{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:32:38Z","timestamp":1786116758851,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["15015"],"award-info":[{"award-number":["15015"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cbpc.2026.110614","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:14:35Z","timestamp":1783494875000},"page":"110614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metal-induced inhibition of Na+\/K+-ATPase and SERCA in the rainbow trout (Oncorhynchus mykiss) heart: Implications for cardiac ion regulation"],"prefix":"10.1016","volume":"308","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2300-6849","authenticated-orcid":false,"given":"Jaakko","family":"Haverinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-1425","authenticated-orcid":false,"given":"Matti","family":"Vornanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110614_bb0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/jeb.201.4.525","article-title":"Ca2+-ATPase activity and Ca2+ uptake by sarcoplastic reticulum in fish heart: effects of thermal acclimation","volume":"201","author":"Aho","year":"1998","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0010","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.scitotenv.2018.04.436","article-title":"Climate and productivity affect total mercury concentration and bioaccumulation rate of fish along a spatial gradient of subarctic lakes","volume":"637\u2013638","author":"Ahonen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110614_bb0015","article-title":"Sulfhydryl groups as targets of mercury toxicity","volume":"15","author":"Ajsuvakova","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.cbpc.2026.110614_bb0020","doi-asserted-by":"crossref","first-page":"F830","DOI":"10.1152\/ajprenal.1992.262.5.F830","article-title":"Mercury blocks Na-K-ATPase by a ligand-dependent and reversible mechanism","volume":"262","author":"Anner","year":"1992","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0025","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/0020-711X(88)90300-X","article-title":"The effect of mercury and aluminum on sodium-potassium-Mg2+ dependent-adenosine triphosphatase activity of Electrophorus electricus (L.) electrocyte","volume":"25","author":"Araujo","year":"1993","journal-title":"Int. J. Biochem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0030","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-4165(73)90178-5","article-title":"The determination of inorganic orthophosphate in biological systems","volume":"320","author":"Atkinson","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2026.110614_bb0035","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/tox.20766","article-title":"Metals (Ag(+), Cd(2+), Cr(6+)) affect ATPase activity in the gill, kidney, and muscle of freshwater fish Oreochromis niloticus following acute and chronic exposures","volume":"28","author":"Atli","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0040","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0005-2744(70)90135-X","article-title":"The effect of hydroxylamine mercaptans. Divalent metals and chelators on (Na+ + K+)-ATPase","volume":"198","author":"Bader","year":"1970","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2026.110614_bb0045","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/etojnl\/vgaf128","article-title":"Effects of inorganic mercury (HgCl2) on electrical excitability of rainbow trout (Oncorhynchus mykiss) heart","volume":"44","author":"Badr","year":"2025","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1260509","article-title":"Chronic exposure to mercury increases arrhythmia and mortality post-acute myocardial infarction in rats","volume":"14","author":"Bello","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0055","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12013-013-9538-3","article-title":"The high energy demand of neuronal cells caused by passive leak currents is not a waste of energy","volume":"67","author":"Berndt","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.cbpc.2026.110614_bb3000","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0008-6363(02)00656-9","article-title":"Intracellular Na+ regulation in cardiac myocytes","volume":"57","author":"Bers","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbpc.2026.110614_bb0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4939-3179-8_16","article-title":"Calcium uptake in crude tissue preparation","volume":"1377","author":"Bidwell","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"18","key":"10.1016\/j.cbpc.2026.110614_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24183247","article-title":"A review on coordination properties of thiol-containing chelating agents towards mercury, cadmium, and lead","volume":"24","author":"Bj\u00f8rklund","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.cbpc.2026.110614_bb0070","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/physrev.1999.79.3.763","article-title":"Sodium\/calcium exchange: its physiological implications","volume":"29","author":"Blaustein","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbpc.2026.110614_bb0075","article-title":"Heavy metal concentrations in five fish species from the Gulf of Guinea and their human health implications","volume":"44","author":"Botwe","year":"2021","journal-title":"Reg. Stud. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110614_bb0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0005-2736(70)90174-4","article-title":"The effect of copper on membrane enzymes","volume":"196","author":"Bowler","year":"1970","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.cbpc.2026.110614_bb0085","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.2040-4603.2017.tb00748.x","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Bravo-Sagua","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0090","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.2754\/avb200776S8S093","article-title":"Distribution of metals in tissues of the common carp (Cyprinus carpio L.)","volume":"76","author":"\u010celechovsk\u00e1","year":"2007","journal-title":"Acta Vet. Brno."