{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:32:30Z","timestamp":1789475550078,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515240032"],"award-info":[{"award-number":["2024A1515240032"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hainan Province","doi-asserted-by":"publisher","award":["326MS0349"],"award-info":[{"award-number":["326MS0349"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["CARS-48-21"],"award-info":[{"award-number":["CARS-48-21"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2026LH01"],"award-info":[{"award-number":["2026LH01"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025D04J0030"],"award-info":[{"award-number":["2025D04J0030"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018565","name":"South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019651","name":"Southern Marine Science and Engineering Guangdong Laboratory","doi-asserted-by":"publisher","award":["SML2024SP003"],"award-info":[{"award-number":["SML2024SP003"]}],"id":[{"id":"10.13039\/501100019651","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbpc.2026.110575","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:47:27Z","timestamp":1778813247000},"page":"110575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Perlucin, a novel C-type lectin from the mud crab Scylla paramamosain, modulates innate immunity and enhances tolerance to Vibrio parahaemolyticus infection and ammonia stress"],"prefix":"10.1016","volume":"307","author":[{"given":"Chang-Hong","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Gang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cbpc.2026.110575_bb0005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/fsim.1996.0029","article-title":"Lectins as defence molecules in vertebrates and invertebrates","volume":"6","author":"Arason","year":"1996","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fsi.2020.05.046","article-title":"A typical C-type lectin, perlucin-like protein, is involved in the innate immune defense of whiteleg shrimp Litopenaeus vannamei","volume":"103","author":"Bi","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110575_bb0015","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2818.2003.01263.x","article-title":"The nacre protein perlucin nucleates growth of calcium carbonate crystals","volume":"212","author":"Blank","year":"2003","journal-title":"J. Microsc."},{"issue":"6","key":"10.1016\/j.cbpc.2026.110575_bb0020","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41577-018-0004-8","article-title":"C-type lectins in immunity and homeostasis","volume":"18","author":"Brown","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0025","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fsi.2019.07.076","article-title":"Characterization of the innate immunity in the mud crab Scylla paramamosain","volume":"93","author":"Chen","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fsi.2020.07.061","article-title":"Effects of Vibrio parahaemolyticus infection on physiological response, histopathology and transcriptome changes in the mud crab (Scylla paramamosain)","volume":"106","author":"Cheng","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ecoenv.2019.04.033","article-title":"Ammonia toxicity in the mud crab (Scylla paramamosain): the mechanistic insight from physiology to transcriptome analysis","volume":"179","author":"Cheng","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110575_bb0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/fsim.2001.0363","article-title":"The virulence of Enterococcus to freshwater prawn Macrobrachium rosenbergii and its immune resistance under ammonia stress","volume":"12","author":"Cheng","year":"2002","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110575_bb0045","first-page":"210","article-title":"Toll-like receptors: an overview from invertebrates to vertebrates","volume":"8","author":"Coscia","year":"2011","journal-title":"Invertebr. Surviv. J."},{"key":"10.1016\/j.cbpc.2026.110575_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2014.12.002","article-title":"C-type lectins in immunity: recent developments","volume":"32","author":"Dambuza","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0055","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.sbi.2015.06.003","article-title":"Recent insights into structures and functions of C-type lectins in the immune system","volume":"34","author":"Drickamer","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0060","doi-asserted-by":"crossref","first-page":"1119574","DOI":"10.3389\/fimmu.2023.1119574","article-title":"Antimicrobial peptides immune modulation role in intracellular bacterial infection","volume":"14","author":"Duarte-Mata","year":"2023","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.cbpc.2026.110575_bb0065","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/ni1102-1033","article-title":"Bacterial strategies for overcoming host innate and adaptive immune responses","volume":"3","author":"Hornef","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0070","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.fsi.2016.08.025","article-title":"Immunological characterization and expression of lily-type lectin in response to environmental stress in turbot (Scophthalmus maximus)","volume":"58","author":"Huang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.cbpc.2026.110575_bb0075","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jaci.2010.01.058","article-title":"Identification and functions of pattern-recognition receptors","volume":"125","author":"Kumagai","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110575_bb0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dci.2014.04.014","article-title":"Identification of a C-type lectin with