{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:38:19Z","timestamp":1761518299450,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002797","name":"Government of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["NMGIRT2216"],"award-info":[{"award-number":["NMGIRT2216"]}],"id":[{"id":"10.13039\/501100002797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.cbpc.2024.109886","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T11:39:37Z","timestamp":1709552377000},"page":"109886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Understanding the toxicity mechanism of gelsemine in zebrafish"],"prefix":"10.1016","volume":"280","author":[{"given":"Chenglong","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelimuge","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhou","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meirong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoquan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cbpc.2024.109886_bb0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/biom10020199","article-title":"Cerevisterol alleviates inflammation via suppression of MAPK\/ NF-\u03baB\/AP-1 and activation of the Nrf2\/HO-1 signaling cascade","volume":"10","author":"Alam","year":"2020","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.cbpc.2024.109886_bb0010","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-8741(00)00346-9","article-title":"Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice","volume":"74","author":"Bousta","year":"2001","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.cbpc.2024.109886_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000172","article-title":"Persistent cAMP-signals triggered by inter- nalized G-protein-coupled receptors","volume":"7","author":"Calebiro","year":"2009","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.cbpc.2024.109886_bb0020","first-page":"101","article-title":"p38 MAPK inhibition alleviates experimental acute pancreatitis in mice: hepatobiliary & pancreatic diseases international","volume":"14","author":"Cao","year":"2015","journal-title":"HBPD INT"},{"key":"10.1016\/j.cbpc.2024.109886_bb0025","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.2147\/JPR.S219084","article-title":"Transcriptome changes in dorsal spinal cord of rats with neuropathic pain","volume":"12","author":"Cao","year":"2019","journal-title":"J. Pain Res."},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0030","first-page":"1133","article-title":"Apigenin exerts anti-inflammatory effects in an Experi- mental model of acute pancreatitis by down-regulating TNF-\u03b1","volume":"33","author":"Charalabopoulos","year":"2019","journal-title":"In Vivo (Athens, Greece)"},{"year":"2022","series-title":"Gelsemine Exerts Neuroprotective Effects on Neonatal Mice with Hypoxic-Ischemic Brain Injury by Suppressing Inflammation and Oxidative Stress Via Nrf2\/HO-1 Pathway: Neurochemical Research","author":"Cheng","key":"10.1016\/j.cbpc.2024.109886_bb0035"},{"issue":"18","key":"10.1016\/j.cbpc.2024.109886_bb0040","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.3390\/ijms231810227","article-title":"SIRT1\/FOXO signaling pathway in breast cancer progression and metastasis","volume":"23","author":"Dilmac","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2024.109886_bb0045","doi-asserted-by":"crossref","first-page":"909084","DOI":"10.3389\/fphar.2022.909084","article-title":"Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model","volume":"13","author":"Dong","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.cbpc.2024.109886_bb0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0973-7847.70916","article-title":"The genus Gelsemium: an update","volume":"4","author":"Dutt","year":"2010","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.cbpc.2024.109886_bb0055","first-page":"55630","article-title":"Histological analyses of acute alcoholic liver injury in zebrafish","volume":"no. 123","author":"Ellis","year":"2017","journal-title":"J. Visual. Exp."},{"issue":"21","key":"10.1016\/j.cbpc.2024.109886_bb0060","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1158\/0008-5472.CAN-12-4573","article-title":"Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer","volume":"73","author":"Garcia-Recio","year":"2013","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0065","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuron.2015.11.001","article-title":"G protein-coupled receptors: dynamic machines for signaling pain and itch","volume":"88","author":"Geppetti","year":"2015","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.cbpc.2024.109886_bb0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u03baB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0075","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.08.016","article-title":"Transgenic expression of PRSS1R122H sensitizes mice to pancreatitis","volume":"158","author":"Huang","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0080","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1053\/j.gastro.2018.06.041","article-title":"Chymotrypsin