},{"key":"10.1016\/j.cbpc.2026.110614_bb0095","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0773.1984.tb01919.x","article-title":"Effect of interaction of heavy metals on (Na+-K+) ATPase and the uptake of 3H-DA and 3H-NA in rat brain synaptosomes","volume":"54","author":"Chandra","year":"1984","journal-title":"Acta Pharmacol. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2022.183868","article-title":"Effect of Fe3+ on Na,K-ATPase: unexpected activation of ATP hydrolysis","volume":"1864","author":"Costa","year":"2022","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"key":"10.1016\/j.cbpc.2026.110614_bb0105","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bbamem.2018.05.014","article-title":"Aluminum inhibits the plasma membrane and sarcoplasmic reticulum Ca2+-ATPases by different mechanisms","volume":"1860","author":"de Sautu","year":"2018","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.cbpc.2026.110614_bb0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","article-title":"Calcium and excitation-contraction coupling in the heart","volume":"121","author":"Eisner","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.cbpc.2026.110614_bb0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0301-0082(94)90015-9","article-title":"Ions and energy in mammalian brain","volume":"43","author":"Erecinska","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0120","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1983.245.1.C1","article-title":"Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum","volume":"245","author":"Fabiato","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0125","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/mawe.200500960","article-title":"Toxic effects of metals: modulation of intracellular calcium homeostasis","volume":"36","author":"Florea","year":"2005","journal-title":"Mater. Werkst."},{"key":"10.1016\/j.cbpc.2026.110614_bb0130","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s002449910010","article-title":"Seasonal changes and tissue distribution of mercury in largemouth bass (Micropterus salmoides) from Dorena reservoir, Oregon","volume":"38","author":"Foster","year":"2000","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0135","doi-asserted-by":"crossref","first-page":"10A","DOI":"10.1016\/S0735-1097(85)80458-7","article-title":"The cellular mechanism of action of cardiac glycosides","volume":"5","author":"Fozzard","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0041-008X(73)90183-X","article-title":"Pharmacodynamics of methyl mercury in the rainbow trout (Salmo gairdneri): tissue uptake, distribution and excretion","volume":"24","author":"Giblin","year":"1973","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0145","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1074\/jbc.M112.446161","article-title":"Sarco (endo) plasmic reticulum calcium ATPase (SERCA) inhibition by sarcolipin is encoded in its luminal tail","volume":"288","author":"Gorski","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0150","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0022-2828(87)80400-5","article-title":"Sodium imbalance as a cause of calcium overload in post-hypoxic reoxygenation injury","volume":"19","author":"Grinwald","year":"1987","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0155","first-page":"1471","article-title":"Ecological impact of heavy metals on aquatic environment with reference to fish and human health","volume":"14","author":"Gulati","year":"2022","journal-title":"J. Appl. Nat. Sci."},{"key":"10.1016\/j.cbpc.2026.110614_bb0160","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0043-1354(80)90143-8","article-title":"An ecological risk index for aquatic pollution-control \u2014 a sedimentological approach","volume":"14","author":"Hakanson","year":"1980","journal-title":"Water Res."},{"key":"10.1016\/j.cbpc.2026.110614_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106374","article-title":"Dual effect of metals on branchial and renal Na,K-ATPase activity in thermally acclimated crucian carp (Carassius carassius) and rainbow trout (Oncorhynchus mykiss)","volume":"254","author":"Haverinen","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0170","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/etc.5161","article-title":"Cardiac toxicity of cadmium involves complex interactions among multiple ion currents in rainbow trout (Oncorhynchus mykiss) ventricular myocytes","volume":"40","author":"Haverinen","year":"2021","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0175","first-page":"109","article-title":"Inhibition of sarcoplasmic reticulum Ca2+-ATPase activity by cadmium, Lead and mercury","volume":"45","author":"Hechtenberg","year":"1991","journal-title":"Enzyme"},{"key":"10.1016\/j.cbpc.2026.110614_bb0180","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated energy budgets for neural computation in the neocortex and cerebellum","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.cbpc.2026.110614_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-020-00305-w","article-title":"Risk assessment of heavy metals in the surface sediment at the drinking water source of the Xiangjiang River in South China","volume":"32","author":"Huang","year":"2020","journal-title":"Environ. Sci. Eur."