{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:45:43Z","timestamp":1791963943129,"version":"4.3.4"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42577313"],"award-info":[{"award-number":["42577313"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42207318"],"award-info":[{"award-number":["42207318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cbpc.2026.110608","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:18:47Z","timestamp":1783120727000},"page":"110608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Reproductive toxicity of benzo[\u03b1]pyrene: Effects, mechanisms, and perspectives"],"prefix":"10.1016","volume":"308","author":[{"given":"Jiangang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim E.L.","family":"Amouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack Chi-Ho","family":"Ip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiezhang","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0005","first-page":"71","article-title":"Ameliorative effects of chitosan in water remediation, endocrine disruption and reproductive impairment of Solea solea after exposure to benzo[\u03b1]pyrene","volume":"16","author":"Abdelmeguid","year":"2024","journal-title":"Int. Aquat. Res."},{"key":"10.1016\/j.cbpc.2026.110608_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2021.109160","article-title":"Gene expression analysis on growth, development and toxicity pathways of male Nile tilapia (Oreochromis niloticus), after acute and sub-chronic benzo[\u03b1]pyrene exposures","volume":"250","author":"Albornoz-Abud","year":"2021","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0015","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.aquatox.2007.03.001","article-title":"The effects of copper and benzo[\u03b1]pyrene on retinoids and reproduction in zebrafish","volume":"82","author":"Alsop","year":"2007","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.reprotox.2012.09.003","article-title":"Endocrine disruptive actions of inhaled benzo[\u03b1]pyrene on ovarian function and fetal survival in fisher F-344 adult rats","volume":"34","author":"Archibong","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2025.114778","article-title":"In vitro effects of polycyclic aromatic hydrocarbons on sex steroid production by Arabian Sea bream Acanthopagrus arabicus ovarian cells","volume":"371","author":"Aysham","year":"2025","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10695-008-9210-9","article-title":"Acute effects of benzo[\u03b1]pyrene on liver phase I and II enzymes, and DNA damage on sea bream Sparus aurata","volume":"35","author":"Banni","year":"2009","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.cbpc.2026.110608_bb0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.reprotox.2017.07.012","article-title":"Polycyclic aromatic hydrocarbons and female reproductive health: a scoping review","volume":"73","author":"Bolden","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/toxsci\/kfu064","article-title":"Benzo[\u03b1]pyrene effects on reproductive endpoints in Fundulus heteroclitus","volume":"140","author":"Booc","year":"2014","journal-title":"Toxicol. Sci."},{"issue":"Suppl. 3","key":"10.1016\/j.cbpc.2026.110608_bb0045","first-page":"451","article-title":"Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air","volume":"110","author":"Bostr\u00f6m","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"11","key":"10.1016\/j.cbpc.2026.110608_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116348","article-title":"Benzo[\u03b1]pyrene\u2014environmental occurrence, human exposure, and mechanisms of toxicity","volume":"23","author":"Bukowska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.cbpc.2026.110608_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413453","article-title":"Influence of benzo[\u03b1]pyrene on different epigenetic processes","volume":"22","author":"Bukowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110608_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2024.142242","article-title":"A multigenerational study can detect the evolutionary response to benzo[\u03b1]pyrene exposure in the non-biting freshwater midge Chironomus riparius","volume":"358","author":"Bulut","year":"2024","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110608_bb0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s13258-018-0743-8","article-title":"Characterization of transcriptional responses mediated by benzo[\u03b1]pyrene stress in a new marine fish model of goby, Mugilogobius chulae","volume":"41","author":"Cai","year":"2019","journal-title":"Genes Genom."