reduces the severity of secretagogue-induced pancreatitis in mice","volume":"155","author":"Jancs\u00f3","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.cbpc.2024.109886_bb0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.pan.2023.02.003","article-title":"Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation","volume":"23","author":"Jancs\u00f3","year":"2023","journal-title":"Pancreatology"},{"issue":"1","key":"10.1016\/j.cbpc.2024.109886_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jep.2014.01.003","article-title":"Medicinal plants of the genus Gelsemium (Gelsemiaceae, Gentianales)\u2014a review of their phytochemistry, pharmacology, toxicology and traditional use","volume":"152","author":"Jin","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"Database issue","key":"10.1016\/j.cbpc.2024.109886_bb0095","first-page":"D480","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1089\/met.2019.0120","article-title":"Role of heparin-binding epidermal growth factor-like growth factor in oxidative stress-associated metabolic diseases","volume":"18","author":"Kim","year":"2020","journal-title":"Metab. Syndr. Relat. Disord."},{"issue":"14","key":"10.1016\/j.cbpc.2024.109886_bb0105","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/bph.13507","article-title":"Functional modulation of glycine receptors by the alkaloid gelsemine","volume":"173","author":"Lara","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cbpc.2024.109886_bb0110","doi-asserted-by":"crossref","DOI":"10.1177\/17534666221122592","article-title":"A prediction model for acute respiratory distress syndrome among patients with severe acute pancreatitis: a retrospective analysis","volume":"16","author":"Lin","year":"2022","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.cbpc.2024.109886_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162664","article-title":"Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish","volume":"876","author":"Lin","year":"2023","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.cbpc.2024.109886_bb0120","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10620-020-06225-2","article-title":"Inhibition of ferroptosis attenuates acute kidney injury in rats with severe acute pancreatitis","volume":"66","author":"Ma","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cbpc.2024.109886_bb0125","doi-asserted-by":"crossref","first-page":"1083189","DOI":"10.3389\/fnmol.2022.1083189","article-title":"Modulation of GABAA receptors and of GABAergic synapses by the natural alkaloid gelsemine","volume":"15","author":"Marileo","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.cbpc.2024.109886_bb0130","series-title":"Applications of Western Blot Technique: From Bench to Bedside: Biochemistry and Molecular Biology Education: A Bimonthly Publication of the International Union of Biochemistry and Molecular Biology, v. 49, no. 4","first-page":"509","author":"Meftahi","year":"2021"},{"issue":"4","key":"10.1016\/j.cbpc.2024.109886_bb0135","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.cbpc.2024.109886_bb0140","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jep.2014.02.048","article-title":"Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells","volume":"153","author":"Olioso","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.cbpc.2024.109886_bb0145","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.cbpc.2024.109886_bb0150","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12906-021-03273-7","article-title":"A network pharmacology-based investigation on the bioactive ingredients and molecular mechanisms of Gelsemium elegans Benth against colorectal cancer","volume":"21","author":"Que","year":"2021","journal-title":"BMC Complement. Med. Therap."},{"key":"10.1016\/j.cbpc.2024.109886_bb0155","article-title":"Molecular mechanism of Gelsemium elegans (Gardner and Champ.) Benth. Against neuropathic pain based on network pharmacology and experimental evidence","volume":"12","author":"Que","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.cbpc.2024.109886_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-8741(03)00267-8","article-title":"Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth","volume":"89","author":"Rujjanawate","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.cbpc.2024.109886_bb0165","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.humpath.2020.07.019","article-title":"Carboxypeptidase A1 and regenerating islet-derived 1\u03b1 as new markers for pancreatic acinar cell carcinoma","volume":"103","author":"Said","year":"2020","journal-title":"Hum. Pathol."},{"issue":"24","key":"10.1016\/j.cbpc.2024.109886_bb0170","doi-asserted-by":"crossref","first-page":"15463","DOI":"10.3390\/ijms232415463","article-title":"Novel p.G250A mutation associated with chronic pancreatitis highlights misfolding-prone region in Carboxypeptidase A1 (CPA1)","volume":"23","author":"S\u00e1ndor","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2024.109886_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157665","article-title":"Transgenic zebrafish (Danio rerio) as an emerging model system in ecotoxicology and toxicology: historical review, recent advances, and trends","volume":"848","author":"Silva Brito","year":"2022","journal-title":"Sci. Total Environ."