},{"key":"10.1016\/j.cbpc.2026.110614_bb0190","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.scitotenv.2017.05.039","article-title":"An alternative approach to risk rank chemicals on the threat they pose to the aquatic environment","volume":"599","author":"Johnson","year":"2017","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110614_bb0195","doi-asserted-by":"crossref","first-page":"16A","DOI":"10.1016\/S0735-1097(85)80459-9","article-title":"Effects of digitalis on cell biochemistry. Sodium pump inhibition","volume":"5","author":"Katz","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1062741","article-title":"Association of mercury exposure with the serum high-sensitivity C-reactive protein level in Korean adults","volume":"11","author":"Kim","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.cbpc.2026.110614_bb0205","first-page":"329","article-title":"In vitro inhibition of Na-K-ATPase by trace metals: relation to renal and cardiovascular damage","volume":"44","author":"Kramer","year":"1986","journal-title":"Nephron"},{"key":"10.1016\/j.cbpc.2026.110614_bb0210","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/14756360500213280","article-title":"Inhibition of Na1\/K1-ATPase and Mg21-ATPase by metal ions and prevention and recovery of inhibited activities by chelators","volume":"20","author":"Krsti\u0107","year":"2005","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/cells12232720","article-title":"The role of glutathione and sulfhydryl groups in cadmium uptake by cultures of the rainbow trout RTG-2 cell line","volume":"12","author":"Lange","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.cbpc.2026.110614_bb0220","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/B:MCBI.0000007255.72746.a6","article-title":"Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses","volume":"255","author":"Leonard","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-4274(96)03696-X","article-title":"Kinetics of Cu2+ inhibition of Na+\/K+-ATPase","volume":"87","author":"Li","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.cbpc.2026.110614_bb0230","doi-asserted-by":"crossref","DOI":"10.1007\/s10661-020-8234-1","article-title":"Heavy metal concentrations in tissues of marine fish and crab collected from the middle coast of Zhejiang Province, China","volume":"192","author":"Liu","year":"2020","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.cbpc.2026.110614_bb0235","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0773.1987.tb01730.x","article-title":"The effect of mercury chloride and methyl mercury on brain microsomal Na+-K+-ATPase after partial delipidisation with Lubrol","volume":"60","author":"Magour","year":"1987","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0240","doi-asserted-by":"crossref","first-page":"115013","DOI":"10.1088\/1748-9326\/abbf7c","article-title":"Distribution and bioaccumulation of heavy metals (Hg, Cd and Pb) in fish: influence of the aquatic environment and climate","volume":"15","author":"Moiseenko","year":"2020","journal-title":"Environ. Res. Lett."},{"key":"10.1016\/j.cbpc.2026.110614_bb0245","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cbpc.2017.09.004","article-title":"Impact of waterborne and trophic mercury exposures on cardiac function of two ecologically distinct Neotropical freshwater fish Brycon amazonicus and Hopias malabaricus","volume":"201","author":"Monteiro","year":"2017","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0250","first-page":"283","article-title":"Inhibitory characteristics of cadmium, lead, and mercury in human sodium and potassium dependent adenosine triphosphatase preparations","volume":"2","author":"Nechay","year":"1978","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0255","article-title":"Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews","volume":"23","author":"Nucera","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cbpc.2026.110614_bb0260","series-title":"Metal Metabolism in Aquatic Environments","first-page":"321","article-title":"Mechanisms of heavy metal accumulation and toxicity in fish","author":"Olsson","year":"1998"},{"key":"10.1016\/j.cbpc.2026.110614_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15040657","article-title":"Full atrioventricular block secondary to acute poisoning mercury: a case report","volume":"15","author":"Peregrina-Ch\u00e1vez","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.cbpc.2026.110614_bb0270","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1006\/jmcc.2001.1366","article-title":"SERCA pump level is a critical determinant of Ca2+ homeostasis and cardiac contractility","volume":"33","author":"Periasamy","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0275","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvm056","article-title":"Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology","volume":"77","author":"Periasamy","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbpc.2026.110614_bb0280","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3181\/00379727-120-30658","article-title":"In vitro inhibition of Na+-K+ and Mg2+ ATPases by mono, di and trivalent cations","volume":"120","author":"Rifkin","year":"1965","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.cbpc.2026.110614_bb0285","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","article-title":"Cellular energy utilization and molecular origin of standard metabolic rate in mammals","volume":"77","author":"Rolfe","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cbpc.2026.110614_bb0290","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/jphysiol.1994.sp020471","article-title":"The energy expenditure of actomyosin-ATPase, Ca2+-ATPase and Na+,K+-ATPase in guinea-pig cardiac ventricular muscle","volume":"481","author":"Schramm","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.gexplo.2024.107472","article-title":"A systematic review on assessment of heavy metals toxicity in freshwater fish species: current scenario and remedial approach","volume":"262","author":"Sharma","year":"2024","journal-title":"J. Geochem. Explor."