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0070","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jhazmat.2010.11.078","article-title":"The combined toxicity of dibutyl phthalate and benzo[\u03b1]pyrene on the reproductive system of male Sprague Dawley rats in vivo","volume":"186","author":"Chen","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.cbpc.2026.110608_bb0075","doi-asserted-by":"crossref","DOI":"10.48130\/newcontam-0025-0022","article-title":"Multigenerational developmental and skeletal toxicity from benzo[\u03b1]pyrene exposure in F0 and F2 medaka: metabolic trade-offs and survival costs","volume":"2","author":"Chen","year":"2026","journal-title":"New Contam"},{"issue":"10","key":"10.1016\/j.cbpc.2026.110608_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/toxics13100886","article-title":"Embryonic benzo[\u03b1]pyrene exposure induces multigenerational reproductive effects on adult male medaka: phenotypic and transcriptomic insights","volume":"13","author":"Chen","year":"2025","journal-title":"Toxics"},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.etap.2003.11.007","article-title":"Effects of bis (2-ethylhexyl) phthalate and benzo[\u03b1]pyrene on the embryos of Japanese medaka (Oryzias latipes)","volume":"16","author":"Chikae","year":"2004","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00227-006-0464-4","article-title":"Time-course uptake and elimination of benzo[\u03b1]pyrene and its damage to reproduction and ensuing reproductive outputs of Pacific oyster, Crassostrea gigas","volume":"151","author":"Choy","year":"2007","journal-title":"Mar. Biol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114617","article-title":"Effects of short-term exposure to environmentally-relevant concentrations of benzo[\u03b1]pyrene-sorbed polystyrene to white seabass (Atractoscion nobilis)","volume":"263","author":"Coffin","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.aquatox.2018.06.005","article-title":"Transcriptome analysis reveals novel insights into the response of low-dose benzo[\u03b1]pyrene exposure in male tilapia","volume":"201","author":"Colli-Dula","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbpc.2014.02.005","article-title":"Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[\u03b1]pyrene exposure","volume":"163","author":"Corrales","year":"2014","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0115","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.aquatox.2013.12.028","article-title":"Multigenerational effects of benzo[\u03b1]pyrene exposure on survival and developmental deformities in zebrafish larvae","volume":"148","author":"Corrales","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ecoenv.2014.09.002","article-title":"Digital gene expression analysis of reproductive toxicity of benzo[\u03b1]pyrene in male scallop Chlamys farreri","volume":"110","author":"Deng","year":"2014","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"9","key":"10.1016\/j.cbpc.2026.110608_bb0135","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1021\/acs.est.6b00490","article-title":"High conservation in transcriptomic and proteomic response of white sturgeon to equipotent concentrations of 2, 3, 7, 8-TCDD, PCB 77, and benzo[\u03b1]pyrene","volume":"50","author":"Doering","year":"2016","journal-title":"Environ. Sci. Technol."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0140","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aquatox.2008.05.006","article-title":"Benzo[\u03b1]pyrene decreases brain and ovarian aromatase mRNA expression in Fundulus heteroclitus","volume":"88","author":"Dong","year":"2008","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0145","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/humrep\/det439","article-title":"In vivo exposure to benzo[\u03b1]pyrene induces significant DNA damage in mouse oocytes and cumulus cells","volume":"29","author":"Einaudi","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cbpc.2026.110608_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111942","article-title":"Intra and extracellular effects of benzo[\u03b1]pyrene on liver, gill and blood of Caspian White fish (Rutilus frissi kutum): Cyto-genotoxicity and histopathology approach","volume":"163","author":"Esmaeilbeigi","year":"2021","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2026.110608_bb0155","doi-asserted-by":"crossref","first-page":"21924","DOI":"10.1007\/s11356-020-08571-0","article-title":"Transcriptomic changes in western mosquitofish (Gambusia affinis) liver following benzo[\u03b1]pyrene exposure","volume":"27","author":"Feng","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2026.110608_bb0160","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.envpol.2018.04.139","article-title":"Embryonic exposure to benzo[\u03b1]pyrene inhibits reproductive capability in adult female zebrafish and correlation with DNA methylation","volume":"240","author":"Gao","year":"2018","journal-title":"Environ. Pollut."},{"issue":"8","key":"10.1016\/j.cbpc.2026.110608_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24086913","article-title":"Short-term exposure to benzo[\u03b1]pyrene causes disruption of GnRH network in zebrafish embryos","volume":"24","author":"Gentile","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9\u201311","key":"10.1016\/j.cbpc.2026.110608_bb0175","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/15287394.2014.887420","article-title":"In vivo effects of environmental concentrations of produced water on the reproductive function of polar cod(Boreogadus saida)","volume":"77","author":"Geraudie","year":"2014","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0180","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ygcen.2009.03.002","article-title":"Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish","volume":"165","author":"Guiguen","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145702","article-title":"Shoaling, boldness, anxiety-like behavior and locomotion in zebrafish (Danio rerio) are altered by acute benzo[\u03b1]pyrene exposure","volume":"774","author":"Hamilton","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/03602532.2011.567391","article-title":"Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents","volume":"43","author":"Higgins","year":"2011","journal-title":"Drug Metab. Rev."