{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:51:55Z","timestamp":1791345115379,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31901183"],"award-info":[{"award-number":["31901183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22276189"],"award-info":[{"award-number":["22276189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbpc.2026.110664","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:41:28Z","timestamp":1787614888000},"page":"110664","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["No overt reproductive impairment in zebrafish following life-cycle exposure to environmentally relevant concentrations of diphenyl phosphate (DPhP)"],"prefix":"10.1016","volume":"310","author":[{"given":"Tong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110664_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.envint.2017.11.028","article-title":"Presence of diphenyl phosphate and aryl-phosphate flame retardants in indoor dust from different microenvironments in Spain and the Netherlands and estimation of human exposure","volume":"112","author":"Bj\u00f6rnsdotter","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.cbpc.2026.110664_bb0010","doi-asserted-by":"crossref","first-page":"15486","DOI":"10.1021\/acs.est.4c04782","article-title":"Biotransformation, bioaccumulation, and bioelimination of Triphenyl phosphate and its dominant metabolite diphenyl phosphate in vivo","volume":"58","author":"Cao","year":"2024","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0015","first-page":"13122","article-title":"Life cycle exposure to environmentally relevant concentrations of diphenyl phosphate (DPhP) inhibits growth and energy metabolism of zebrafish in a sex-specific manner","volume":"55","author":"Chen","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.9734\/ajfar\/2023\/v24i5646","article-title":"Estimation of fecundity and gonadosomatic index (GSI) of Somileptes gongota (Hamilton, 1822) from the river Padma in Rajshahi District, Bangladesh","volume":"24","author":"Datta","year":"2023","journal-title":"Asian J. Fish. Aquat. Res."},{"key":"10.1016\/j.cbpc.2026.110664_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/fishes7040188","article-title":"Parental effects and reproductive potential of fish and marine invertebrates: cross-generational impact of environmental experiences","volume":"7","author":"Dom\u00ednguez-Petit","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.cbpc.2026.110664_bb0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconhyd.2019.01.002","article-title":"Assessment of impacts of diphenyl phosphate on groundwater and near-surface environments: sorption and toxicity","volume":"221","author":"Funk","year":"2019","journal-title":"J. Contam. Hydrol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0035","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.theriogenology.2019.07.020","article-title":"Androgen signaling in male fishes: examples of anti-androgenic chemicals that cause reproductive disorders","volume":"139","author":"Golshan","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.cbpc.2026.110664_bb0040","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.aquatox.2006.04.007","article-title":"Altered gene expression: a mechanism for reproductive toxicity in zebrafish exposed to benzo[a]pyrene","volume":"78","author":"Hoffmann","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.envpol.2015.10.018","article-title":"Reproduction impairment and endocrine disruption in female zebrafish after long-term exposure to MC-LR: a life cycle assessment","volume":"208","author":"Hou","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110664_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109321","article-title":"Estrogenic and growth inhibitory responses to organophosphorus flame retardant metabolites in zebrafish embryos","volume":"256","author":"Lee","year":"2022","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0055","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1095\/biolreprod.110.086363","article-title":"Insulin-like growth factor 3 is involved in oocyte maturation in Zebrafish1","volume":"84","author":"Li","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.cbpc.2026.110664_bb0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.chemosphere.2015.11.041","article-title":"Waterborne fluoride exposure changed the structure and the expressions of steroidogenic-related genes in gonads of adult zebrafish (Danio rerio)","volume":"145","author":"Li","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110664_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113810","article-title":"Occurrence and ecological implications of organophosphate triesters and diester degradation products in wastewater, river water, and tap water","volume":"259","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.cbpc.2026.110664_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117458","article-title":"Reproductive hormones, organophosphate esters and semen quality: exploring associations and mediation effects among men from an infertility clinic","volume":"240","author":"Li","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.cbpc.2026.110664_bb0075","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1021\/acs.est.4c09573","article-title":"Organophosphate esters, sperm mitochondrial DNA copy number, and semen quality: a longitudinal study with repeated measurements","volume":"59","author":"Li","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0080","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquatox.2015.01.006","article-title":"Long-term exposure to environmentally relevant concentrations of progesterone and norgestrel affects sex differentiation in zebrafish (Danio