{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:41:26Z","timestamp":1775742086963,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["19\/2551-0001-873-8"],"award-info":[{"award-number":["19\/2551-0001-873-8"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302167\/2022-6"],"award-info":[{"award-number":["302167\/2022-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.cbpc.2023.109653","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T06:06:31Z","timestamp":1683698791000},"page":"109653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Pyrethroid-based insecticides exert transgenerational, persistent, and chronic effects in Caenorhabditis elegans"],"prefix":"10.1016","volume":"270","author":[{"given":"Wagner Antonio","family":"Tamagno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Pompermaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Jos\u00e9 Gil","family":"Barcellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2023.109653_bb0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.mcn.2010.10.001","article-title":"C. elegans multi-dendritic sensory neurons: morphology and function","volume":"46","author":"Albeg","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.cbpc.2023.109653_bb0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10646-012-1004-2","article-title":"Use of transgenic GFP reporter strains of the nematode Caenorhabditis elegans to investigate the patterns of stress responses induced by pesticides and by organic extracts from agricultural soils","volume":"22","author":"Anbalagan","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.cbpc.2023.109653_bb0015","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1897\/03-264","article-title":"Assessing behavioral toxicity with Caenorhabditis elegans","volume":"23","author":"Anderson","year":"2004","journal-title":"Environ.Toxicol.Chem."},{"key":"10.1016\/j.cbpc.2023.109653_bb0020","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1126\/science.282.5396.2028","article-title":"Neurobiology of the Caenorhabditis elegans genome","volume":"282","author":"Bargmann","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2023.109653_bb0025","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.ecolind.2016.03.048","article-title":"Bioaccumulation and biochemical response in South American native species exposed to zinc: boosted regression trees as novel tool for biomarkers selection","volume":"67","author":"Bertrand","year":"2016","journal-title":"Ecol. Indic."},{"key":"10.1016\/j.cbpc.2023.109653_bb0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ntt.2008.12.004","article-title":"Medium-and high-throughput screening of neurotoxicants using C. elegans","volume":"32","author":"Boyd","year":"2010","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.cbpc.2023.109653_bb9025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2023.109653_bb0035","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/tx8004949","article-title":"Pest toxicology: the primary mechanisms of pesticide action","volume":"22","author":"Casida","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0040","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1007\/s11356-019-07463-2","article-title":"Toxicity assessment of municipal sewage treatment plant effluent by an integrated biomarker response in the liver of crucian carp (Carassius auratus)","volume":"27","author":"Chang","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2023.109653_bb0045","article-title":"Acute toxicity of organophosphate pesticide profenofos, pyrethroid pesticide \u03bb cyhalothrin and biopesticide azadirachtin and their sublethal effects on growth and oxidative stress enzymes in benthic oligochaete worm, Tubifex tubifex","volume":"242","author":"Chatterjee","year":"2021","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0050","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nature01170","article-title":"Antagonistic pathways in neurons exposed to body fluid regulate social feeding in Caenorhabditis elegans","volume":"419","author":"Coates","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2023.109653_bb9030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.taap.2003.09.013","article-title":"The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity","volume":"194","author":"Cole","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0065","series-title":"Oxford Research Encyclopedia of Neuroscience","article-title":"Caenorhabditis elegans feeding behaviors","author":"Dalli\u00e8re","year":"2017"},{"key":"10.1016\/j.cbpc.2023.109653_bb9010","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0092-8674(00)81609-8","article-title":"Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans","volume":"94","author":"De Bono","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2023.109653_bb0070","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nature01169","article-title":"Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli","volume":"419","author":"de Bono","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2023.109653_bb0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.chemosphere.2012.04.013","article-title":"Biomarker responses as indication of contaminant effects in Oreochromis niloticus","volume":"89","author":"dos Santos Carvalho","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2023.109653_bb0055","author":"FAO"},{"key":"10.1016\/j.cbpc.2023.109653_bb9015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature02714","article-title":"Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue","volume":"430","author":"Gray","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2023.109653_bb0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbagen.2005.04.033","article-title":"Hazardous effect of organophosphate compound, dichlorvos in transgenic Drosophila melanogaster (hsp70-lacZ): induction of hsp70, anti-oxidant enzymes and inhibition of acetylcholinesterase","volume":"1725","author":"Gupta","year":"2005","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.cbpc.2023.109653_bb0085","series-title":"Oxidant-antioxidant system: role and significance in human body","author":"Irshad","year":"2002"},{"key":"10.1016\/j.cbpc.2023.109653_bb0090","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuro.2020.11.001","article-title":"C. elegans pharyngeal pumping provides a whole organism bio-assay to investigate anti-cholinesterase intoxication and antidotes","volume":"82","author":"Izquierdo","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbpc.2023.109653_bb9020","doi-asserted-by":"crossref","first-page":"E1263","DOI":"10.1073\/pnas.1621274114","article-title":"Dissection of neuronal gap junction circuits that regulate social behavior in Caenorhabditis elegans","volume":"114","author":"Jang","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbpc.2023.109653_bb0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10311-015-0513-7","article-title":"Chlorpyrifos: pollution and remediation","volume":"13","author":"John","year":"2015","journal-title":"Environ. Chem. Lett."