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0195","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.aquatox.2006.04.007","article-title":"Altered gene expression: a mechanism for reproductive toxicity in zebrafish exposed to benzo[\u03b1]pyrene","volume":"78","author":"Hoffmann","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111288","article-title":"Benzo[\u03b1]pyrene promotes autophagy to impair endometrial decidualization via inhibiting CXCL12\/CXCR4 axis","volume":"405","author":"Huang","year":"2025","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0205","first-page":"223","article-title":"Assessment of in vitro oocyte maturation in two gobiid fish species, Chasmichthys dolichognathus and Tridentiger trigonocephalus after exposure to benzo[\u03b1]pyrene","volume":"15","author":"Hwang","year":"2011","journal-title":"Dev. Reprod."},{"issue":"5","key":"10.1016\/j.cbpc.2026.110608_bb0210","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0890-6238(03)00071-6","article-title":"Disruption of testicular steroidogenesis and epididymal function by inhaled benzo[\u03b1]pyrene","volume":"17","author":"Inyang","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chemosphere.2016.07.091","article-title":"Transcriptomic responses of Perna viridis embryo to benzo[\u03b1]pyrene exposure elucidated by RNA sequencing","volume":"163","author":"Jiang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110608_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108549","article-title":"A low dose of benzo[\u03b1]pyrene during prepuberty in male rats generated immediate oxidative stress in the testes and compromised steroidogenic enzymes\/proteins","volume":"124","author":"Jorge","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128016","article-title":"Exposure to benzo[\u03b1]pyrene from juvenile period to peripubertal impairs male reproductive parameters in adult rats","volume":"263","author":"Jorge","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110608_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153585","article-title":"Paternal low-dose benzo[\u03b1]pyrene exposure in rats impairs sexual development and fertility of the paternal lineage in F2 generation: a transgenerational study","volume":"494","author":"Jorge","year":"2023","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0240","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.aquatox.2009.08.003","article-title":"Effects of benzo[\u03b1]pyrene on mitochondrial and nuclear DNA damage in Atlantic killifish (Fundulus heteroclitus) from a creosote-contaminated and reference site","volume":"95","author":"Jung","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0245","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ygcen.2015.03.013","article-title":"Disruption of the rainbow trout reproductive endocrine axis by the polycyclic aromatic hydrocarbon benzo[\u03b1]pyrene","volume":"219","author":"Kennedy","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0250","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquatox.2008.08.016","article-title":"Energy intake affects the biotransformation rate, scope for induction, and metabolite profile of benzo[\u03b1]pyrene in rainbow trout","volume":"90","author":"Kennedy","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0255","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.aquatox.2014.04.008","article-title":"Effects of benzo[\u03b1]pyrene on whole cytochrome P450-involved molecular responses in the marine medaka Oryzias melastigma","volume":"152","author":"Kim","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106658","article-title":"Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo[\u03b1]pyrene in Danio rerio","volume":"263","author":"Kozal","year":"2023","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0270","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.etap.2015.03.010","article-title":"Benzo[\u03b1]pyrene-induced cytochrome p4501A expression of four freshwater fishes (Oryzias latipes, Danio rerio, Cyprinus carpio, and Zacco platypus)","volume":"39","author":"Lee","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0275","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.envpol.2016.11.029","article-title":"Exposure to benzo[\u03b1]pyrene impairs decidualization and decidual angiogenesis in mice during early pregnancy","volume":"222","author":"Li","year":"2017","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0280","article-title":"Prenatal exposure to benzo[\u03b1]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally","volume":"13","author":"Lim","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110608_bb0285","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.envpol.2017.12.099","article-title":"TERT regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to BPDE in vitro and to B[\u03b1]P in vivo","volume":"235","author":"Ling","year":"2018","journal-title":"Environ. Pollut."