{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:01:14Z","timestamp":1785430874649,"version":"3.56.0"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"The Leverhulme Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cbpc.2026.110601","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:23:43Z","timestamp":1781627023000},"page":"110601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ontogenetic variation in Milos viper (Macrovipera schweizeri) venom composition and biochemical activity"],"prefix":"10.1016","volume":"308","author":[{"given":"Ignazio","family":"Avella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Damm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja Anna","family":"Sm\u00f3\u0142ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilien","family":"Uhrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Cabrera-Orefice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Eichberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"Hardes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hurka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Daftsios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo R.","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"W\u00fcster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"L\u00fcddecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110601_bb0005","first-page":"200","article-title":"Relationship of venom ontogeny and diet in Bothrops","volume":"55","author":"Andrade","year":"1999","journal-title":"Herpetologica"},{"key":"10.1016\/j.cbpc.2026.110601_bb0010","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.toxicon.2012.03.001","article-title":"C-type lectin-like proteins from snake venoms","volume":"60","author":"Arlinghaus","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0015","series-title":"Snakes: Ecology and Behavior","first-page":"87","article-title":"Foraging theory and prey size - predator size relations in snakes","author":"Arnold","year":"1993"},{"key":"10.1016\/j.cbpc.2026.110601_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2022.104613","article-title":"Interpopulational variation and ontogenetic shift in the venom composition of Lataste\u2019s viper (Vipera latastei, Bosc\u00e1 1878) from northern Portugal","volume":"263","author":"Avella","year":"2022","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135041","article-title":"Proteogenomics-guided functional venomics resolves the toxin arsenal and activity of Deinagkistrodon acutus venom","volume":"278","author":"Avella","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s44185-025-00090-w","article-title":"The biology and toxinology of blunt-nosed vipers","volume":"4","author":"Avella","year":"2025","journal-title":"Npj Biodivers."},{"key":"10.1016\/j.cbpc.2026.110601_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2025.106081","article-title":"Haemostasis-altering effects of Milos viper (Macrovipera schweizeri) venom","volume":"107","author":"Avella","year":"2025","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cbpc.2026.110601_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0013439","article-title":"Venomics of the Arabian saw-scaled viper (Echis coloratus) through transcriptome-guided proteomics and in vitro functional profiling","volume":"19","author":"Avella","year":"2025","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cbpc.2026.110601_bb0045","series-title":"DATASET - Mass Spectrometry - Snake Venom Proteomics of Macrovipera schweizeri (Age Variation)","author":"Avella","year":"2026"},{"key":"10.1016\/j.cbpc.2026.110601_bb0050","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1098\/rspb.2009.0048","article-title":"Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution","volume":"276","author":"Barlow","year":"2009","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0041-0101(66)90070-5","article-title":"Electrophoretic patterns of venoms from species of Crotalidae and Elapidae snakes","volume":"4","author":"Bertke","year":"1966","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0060","first-page":"13","article-title":"Feeding ecology of Vipera latastei in northern Portugal: ontogenetic shifts, prey size and seasonal variations","volume":"14","author":"Brito","year":"2004","journal-title":"Herpetol. J."},{"key":"10.1016\/j.cbpc.2026.110601_bb0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cbpc.2026.110601_bb0070","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","article-title":"Snake venom disintegrins: evolution of structure and function","volume":"45","author":"Calvete","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0075","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/pr9008749","article-title":"Snake venomics of the central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America","volume":"9","author":"Calvete","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2026.110601_bb0080","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tips.2020.05.006","article-title":"Causes and consequences of snake venom