rerio)","volume":"160","author":"Liang","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0085","article-title":"Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"issue":"135","key":"10.1016\/j.cbpc.2026.110664_bb0090","first-page":"104","article-title":"Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio)","volume":"134","author":"Liu","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.cbpc.2026.110664_bb0100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ygcen.2009.05.022","article-title":"Oogenesis in teleosts: how fish eggs are formed","volume":"165","author":"Lubzens","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/15376516.2021.1998276","article-title":"Characterization of diphenyl phthalate as an agonist for estrogen receptor: an in vitro and in silico study","volume":"32","author":"Lv","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.cbpc.2026.110664_bb0110","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41598-025-30370-1","article-title":"Seasonal dynamics of plasma estradiol 17\u03b2 level, gonadosomatic index, and ovarian development in female golden trevally (Gnathanodon speciosus)","volume":"16","author":"Pham","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110664_bb0115","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.chemosphere.2011.11.053","article-title":"Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain)","volume":"86","author":"Rodil","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110664_bb0120","doi-asserted-by":"crossref","DOI":"10.1289\/EHP6826","article-title":"In vivo characterization of the toxicological properties of DPhP, one of the main degradation products of aryl phosphate esters","volume":"128","author":"Selmi-Ruby","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.cbpc.2026.110664_bb0125","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3390\/ijms16022767","article-title":"Molecular characterization of three gonadotropin subunits and their expression patterns during ovarian maturation in Cynoglossus semilaevis","volume":"16","author":"Shi","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110664_bb0130","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1021\/acs.est.6b02187","article-title":"Organophosphate flame retardants and plasticizers in aqueous solution: pH-dependent hydrolysis, kinetics, and pathways","volume":"50","author":"Su","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0135","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.tiv.2015.08.012","article-title":"Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophen","volume":"29","author":"Van Den Eede","year":"2015","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.cbpc.2026.110664_bb0140","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.chemosphere.2012.03.067","article-title":"Phosphorus flame retardants: properties, production, environmental occurrence, toxicity and analysis","volume":"88","author":"Van Der Veen","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.cbpc.2026.110664_bb0145","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1530\/REP-17-0208","article-title":"Sex steroids differentially regulate fshb, lhb and gnrhr expression in Atlantic cod (Gadus morhua)","volume":"154","author":"Von Krogh","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.cbpc.2026.110664_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105655","article-title":"Exposure of zebrafish to environmentally relevant concentrations of mercury during early life stages impairs subsequent reproduction in adults but can be recovered in offspring","volume":"229","author":"Xie","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0155","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aquatox.2017.02.013","article-title":"Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis","volume":"185","author":"Yin","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0160","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1021\/acs.est.2c06735","article-title":"Regional distribution of atmospheric organophosphate tri-\/Diesters in the Pearl River Delta: possible emission, photo-degradation, and atmospheric transportation","volume":"57","author":"Zeng","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0165","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1021\/acs.est.7b01237","article-title":"Potential glucocorticoid and mineralocorticoid effects of nine organophosphate flame retardants","volume":"51","author":"Zhang","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0170","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1021\/acs.est.9b07874","article-title":"New insights in the endocrine disrupting effects of three primary metabolites of organophosphate flame retardants","volume":"54","author":"Zhang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.aquatox.2016.06.018","article-title":"Reproductive toxicity of inorganic mercury exposure in adult zebrafish: histological damage, oxidative stress, and alterations of sex hormone and gene expression in the hypothalamic-pituitary-gonadal axis","volume":"177","author":"Zhang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110664_bb0180","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ygcen.2009.04.017","article-title":"Neuroendocrinology of reproduction in teleost fish","volume":"165","author":"Zohar","year":"2010","journal-title":"Gen. Comp. Endocrinol."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600222X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153204562600222X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:31:38Z","timestamp":1791343898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153204562600222X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":36,"alternative-id":["S153204562600222X"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110664","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No overt reproductive impairment in zebrafish following life-cycle exposure to environmentally relevant concentrations of diphenyl phosphate (DPhP)","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110664","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110664"}}