},{"issue":"12","key":"10.1016\/j.cbpc.2026.110608_bb0295","article-title":"Effects of benzo[\u03b1]pyrene on the endometrial receptivity and embryo implantation in mice: an experimental study","volume":"16","author":"Mardanshahi","year":"2019","journal-title":"Int. J. Reprod. BioMed."},{"issue":"18","key":"10.1016\/j.cbpc.2026.110608_bb0300","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1080\/10643389.2021.1915052","article-title":"Benzo[\u03b1]pyrene osteotoxicity and the regulatory roles of genetic and epigenetic factors: a review","volume":"52","author":"Mo","year":"2022","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"issue":"19","key":"10.1016\/j.cbpc.2026.110608_bb0305","doi-asserted-by":"crossref","first-page":"12271","DOI":"10.1021\/acs.est.0c02416","article-title":"Multigenerational impacts of benzo[\u03b1]pyrene on bone modeling and remodeling in medaka (Oryzias latipes)","volume":"54","author":"Mo","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0310","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2014.973934","article-title":"Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[\u03b1]pyrene in drinking water","volume":"45","author":"Moffat","year":"2015","journal-title":"Crit. Rev. Toxicol."},{"issue":"10","key":"10.1016\/j.cbpc.2026.110608_bb0315","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/humrep\/deq205","article-title":"The transgenerational impact of benzo[\u03b1]pyrene on murine male fertility","volume":"25","author":"Mohamed","year":"2010","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0320","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0166-445X(99)00055-7","article-title":"Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.)","volume":"48","author":"Monteiro","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0325","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.toxrep.2018.02.018","article-title":"Effects of the environmental endocrine disrupting compound benzo[\u03b1]pyrene on thyroidal status of abu mullet (Liza abu) during short-term exposure","volume":"5","author":"Movahedinia","year":"2018","journal-title":"Toxicol. Rep."},{"issue":"9","key":"10.1016\/j.cbpc.2026.110608_bb0330","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1080\/10934529.2020.1767452","article-title":"Benzo[\u03b1]pyrene constrains embryo development via oxidative stress induction and modulates the transcriptional responses of molecular biomarkers in the marine medaka Oryzias javanicus","volume":"55","author":"Nam","year":"2020","journal-title":"J. Environ. Sci. Health A"},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0335","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.reprotox.2007.10.012","article-title":"Quantification of benzo[\u03b1]pyrene and other PAHs in the serum and follicular fluid of smokers versus non-smokers","volume":"25","author":"Neal","year":"2008","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0340","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/humrep\/del487","article-title":"Follicle growth is inhibited by benzo[\u03b1]pyrene, at concentrations representative of human exposure, in an isolated rat follicle culture assay","volume":"22","author":"Neal","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cbpc.2026.110608_bb0345","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s00128-012-0895-1","article-title":"Toxicity, feeding rate and growth rate response to sub-lethal concentrations of anthracene and benzo[\u03b1]pyrene in milkfish Chanos chanos (Forskkal)","volume":"90","author":"Palanikumar","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0350","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ecoenv.2011.08.028","article-title":"Biochemical response of anthracene and benzo[\u03b1]pyrene in milkfish Chanos chanos","volume":"75","author":"Palanikumar","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110608_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116545","article-title":"Benzo[\u03b1]pyrene-induced multigenerational changes in gene expression, behavior, and DNA methylation are primarily influenced by paternal exposure","volume":"469","author":"Pandelides","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0360","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.aquatox.2005.12.009","article-title":"Effects of benzo[\u03b1]pyrene exposure on killifish (Fundulus heteroclitus) aromatase activities and mRNA","volume":"77","author":"Patel","year":"2006","journal-title":"Aquat. Toxicol."