{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:22:10Z","timestamp":1788236530573,"version":"build-2803163510"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-02216962"],"award-info":[{"award-number":["RS-2025-02216962"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-23323645"],"award-info":[{"award-number":["RS-2025-23323645"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2025-00557121"],"award-info":[{"award-number":["RS-2025-00557121"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2025-25400201"],"award-info":[{"award-number":["RS-2025-25400201"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2022R1I1A1A01053162"],"award-info":[{"award-number":["2022R1I1A1A01053162"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.cbpc.2025.110393","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:14:56Z","timestamp":1763648096000},"page":"110393","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Developmental hepatotoxicity induced by flusilazole in zebrafish: Mechanistic insights into mitochondrial dysfunction, oxidative stress, ferroptosis, and regenerative impairment"],"prefix":"10.1016","volume":"300","author":[{"given":"Hojun","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisoo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garam","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Min","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwonhwa","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whasun","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunwoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2025.110393_bb0005","first-page":"181","article-title":"Ultrastructure and arrangement of hepatocyte cords in the duckling\u2019s liver","volume":"150","author":"Abdelwahab","year":"1987","journal-title":"J. Anat."},{"key":"10.1016\/j.cbpc.2025.110393_bb0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cotox.2018.10.003","article-title":"Lipid peroxidation derived reactive aldehydes in alcoholic liver disease","volume":"13","author":"Ali","year":"2019","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.cbpc.2025.110393_bb0015","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s12276-023-01137-3","article-title":"Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy","volume":"56","author":"An","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cbpc.2025.110393_bb0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13273-025-00521-6","article-title":"Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases","volume":"21","author":"An","year":"2025","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0025","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/JPER.17-0716","article-title":"The role of caspase-8, caspase-9, and apoptosis inducing factor in periodontal disease","volume":"90","author":"Aral","year":"2019","journal-title":"J. Periodontol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0030","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.cbpc.2025.110393_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2025.121092","article-title":"Triazoles in the environment: An update on occurrence, fate, health hazards, and removal techniques","volume":"271","author":"Bian","year":"2025","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbpc.2025.110393_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2210-8-8","article-title":"Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line","volume":"8","author":"Bopp","year":"2008","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.cbpc.2025.110393_bb0050","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199814","article-title":"Signalling pathways and transcriptional regulators orchestrating liver development and cancer","volume":"148","author":"Campbell","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2025.110393_bb0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.stem.2019.11.001","article-title":"Broad distribution of hepatocyte proliferation in liver homeostasis and regeneration","volume":"26","author":"Chen","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cbpc.2025.110393_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in Ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0065","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.10.003","article-title":"Unexpected role of ceruloplasmin in intestinal iron absorption","volume":"2","author":"Cherukuri","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.cbpc.2025.110393_bb0070","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1053\/j.gastro.2013.10.019","article-title":"Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish","volume":"146","author":"Choi","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbpc.2025.110393_bb0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.121637","article-title":"The widespread presence of triazole fungicides in greenhouse soils in Shandong Province, China: a systematic study on human health and ecological risk assessments","volume":"328","author":"Dong","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110393_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113309","article-title":"In vitro and in vivo endocrine disrupting effects of the azole fungicides triticonazole and flusilazole","volume":"255","author":"Draskau","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110393_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128468","article-title":"Transcriptome analysis of fetal rat testis following intrauterine exposure to the azole fungicides triticonazole and flusilazole reveals subtle changes despite adverse endocrine effects","volume":"264","author":"Draskau","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2025.110393_bb0095","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.toxlet.2014.11.020","article-title":"A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine a, amiodarone and acetaminophen","volume":"232","author":"Driessen","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2025.110393_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106322","article-title":"Transcriptome analysis reveals hepatotoxicity in zebrafish induced by cyhalofop-butyl","volume":"252","author":"Duan","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0105","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1038\/s41467-021-23752-2","article-title":"Targeted