{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:51:56Z","timestamp":1791345116474,"version":"4.3.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.cbpc.2026.110685","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:50:49Z","timestamp":1788796249000},"page":"110685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acute high carbonate alkalinity alters ion regulatory functions, chitin turnover, and intestinal microbial communities in Penaeus monodon"],"prefix":"10.1016","volume":"310","author":[{"given":"Yiming","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Juin","family":"Tay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongli","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihe","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifang","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110685_bb0015","doi-asserted-by":"crossref","first-page":"11722","DOI":"10.1038\/s41598-021-91155-w","article-title":"Genes encoding putative bicarbonate transporters as a missing molecular link between molt and mineralization in crustaceans","volume":"11","author":"Abehsera","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110685_bb0005","article-title":"Binary gene expression patterning of the molt cycle: the case of chitin metabolism","volume":"10","author":"Abehsera","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2026.110685_bb0010","article-title":"Binary gene expression patterning of the molt cycle: the case of chitin metabolism","volume":"10","author":"Abehsera","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2026.110685_bb0020","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cbpb.2003.10.012","article-title":"Calcium regulation in crustaceans during the molt cycle: a review and update","volume":"137","author":"Ahearn","year":"2004","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0025","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaci.2009.04.016","article-title":"Sarcoplasmic calcium-binding protein is an EF-hand\u2013type protein identified as a new shrimp allergen","volume":"124","author":"Ayuso","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41538-026-00787-7","article-title":"Challenges and strategies for globally resilient shrimp aquaculture","volume":"10","author":"Campbell","year":"2026","journal-title":"npj Sci. Food"},{"key":"10.1016\/j.cbpc.2026.110685_bb0035","article-title":"Understanding the host-microbe-environment interactions: intestinal microbiota and transcriptomes of black tiger shrimp Penaeus monodon at different salinity levels","volume":"546","author":"Chaiyapechara","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2026.110685_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737371","article-title":"Understanding the host-microbe-environment interactions: intestinal microbiota and transcriptomes of black tiger shrimp Penaeus monodon at different salinity levels","volume":"546","author":"Chaiyapechara","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2026.110685_bb0045","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12866-024-03407-0","article-title":"Low salinity stress increases the risk of Vibrio parahaemolyticus infection and gut microbiota dysbiosis in Pacific white shrimp","volume":"24","author":"Chang","year":"2024","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0050","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fmars.2014.00080","article-title":"Insights on nitrate respiration by Shewanella","volume":"1","author":"Chen","year":"2015","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0055","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.5382","article-title":"A meta-analysis reveals the environmental and host factors shaping the structure and function of the shrimp microbiota","volume":"6","author":"Cornejo-Granados","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.cbpc.2026.110685_bb0060","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41586-020-2616-y","article-title":"The future of food from the sea","volume":"588","author":"Costello","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cbpc.2026.110685_bb0065","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ncb0905-847","article-title":"The lysosome turns fifty","volume":"7","author":"de Duve","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1242\/jeb.195.1.109","article-title":"Calcium transport in gill plasma membranes of the crab Carcinus maenas: evidence for carriers driven by ATP and a Na+ gradient","volume":"195","author":"Flik","year":"1994","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0080","article-title":"Effects of carbonate alkalinity on antioxidants, immunity and intestinal flora of Penaeus vannamei","volume":"12","author":"Gao","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.cbpc.2026.110685_bb0085","article-title":"Effects of carbonate alkalinity on antioxidants, immunity and intestinal flora of Penaeus vannamei","volume":"10","author":"Gao","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.cbpc.2026.110685_bb0075","article-title":"Acute ammonia causes pathogenic dysbiosis of shrimp gut biofilms","volume":"25","author":"Gao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0090","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12192-019-00987-z","article-title":"Characterization, functional analysis, and expression levels of three carbonic anhydrases in response to pH and saline-alkaline stresses in the ridgetail white prawn Exopalaemon carinicauda","volume":"24","author":"Ge","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.cbpc.2026.110685_bb0095","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s12192-019-00987-z","article-title":"Characterization, functional analysis, and expression levels of three carbonic anhydrases in response to pH and saline\u2013alkaline stresses in the ridgetail white prawn Exopalaemon carinicauda","volume":"24","author":"Ge","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.cbpc.2026.110685_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1031828","article-title":"Highly sensitive and specific responses of shrimp gill cells to high pH stress based on single cell RNA-seq analysis","volume":"10","author":"Ge","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114902","article-title":"Effect of high alkalinity on shrimp gills: histopathological alternations and cell specific responses","volume":"256","author":"Ge","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110685_bb0110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s43705-021-00029-9","article-title":"Transcriptome architecture and regulation at environmental transitions in flavobacteria: the case of an important fish pathogen","volume":"1","author":"Gu\u00e9rin","year":"2021","journal-title":"ISME Commun."