},{"issue":"23","key":"10.1016\/j.cbpc.2024.109886_bb0180","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1016\/j.chroma.2011.04.025","article-title":"Preparative separation of alkaloids from Gelsemium elegans Benth. using pH-zone-refining counter-current chromatography","volume":"1218","author":"Su","year":"2011","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.cbpc.2024.109886_bb0185","first-page":"7","article-title":"FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR\/MAPK\/NF-\u03baB pathway in airway epithelial cells","volume":"9","author":"Tan","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"5","key":"10.1016\/j.cbpc.2024.109886_bb0190","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.exger.2013.02.020","article-title":"Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16\/FOXO in dietary restriction pathway","volume":"48","author":"Wan","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cbpc.2024.109886_bb0195","article-title":"Advances of zebrafish in neurodegenerative disease: from models to drug discovery","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.cbpc.2024.109886_bb0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-213X-10-3","article-title":"The role of vasculature and blood circulation in zebrafish swimbladder development","volume":"10","author":"Winata","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.cbpc.2024.109886_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2023.09.037","article-title":"Antinociceptive effect of gelsenicine, principal toxic alkaloids of gelsemium, on prostaglandin E2-induced hyperalgesia in mice: comparison with gelsemine and koumine","volume":"681","author":"Xu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2024.109886_bb0210","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.6093","article-title":"Effects of gelsemine on oxidative stress and DNA damage responses of Tetrahymena thermophila","volume":"6","author":"Ye","year":"2018","journal-title":"PeerJ"},{"issue":"2","key":"10.1016\/j.cbpc.2024.109886_bb0215","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"issue":"10","key":"10.1016\/j.cbpc.2024.109886_bb0220","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/biom9100559","article-title":"Koumine promotes ROS production to suppress hepatocellular carcinoma cell proliferation via NF-\u03baB and ERK\/p38 MAPK signaling","volume":"9","author":"Yuan","year":"2019","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.cbpc.2024.109886_bb0225","doi-asserted-by":"crossref","first-page":"G816","DOI":"10.1152\/ajpgi.00004.2019","article-title":"Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in mice","volume":"316","author":"Zhan","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"11","key":"10.1016\/j.cbpc.2024.109886_bb0230","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.pain.2013.07.027","article-title":"Gelsemine, a principal alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal \u03b13 glycine recep- tors","volume":"154","author":"Zhang","year":"2013","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.cbpc.2024.109886_bb0235","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2217\/fon-2021-0394","article-title":"Biomarker subset analysis of a phase IIIb, open-label study of afatinib in EGFR tyrosine kinase inhibitor-naive patients with EGFRm+ non-small-cell lung cancer","volume":"18","author":"Zhao","year":"2022","journal-title":"Future Oncol. (London, England)"},{"issue":"11","key":"10.1016\/j.cbpc.2024.109886_bb0240","first-page":"204","article-title":"SPINK1, PRSS1, CTRC, and CFTR genotypes influence disease onset and clinical outcomes in chronic pancreatitis: clinical and translational","volume":"9","author":"Zou","year":"2018","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.cbpc.2024.109886_bb0245","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00439-022-02436-x","article-title":"Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis","volume":"141","author":"Zou","year":"2022","journal-title":"Hum. Genet."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045624000541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045624000541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:34:10Z","timestamp":1761518050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045624000541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":49,"alternative-id":["S1532045624000541"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2024.109886","relation":{},"ISSN":["1532-0456"],"issn-type":[{"type":"print","value":"1532-0456"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the toxicity mechanism of gelsemine in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2024.109886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109886"}}