{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:22:20Z","timestamp":1784082140207,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.cbpc.2025.110347","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:18:42Z","timestamp":1757909922000},"page":"110347","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Neuroprotective effect of ferulic acid in valproic acid induced autism like behaviour in zebrafish via modulation of PI3K\/AKT\/mTOR pathway"],"prefix":"10.1016","volume":"299","author":[{"given":"Dhrita","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-6632","authenticated-orcid":false,"given":"Shamsher","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2025.110347_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.beproc.2012.10.014","article-title":"Exploratory behaviour in the open field test adapted for larval zebrafish: impact of environmental complexity","volume":"92","author":"Ahmad","year":"2013","journal-title":"Behav. Process."},{"issue":"5","key":"10.1016\/j.cbpc.2025.110347_bb0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2217\/epi-2023-0428","article-title":"Unlocking the epigenetic symphony: histone acetylation\u2019s impact on neurobehavioral change in neurodegenerative disorders","volume":"16","author":"Basavarajappa","year":"2024","journal-title":"Epigenomics"},{"issue":"4","key":"10.1016\/j.cbpc.2025.110347_bb0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11011-025-01579-w","article-title":"Protective mechanism of apigenin in proton pump inhibitor-associated progressive cognitive impairment in adult zebrafish via targeting GSK-3\u03b2 pathway","volume":"40","author":"Bhratee","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.cbpc.2025.110347_bb0020","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s00213-013-3340-1","article-title":"Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish","volume":"231","author":"Braida","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.cbpc.2025.110347_bb0025","series-title":"Zebrafish Neurobehavioral Protocols","first-page":"1","article-title":"Video-aided analysis of zebrafish locomotion and anxiety-related behavioral responses","author":"Cachat","year":"2011"},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2025.110347_bb0030","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1570-0232(02)00618-9","article-title":"Analytical methods to investigate glutathione and related compounds in biological and pathological processes","volume":"781","author":"Camera","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.cbpc.2025.110347_bb0035","article-title":"Exploring pathological targets and advancing pharmacotherapy in autism spectrum disorder: contributions of glial cells and heavy metals","author":"Chatterjee","year":"2025","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.cbpc.2025.110347_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ntt.2018.01.002","article-title":"Developmental and behavioral alterations in zebrafish embryonically exposed to valproic acid (VPA): an aquatic model for autism","volume":"66","author":"Chen","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"issue":"7","key":"10.1016\/j.cbpc.2025.110347_bb0045","first-page":"811","article-title":"Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies","volume":"9","author":"Dang","year":"2016","journal-title":"Dis. Model. Mech."},{"issue":"18","key":"10.1016\/j.cbpc.2025.110347_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/nu14183709","article-title":"Recent advances in the neuroprotective properties of ferulic acid in Alzheimer\u2019s disease: a narrative review","volume":"14","author":"Di Giacomo","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.cbpc.2025.110347_bb0055","doi-asserted-by":"crossref","first-page":"260","DOI":"10.30802\/AALAS-CM-22-000123","article-title":"Assessment of risperidone toxicity in zebrafish (Danio rerio) embryos","volume":"73","author":"Fukushima","year":"2023","journal-title":"Comp. Med."},{"issue":"6","key":"10.1016\/j.cbpc.2025.110347_bb0060","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1601-183X.2009.00488.x","article-title":"Acute and chronic alcohol dose: population differences in behavior and neurochemistry of zebrafish","volume":"8","author":"Gerlai","year":"2009","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.cbpc.2025.110347_bb0065","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0076-6879(07)00823-3","article-title":"Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization","volume":"440","author":"Giustarini","year":"2008","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.12655","article-title":"Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment","volume":"23","author":"Golpich","year":"2017","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cbpc.2025.110347_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12858-018-0097-5","article-title":"Simple spectrophotometric assay for measuring catalase activity in biological tissues","volume":"19","author":"Hadwan","year":"2018","journal-title":"BMC Biochem."},{"key":"10.1016\/j.cbpc.2025.110347_bb0085","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2016.08.011","article-title":"Ferulic acid exhibits antiepileptogenic effect and prevents oxidative stress and cognitive impairment in the kindling model of epilepsy","volume":"179","author":"Hassanzadeh","year":"2017","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0090","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"issue":"Suppl. 1","key":"10.1016\/j.cbpc.2025.110347_bb0095","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.21037\/tp.2019.09.09","article-title":"Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation","volume":"9","author":"Hodges","year":"2020","journal-title":"Transl. Pediatr."