{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:16:36Z","timestamp":1778818596685,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006250","name":"Southwest University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.cbpc.2026.110544","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:11:23Z","timestamp":1775898683000},"page":"110544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genome-wide identification and single-cell transcriptomic analysis of the mcm gene family in zebrafish reveals its role in TCDD-induced reproductive toxicity"],"prefix":"10.1016","volume":"306","author":[{"given":"Wenbo","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manting","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110544_bb0005","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvaa010","article-title":"TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads","volume":"6","author":"Akemann","year":"2020","journal-title":"Environ. Epigenet."},{"key":"10.1016\/j.cbpc.2026.110544_bb0010","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0015","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1021\/acschembio.9b00255","article-title":"Sensor I regulated ATPase activity of FleQ is essential for motility to biofilm transition in pseudomonas aeruginosa","volume":"14","author":"Banerjee","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0020","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1074\/mcp.M115.048991","article-title":"Quantitative proteomics reveals dynamic interactions of the minichromosome maintenance complex (MCM) in the cellular response to etoposide induced DNA damage*","volume":"14","author":"Drissi","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.cbpc.2026.110544_bb0025","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1080\/15384101.2018.1553336","article-title":"Destabilization of the MiniChromosome maintenance (MCM) complex modulates the cellular response to DNA double strand breaks","volume":"17","author":"Drissi","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cbpc.2026.110544_bb0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/MMBR.68.1.109-131.2004","article-title":"Eukaryotic MCM proteins: beyond replication initiation","volume":"68","author":"Forsburg","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.cbpc.2026.110544_bb0035","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jbiotec.2020.12.010","article-title":"Comparative genomic analysis reveals evolutionary and structural attributes of MCM gene family in arabidopsis thaliana and oryza sativa","volume":"327","author":"Gill","year":"2021","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-24643-1","article-title":"The nanos1 gene was duplicated in early vertebrates and the two paralogs show different gonadal expression profiles in a shark","volume":"8","author":"Gribouval","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110544_bb0045","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac060","article-title":"Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq","volume":"1","author":"Haimbaugh","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.cbpc.2026.110544_bb0050","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.3390\/ijms20215346","article-title":"Functional comparison of human and zebra fish FKBP52 confirms the importance of the proline-rich loop for regulation of steroid hormone receptor activity","volume":"20","author":"Harris","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110544_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106737","article-title":"Molecular functions of MCM8 and MCM9 and their associated pathologies","volume":"26","author":"Helderman","year":"2023","journal-title":"Iscience"},{"key":"10.1016\/j.cbpc.2026.110544_bb0060","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/bioinformatics\/btu817","article-title":"GSDS 2.0: an upgraded gene feature visualization server","volume":"31","author":"Hu","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbpc.2026.110544_bb0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gene.2013.01.054","article-title":"Identification, quantification, and evolutionary analysis of a novel isoform of MCM9","volume":"519","author":"Jeffries","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.cbpc.2026.110544_bb0070","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.reprotox.2020.02.008","article-title":"Dioxin male rat reproductive toxicity mode of action and relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran characterized by fetal pituitary and testis transcriptome profiling","volume":"93","author":"Johnson","year":"2020","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0075","article-title":"The evidence of in-vivo and in-vitro studies on microplastic and nano plastic toxicity in mammals: a possible threat for an upcoming generation?","volume":"132","author":"Kauts","year":"2023","journal-title":"Phys. Chem. Earth. A\/B\/C\/"},{"key":"10.1016\/j.cbpc.2026.110544_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109402","article-title":"Characterization of type II IFNs and their receptors in a cyprinid fish, the blunt snout bream megalobrama amblycephala","volume":"146","author":"Li","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0085","article-title":"The characteristics of aminotransferases gene family in ruditapes philippinarum and its response to salinity stresses","volume":"290","author":"Liu","year":"2025","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbd.2025.101436","article-title":"Genome-wide identification of aquaporin and their potential role in osmotic pressure regulation in ruditapes philippinarum","volume":"54","author":"Liu","year":"2025","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"10.1016\/j.cbpc.2026.110544_bb0095","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein\u2013ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104957","article-title":"Ercc2\/xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress","volume":"25","author":"Ma","year":"2022","journal-title":"Iscience"},{"key":"10.1016\/j.cbpc.2026.110544_bb0105","article-title":"CDD\/SPARCLE: functional classification of proteins via subfamily domain architectures","volume":"45","author":"Marchler-Bauer","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0110","series-title":"Characterization of MCM8\/9 in DNA Repair","author":"McKinzey","year":"2023"},{"key":"10.1016\/j.cbpc.2026.110544_bb0115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.toxlet.2011.09.019","article-title":"Direct and indirect impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on adult mouse Leydig cells: an in vitro study","volume":"207","author":"Naville","year":"2011","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2026.110544_bb0120","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s10695-024-01360-3","article-title":"Messenger RNA transcription levels of neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex components in the olfactory nerve system of the anadromous pacific salmon, masu salmon oncorhynchus masou","volume":"50","author":"Ogihara","year":"2024","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpc.2026.110544_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009462","article-title":"The etiology of down syndrome: maternal MCM9 polymorphisms increase risk of reduced recombination and nondisjunction of chromosome 21 during meiosis I within