{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:51:46Z","timestamp":1791345106131,"version":"4.3.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J01268"],"award-info":[{"award-number":["2024J01268"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbpc.2026.110682","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:03:14Z","timestamp":1788364994000},"page":"110682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrating transcriptomics and phenotypic profiling reveals caffeic acid-induced multi-organ developmental toxicity in zebrafish"],"prefix":"10.1016","volume":"310","author":[{"given":"Jun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guirong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110682_bib1","author":"Andrews"},{"key":"10.1016\/j.cbpc.2026.110682_bib2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/cvr\/cvr098","article-title":"Zebrafish as a model to study cardiac development and human cardiac disease","volume":"91","author":"Bakkers","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.cbpc.2026.110682_bib3","first-page":"120","article-title":"Zebrafish as a model system for biomedical studies","volume":"56","author":"Belyaeva","year":"2010","journal-title":"Biomed. Chem."},{"key":"10.1016\/j.cbpc.2026.110682_bib4","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1242\/dev.00838","article-title":"Mutation of weak atrium\/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish","volume":"130","author":"Berdougo","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2026.110682_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/ilar\/ilw040","article-title":"Zebrafish models of human disease: gaining insight into human disease at ZFIN","volume":"58","author":"Bradford","year":"2017","journal-title":"ILAR J."},{"key":"10.1016\/j.cbpc.2026.110682_bib6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nature06801","article-title":"The developmental genetics of congenital heart disease","volume":"451","author":"Bruneau","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2026.110682_bib7","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.1021\/acs.jafc.9b02078","article-title":"Protective effect of caffeic acid against Alzheimer's disease pathogenesis via modulating cerebral insulin signaling, \u03b2-amyloid accumulation, and synaptic plasticity in hyperinsulinemic rats","volume":"67","author":"Chang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2026.110682_bib8","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cbpc.2026.110682_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147631","article-title":"Adjuvant properties of caffeic acid in cancer treatment","volume":"25","author":"Cortez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110682_bib10","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1007\/s12011-020-02518-9","article-title":"Ameliorative effects of caffeic acid against arsenic-induced testicular injury in mice","volume":"199","author":"Dehdashti Moghadam","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.cbpc.2026.110682_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jece.2024.112424","article-title":"Effectively accelerated degradation of bisphenol A in Fe3O4\/PMS system by caffeic acid","volume":"12","author":"Ding","year":"2024","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.cbpc.2026.110682_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.00541","article-title":"Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma","volume":"9","author":"Esp\u00edndola","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cbpc.2026.110682_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biology10040252","article-title":"The zebrafish xenograft models for investigating cancer and cancer therapeutics","volume":"10","author":"Gamble","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.cbpc.2026.110682_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.fsi.2019.04.067","article-title":"The zebrafish: a research model to understand the evolution of vertebrate immunity","volume":"90","author":"Garc\u00eda-Moreno","year":"2019","journal-title":"Fish & shellfish immunology"},{"key":"10.1016\/j.cbpc.2026.110682_bib15","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.2174\/0113892010309341240517071344","article-title":"Revealing the curative possibilities: a comprehensive exploration of caffeic acid","volume":"26","author":"Goyal","year":"2025","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110682_bib16","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1389557516666161130100947","article-title":"Protective effects of caffeic acid and the Alzheimer's brain: an update","volume":"17","author":"Habtemariam","year":"2017","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.cbpc.2026.110682_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.123.1.1","article-title":"The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio","volume":"123","author":"Haffter","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.cbpc.2026.110682_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vascn.2012.10.003","article-title":"A zebrafish phenotypic assay for assessing drug-induced hepatotoxicity","volume":"67","author":"He","year":"2013","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.cbpc.2026.110682_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cbpc.2026.110682_bib20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1124\/jpet.106.105163","article-title":"Antihyperglycemic and antioxidant properties of caffeic acid in db\/db mice","volume":"318","author":"Jung","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.cbpc.2026.110682_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3940(96)13021-4","article-title":"Zebrafish elav\/HuC homologue as a very early neuronal marker","volume":"216","author":"Kim","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbpc.2026.110682_bib22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110682_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.cbpc.2026.110682_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jff.2010.02.003","article-title":"Caffeic acid derivatives in dried Lamiaceae and Echinacea purpurea products","volume":"2","author":"Lee","year":"2010","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.cbpc.2026.110682_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cbpc.2026.110682_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113482","article-title":"Chlorogenic acid as an indispensible partner of caffeic acid in coffee via selective regulation of prooxidative actions of caffeic acid","volume":"173","author":"Li","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.cbpc.2026.110682_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/biom11091300","article-title":"Progress in gene-editing technology of zebrafish","volume":"11","author":"Li","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.cbpc.2026.110682_bib28","article-title":"Potential mechanisms underlying carbimazole-induced cardiotoxicity and hepatotoxicity in zebrafish","author":"Liu","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110682_bib29","article-title":"Bioconcentration and oxidative stress effects of phenolic acids in zebrafish (Danio rerio)","volume":"258","author":"Liu","year":"2023","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110682_bib30","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1021\/jf0200570","article-title":"Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics","volume":"50","author":"Llorach","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2026.110682_bib31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/ar.20768","article-title":"Characterization and classification of zebrafish brain morphology mutants","volume":"292","author":"Lowery","year":"2009","journal-title":"Anat. Rec."