{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:16:06Z","timestamp":1792156566261,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012404","name":"Fuyang Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M722627"],"award-info":[{"award-number":["2022M722627"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024KYQD0125"],"award-info":[{"award-number":["2024KYQD0125"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cbpc.2026.110577","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:47:19Z","timestamp":1778813239000},"page":"110577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Polystyrene microplastic exposure induces hepatic damage via immune-modulated autophagy and ferroptosis in Nile tilapia (Oreochromis niloticus)"],"prefix":"10.1016","volume":"307","author":[{"given":"Feilong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changle","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshou","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengrui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110577_bb0005","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1080\/15548627.2024.2367356","article-title":"Dysregulation of pancreatic \u03b2-cell autophagy and the risk of type 2 diabetes","volume":"20","author":"Al-Kuraishy","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.cbpc.2026.110577_bb0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq-a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbpc.2026.110577_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2026.107813","article-title":"Gauging the effects of a chronic exposure to polystyrene nanoplastics in the liver and intestine of Carassius auratus","volume":"295","author":"Balasch","year":"2026","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0020","doi-asserted-by":"crossref","first-page":"14335","DOI":"10.1021\/acs.jmedchem.3c01373","article-title":"Targeting the tyrosine kinase 2 (TYK2) pseudokinase domain: discovery of the selective TYK2 inhibitor ABBV-712","volume":"66","author":"Breinlinger","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbpc.2026.110577_bb0025","article-title":"Immunotoxicity responses to polystyrene nano-plastics and their related mechanisms in the liver of zebrafish (Danio rerio) larvae","volume":"61","author":"Cheng","year":"2022","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbpc.2026.110577_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114539","article-title":"Polystyrene microplastics induced inflammation with activating the tlr2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio)","volume":"251","author":"Cui","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131916","article-title":"Sub-chronic exposure of Oreochromis niloticus to environmentally relevant concentrations of smaller microplastics: accumulation and toxico-physiological responses","volume":"458","author":"Das","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.125884","article-title":"Rapid egestion of microplastics in juvenile barramundi: no evidence of gut retention or tissue translocation","volume":"370","author":"Dawson","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110577_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116455","article-title":"Sub-chronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)","volume":"279","author":"Del Piano","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.139461","article-title":"In vivo effects on the immune function of fathead minnow (Pimephales promelas) following ingestion and intraperitoneal injection of polystyrene nanoplastics","volume":"735","author":"Elizalde-Vel\u00e1zquez","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110577_bb0055","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12989-020-00372-0","article-title":"Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine","volume":"17","author":"Feng","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109703","article-title":"The immune function of heme oxygenase-1 (HO-1) from Nile tilapia (Oreochromis niloticus) in response to bacterial infection","volume":"151","author":"Feng","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s00018-024-05199-y","article-title":"The impact of nanomaterials on autophagy across health and disease conditions","volume":"81","author":"Florance","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpc.2026.110577_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124187","article-title":"Microplastics and associated contaminants in the aquatic environment: a review on their ecotoxicological effects, trophic transfer, and potential impacts to human health","volume":"405","author":"Huang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132295","article-title":"Size- and oxidative potential-dependent toxicity of environmentally relevant expanded polystyrene styrofoam microplastics to macrophages","volume":"459","author":"Jeon","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125423","article-title":"Toxic effects on bioaccumulation, hematological parameters, oxidative stress, immune responses and neurotoxicity in fish exposed to microplastics: a review","volume":"413","author":"Kim","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2021.112661","article-title":"Oxidative stress induced by nano-plastics in the liver of juvenile large yellow croaker Larimichthys crocea","volume":"170","author":"Li","year":"2021","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2026.110577_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114564","article-title":"From marine to freshwater environment: a review of the ecotoxicological effects of microplastics","volume":"251","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140961","article-title":"Metabolic profiles and protein expression responses of Pacific oyster (Crassostrea gigas) to polystyrene microplastic stress","volume":"462","author":"Liu","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.cbpc.2026.110577_bb0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2-\u25b3\u25b3Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cbpc.2026.110577_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118687","article-title":"Effects of chronic co-exposure polystyrene nano-plastics and cadmium on liver function in Prussian carp (Carassius gibelio)","volume":"302","author":"Luo","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.178363","article-title":"N6-methyladenosine