},{"issue":"8","key":"10.1016\/j.cbpc.2026.110608_bb0365","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/tox.23164","article-title":"Effect of prenatal exposure to benzo[\u03b1]pyrene on ovarian toxicity and reproductive dysfunction: protective effect of atorvastatin in the embryonic period","volume":"36","author":"Rahmani","year":"2021","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0370","series-title":"Reproductive and Developmental Toxicology","first-page":"759","article-title":"Reproductive toxicity of polycyclic aromatic hydrocarbons","author":"Ramesh","year":"2022"},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0375","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/0960327113489050","article-title":"Metabolism of the environmental toxicant benzo[\u03b1]pyrene by subcellular fractions of human ovary","volume":"33","author":"Rekhadevi","year":"2014","journal-title":"Hum. Exp. Toxicol."},{"issue":"7","key":"10.1016\/j.cbpc.2026.110608_bb0380","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/acs.estlett.8b00272","article-title":"Metabolome profiling of fish muscle tissue exposed to benzo[\u03b1]pyrene using in vivo solid-phase microextraction","volume":"5","author":"Roszkowska","year":"2018","journal-title":"Environ. Sci. Technol. Lett."},{"issue":"10","key":"10.1016\/j.cbpc.2026.110608_bb0385","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105833","article-title":"Short-term exposure effects of the environmental endocrine disruptor benzo[\u03b1]pyrene on thyroid axis function in zebrafish","volume":"23","author":"Rurale","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0390","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.reprotox.2010.12.006","article-title":"Effect of in vitro exposure to benzo[\u03b1]pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation","volume":"31","author":"Sadeu","year":"2011","journal-title":"Reprod. Toxicol."},{"issue":"43","key":"10.1016\/j.cbpc.2026.110608_bb0395","doi-asserted-by":"crossref","first-page":"61290","DOI":"10.1007\/s11356-021-15065-0","article-title":"Biomarker responses and histological damage in the gill, liver, and gonad of Cyprinus carpio with benzo[\u03b1]pyrene exposure","volume":"28","author":"Sha","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"7","key":"10.1016\/j.cbpc.2026.110608_bb0400","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jat.3958","article-title":"Using ovarian and brain cell culture from the mullet, Liza klunzingeri, to assess the inhibitory effects of benzo[\u03b1]pyrene on aromatase activity","volume":"40","author":"Sheibani","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41021-017-0076-x","article-title":"Modulation of benzo[\u03b1]pyrene\u2013DNA adduct formation by CYP1 inducer and inhibitor","volume":"39","author":"Shiizaki","year":"2017","journal-title":"Genes Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128448","article-title":"Effects of pyrene and benzo[\u03b1]pyrene on the reproduction and newborn morphology and behavior of the freshwater planarian Girardia tigrina","volume":"264","author":"Sim\u00e3o","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110608_bb0415","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.scitotenv.2018.10.261","article-title":"Transcriptomic analysis reveals dose-dependent modes of action of benzo[\u03b1]pyrene in polar cod (Boreogadus saida)","volume":"653","author":"Song","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"13","key":"10.1016\/j.cbpc.2026.110608_bb0420","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1021\/acs.est.5b00176","article-title":"Benzo[\u03b1]pyrene metabolism and EROD and GST biotransformation activity in the liver of red-and white-blooded Antarctic fish","volume":"49","author":"Strobel","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17030970","article-title":"Long-term exposure to benzo[\u03b1]pyrene affects sexual differentiation and embryos toxicity in three generations of marine medaka (Oryzias melastigma)","volume":"17","author":"Sun","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.cbpc.2026.110608_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119385","article-title":"Multigenerational and persistent toxicity of environmentally relevant concentrations of benzo[\u03b1]pyrene in marine medaka (Oryzias melastigma)","volume":"306","author":"Sun","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110608_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2023.108394","article-title":"Developmental exposure to polycyclic aromatic hydrocarbons (PAHs): focus on benzo[\u03b1]pyrene neurotoxicity","volume":"119","author":"Tartaglione","year":"2023","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0440","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.aquatox.2013.09.031","article-title":"An investigation of endocrine disrupting effects and toxic mechanisms modulated by benzo[\u03b1]pyrene in female scallop Chlamys farreri","volume":"144","author":"Tian","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116109","article-title":"Transgenerational metabolic disorders and reproduction defects induced by benzo[\u03b1]pyrene in Xenopus tropicalis","volume":"269","author":"Usal","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118418","article-title":"Exposure to a mixture of benzo[\u03b1]pyrene and triclosan induces multi-and transgenerational metabolic disorders associated with decreased female investment in reproduction in