antiviral and antibacterial activity from pacific white shrimp Litopenaeus vannamei","volume":"46","author":"Li","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0085","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2-\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cbpc.2026.110575_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108621","article-title":"A novel C-type lectin for Litopenaeus vannamei involved in the innate immune response against Vibrio infection","volume":"135","author":"Luo","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.cbpc.2026.110575_bb0095","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","article-title":"Hsp70 chaperones: cellular functions and molecular mechanism","volume":"62","author":"Mayer","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpc.2026.110575_bb0100","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/jnr.1222","article-title":"Ammonia-induced production of free radicals in primary cultures of rat astrocytes","volume":"66","author":"Murthy","year":"2001","journal-title":"J. Neurosci. Res."},{"issue":"12","key":"10.1016\/j.cbpc.2026.110575_bb0105","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.biocel.2005.06.012","article-title":"Extracellular superoxide dismutase","volume":"37","author":"Nozik-Grayck","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110575_bb0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000441475","article-title":"High innate immune specificity through diversified C-type lectin-like domain proteins in invertebrates","volume":"8","author":"Pees","year":"2016","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.cbpc.2026.110575_bb0115","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.fsi.2019.04.034","article-title":"C-type lectin response to bacterial infection and ammonia nitrogen stress in tiger shrimp (Penaeus monodon)","volume":"90","author":"Qin","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0120","article-title":"A new C-type lectin homolog SpCTL6 exerting immunoprotective effect and regulatory role in mud crab Scylla paramamosain","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jip.2021.107701","article-title":"Monodon baculovirus (MBV) infects wild mud crab, Scylla serrata","volume":"187","author":"Rajendran","year":"2022","journal-title":"J. Invertebr. Pathol."},{"issue":"1\u221212","key":"10.1016\/j.cbpc.2026.110575_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0025-326X(02)00227-8","article-title":"Ammonia toxicity in fish","volume":"45","author":"Randall","year":"2002","journal-title":"Mar. Pollut. Bull."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110575_bb0135","first-page":"262","article-title":"Antimicrobial peptides in crustaceans","volume":"7","author":"Rosa","year":"2010","journal-title":"Invertebr. Surviv. J."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110575_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17221\/8763-VETMED","article-title":"Morphologic evaluation of the gills as a tool in the diagnostics of pathological conditions in fish and pollution in the aquatic environment: a review","volume":"61","author":"Strzyzewska","year":"2016","journal-title":"Vet. Med."},{"issue":"6","key":"10.1016\/j.cbpc.2026.110575_bb0145","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cbpc.2026.110575_bb0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3354\/dao03443","article-title":"Cytopathology and immune response in the hepatopancreas of decapod crustaceans","volume":"138","author":"Vogt","year":"2020","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.cbpc.2026.110575_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.110028","article-title":"A novel perlucin with immune regulatory functions protects Litopenaeus vannamei against Vibrio parahaemolyticus infection","volume":"155","author":"Wang","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110575_bb0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.dci.2018.02.016","article-title":"C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain","volume":"84","author":"Wei","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110575_bb0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/bbrc.1999.1907","article-title":"Purification and characterization of perlucin and perlustrin, two new proteins from the shell of the mollusc Haliotis laevigata","volume":"267","author":"Weiss","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cbpc.2026.110575_bb0170","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.fsi.2016.10.004","article-title":"Identification of a C-type lectin from tilapia (Oreochromis niloticus) and its functional characterization under low-temperature stress","volume":"58","author":"Yang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"24","key":"10.1016\/j.cbpc.2026.110575_bb0175","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1111\/j.1742-4658.2005.05031.x","article-title":"The C-type lectin-like domain superfamily","volume":"272","author":"Zelensky","year":"2005","journal-title":"FEBS J."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600133X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600133X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T19:25:17Z","timestamp":1783193117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153204562600133X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":35,"alternative-id":["S153204562600133X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110575","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perlucin, a novel C-type lectin from the mud crab Scylla paramamosain, modulates innate immunity and enhances tolerance to Vibrio parahaemolyticus infection and ammonia stress","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110575"}}