{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:02:07Z","timestamp":1776304927204,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401512ZYTS"],"award-info":[{"award-number":["YDZJ202401512ZYTS"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cbpc.2025.110191","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:02:07Z","timestamp":1741752127000},"page":"110191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Selenium-enriched Bacillus subtilis attenuates emamectin benzoate-induced liver injury in grass carp through inhibiting inflammation and ferroptosis via activating Nrf2 signaling pathway"],"prefix":"10.1016","volume":"294","author":[{"given":"Fengyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhe","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2025.110191_bb0005","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Cell Res."},{"key":"10.1016\/j.cbpc.2025.110191_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.105941","article-title":"New insights into resveratrol attenuates hepatotoxicity in emamectin benzoate-exposed grass carp ( idella) via NO system\/NF-\u03baB signaling pathway","volume":"202","author":"Bi","year":"2024","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.cbpc.2025.110191_bb0015","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.clnu.2012.05.016","article-title":"Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice","volume":"31","author":"Foligne","year":"2012","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.cbpc.2025.110191_bb0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5487\/TR.2013.29.3.165","article-title":"Recent updates on acetaminophen hepatotoxicity: the role of nrf2 in hepatoprotection","volume":"29","author":"Gum","year":"2013","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.cbpc.2025.110191_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13040","article-title":"The complex roles of neutrophils in APAP-induced liver injury","volume":"54","author":"Guo","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cbpc.2025.110191_bb0030","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1039\/C5FO00290G","article-title":"A comparison of antioxidative and anti-inflammatory activities of sword beans and soybeans fermented with Bacillus subtilis","volume":"6","author":"Han","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.cbpc.2025.110191_bb0035","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/eji.200535261","article-title":"Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury","volume":"36","author":"Ishida","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1517\/17425255.1.3.389","article-title":"Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity","volume":"1","author":"Jaeschke","year":"2005","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0045","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/etc.209","article-title":"Acute toxicity of Emamectin benzoate and its Desmethyl metabolite to","volume":"29","author":"Kuo","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2025.110191_bb0050","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.bbagen.2017.05.019","article-title":"Ferroptosis: role of lipid peroxidation, iron and ferritinophagy","volume":"1861","author":"Latunde-Dada","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.cbpc.2025.110191_bb0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2012.01.014","article-title":"Recent developments in acute liver failure","volume":"26","author":"Lee","year":"2012","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106017","article-title":"Emamectin benzoate exposure induced carp kidney injury by triggering mitochondrial oxidative stress to accelerate ferroptosis and autophagy","volume":"203","author":"Li","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0065","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jnutbio.2018.04.011","article-title":"Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis","volume":"58","author":"Liu","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cbpc.2025.110191_bb0070","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/hep.21175","article-title":"Neutrophil depletion protects against murine acetaminophen hepatotoxicity","volume":"43","author":"Liu","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.cbpc.2025.110191_bb0075","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpc.2025.110191_bb0080","doi-asserted-by":"crossref","unstructured":"Mallik, S. K., Singh, S., Shahi, N., Patil, P. K., Kala, K., Pathak, R., Giri, A. K., Das, P., Tandel, R. S., Chandra, S., Krishna, N., Ravindran, R. & Pandey, P. K. (2023) Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters, front Pharmacol. 14.","DOI":"10.3389\/fphar.2023.1106124"},{"key":"10.1016\/j.cbpc.2025.110191_bb0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10565-021-09624-x","article-title":"Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury","volume":"38","author":"Niu","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0090","doi-asserted-by":"crossref","first-page":"3140673","DOI":"10.1155\/2017\/3140673","article-title":"Oxidative stress and inflammation in hepatic diseases: current and future therapy","volume":"2017","author":"Reyes-Gordillo","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.cbpc.2025.110191_bb0095","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1574-6941.2009.00703.x","article-title":"Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage","volume":"69","author":"Rishi","year":"2009","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0100","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10695-022-01046-8","article-title":"Selenium-enriched Bacillus subtilis reduces the effects of mercury-induced on inflammation and intestinal microbes in carp (Cyprinus carpio var. specularis)","volume":"48","author":"Shang","year":"2022","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpc.2025.110191_bb0105","first-page":"257","author":"Shi","year":"2024","journal-title":"Combined exposure of emamectin benzoate and microplastics induces tight junction disorder, immune disorder and inflammation in carp midgut via lysosome\/ROS\/ferroptosis pathway, Water Res."},{"key":"10.1016\/j.cbpc.2025.110191_bb0110","first-page":"3106","article-title":"Emamectin benzoate and microplastics led to skeletal muscle atrophy in common carp via induced oxidative stress","volume":"73","author":"Sun","year":"2025","journal-title":"Mitochondrial Dysfunction, and Protein Synthesis and Degradation Imbalance, J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2025.110191_bb0115","doi-asserted-by":"crossref","first-page":"23199","DOI":"10.1007\/s11356-020-08923-w","article-title":"Biopesticide emamectin benzoate in the liver of male mice: evaluation of oxidative toxicity with stress protein","volume":"27","author":"Temiz","year":"2020","journal-title":"DNA oxidation, and apoptosis biomarkers, Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2025.110191_bb0120","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.1007\/s11356-021-16373-1","article-title":"In vivo neurotoxic effects of emamectin benzoate in male mice: evaluation with enzymatic and biomolecular multi-biomarkers","volume":"29","author":"Temiz","year":"2022","journal-title":"Environ. Sci. Pollut. R."},{"key":"10.1016\/j.cbpc.2025.110191_bb0125","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41419-020-02961-5","article-title":"(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbpc.2025.110191_bb0130","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00204-020-02722-5","article-title":"Acetaminophen-induced hepatotoxicity: different mechanisms of acetaminophen-induced ferroptosis and mitochondrial damage","volume":"94","author":"Yamada","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110191_bb0135","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1039\/D1FO01158H","article-title":"Selenium enriched Bacillus subtilis yb-1114246 activated the TLR2-NF-kappaB1 signaling pathway to regulate chicken intestinal beta-defensin 1 expression","volume":"12","author":"Yang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.cbpc.2025.110191_bb0140","doi-asserted-by":"crossref","unstructured":"Zhang, X. H., Zhang, F. Y., Li, M. S., Sun, Q. S., Li, Y. H., Fu, Y. H. & Zhang, Y. (2025) Epicatechin attenuates emamectin benzoate-induced liver injury in grass carp by activating Nrf2\/GPX4 signaling pathway, fish shellfish Immun. 157.","DOI":"10.1016\/j.fsi.2025.110118"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625000729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625000729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:33:25Z","timestamp":1765485205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045625000729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":28,"alternative-id":["S1532045625000729"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110191","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium-enriched Bacillus subtilis attenuates emamectin benzoate-induced liver injury in grass carp through inhibiting inflammation and ferroptosis via activating Nrf2 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110191"}}