Silurana(Xenopus)tropicalis","volume":"292","author":"Usal","year":"2022","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0455","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/em.20516","article-title":"DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo[\u03b1]pyrene","volume":"51","author":"Verhofstad","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0460","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/toxsci\/kfq325","article-title":"Evaluation of benzo[\u03b1]pyrene-induced gene mutations in male germ cells","volume":"119","author":"Verhofstad","year":"2011","journal-title":"Toxicol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.cbpc.2026.110608_bb0465","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2008.01.052","article-title":"Acute effects of benzo[\u03b1]pyrene, anthracene and a fuel oil on biomarkers of the common goby Pomatoschistus microps (Teleostei, Gobiidae)","volume":"395","author":"Vieira","year":"2008","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0470","doi-asserted-by":"crossref","first-page":"13877","DOI":"10.1007\/s11356-014-2585-5","article-title":"Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment","volume":"21","author":"Vignet","year":"2014","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110608_bb0475","doi-asserted-by":"crossref","DOI":"10.1093\/eep\/dvac013","article-title":"Assessment of parental benzo[\u03b1]pyrene exposure-induced cross-generational neurotoxicity and changes in offspring sperm DNA methylome in medaka fish","volume":"8","author":"Wan","year":"2022","journal-title":"Environ. Epigenet."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0480","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/toxsci\/kfl072","article-title":"CYP1C1 messenger RNA expression is inducible by benzo[\u03b1]pyrene in Fundulus heteroclitus embryos and adults","volume":"93","author":"Wang","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2026.110608_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116630","article-title":"Benzo[\u03b1]pyrene exposure disrupts the organelle distribution and function of mouse oocytes","volume":"281","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110608_bb0490","article-title":"Study on epigenotoxicity, sex hormone synthesis, and DNA damage of benzo[\u03b1]pyrene in the testis of male Ruditapes philippinarum","volume":"912","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2019.108579","article-title":"Identification of GnRH2 and GnRH3 and their expression during brood pouch growth and short-term benzo[\u03b1]pyrene exposure in lined seahorse (Hippocampus erectus)","volume":"225","author":"Wang","year":"2019","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0500","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cbpc.2015.06.001","article-title":"Short-term exposure to benzo[\u03b1]pyrene disrupts reproductive endocrine status in the swimming crab Portunus trituberculatus","volume":"174","author":"Wen","year":"2015","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0505","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.envpol.2015.10.019","article-title":"Short-term exposure to benzo[\u03b1]pyrene causes oxidative damage and affects haemolymph steroid levels in female crab Portunus trituberculatus","volume":"208","author":"Wen","year":"2016","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0510","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aquatox.2007.08.007","article-title":"Investigating the relationship between embryotoxic and genotoxic effects of benzo[\u03b1]pyrene, 17\u03b1-ethinylestradiol and endosulfan on Crassostrea gigas embryos","volume":"85","author":"Wessel","year":"2007","journal-title":"Aquat. Toxicol."},{"issue":"8","key":"10.1016\/j.cbpc.2026.110608_bb0515","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/etc.5620180835","article-title":"Heritable reproductive effects of benzo[\u03b1]pyrene on the fathead minnow (Pimephales promelas)","volume":"18","author":"White","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2026.110608_bb0520","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.aquatox.2014.09.001","article-title":"Benzo[\u03b1]pyrene exposure causes adaptive changes in p53 and CYP1A gene expression in Brown bullhead (Ameiurus nebulosus)","volume":"156","author":"Williams","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0525","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s13530-011-0076-3","article-title":"Identification of differentially expressed genes in liver of marine medaka fish exposed to benzo[\u03b1]pyrene","volume":"3","author":"Won","year":"2011","journal-title":"Toxicol. Environ. Heal. Sci."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0535","first-page":"283","article-title":"Heterologous microarray hybridization used for differential gene expression profiling in benzo[\u03b1]pyrene-exposed marine medaka","volume":"5","author":"Woo","year":"2009","journal-title":"Mol. Cell. Toxicol."},{"issue":"4","key":"10.1016\/j.cbpc.2026.110608_bb0540","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00343-017-6024-6","article-title":"Reproductive toxicity assessment of benzo[\u03b1]pyrene in the marine polychaete Perinereis nuntia","volume":"35","author":"Wu","year":"2017","journal-title":"Chin. J. Oceanol. Limnol."