},{"key":"10.1016\/j.cbpc.2026.110682_bib32","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1039\/C3AY41807C","article-title":"Caffeic acid: a review of its potential use in medications and cosmetics","volume":"6","author":"Magnani","year":"2014","journal-title":"Anal. Methods"},{"key":"10.1016\/j.cbpc.2026.110682_bib33","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.neulet.2016.08.044","article-title":"Caffeic acid attenuates lipopolysaccharide-induced sickness behaviour and neuroinflammation in mice","volume":"632","author":"Mallik","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cbpc.2026.110682_bib34","first-page":"1","article-title":"Zebrafish as a model for toxicological perturbation of yolk and nutrition in the early embryo","volume":"83","author":"McGrath","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.cbpc.2026.110682_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2019.103244","article-title":"Study of new sources of six chlorogenic acids and caffeic acid","volume":"82","author":"Meinhart","year":"2019","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.cbpc.2026.110682_bib36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0960-9822(00)00048-8","article-title":"Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate","volume":"4","author":"Mullins","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cbpc.2026.110682_bib37","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","article-title":"Gene regulatory networks in the evolution and development of the heart","volume":"313","author":"Olson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2026.110682_bib38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110682_bib39","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3109\/02652048.2015.1094531","article-title":"Evaluation of antibacterial activity of caffeic acid encapsulated by \u03b2-cyclodextrins","volume":"32","author":"Pinho","year":"2015","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.cbpc.2026.110682_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-010-0655-7","article-title":"Inhibitory effect of caffeic acid on cancer cell proliferation by oxidative mechanism in human HT-1080 fibrosarcoma cell line","volume":"349","author":"Rajendra Prasad","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cbpc.2026.110682_bib41","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI58644","article-title":"Innate immunity in the central nervous system","volume":"122","author":"Ransohoff","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cbpc.2026.110682_bib42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cbpc.2026.110682_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s40572-018-0183-2","article-title":"Zebrafish as a model for toxicological perturbation of yolk and nutrition in the early embryo","volume":"5","author":"Sant","year":"2018","journal-title":"Curr. Environ. Health Rep."},{"key":"10.1016\/j.cbpc.2026.110682_bib44","first-page":"187","article-title":"Zebrafish (Danio rerio) as a model organism for investigating endocrine disruption","volume":"149","author":"Segner","year":"2009","journal-title":"Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.cbpc.2026.110682_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/nu12082190","article-title":"Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their metabolites","volume":"12","author":"Sova","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.cbpc.2026.110682_bib46","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-\u03b1","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2026.110682_bib47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/291293a0","article-title":"Production of clones of homozygous diploid zebra fish (Brachydanio rerio)","volume":"291","author":"Streisinger","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2026.110682_bib48","first-page":"1","article-title":"Phenolic acids: natural versatile molecules with promising therapeutic applications","volume":"14","author":"Taofiq","year":"2017","journal-title":"Biotechnol. Rep."},{"key":"10.1016\/j.cbpc.2026.110682_bib49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ydbio.2008.07.037","article-title":"Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number","volume":"322","author":"Targoff","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cbpc.2026.110682_bib50","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbadis.2010.10.011","article-title":"Behavioural assessments of neurotoxic effects and neurodegeneration in zebrafish","volume":"1812","author":"Tierney","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cbpc.2026.110682_bib51","article-title":"ClusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Cambridge (Mass.))"},{"issue":"8","key":"10.1016\/j.cbpc.2026.110682_bib52","first-page":"4415","article-title":"Environmental transport, transformation, and ecological risks of emerging contaminants in China","volume":"54","author":"Zhang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.cbpc.2026.110682_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jes.2020.07.019","article-title":"Comparison of developmental toxicity of different surface modified CdSe\/ZnS QDs in zebrafish embryos","volume":"100","author":"Zheng","year":"2021","journal-title":"J. Environ. Sci."}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:25:33Z","timestamp":1791343533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626002401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":53,"alternative-id":["S1532045626002401"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110682","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating transcriptomics and phenotypic profiling reveals caffeic acid-induced multi-organ developmental toxicity in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110682","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110682"}}