PI3K\/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia","volume":"12","author":"Ecker","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbpc.2025.110393_bb0110","doi-asserted-by":"crossref","first-page":"1226044","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0115","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400313R","article-title":"Mitochondrial membrane potential and oxidative stress interact to regulate Oma1-dependent processing of Opa1 and mitochondrial dynamics","volume":"38","author":"Fogo","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.cbpc.2025.110393_bb0120","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2025.110393_bb0125","doi-asserted-by":"crossref","first-page":"6802782","DOI":"10.1155\/2023\/6802782","article-title":"Health risk assessment of pesticide residues in drinking Water of upper Jhelum region in Kashmir Valley-India by GC-MS\/MS","volume":"2023","author":"Ganaie","year":"2023","journal-title":"Int J Anal Chem"},{"key":"10.1016\/j.cbpc.2025.110393_bb0130","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.ajpath.2018.03.008","article-title":"Understanding liver regeneration: from mechanisms to regenerative medicine","volume":"188","author":"Gilgenkrantz","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0135","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jhep.2015.06.015","article-title":"Structural and functional hepatocyte polarity and liver disease","volume":"63","author":"Gissen","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0140","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1053\/j.gastro.2015.08.034","article-title":"Zebrafish: an important tool for liver disease research","volume":"149","author":"Goessling","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cbpc.2025.110393_bb0145","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1530\/JME-15-0313","article-title":"Regulation of liver development: implications for liver biology across the lifespan","volume":"56","author":"Gruppuso","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature10400","article-title":"Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis","volume":"477","author":"Gunther","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2025.110393_bb0155","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s10661-024-13170-4","article-title":"Health risk assessment of triazole fungicides around a pesticide factory in China","volume":"196","author":"Guo","year":"2024","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.cbpc.2025.110393_bb0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/mnfr.200700527","article-title":"Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics\/redox state","volume":"53","author":"Hail","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.cbpc.2025.110393_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155187","article-title":"Fraxetin reduces endometriotic lesions through activation of ER stress, induction of mitochondria-mediated apoptosis, and generation of ROS","volume":"123","author":"Ham","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbpc.2025.110393_bb0170","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1089\/ars.2011.4123","article-title":"Redox regulation of mitochondrial function","volume":"16","author":"Handy","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpc.2025.110393_bb0175","doi-asserted-by":"crossref","first-page":"9666","DOI":"10.1073\/pnas.171301998","article-title":"p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD","volume":"98","author":"Harada","year":"2001","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.cbpc.2025.110393_bb0180","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/toxsci\/kfs092","article-title":"Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure","volume":"127","author":"Hermsen","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2025.110393_bb0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/9781118102138.ch8","article-title":"Hepatotoxicity testing in larval zebrafish","author":"Hill","year":"2011","journal-title":"Zebrafish"},{"key":"10.1016\/j.cbpc.2025.110393_bb0190","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s13273-024-00436-8","article-title":"Tolylfluanid induces developmental toxicity via liver dysfunction in zebrafish embryos","volume":"20","author":"Hong","year":"2024","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0195","article-title":"Evaluation of organ developmental toxicity of environmental toxicants using zebrafish embryos","volume":"47","author":"Hong","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cbpc.2025.110393_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136364","article-title":"Propanil impairs organ development in zebrafish by inducing apoptosis and inhibiting mitochondrial respiration","volume":"480","author":"Hong","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2025.110393_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2023.105452","article-title":"Exposure to the fungicide prothioconazole and its metabolite prothioconazole-desthio induced hepatic metabolism disorder and oxidative stress in mice","volume":"193","author":"Hu","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ydbio.2007.05.028","article-title":"The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis","volume":"308","author":"Hunter","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0215","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4161\/org.4.3.6849","article-title":"Early developmental influences on hepatic organogenesis","volume":"4","author":"Hyatt","year":"2008","journal-title":"Organogenesis"},{"key":"10.1016\/j.cbpc.2025.110393_bb0220","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/bmc.3634","article-title":"Simultaneous detection of fluquinconazole and flusilazole in lettuce using gas chromatography with a nitrogen phosphorus detector: decline patterns at two different locations","volume":"30","author":"Im","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.cbpc.2025.110393_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112155","article-title":"Investigation of steatosis profiles induced by pesticides using liver organ-on-chip