},{"issue":"7","key":"10.1016\/j.cbpc.2026.110608_bb0545","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/etc.5620220720","article-title":"Evaluation of biomarkers of exposure and effect in juvenile areolated grouper (Epinephelus areolatus) on foodborne exposure to benzo[\u03b1]pyrene","volume":"22","author":"Wu","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0550","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.toxlet.2010.09.015","article-title":"Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague\u2013Dawley rats following combined oral exposure to benzo[\u03b1]pyrene and di-(2-ethylhexyl) phthalate","volume":"199","author":"Xu","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2026.110608_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111561","article-title":"Melatonin alleviates benzo[\u03b1]pyrene-induced ovarian corpus luteum dysfunction by suppressing excessive oxidative stress and apoptosis","volume":"207","author":"Xu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110608_bb0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114531","article-title":"Exposure to benzo[\u03b1]pyrene promotes proliferation and inhibits differentiation of stromal cells in mice during decidualization","volume":"251","author":"Xu","year":"2023","journal-title":"Ecotox. Environ. Safe."},{"key":"10.1016\/j.cbpc.2026.110608_bb0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106504","article-title":"Benzo[\u03b1]pyrene exposure in early life suppresses spermatogenesis in adult male zebrafish and association with the methylation of germ cell-specific genes","volume":"258","author":"Xu","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.142032","article-title":"Temporal transcriptome analysis in female scallop Chlamys farreri: first molecular insights into the disturbing mechanism on lipid metabolism of reproductive-stage dependence under benzo[\u03b1]pyrene exposure","volume":"746","author":"Xu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.125569","article-title":"Reproductive toxicity and molecular mechanisms of benzo[\u03b1]pyrene exposure on ovary, testis, and brood pouch of sex-role-reversed seahorses (Hippocampus erectus)","volume":"367","author":"Xue","year":"2025","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105193","article-title":"Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[\u03b1]pyrene and ethynylestradiol: insights into anti-estrogenic effects","volume":"75","author":"Yadetie","year":"2021","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cbpc.2026.110608_bb0585","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.aquatox.2018.06.003","article-title":"RNA-Seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision-cut liver slices exposed to benzo[\u03b1]pyrene and 17\u03b1-ethynylestradiol","volume":"201","author":"Yadetie","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0590","doi-asserted-by":"crossref","first-page":"9036","DOI":"10.1007\/s11356-016-6168-5","article-title":"Modulation of 17\u03b2-estradiol induced estrogenic responses in male goldfish (Carassius auratus) by benzo[\u03b1]pyrene and ketoconazole","volume":"23","author":"Yan","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2026.110608_bb0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.110125","article-title":"Benzo[\u03b1]pyrene exposure disrupts steroidogenesis and impairs spermatogenesis in diverse reproductive stages of male scallop (Chlamys farreri)","volume":"191","author":"Yang","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbpc.2026.110608_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117084","article-title":"Damages to biological macromolecules in gonadal subcellular fractions of scallop Chlamys farreri following benzo[\u03b1]pyrene exposure: contribution to inhibiting gonadal development and reducing fertility","volume":"283","author":"Yang","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0605","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.138585","article-title":"Benzo[\u03b1]pyrene exposure induced reproductive endocrine-disrupting effects via the steroidogenic pathway and estrogen signaling pathway in female scallop Chlamys farreri","volume":"726","author":"Yang","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jes.2019.12.015","article-title":"Exposure to polycyclic aromatic hydrocarbons and risk for premature ovarian failure and reproductive hormones imbalance","volume":"91","author":"Ye","year":"2020","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.cbpc.2026.110608_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115437","article-title":"The intergenerational toxic effects on offspring of medaka fish Oryzias melastigma from parental benzo[\u03b1]pyrene exposure via interference of the circadian rhythm","volume":"267","author":"Yin","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0620","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.aquatox.2018.08.014","article-title":"Growth, energy metabolism and transcriptomic responses in Chinese mitten crab (Eriocheir sinensis) to benzo[\u03b1]pyrene toxicity","volume":"203","author":"Yu","year":"2018","journal-title":"Aquat. Toxicol."