variation","volume":"41","author":"Casewell","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0085","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1021\/acs.jmedchem.3c00097","article-title":"Catalytically active snake venom PLA2 enzymes: an overview of its elusive mechanisms of reaction: miniperspective","volume":"66","author":"Castro-Amorim","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.cbpc.2026.110601_bb0090","series-title":"Macrovipera schweizeri (Werner, 1935): Comparison of the Populations of Milos and Sifnos Islands (SW Cyclades) (Serpentes Viperidae)","author":"Cattaneo","year":"2020"},{"key":"10.1016\/j.cbpc.2026.110601_bb0095","series-title":"Demography of the Monocled Cobra (Naja kaouthia) in the Central Region of Thailand","author":"Chaitae","year":"2011"},{"key":"10.1016\/j.cbpc.2026.110601_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/toxins17080398","article-title":"Heating up the blunts: prothrombin activation, with factor Va as an obligate cofactor, is the dominant procoagulant mechanism of blunt-nosed viper venoms (Macrovipera species)","volume":"17","author":"Champagne","year":"2025","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cbpc.2017.04.007","article-title":"Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)","volume":"197","author":"Cipriani","year":"2017","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0110","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1093\/bioinformatics\/btp163","article-title":"Biopython: freely available Python tools for computational molecular biology and bioinformatics","volume":"25","author":"Cock","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbpc.2026.110601_bb0115","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/379537a0","article-title":"Diet and snake venom evolution","volume":"379","author":"Daltry","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2026.110601_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/toxins13060427","article-title":"Old world vipers\u2014a review about snake venom proteomics of Viperinae and their variations","volume":"13","author":"Damm","year":"2021","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biochi.2024.07.008","article-title":"Venom variation among the three subspecies of the North African mountain viper Vipera monticola Saint Girons 1953","author":"Damm","year":"2024","journal-title":"Biochimie"},{"key":"10.1016\/j.cbpc.2026.110601_bb0130","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jproteome.4c00171","article-title":"Venomics and peptidomics of Palearctic vipers: a clade-wide analysis of seven taxa of the genera Vipera, Montivipera, Macrovipera, and Daboia across T\u00fcrkiye","author":"Damm","year":"2024","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2026.110601_bb0135","first-page":"111","article-title":"Taxonomy, biology and natural history of the Milos viper Macrovipera schweizeri (Werner, 1935): literature review and observations on autumnal activity and importance of residual pools","volume":"45","author":"Di Nicola","year":"2022","journal-title":"Spixiana"},{"key":"10.1016\/j.cbpc.2026.110601_bb0140","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom L-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11030136","article-title":"Structurally robust and functionally highly versatile\u2014C-type lectin (-related) proteins in snake venoms","volume":"11","author":"Eble","year":"2019","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12120791","article-title":"Size matters: an evaluation of the molecular basis of ontogenetic modifications in the composition of Bothrops jararacussu snake venom","volume":"12","author":"Freitas-de-Sousa","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0155","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.toxicon.2006.06.005","article-title":"Sexual dimorphism in venom of Bothrops jararaca (Serpentes: Viperidae)","volume":"48","author":"Furtado","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/icb\/1.2.217","article-title":"The feeding mechanism of snakes and its possible evolution","volume":"1","author":"Gans","year":"1961","journal-title":"Am. Zool."},{"key":"10.1016\/j.cbpc.2026.110601_bb0165","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jprot.2014.01.019","article-title":"Proteomic and biochemical analyses of short-tailed pit viper (Gloydius brevicaudus) venom: age-related variation and composition\u2013activity correlation","volume":"105","author":"Gao","year":"2014","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14100716","article-title":"Comparative venom proteomics of Iranian, Macrovipera lebetina cernovi, and Cypriot, Macrovipera lebetina lebetina, giant vipers","volume":"14","author":"Ghezellou","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0175","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.toxicon.2009.01.034","article-title":"Functional basis of a molecular adaptation: prey-specific toxic effects of venom from Sistrurus rattlesnakes","volume":"53","author":"Gibbs","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067220","article-title":"Phylogeny-based comparative analysis of venom proteome variation in a clade of rattlesnakes (Sistrurus