model and omics analysis","volume":"152","author":"Jellali","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2023.149182","article-title":"Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish","volume":"686","author":"Jin","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2025.110393_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104998","article-title":"Flusilazole-induced damage to SerW3 cells via cytotoxicity, oxidative stress and lipid metabolism: An in vitro study","volume":"180","author":"Karacaoglu","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.109993","article-title":"Flusilazole induced developmental toxicity, neurotoxicity, and cardiovascular toxicity via apoptosis and oxidative stress in zebrafish","volume":"284","author":"Lee","year":"2024","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"10.1016\/j.cbpc.2025.110393_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.176441","article-title":"Resmethrin induces implantation failure by disrupting calcium homeostasis and forcing mitochondrial defects in porcine trophectoderm and uterine luminal epithelial cells","volume":"954","author":"Lee","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2025.110393_bb0250","first-page":"1271","article-title":"Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development","volume":"6","author":"Liu","year":"2013","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.cbpc.2025.110393_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ma13245729","article-title":"Multi-walled carbon nanotubes for magnetic solid-phase extraction of six heterocyclic pesticides in environmental water samples followed by HPLC-DAD determination","volume":"13","author":"Ma","year":"2020","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.cbpc.2025.110393_bb0260","doi-asserted-by":"crossref","first-page":"27775","DOI":"10.1021\/acs.jafc.4c06923","article-title":"Stereoselective in vitro metabolism, hepatotoxicity, and cytotoxic effects of four enantiomers of the fungicide Propiconazole","volume":"72","author":"Ma","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2025.110393_bb0265","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.bbabio.2007.10.013","article-title":"The polypeptides COX2A and COX2B are essential components of the mitochondrial cytochrome c oxidase of toxoplasma gondii","volume":"1777","author":"Morales-Sainz","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2025.110393_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020356","article-title":"Cell imaging counting as a novel ex vivo approach for investigating drug-induced hepatotoxicity in zebrafish larvae","volume":"18","author":"Nguyen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2025.110393_bb0275","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1074\/jbc.RA119.009548","article-title":"Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1","volume":"295","author":"Nishizawa","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2025.110393_bb0280","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163929","article-title":"Biliary epithelial cells are facultative liver stem cells during liver regeneration in adult zebrafish","volume":"8","author":"Oderberg","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.cbpc.2025.110393_bb0285","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1089\/ars.2019.7962","article-title":"Mitochondrial superoxide dismutase: what the established, the intriguing, and the novel reveal about a key cellular redox switch","volume":"32","author":"Palma","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cbpc.2025.110393_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106105","article-title":"Transcriptomic and physiological analysis of endocrine disrupting chemicals impacts on 3D zebrafish liver cell culture system","volume":"245","author":"Park","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0295","article-title":"Analysis of mitochondrial membrane potential, ROS, and calcium","volume":"48","author":"Park","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cbpc.2025.110393_bb0300","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41392-024-02080-z","article-title":"Cyclin-dependent protein kinases and cell cycle regulation in biology and disease","volume":"10","author":"Pellarin","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cbpc.2025.110393_bb0305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1749-6632.2010.05634.x","article-title":"Oxidative stress caused by mitochondrial calcium overload","volume":"1201","author":"Peng","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.cbpc.2025.110393_bb0310","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","article-title":"Liver immunology and its role in inflammation and homeostasis","volume":"13","author":"Robinson","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0315","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6346-1_2","article-title":"Mitochondrial membrane potential assay","volume":"1473","author":"Sakamuru","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2021.106396","article-title":"In situ self-assembled coating of surfactant-mixed metal hydroxide on Fe3O4@ SiO2 magnetic composite for dispersive solid phase microextraction prior to HPLC analysis of triazole fungicides","volume":"168","author":"Seebunrueng","year":"2021","journal-title":"Microchem. J."