{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:31:11Z","timestamp":1755217871903,"version":"3.43.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.cbpc.2025.110289","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:17:17Z","timestamp":1752592637000},"page":"110289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pyraclostrobin disrupts ion regulation by suppressing mitochondrion-rich ionocyte differentiation in zebrafish embryos"],"prefix":"10.1016","volume":"297","author":[{"given":"Li-Yih","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-Hsuan","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan-Yi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun-Lin","family":"Horng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2025.110289_bb0005","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/03601230701316465","article-title":"Review of strobilurin fungicide chemicals","volume":"42","author":"Balba","year":"2007","journal-title":"J. Environ. Sci. Health B"},{"key":"10.1016\/j.cbpc.2025.110289_bb0010","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ps.520","article-title":"The strobilurin fungicides","volume":"58","author":"Bartlett","year":"2002","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.cbpc.2025.110289_bb0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/bdrc.20215","article-title":"Development of zebrafish epidermis","volume":"93","author":"Chang","year":"2011","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.cbpc.2025.110289_bb0020","doi-asserted-by":"crossref","first-page":"R1192","DOI":"10.1152\/ajpregu.90973.2008","article-title":"The transcription factor, glial cell missing 2, is involved in differentiation and functional regulation of H+-ATPase-rich cells in zebrafish (Danio rerio)","volume":"296","author":"Chang","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0025","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.chemosphere.2015.11.116","article-title":"Fate and transport of agriculturally applied fungicidal compounds, azoxystrobin and propiconazole","volume":"146","author":"Edwards","year":"2016","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.cbpc.2025.110289_bb0030","doi-asserted-by":"crossref","first-page":"16215","DOI":"10.1038\/s41598-017-16381-7","article-title":"Potassium regulation in medaka (Oryzias latipes) larvae acclimated to fresh water: passive uptake and active secretion by the skin cells","volume":"7","author":"Horng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2025.110289_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105703","article-title":"Vincristine exposure impairs skin keratinocytes, ionocytes, and lateral-line hair cells in developing zebrafish embryos","volume":"230","author":"Hung","year":"2021","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0040","first-page":"205","article-title":"Gill ionic transport, acid-base regulation, and nitrogen excretion","volume":"4","author":"Hwang","year":"2013","journal-title":"The physiology of fishes"},{"key":"10.1016\/j.cbpc.2025.110289_bb0045","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.envpol.2019.07.081","article-title":"Mitochondrial dysfunction, apoptosis and transcriptomic alterations induced by four strobilurins in zebrafish (Danio rerio) early life stages","volume":"253","author":"Jiang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110289_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106203","article-title":"Acute exposure to polystyrene nanoplastics impairs skin cells and ion regulation in zebrafish embryos","volume":"248","author":"Kantha","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116087","article-title":"Molecular mechanisms of developmental toxicities of azoxystrobin and pyraclostrobin toward zebrafish (Danio rerio) embryos: visualization of abnormal development using two transgenic lines","volume":"270","author":"Kim","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110289_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124980","article-title":"Developmental toxicity in embryo-larval zebrafish (Danio rerio) exposed to strobilurin fungicides (azoxystrobin and pyraclostrobin)","volume":"241","author":"Kumar","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2025.110289_bb0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1242\/jeb.091603","article-title":"The physiology of fish at low pH: the zebrafish as a model system","volume":"217","author":"Kwong","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2019.105263","article-title":"Silver nanoparticle exposure impairs ion regulation in zebrafish embryos","volume":"214","author":"Lee","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128051","article-title":"Exposure to copper nanoparticles impairs ion uptake, and acid and ammonia excretion by ionocytes in zebrafish embryos","volume":"261","author":"Lee","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2025.110289_bb0080","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.chemosphere.2018.05.146","article-title":"Developmental toxicity, oxidative stress and immunotoxicity induced by