},{"key":"10.1016\/j.cbpc.2023.109653_bb0100","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.3390\/ijerph110504589","article-title":"Cyanobacterial xenobiotics as evaluated by a Caenorhabditis elegans neurotoxicity screening test","volume":"11","author":"Ju","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.cbpc.2023.109653_bb0105","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1007\/s11064-008-9725-6","article-title":"Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes","volume":"33","author":"Kaizer","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.cbpc.2023.109653_bb0110","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.copbio.2019.12.011","article-title":"Caenorhabditis elegans as a model system for human diseases","volume":"63","author":"Markaki","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0115","doi-asserted-by":"crossref","first-page":"20672","DOI":"10.1073\/pnas.1106134109","article-title":"Neuronal and molecular substrates for optimal foraging in Caenorhabditis elegans","volume":"108","author":"Milward","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbpc.2023.109653_bb0125","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bcab.2017.09.006","article-title":"Hepatic oxidative stress, genotoxicity and histopathological alteration in fresh water fish Labeo rohita exposed to organophosphorus pesticide profenofos","volume":"12","author":"Nataraj","year":"2017","journal-title":"Biocatal.Agric.Biotechnol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jff.2016.08.012","article-title":"Anthocyanin-rich extract of Acai (Euterpe precatoria Mart.) mediates neuroprotective activities in Caenorhabditis elegans","volume":"26","author":"Peixoto","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.cbpc.2023.109653_bb0140","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/15287390902841532","article-title":"Evaluation of pesticide toxicities with differing mechanisms using Caenorhabditis elegans","volume":"72","author":"Ruan","year":"2009","journal-title":"J. Toxic. Environ. Health A"},{"key":"10.1016\/j.cbpc.2023.109653_bb0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00424-014-1574-3","article-title":"Mechanosensory molecules and circuits in C. elegans","volume":"467","author":"Schafer","year":"2015","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep07387","article-title":"Natural RNA interference directs a heritable response to the environment","volume":"4","author":"Schott","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2023.109653_bb0155","series-title":"Biological Controls for Preventing Food Deterioration","first-page":"1","article-title":"Biologicals","author":"Sharma","year":"2014"},{"key":"10.1016\/j.cbpc.2023.109653_bb0160","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.ecoenv.2010.02.003","article-title":"Cypermethrin elicited responses in heat shock protein and feeding in Caenorhabditis elegans","volume":"73","author":"Shashikumar","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2023.109653_bb0165","first-page":"265","article-title":"Insect glutathione S-transferase: a review of comparative genomic studies and response to xenobiotics","volume":"65","author":"Shou-Min","year":"2012","journal-title":"Bull. Insectol."},{"key":"10.1016\/j.cbpc.2023.109653_bb0170","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/bdr2.1661","article-title":"Effects of low-dose chlorpyrifos on neurobehavior and potential mechanisms: a review of studies in rodents, zebrafish, and Caenorhabditis elegans","volume":"112","author":"Silva","year":"2020","journal-title":"Birth Defects Res."},{"key":"10.1016\/j.cbpc.2023.109653_bb0180","first-page":"58","article-title":"Implementation of artificial intelligence in agriculture for optimisation of irrigation and application of pesticides and herbicides","volume":"4","author":"Talaviya","year":"2020","journal-title":"Artif.Intell.Agric."},{"issue":"4","key":"10.1016\/j.cbpc.2023.109653_bb0185","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13981","article-title":"Fruit extract of red pitaya (Hylocereus undatus) prevents and reverses stress-induced impairments in the cholinergic and antioxidant systems of Caenorhabditis elegans","volume":"46","author":"Tamagno","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.cbpc.2023.109653_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120301","article-title":"Household prallethrin-based insecticide toxicity on different C. elegans life stage: a possible sign of Huntington Disease","volume":"314","author":"Tamagno","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2023.109653_bb0195","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14147","article-title":"Neuroprotective and antioxidant effects of pitaya fruit on Cu-induced stress in adult zebrafish","volume":"46","author":"Tamagno","year":"2022","journal-title":"J. Food Biochem."},{"issue":"3","key":"10.1016\/j.cbpc.2023.109653_bb0200","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.14050","article-title":"Pitaya fruit extract ameliorates the healthspan on copper-induced toxicity of Caenorhabditis elegans","volume":"46","author":"Tamagno","year":"2022","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.cbpc.2023.109653_bb9035","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13139","article-title":"Buti\u00b4a fruit extract (Butia eriospatha) protects against oxidative damage and increases lifespan on Caenorhabditis elegans","volume":"44","author":"Tambara","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.cbpc.2023.109653_bb0205","first-page":"1","article-title":"Acute exposure of deltamethrin and chlorpyrifos on the locomotion of Caenorhabditis elegans","volume":"16","author":"Thakur","year":"2019","journal-title":"J.Undergrad.Res."},{"key":"10.1016\/j.cbpc.2023.109653_bb9000","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/neu.10245","article-title":"Functional mapping of neurons that control locomotory behavior in Caenorhabditis elegans","volume":"56","author":"Tsalik","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.cbpc.2023.109653_bb9005","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.1162011","article-title":"Fat metabolism links germline stem cells and longevity in C. elegans","volume":"322","author":"Wang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2023.109653_bb0210","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/701758","article-title":"From pathways to targets: understanding the mechanisms behind polyglutamine disease","volume":"2014","author":"Weber","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.cbpc.2023.109653_bb0060","series-title":"Safety of Pyrethroids for Public Health Use","author":"World Health Organization","year":"2005"},{"key":"10.1016\/j.cbpc.2023.109653_bb0215","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.pestbp.2017.03.005","article-title":"Deltamethrin affects the expression of voltage-gated calcium channel \u03b11 subunits and the locomotion, egg-laying, foraging behavior of Caenorhabditis elegans","volume":"138","author":"Zeng","year":"2017","journal-title":"Pestic. Biochem. Physiol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045623001084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045623001084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T13:23:31Z","timestamp":1736429011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045623001084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":48,"alternative-id":["S1532045623001084"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2023.109653","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyrethroid-based insecticides exert transgenerational, persistent, and chronic effects in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2023.109653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109653"}}