},{"key":"10.1016\/j.cbpc.2026.110614_bb0300","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s42108-024-00284-1","article-title":"Exploring the impact of heavy metals toxicity in the aquatic ecosystem","volume":"9","author":"Sharma","year":"2025","journal-title":"Int. J. Energy Water Resour."},{"key":"10.1016\/j.cbpc.2026.110614_bb0305","doi-asserted-by":"crossref","DOI":"10.1007\/s00027-024-01121-7","article-title":"Heavy metal contamination in fish: sources, mechanisms and consequences","volume":"86","author":"Singh","year":"2024","journal-title":"Aquat. Sci."},{"key":"10.1016\/j.cbpc.2026.110614_bb0310","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-3002(57)90343-8","article-title":"The influence of some cations on an adenosine triphosphatase from peripheral nerves","volume":"23","author":"Skou","year":"1957","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2026.110614_bb0315","article-title":"ATP consumption by sarcoplasmic reticulum Ca2+ pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle","volume":"8","author":"Smith","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.cbpc.2026.110614_bb0320","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0269-7491(03)00051-4","article-title":"Fish mercury levels in lakes\u2014adjusting for Hg and fish-size covariation","volume":"125","author":"Sonesten","year":"2003","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110614_bb0325","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.scitotenv.2011.10.039","article-title":"How does climate change influence Arctic mercury?","volume":"414","author":"Stern","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.cbpc.2026.110614_bb0330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/01.HYP.6.1.20","article-title":"Cadmium effect on the Na, K-ATPase system in cultured vascular smooth muscle cells","volume":"6","author":"Tokushige","year":"1984","journal-title":"Hypertension"},{"key":"10.1016\/j.cbpc.2026.110614_bb0335","doi-asserted-by":"crossref","first-page":"52382","DOI":"10.1074\/jbc.M409336200","article-title":"HSP70 binds to the fast-twitch skeletal muscle sarco (endo) plasmic reticulum Ca2+-ATPase (SERCA1a) and prevents thermal inactivation","volume":"279","author":"Tupling","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0340","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ecoenv.2017.08.064","article-title":"Metal bioavailability in ecological risk assessment of freshwater ecosystems: from science to environmental management","volume":"147","author":"V\u00e4\u00e4n\u00e4nen","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110614_bb0345","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211997","article-title":"Skeletal and cardiac muscle calcium transport regulation in health and disease","volume":"42","author":"Valentim","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.cbpc.2026.110614_bb0350","doi-asserted-by":"crossref","first-page":"8321","DOI":"10.3390\/s8128321","article-title":"Na+,K+-ATPase as the target enzyme for organic and inorganic compounds","volume":"8","author":"Vasi\u0107","year":"2008","journal-title":"Sensors (Basel, Switzerland)"},{"key":"10.1016\/j.cbpc.2026.110614_bb0355","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00360-020-01313-1","article-title":"Effects of acute warming on cardiac and myotomal sarco(endo)plasmic reticulum ATPase (SERCA) of thermally acclimated brown trout (Salmo trutta)","volume":"191","author":"Vornanen","year":"2021","journal-title":"J. Comp. Physiol. B"},{"key":"10.1016\/j.cbpc.2026.110614_bb0360","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.247446","article-title":"Cardiac arrhythmias in fish induced by natural and anthropogenic changes in environmental conditions","volume":"227","author":"Vornanen","year":"2024","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2026.110614_bb0365","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/A:1017918013293","article-title":"Molecular mechanisms of metal toxicity and carcinogenesis","volume":"222","author":"Wang","year":"2001","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbpc.2026.110614_bb0370","doi-asserted-by":"crossref","first-page":"8244","DOI":"10.1007\/s11356-016-6333-x","article-title":"A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment","volume":"23","author":"Wu","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.cbpc.2026.110614_bb0375","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13395-021-00280-7","article-title":"The SarcoEndoplasmic Reticulum Calcium ATPase (SERCA) pump: a potential target for intervention in aging and skeletal muscle pathologies","volume":"11","author":"Xu","year":"2021","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.cbpc.2026.110614_bb0380","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.lfs.2003.09.046","article-title":"Mercury-induced Ca2+ increase and cytotoxicity in renal tubular cells","volume":"74","author":"Yeh","year":"2004","journal-title":"Life Sci."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology &amp; Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626001729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:03:19Z","timestamp":1786017799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626001729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":77,"alternative-id":["S1532045626001729"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110614","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal-induced inhibition of Na+\/K+-ATPase and SERCA in the rainbow trout (Oncorhynchus mykiss) heart: Implications for cardiac ion regulation","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110614"}}