three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in zebrafish embryos","volume":"207","author":"Li","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2025.110289_bb0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.envpol.2019.04.122","article-title":"Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae","volume":"251","author":"Li","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110289_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17111783","article-title":"The control of calcium metabolism in zebrafish (Danio rerio)","volume":"17","author":"Lin","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cbpc.2025.110289_bb0095","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/322159","article-title":"Modification of morphology and function of integument mitochondria-rich cells in tilapia larvae (Oreochromis mossambicus) acclimated to ambient chloride levels","volume":"74","author":"Lin","year":"2001","journal-title":"Physiol. Biochem. Zool."},{"key":"10.1016\/j.cbpc.2025.110289_bb0100","doi-asserted-by":"crossref","first-page":"C371","DOI":"10.1152\/ajpcell.00281.2005","article-title":"Proton pump-rich cell secretes acid in skin of zebrafish larvae","volume":"290","author":"Lin","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139031","article-title":"Embryonic development and oxidative stress effects in the larvae and adult fish livers of zebrafish (Danio rerio) exposed to the strobilurin fungicides, kresoxim-methyl and pyraclostrobin","volume":"729","author":"Mao","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2025.110289_bb0110","doi-asserted-by":"crossref","first-page":"C1625","DOI":"10.1152\/ajpcell.00255.2008","article-title":"Ammonia excretion by the skin of zebrafish (Danio rerio) larvae","volume":"295","author":"Shih","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.cbpc.2025.110289_bb0115","doi-asserted-by":"crossref","first-page":"R84","DOI":"10.1152\/ajpregu.00318.2011","article-title":"Rhcg1 and NHE3b are involved in ammonium-dependent sodium uptake by zebrafish larvae acclimated to low-sodium water","volume":"302","author":"Shih","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0120","doi-asserted-by":"crossref","first-page":"R1130","DOI":"10.1152\/ajpregu.00550.2012","article-title":"Rhcg1 and Rhbg mediate ammonia excretion by ionocytes and keratinocytes in the skin of zebrafish larvae: H+-ATPase-linked active ammonia excretion by ionocytes","volume":"304","author":"Shih","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0125","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jhazmat.2009.10.084","article-title":"Occurrence and removal of fungicides in municipal sewage treatment plant","volume":"175","author":"Stamatis","year":"2010","journal-title":"J. Hazard. Mater."},{"year":"2021","series-title":"Pyraclostrobin \u2013 Proposed Interim Registration Review Decision (EPA-HQ-OPP-2014-0051)","author":"USEPA Office of Pesticide Programs","key":"10.1016\/j.cbpc.2025.110289_bb0130"},{"key":"10.1016\/j.cbpc.2025.110289_bb0135","doi-asserted-by":"crossref","first-page":"R1650","DOI":"10.1152\/ajpregu.00119.2009","article-title":"Role of SLC12A10.2, a Na-cl cotransporter-like protein, in a cl uptake mechanism in zebrafish (Danio rerio)","volume":"296","author":"Wang","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124490","article-title":"Pyraclostrobin induces developmental toxicity and cardiotoxicity through oxidative stress and inflammation in zebrafish embryos","volume":"358","author":"Wu","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110289_bb0145","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/jfb.12915","article-title":"Genome-wide identification of suitable zebrafish Danio rerio reference genes for normalization of gene expression data by RT-qPCR","volume":"88","author":"Xu","year":"2016","journal-title":"J. Fish Biol."},{"key":"10.1016\/j.cbpc.2025.110289_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116277","article-title":"Evaluation and comparison of the mitochondrial and developmental toxicity of three strobilurins in zebrafish embryo\/larvae","volume":"270","author":"Yang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110289_bb0155","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1021\/acs.est.8b04392","article-title":"Fungicides: an overlooked pesticide class?","volume":"53","author":"Zubrod","year":"2019","journal-title":"Environ. Sci. Technol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562500170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562500170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:25:52Z","timestamp":1754429152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153204562500170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":31,"alternative-id":["S153204562500170X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110289","relation":{},"ISSN":["1532-0456"],"issn-type":[{"type":"print","value":"1532-0456"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyraclostrobin disrupts ion regulation by suppressing mitochondrion-rich ionocyte differentiation in zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110289"}}