},{"key":"10.1016\/j.cbpc.2025.110347_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146675","article-title":"Prenatal exposure to valproic acid reduces social responses and alters mRNA levels of opioid receptor and pre-pro-peptide in discrete brain regions of adolescent and adult male rats","volume":"1732","author":"Hughes","year":"2020","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2013.12.002","article-title":"Zebrafish as an emerging model for studying complex brain disorders","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cbpc.2025.110347_bb0115","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2022.07.004","article-title":"AlCl(3) induced learning and memory deficit in zebrafish","volume":"92","author":"Kaur","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.cbpc.2025.110347_bb0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuro.2022.07.004","article-title":"AlCl3 induced learning and memory deficit in zebrafish","volume":"92","author":"Kaur","year":"2022","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0125","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41380-024-02725-z","article-title":"The multifaceted role of mitochondria in autism spectrum disorder","volume":"30","author":"Khaliulin","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pharep.2013.06.012","article-title":"Oral dosing in adult zebrafish: proof-of-concept using pharmacokinetics and pharmacological evaluation of carbamazepine","volume":"66","author":"Kulkarni","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.cbpc.2025.110347_bb0135","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.btre.2014.09.002","article-title":"Potential applications of ferulic acid from natural sources","volume":"4","author":"Kumar","year":"2014","journal-title":"Biotechnol. Rep. (Amst.)"},{"key":"10.1016\/j.cbpc.2025.110347_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.cbpc.2025.110347_bb0145","doi-asserted-by":"crossref","first-page":"800","DOI":"10.24272\/j.issn.2095-8137.2021.251","article-title":"Understanding autism spectrum disorders with animal models: applications, insights, and perspectives","volume":"42","author":"Li","year":"2021","journal-title":"Zool. Res."},{"key":"10.1016\/j.cbpc.2025.110347_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2023.109783","article-title":"The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model","volume":"275","author":"Li","year":"2024","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2025.110347_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2016.00201","article-title":"Social preference deficits in juvenile zebrafish induced by early chronic exposure to sodium valproate","volume":"10","author":"Liu","year":"2016","journal-title":"Front. Behav. Neurosci."},{"issue":"6","key":"10.1016\/j.cbpc.2025.110347_bb0160","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3109\/10715769809065821","article-title":"Measurement of lipid peroxidation","volume":"28","author":"Moore","year":"1998","journal-title":"Free Radic. Res."},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0165","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/nu16020294","article-title":"Improving the effect of Ferulic acid on inflammation and insulin resistance by regulating the JNK\/ERK and NF-\u03baB pathways in TNF-\u03b1-treated 3T3-L1 adipocytes","volume":"16","author":"Park","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.cbpc.2025.110347_bb0175","series-title":"StatPearls","article-title":"Valproic acid","author":"Rahman","year":"2024"},{"issue":"14","key":"10.1016\/j.cbpc.2025.110347_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147688","article-title":"Short- and long-term neurobehavioral effects of developmental exposure to valproic acid in zebrafish","volume":"25","author":"Ricarte","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jaac.2011.11.010","article-title":"Effects of risperidone and parent training on adaptive functioning in children with pervasive developmental disorders and serious behavioral problems","volume":"51","author":"Scahill","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.cbpc.2025.110347_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.1019368","article-title":"Zebrafish aversion to infrasound in an open field test","volume":"16","author":"Scatterty","year":"2023","journal-title":"Front. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.cbpc.2025.110347_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jmau.2015.12.002","article-title":"Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide","volume":"4","author":"Shaibah","year":"2016","journal-title":"J. Microsc. Ultrastruct."},{"issue":"2","key":"10.1016\/j.cbpc.2025.110347_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ph11020056","article-title":"Inflammation and neuro-immune dysregulations in autism spectrum disorders","volume":"11","author":"Siniscalco","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0205","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nprot.2010.165","article-title":"Embedding, serial sectioning and staining of zebrafish embryos using JB-4 resin","volume":"6","author":"Sullivan-Brown","year":"2011","journal-title":"Nat. Protoc."},{"issue":"17","key":"10.1016\/j.cbpc.2025.110347_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713446","article-title":"Duality of valproic acid effects on inflammation, oxidative stress and autophagy in human eosinophilic cells","volume":"24","author":"Uzel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.cbpc.2025.110347_bb0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.eplepsyres.2007.11.005","article-title":"Increased oxidative stress in epileptic children treated with valproic acid","volume":"78","author":"Verrotti","year":"2008","journal-title":"Epilepsy Res."},{"issue":"1","key":"10.1016\/j.cbpc.2025.110347_bb0220","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nprot.2009.197","article-title":"Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue","volume":"5","author":"Weydert","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cbpc.2025.110347_bb0225","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/978-1-61779-328-8_27","article-title":"Determination of neurotransmitter levels in models of Parkinson\u2019s disease by HPLC-ECD","volume":"793","author":"Yang","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.cbpc.2025.110347_bb0230","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.stemcr.2017.04.006","article-title":"PI3K\/AKT\/mTOR signaling mediates valproic acid-induced neuronal differentiation of neural stem cells through epigenetic modifications","volume":"8","author":"Zhang","year":"2017","journal-title":"Stem Cell Rep."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625002285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625002285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T07:37:07Z","timestamp":1780126627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045625002285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"alternative-id":["S1532045625002285"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110347","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective effect of ferulic acid in valproic acid induced autism like behaviour in zebrafish via modulation of PI3K\/AKT\/mTOR pathway","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110347","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110347"}}