sp.)","volume":"8","author":"Gibbs","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2026.110601_bb0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1655\/HERPETOLOGICA-D-16-00055","article-title":"Museum specimens bias measures of snake diet: a case study using the ambush-foraging puff adder (Bitis arietans)","volume":"73","author":"Glaudas","year":"2017","journal-title":"Herpetologica"},{"key":"10.1016\/j.cbpc.2026.110601_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8040093","article-title":"Hemorrhage caused by snake venom metalloproteinases: a journey of discovery and understanding","volume":"8","author":"Guti\u00e9rrez","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0195","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1073\/pnas.89.22.10915","article-title":"Amino acid substitution matrices from protein blocks","volume":"89","author":"Henikoff","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0200","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1042\/BST20200110","article-title":"Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase","volume":"48","author":"Hiu","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.cbpc.2026.110601_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14050358","article-title":"Venomics of the central European Myrmicine ants Myrmica rubra and Myrmica ruginodis","volume":"14","author":"Hurka","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0210","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.3390\/toxins5122621","article-title":"Venom down under: dynamic evolution of Australian elapid snake toxins","volume":"5","author":"Jackson","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0215","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1021\/acs.jproteome.9b00077","article-title":"Venom composition in a phenotypically variable pit viper (Trimeresurus insularis) across the lesser Sunda archipelago","volume":"18","author":"Jones","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.cbpc.2026.110601_bb0220","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biochi.2025.05.009","article-title":"Ontogenetic variation in coagulotoxic activity and antivenom efficacy of Central American pit viper venoms (Cerrophidion, Metlapilcoatlus, Ophryacus and Porthidium)","volume":"235","author":"Jones","year":"2025","journal-title":"Biochimie"},{"key":"10.1016\/j.cbpc.2026.110601_bb0225","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.toxicon.2004.10.018","article-title":"Tox-Prot, the toxin protein annotation program of the Swiss-Prot protein knowledgebase","volume":"45","author":"Jungo","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0230","author":"Jungo"},{"key":"10.1016\/j.cbpc.2026.110601_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/ece3.11598","article-title":"Gape-limited invasive predator frequently kills avian prey that are too large to swallow","volume":"14","author":"Kastner","year":"2024","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/toxins16120520","article-title":"Age is just a number: ontogenetic conservation in activation of blood clotting factors VII, X, and XII by Caucasus blunt-nosed viper (Macrovipera lebetina obtusa) venoms","volume":"16","author":"Kempson","year":"2024","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0245","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000092424","article-title":"Serine proteases affecting blood coagulation and fibrinolysis from snake venoms","volume":"34","author":"Kini","year":"2005","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"10.1016\/j.cbpc.2026.110601_bb0250","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0041-0101(92)90869-7","article-title":"Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor","volume":"30","author":"Kini","year":"1992","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2024.105320","article-title":"Ontogeny, not prey availability, underlies allopatric venom variability in insular and mainland populations of Vipera ammodytes","volume":"310","author":"Laku\u0161i\u0107","year":"2025","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/toxins16100438","article-title":"The toxin diversity, cytotoxicity, and enzymatic activity of cape cobra (Naja nivea) venom","volume":"16","author":"L\u00fcddecke","year":"2024","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0265","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s42003-025-09015-6","article-title":"Comparative venomics suggests an evolutionary adaption of spider venom from predation to defense","volume":"8","author":"L\u00fcddecke","year":"2025","journal-title":"Commun. Biol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0270","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.toxicon.2006.01.007","article-title":"Venom of the Brown Treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity","volume":"47","author":"Mackessy","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0275","series-title":"Biology of the Vipers","first-page":"307","article-title":"Ecological and phylogenetic correlates of feeding habits in Neotropical pitvipers of the genus