},{"issue":"29","key":"10.1016\/j.cbpc.2026.110608_bb0625","doi-asserted-by":"crossref","first-page":"15037","DOI":"10.1021\/acs.est.5c05619","article-title":"Life-cycle benzo[\u03b1]pyrene exposure induces sex-specific reproductive impairment, feminization, and transgenerational disruption in marine medaka (Oryzias melastigma)","volume":"59","author":"Zeb","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2025.119211","article-title":"Parental benzo[\u03b1]pyrene exposure and timing of reproduction determine the magnitude and persistence of transgenerational toxicity in marine medaka (Oryzias melastigma)","volume":"225","author":"Zeb","year":"2026","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.cbpc.2026.110608_bb0635","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ecoenv.2015.07.001","article-title":"Exposure of sea bream (Sparus aurata) to toxic concentrations of benzo[\u03b1]pyrene: possible human health effect","volume":"122","author":"Zena","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0640","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/molehr\/5.2.125","article-title":"Detection of benzo[\u03b1]pyrene diol epoxide-DNA adducts in embryos from smoking couples: evidence for transmission by spermatozoa","volume":"5","author":"Zenzes","year":"1999","journal-title":"Mol. Hum. Reprod."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110608_bb0645","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.fertnstert.2014.11.013","article-title":"Benzo[\u03b1]pyrene disrupts mouse preimplantation embryo development","volume":"103","author":"Zhan","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cbpc.2026.110608_bb0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.reprotox.2024.108596","article-title":"Transcriptomic and proteomic features of a mouse model of sperm DNA damage induced by benzo[\u03b1]pyrene","volume":"126","author":"Zhang","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0655","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175877","article-title":"Benzo[\u03b1]pyrene exposure during pregnancy leads to germ cell apoptosis in male mice offspring via affecting histone modifications and oxidative stress levels","volume":"952","author":"Zhang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0660","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.118959","article-title":"Apoptosis and blood-testis barrier disruption during male reproductive dysfunction induced by PAHs of different molecular weights","volume":"300","author":"Zhang","year":"2022","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0665","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.chemosphere.2019.04.092","article-title":"Paternal benzo[\u03b1]pyrene exposure alters the sperm DNA methylation levels of imprinting genes in F0 generation mice and their unexposed F1-2 male offspring","volume":"228","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110608_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.175042","article-title":"The dual effects of benzo[\u03b1]pyrene\/benzo[\u03b1]pyrene-7, 8-dihydrodiol-9, 10-epoxide on DNA methylation","volume":"950","author":"Zhao","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110608_bb0675","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fct.2014.04.021","article-title":"Exposure of mice to benzo[\u03b1]pyrene impairs endometrial receptivity and reduces the number of implantation sites during early pregnancy","volume":"69","author":"Zhao","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"22","key":"10.1016\/j.cbpc.2026.110608_bb0680","doi-asserted-by":"crossref","first-page":"13068","DOI":"10.1021\/es403260b","article-title":"Modulation of benzo[\u03b1]pyrene-induced toxic effects in Japanese medaka (Oryzias latipes) by 2, 2\u2032, 4, 4\u2032-tetrabromodiphenyl ether","volume":"47","author":"Zhao","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110608_bb0685","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2005.03.005","article-title":"Effect of tributyltin, benzo[\u03b1]pyrene and their mixture exposure on the sex hormone levels in gonads of cuvier (Sebastiscus marmoratus)","volume":"20","author":"Zheng","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110608_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122844","article-title":"Study on reproductive endocrine disturbance and DNA damage mechanism of female Ruditapes philippinarum under benzo[\u03b1]pyrene stress","volume":"340","author":"Zheng","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110608_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112928","article-title":"Transcriptome aberration associated with altered locomotor behavior of zebrafish (Danio rerio) caused by waterborne benzo[\u03b1]pyrene","volume":"227","author":"Zhou","year":"2021","journal-title":"Ecotox. Environ. Safe."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:48:20Z","timestamp":1785970100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":131,"alternative-id":["S1532045626001663"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110608","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproductive toxicity of benzo[\u03b1]pyrene: Effects, mechanisms, and perspectives","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110608"}}