oocyte","volume":"17","author":"Pal","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbpc.2026.110544_bb0130","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1210\/en.2004-1454","article-title":"Minireview: transcriptional regulation of gonadal development and differentiation","volume":"146","author":"Park","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.cbpc.2026.110544_bb0135","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky448","article-title":"HMMER web server: 2018 update","volume":"46","author":"Potter","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.851719","article-title":"Single cell transcriptome sequencing of zebrafish testis revealed novel spermatogenesis marker genes and stronger Leydig-germ cell paracrine interactions","volume":"13","author":"Qian","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.cbpc.2026.110544_bb0145","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1101\/gr.150466.112","article-title":"Complex expression dynamics and robustness in C. elegans insulin networks","volume":"23","author":"Ritter","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0150","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/taap.1998.8388","article-title":"Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: ah receptor and ARNT expression, CYP1A1 induction, and ah receptor down-regulation","volume":"150","author":"Roman","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2023.107360","article-title":"Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on Holstein bull testis after sexual maturity","volume":"258","author":"Sahlu","year":"2023","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.cbpc.2026.110544_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.137515","article-title":"Single-cell RNA sequencing reveals tissue-specific transcriptomic changes induced by perfluorooctanesulfonic acid (PFOS) in larval zebrafish (Danio rerio)","volume":"489","author":"Satbhai","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110544_bb0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41559-021-01580-3","article-title":"Gene family evolution underlies cell-type diversification in the hypothalamus of teleosts","volume":"6","author":"Shafer","year":"2021","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0170","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/ijms22010278","article-title":"Disruption of Abcc6 transporter in zebrafish causes ocular calcification and cardiac fibrosis","volume":"22","author":"Sun","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110544_bb0175","doi-asserted-by":"crossref","first-page":"18085","DOI":"10.1021\/acsnano.4c06298","article-title":"MicroRNA and gut microbiota alter intergenerational effects of paternal exposure to polyethylene nanoplastics","volume":"18","author":"Sun","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.cbpc.2026.110544_bb0180","article-title":"Conformational ensembles of the human intrinsically disordered proteome: bridging chain compaction with function and sequence conservation","author":"Tesei","year":"2023","journal-title":"Biorxiv"},{"key":"10.1016\/j.cbpc.2026.110544_bb0185","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/bs.apcsb.2018.11.005","article-title":"Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: a computational approach","author":"Thirumal Kumar","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0190","doi-asserted-by":"crossref","DOI":"10.1007\/s10875-024-01653-5","article-title":"Impaired STING activation due to a variant in the E3 ubiquitin ligase AMFR in a patient with severe VZV infection and hemophagocytic lymphohistiocytosis","volume":"44","author":"Thomsen","year":"2024","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/B978-0-12-409548-9.11758-0","article-title":"Developmental and reproductive toxicity of TCDD, lead and mercury","author":"Thorsrud","year":"2019","journal-title":"Encycl. Environ. Health"},{"key":"10.1016\/j.cbpc.2026.110544_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008514","article-title":"An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs","volume":"15","author":"Tian","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cbpc.2026.110544_bb0205","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molcel.2015.07.010","article-title":"MCM9 is required for mammalian DNA mismatch repair","volume":"59","author":"Traver","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cbpc.2026.110544_bb0210","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s11103-011-9836-3","article-title":"Plant MCM proteins: role in DNA replication and beyond","volume":"77","author":"Tuteja","year":"2011","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0215","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.biochem.68.1.649","article-title":"MCM proteins in DNA replication","volume":"68","author":"Tye","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cbpc.2026.110544_bb0220","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1248\/jhs.47.136","article-title":"Proteome analysis of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine testicular Leydig and Sertoli cells","volume":"47","author":"Uchida","year":"2001","journal-title":"J. Health Sci."},{"key":"10.1016\/j.cbpc.2026.110544_bb0225","article-title":"The conserved domain database in 2023","volume":"51","author":"Wang","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110544_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2017.00013","article-title":"Gap junction in the teleost fish lineage: duplicated connexins may contribute to skin pattern formation and body shape determination","volume":"5","author":"Watanabe","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0235","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2091-14-5","article-title":"Expression, purification and biochemical characterization of schizosaccharomyces pombe Mcm4, 6 and 7","volume":"14","author":"Xu","year":"2013","journal-title":"BMC Biochem."},{"key":"10.1016\/j.cbpc.2026.110544_bb0240","doi-asserted-by":"crossref","DOI":"10.1186\/s12935-022-02580-4","article-title":"Technique integration of single-cell RNA sequencing with spatially resolved transcriptomics in the tumor microenvironment","volume":"22","author":"Yan","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cbpc.2026.110544_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.crstbi.2025.100170","article-title":"Expose flexible conformations for intrinsically disordered protein","volume":"10","author":"Yang","year":"2025","journal-title":"Curr. Res. Struct. Biol."},{"key":"10.1016\/j.cbpc.2026.110544_bb0250","article-title":"Endoderm jagged induces liver and pancreas duct lineage in zebrafish","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cbpc.2026.110544_bb0255","doi-asserted-by":"crossref","DOI":"10.1007\/s10875-024-01735-4","article-title":"A novel homozygous RHOH variant associated with T cell dysfunction and recurrent opportunistic infections","volume":"44","author":"Zhou","year":"2024","journal-title":"J. Clin. Immunol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:59:42Z","timestamp":1778817582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153204562600102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":51,"alternative-id":["S153204562600102X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110544","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide identification and single-cell transcriptomic analysis of the mcm gene family in zebrafish reveals its role in TCDD-induced reproductive toxicity","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110544"}}