Bothrops","author":"Martins","year":"2002"},{"key":"10.1016\/j.cbpc.2026.110601_bb0280","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.toxicon.2005.11.007","article-title":"Sex-based individual variation of snake venom proteome among eighteen Bothrops jararaca siblings","volume":"47","author":"Menezes","year":"2006","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0285","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.toxicon.2016.04.049","article-title":"An analysis of venom ontogeny and prey-specific toxicity in the Monocled cobra (Naja kaouthia)","volume":"119","author":"Modahl","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0290","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00018-008-8113-3","article-title":"Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action","volume":"65","author":"Montecucco","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0295","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.2174\/138161207782023711","article-title":"Importance of Snake venom metalloproteinases in cell biology: effects on platelets, inflammatory and endothelial cells","volume":"13","author":"Moura-da-Silva","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cbpc.2026.110601_bb0300","article-title":"The InterPro database and tools for protein domain analysis","volume":"21","author":"Mulder","year":"2008","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.cbpc.2026.110601_bb0305","series-title":"Snakes: Ecology and Evolutionary Biology","first-page":"1624","article-title":"Foraging ecology","author":"Mushinsky","year":"1987"},{"key":"10.1016\/j.cbpc.2026.110601_bb0310","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giad116","article-title":"ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages","volume":"13","author":"Nachtigall","year":"2024","journal-title":"GigaScience"},{"key":"10.1016\/j.cbpc.2026.110601_bb0315","series-title":"Handb. Reptil. Amphib. Eur. Schlangen III","first-page":"43","article-title":"Macrovipera schweizeri (Werner, 1935) \u2013 Kykladenviper","author":"Nilson","year":"2005"},{"key":"10.1016\/j.cbpc.2026.110601_bb0320","series-title":"Islands and Snakes: Isolation and Adaptive Evolution","first-page":"181","article-title":"The ecology and conservation of the Milos viper, Macrovipera schweizeri","author":"Nilson","year":"2019"},{"key":"10.1016\/j.cbpc.2026.110601_bb0325","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1163\/156853899X00411","article-title":"Ecology and conservation of the Milos viper, Macrovipera schweizeri (Werner, 1935)","volume":"20","author":"Nilson","year":"1999","journal-title":"Amphibia-Reptilia"},{"key":"10.1016\/j.cbpc.2026.110601_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxcx.2020.100052","article-title":"Snake venom metalloproteinases (SVMPs): a structure-function update","volume":"7","author":"Olaoba","year":"2020","journal-title":"Toxicon X"},{"key":"10.1016\/j.cbpc.2026.110601_bb0335","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.toxicon.2008.10.002","article-title":"Interspecific variation in venom composition and toxicity of Brazilian snakes from Bothrops genus","volume":"52","author":"Queiroz","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0340","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.cbpc.2005.11.005","article-title":"Snake venom metalloproteases \u2014 structure and function of catalytic and disintegrin domains","volume":"142","author":"Ramos","year":"2006","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0345","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giac024","article-title":"The rise of genomics in snake venom research: recent advances and future perspectives","volume":"11","author":"Rao","year":"2022","journal-title":"GigaScience"},{"key":"10.1016\/j.cbpc.2026.110601_bb0350","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1163\/156853880X00123","article-title":"Modifications s\u00e9lectives du r\u00e9gime des Vip\u00e8res (Reptilia: Viperidae) lors de la croissance","volume":"1","author":"Saint Girons","year":"1980","journal-title":"Amphibia-Reptilia"},{"key":"10.1016\/j.cbpc.2026.110601_bb0355","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jprot.2008.05.003","article-title":"Snake venomics of the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei","volume":"71","author":"Sanz","year":"2008","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0360","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jprot.2015.03.015","article-title":"Comparative venomics of the prairie rattlesnake (Crotalus viridis viridis) from Colorado: identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom CroFab\u00ae","volume":"121","author":"Saviola","year":"2015","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0365","series-title":"Handbuch der Reptilien und Amphibien Europas. Schlangen III","first-page":"25","article-title":"Macrovipera lebetina (Linnaeus, 1758) \u2013 Levante-Otter","author":"\u0160\u010derbak","year":"2005"},{"key":"10.1016\/j.cbpc.2026.110601_bb0370","series-title":"Journal of Chromatography Library","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0301-4770(08)60531-X","article-title":"Reversed-phase