},{"key":"10.1016\/j.cbpc.2025.110393_bb0325","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cbpc.2025.110393_bb0330","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s13273-025-00534-1","article-title":"Environmental and toxicological effects of carbamate pesticides on zebrafish embryogenesis","volume":"21","author":"Seomoon","year":"2025","journal-title":"Molecular & Cellular Toxicology"},{"key":"10.1016\/j.cbpc.2025.110393_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/cells12182246","article-title":"Zebrafish as a useful model system for human liver disease","volume":"12","author":"Shimizu","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.cbpc.2025.110393_bb0340","doi-asserted-by":"crossref","first-page":"55863","DOI":"10.18632\/oncotarget.10150","article-title":"Cytoplasmic vacuolization in cell death and survival","volume":"7","author":"Shubin","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cbpc.2025.110393_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155383","article-title":"Osthole impairs mitochondrial metabolism and the autophagic flux in colorectal cancer","volume":"125","author":"Song","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.cbpc.2025.110393_bb0350","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s12032-011-9989-6","article-title":"A potential role for the homeoprotein Hhex in hepatocellular carcinoma progression","volume":"29","author":"Su","year":"2012","journal-title":"Med. Oncol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0355","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev-biophys-092622-094853","article-title":"Mitochondrial ion channels","volume":"52","author":"Szabo","year":"2023","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.cbpc.2025.110393_bb0360","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3892\/ijo.2013.1843","article-title":"Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis","volume":"42","author":"Tan","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0365","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s41232-016-0025-2","article-title":"Liver regeneration and fibrosis after inflammation","volume":"36","author":"Tanaka","year":"2016","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.cbpc.2025.110393_bb0370","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s13311-020-00929-z","article-title":"FTH1 inhibits Ferroptosis through Ferritinophagy in the 6-OHDA model of Parkinson\u2019s disease","volume":"17","author":"Tian","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cbpc.2025.110393_bb0375","doi-asserted-by":"crossref","first-page":"55001","DOI":"10.1289\/EHP7484","article-title":"Trends in agricultural Triazole fungicide use in the United States, 1992-2016 and possible implications for antifungal-resistant Fungi in human disease","volume":"129","author":"Toda","year":"2021","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbpc.2025.110393_bb0380","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/s42003-024-07357-1","article-title":"Enhancement of adult liver regeneration in mice through the hepsin-mediated epidermal growth factor receptor signaling pathway","volume":"7","author":"Tsai","year":"2024","journal-title":"Commun Biol"},{"key":"10.1016\/j.cbpc.2025.110393_bb0385","first-page":"177","article-title":"Pesticide exposure and liver cancer: a review","volume":"28","author":"VoPham","year":"2017","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.cbpc.2025.110393_bb0390","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-genet-102108-134850","article-title":"The role of mitochondria in apoptosis*","volume":"43","author":"Wang","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cbpc.2025.110393_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120806","article-title":"Joint toxic effects of thiamethoxam and flusilazole on the adult worker honey bees (Apis mellifera L.)","volume":"317","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110393_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127479","article-title":"New insights into potential estrogen agonistic activity of triazole fungicides and coupled metabolic disturbance","volume":"424","author":"Wang","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2025.110393_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122182","article-title":"New insights into triazole fungicide-caused hematopoietic abnormality in zebrafish based on GRalpha screening developmental toxicity","volume":"334","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2025.110393_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.160286","article-title":"Environmental exposure to triazole fungicide causes left-right asymmetry defects and contributes to abnormal heart development in zebrafish embryos by activating PPARgamma-coupled Wnt\/beta-catenin signaling pathway","volume":"859","author":"Wang","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2025.110393_bb0415","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s42003-021-02564-6","article-title":"The multiple mechanisms of MCL1 in the regulation of cell fate","volume":"4","author":"Widden","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.cbpc.2025.110393_bb0420","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cbpc.2025.110393_bb0425","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3960\/jslrt.22023","article-title":"Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma","volume":"62","author":"Yano","year":"2022","journal-title":"J. Clin. Exp. Hematop."},{"key":"10.1016\/j.cbpc.2025.110393_bb0430","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-022-05027-w","article-title":"TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cbpc.2025.110393_bb0435","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00128-011-0203-5","article-title":"Residue and dissipation dynamics of flusilazole in apple and soil","volume":"86","author":"Yu","year":"2011","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0440","article-title":"Mitochondrial ca(2+) homeostasis: emerging roles and clinical significance in cardiac remodeling","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2025.110393_bb0445","article-title":"A dual role of HGF-ERK signaling in IL6\/HGF-induced hepatocyte proliferation","volume":"19","author":"Zhang","year":"2025","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cbpc.2025.110393_bb0450","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625002741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045625002741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:00:34Z","timestamp":1768744834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045625002741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":90,"alternative-id":["S1532045625002741"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110393","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental hepatotoxicity induced by flusilazole in zebrafish: Mechanistic insights into mitochondrial dysfunction, oxidative stress, ferroptosis, and regenerative impairment","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2025.110393","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110393"}}