RNA methylation regulates microplastics-induced cell senescence in the rainbow trout liver","volume":"961","author":"Ma","year":"2025","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110577_bb0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41584-024-01093-w","article-title":"Tyk2: an emerging therapeutic target in rheumatic disease","volume":"20","author":"Morand","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101679","article-title":"Complex interplay between autophagy and oxidative stress in the development of pulmonary disease","volume":"36","author":"Ornatowski","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136100","article-title":"Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment","volume":"480","author":"Park","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0135","doi-asserted-by":"crossref","first-page":"eabe4627","DOI":"10.1126\/scisignal.abe4627","article-title":"Ifnar1 and ifnar2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs","volume":"14","author":"Shemesh","year":"2021","journal-title":"Sci. Signal."},{"key":"10.1016\/j.cbpc.2026.110577_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118986","article-title":"Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS\/STING pathway","volume":"300","author":"Shen","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110577_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115850","article-title":"Microplastic-induced NAFLD: hepatoprotective effects of nanosized selenium","volume":"272","author":"Shen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.marenvres.2024.106423","article-title":"Hazards of microplastics exposure to liver function in fishes: a systematic review and meta-analysis","volume":"196","author":"Sun","year":"2024","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.cbpc.2026.110577_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127237","article-title":"Effects of ingestion of polyethylene microplastics on survival rate, opercular respiration rate and swimming performance of African catfish (Clarias gariepinus)","volume":"423","author":"Tongo","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0160","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.3390\/ijms221810170","article-title":"Dnmt3aa but not dnmt3ab is required for maintenance of gametogenesis in Nile tilapia (Oreochromis niloticus)","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110577_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113540","article-title":"Enrichment of polystyrene microplastics induces histological damage, oxidative stress, Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus)","volume":"237","author":"Wang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0170","doi-asserted-by":"crossref","first-page":"14127","DOI":"10.1021\/acs.est.3c02769","article-title":"Nano-plastic exposure at environmental concentrations disrupts hepatic lipid metabolism through oxidative stress induction and endoplasmic reticulum homeostasis perturbation","volume":"57","author":"Wang","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122493","article-title":"Meta-analysis of the effects of microplastic on fish: insights into growth, survival, reproduction, oxidative stress, and gut microbiota diversity","volume":"267","author":"Wang","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2026.110577_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107422","article-title":"Prepubertal exposure to 17\u03b2-estradiol downregulates motor protein genes, impairs sperm flagella formation, and reduces fertility in Nile tilapia (Oreochromis niloticus)","volume":"285","author":"Wang","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107649","article-title":"Hepatic cyp24a1 serves as a biomarker for diagnosing polystyrene microplastic exposure in Nile tilapia (Oreochromis niloticus)","volume":"290","author":"Wang","year":"2026","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2026.107829","article-title":"Time-dependent biphasic dysregulation of autophagy and innate immunity underlies polystyrene microplastics-induced hepatotoxicity in Nile tilapia","volume":"295","author":"Wang","year":"2026","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0195","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1080\/15548627.2025.2481126","article-title":"Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease","volume":"21","author":"Wei","year":"2025","journal-title":"Autophagy"},{"key":"10.1016\/j.cbpc.2026.110577_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118741","article-title":"Association between long-term exposure of polystyrene microplastics and exacerbation of seizure symptoms: evidence from multiple approaches","volume":"302","author":"Xie","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110577_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.170518","article-title":"Polyethylene microplastics induced gut microbiota dysbiosis leading to liver injury via the TLR2\/NF-\u03baB\/NLRP3 pathway in mice","volume":"917","author":"Xu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110577_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131236","article-title":"Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps","volume":"452","author":"Yin","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110577_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.110080","article-title":"Impact of microplastics exposure on liver health: a comprehensive meta-analysis","volume":"288","author":"Zhang","year":"2025","journal-title":"Comp. Biochem. Physiol. C. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110577_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112882","article-title":"Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL\/6J mice through polarization of macrophages and increased infiltration of natural killer cells","volume":"227","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:17:40Z","timestamp":1784146660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626001353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":44,"alternative-id":["S1532045626001353"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110577","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polystyrene microplastic exposure induces hepatic damage via immune-modulated autophagy and ferroptosis in Nile tilapia (Oreochromis niloticus)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110577"}}