chromatography","author":"Schl\u00fcter","year":"2000"},{"key":"10.1016\/j.cbpc.2026.110601_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1254058","article-title":"Venomics of the Milos viper (Macrovipera schweizeri) unveils patterns of venom composition and exochemistry across blunt-nosed viper venoms","volume":"10","author":"Schulte","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108530","article-title":"In vitro assessment of enzymatic activities, haemolytic potential, and cytotoxic effects of Mangshan pit viper (Protobothrops mangshanensis) venom","volume":"266","author":"Schulte","year":"2025","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0385","series-title":"Ontogenetic Variation in Composition and Bioactivity of Common Adder (Vipera berus) Venom Revealed by Genome-guided Proteomics and In Vitro Functional Assays","author":"Schulte","year":"2026"},{"key":"10.1016\/j.cbpc.2026.110601_bb0390","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12915-024-01960-8","article-title":"From birth to bite: the evolutionary ecology of India\u2019s medically most important snake venoms","volume":"22","author":"Senji Laxme","year":"2024","journal-title":"BMC Biol."},{"key":"10.1016\/j.cbpc.2026.110601_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2022.107187","article-title":"Analytical strategies in venomics","volume":"175","author":"Slagboom","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.cbpc.2026.110601_bb0400","series-title":"Foraging Theory","author":"Stephens","year":"1986"},{"key":"10.1016\/j.cbpc.2026.110601_bb0405","series-title":"Phylogenie und Phylogeographie eurasischer Viperinae unter besonderer Ber\u00fccksichtigung der orientalischen Vipern der Gattungen Montivipera und Macrovipera","author":"St\u00fcmpel","year":"2012"},{"key":"10.1016\/j.cbpc.2026.110601_bb0410","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jprot.2015.09.015","article-title":"Ecological venomics: how genomics, transcriptomics and proteomics can shed new light on the ecology and evolution of venom","volume":"135","author":"Sunagar","year":"2016","journal-title":"J. Proteome"},{"key":"10.1016\/j.cbpc.2026.110601_bb0415","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12030175","article-title":"Cysteine-rich secretory proteins (CRISPs) from venomous snakes: an overview of the functional diversity in a large and underappreciated superfamily","volume":"12","author":"Tadokoro","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0420","doi-asserted-by":"crossref","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the universal protein knowledgebase in 2025","volume":"53","author":"The UniProt Consortium","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cbpc.2026.110601_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12020105","article-title":"Snake C-type lectins potentially contribute to the prey immobilization in Protobothrops mucrosquamatus and Trimeresurus stejnegeri venoms","volume":"12","author":"Tian","year":"2020","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108966","article-title":"Bothrops mattogrossensis snake venom: how age and sex shape the chemistry of the envenoming","volume":"272","author":"Tsuboi-Sato","year":"2026","journal-title":"Toxicon"},{"key":"10.1016\/j.cbpc.2026.110601_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14080538","article-title":"Fibrinogenolysis in venom-induced consumption coagulopathy after Viperidae snakebites: a pilot study","volume":"14","author":"Valenta","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.cbpc.2026.110601_bb0440","author":"World Health Organization (WHO)"},{"key":"10.1016\/j.cbpc.2026.110601_bb0445","first-page":"1","article-title":"Snake venom PLA2, a promising target for broad-spectrum antivenom drug development","volume":"2017","author":"Xiao","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.cbpc.2026.110601_bb0450","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxlet.2018.02.004","article-title":"Synergistic strategies of predominant toxins in snake venoms","volume":"287","author":"Xiong","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2026.110601_bb0455","article-title":"When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species","volume":"286","author":"Zancolli","year":"2019","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.cbpc.2026.110601_bb0460","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cbpc.2007.02.009","article-title":"Variability in expression of Bothrops insularis snake venom proteases: an ontogenetic approach","volume":"145","author":"Zelanis","year":"2007","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:59:52Z","timestamp":1785427192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626001596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":92,"alternative-id":["S1532045626001596"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110601","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ontogenetic variation in Milos viper (Macrovipera schweizeri) venom composition and biochemical activity","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110601"}}