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Physiol."},{"key":"10.1016\/j.cbpc.2026.110631_bb0400","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1182\/blood-2003-10-3638","article-title":"Role of the CXCR4\/SDF-1 chemokine axis in circulating neutrophil homeostasis","volume":"104","author":"Suratt","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.cbpc.2026.110631_bb0405","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1095-8649.1986.tb04951.x","article-title":"Morphological and phagocytic characteristics of peritoneal exudate cells in tilapia, Oreochromis niloticus (Trewavas), and carp, Cyprinus carpio L","volume":"29","author":"Suzuki","year":"1986","journal-title":"J. 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