic nutraceuticals","author":"Sawikr","year":"2017"},{"key":"10.1016\/j.cbpc.2022.109500_bb0250","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s11357-012-9438-2","article-title":"Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila","volume":"35","author":"Shen","year":"2013","journal-title":"Age (Omaha)"},{"key":"10.1016\/j.cbpc.2022.109500_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21060708","article-title":"Antioxidative and antidiabetic effects of natural polyphenols and isoflavones","volume":"21","author":"Umeno","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.cbpc.2022.109500_bb0260","doi-asserted-by":"crossref","first-page":"184","DOI":"10.34172\/apb.2020.023","article-title":"The role of natural antioxidants against reactive oxygen species produced by cadmium toxicity: a review","volume":"10","author":"Unsal","year":"2020","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.cbpc.2022.109500_bb0270","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides","volume":"233","author":"Wolff","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2022.109500_bb0275","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.2147\/DDDT.S227499","article-title":"Hesperidin: a therapeutic agent for obesity","volume":"13","author":"Xiong","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.cbpc.2022.109500_bb0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-020-02339-6","article-title":"Cadmium chloride \u00ad ( CdCl 2 ) elicitation improves reserpine and ajmalicine yield in Rauvolfia serpentina as revealed by high - performance thin - layer chromatography ( HPTLC )","volume":"10","author":"Zafar","year":"2020","journal-title":"3 Biotech"},{"key":"10.1016\/j.cbpc.2022.109500_bb0285","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.biopha.2016.11.089","article-title":"ScienceDirect hesperetin protects against H 2 O 2 -triggered oxidative damage via upregulation of the Keap1-Nrf2\/HO-1 signal pathway in ARPE-19 cells","volume":"88","author":"Zhu","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045622002356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045622002356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:32:38Z","timestamp":1761517958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045622002356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":53,"alternative-id":["S1532045622002356"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2022.109500","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An assessment of the ameliorative role of hesperidin in Drosophila melanogaster model of cadmium chloride-induced toxicity","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2022.109500","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109500"}}