},{"key":"10.1016\/j.cbpc.2026.110685_bb0115","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3389\/fphys.2012.00431","article-title":"Multiple functions of the crustacean gill: osmotic\/ionic regulation, acid-base balance, ammonia excretion, and bioaccumulation of toxic metals","volume":"3","author":"Henry","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2024.741510","article-title":"Ammonia nitrogen stress induces dysbiosis of the intestinal bacterial community and facilitates the enrichment of pathogenic bacteria in intestines of shrimp","volume":"595","author":"Hou","year":"2025","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2026.110685_bb0125","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fmars.2022.983615","article-title":"Effects of carbonate alkalinity on branchial gene expression in the large-scale loach (Paramisgurnus dabryanus)","volume":"9","author":"Huang","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0130","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1186\/s12864-024-10659-7","article-title":"Identification of the effects of alkalinity exposure on the gills of oriental river prawns, Macrobrachium nipponense","volume":"25","author":"Jin","year":"2024","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2026.110685_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7007-5-45","article-title":"Gene expression profiling of cuticular proteins across the moult cycle of the crab Portunus pelagicus","volume":"5","author":"Kuballa","year":"2007","journal-title":"BMC Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0140","doi-asserted-by":"crossref","first-page":"e0216222","DOI":"10.1128\/aem.02162-22","article-title":"Investigation of the genus Flavobacterium as a reservoir for fish-pathogenic bacterial species: the case of Flavobacterium collinsii","volume":"89","author":"Lee","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0145","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1128\/AEM.70.4.1944-1955.2004","article-title":"Occurrence and phylogenetic diversity of Sphingomonas strains in soils contaminated with polycyclic aromatic hydrocarbons","volume":"70","author":"Leys Natalie","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0150","article-title":"Differential degradation of petroleum hydrocarbons by Shewanella putrefaciens under aerobic and anaerobic conditions","volume":"15","author":"Li","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0155","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.fsi.2013.05.006","article-title":"Combined effects of carbonate alkalinity and pH on survival, growth and haemocyte parameters of the Venus clam Cyclina sinensis","volume":"35","author":"Lin","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11802-008-0077-2","article-title":"Effect of salinity on hemolymph osmotic pressure, sodium concentration and Na+-K+-ATPase activity of gill of Chinese crab, Eriocheir sinensis","volume":"7","author":"Liu","year":"2008","journal-title":"J. Ocean Univ. China"},{"key":"10.1016\/j.cbpc.2026.110685_bb0165","doi-asserted-by":"crossref","first-page":"11395","DOI":"10.1038\/s41598-022-14783-w","article-title":"Whole-body transcriptome analysis provides insights into the cascade of sequential expression events involved in growth, immunity, and metabolism during the molting cycle in Scylla paramamosain","volume":"12","author":"Liu","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110685_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104410","article-title":"The juvenile hormone epoxide hydrolase homolog in Penaeus vannamei plays immune-related functions","volume":"132","author":"Liu","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0175","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/s41559-018-0519-1","article-title":"Function and functional redundancy in microbial systems","volume":"2","author":"Louca","year":"2018","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12864-016-2373-3","article-title":"De novo transcriptome assembly for the lobster Homarus americanus and characterization of differential gene expression across nervous system tissues","volume":"17","author":"McGrath","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2026.110685_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500323","article-title":"Four billion people facing severe water scarcity","volume":"2","author":"Mekonnen","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cbpc.2026.110685_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2020.111736","article-title":"Soil salinity under climate change: challenges for sustainable agriculture and food security","volume":"280","author":"Mukhopadhyay","year":"2021","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.cbpc.2026.110685_bb0200","first-page":"2019","article-title":"Short Chain Fatty Acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0210","doi-asserted-by":"crossref","first-page":"6585","DOI":"10.1021\/acs.jafc.3c08435","article-title":"Shrimp cultured in low-salt saline\u2013alkali water has a better amino acid nutrition and umamicomparison of flavors between saline\u2013alkali water- and seawater-cultured Litopenaeus vannamei","volume":"72","author":"Qin","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cbpc.2026.110685_bb0205","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3389\/fmars.2021.759923","article-title":"Comparative transcriptomic and proteomic analysis of Exopalaemon carinicauda in response to alkalinity stress","volume":"8","author":"Qin","year":"2021","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/fishes11040202","article-title":"Adaptation mechanisms of aquatic animals to saline\u2013alkaline water aquaculture: physiological, energetic and molecular perspectives","volume":"11","author":"Qu","year":"2026","journal-title":"Fishes"},{"key":"10.1016\/j.cbpc.2026.110685_bb0220","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.aquaculture.2011.12.024","article-title":"Cuticular chitin synthase and chitinase mRNA of whiteleg shrimp Litopenaeus vannamei during the molting cycle","volume":"330-333","author":"Rocha","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2026.110685_bb0225","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fmicb.2022.904815","article-title":"Vibriosis outbreaks in aquaculture: addressing environmental and public health concerns and preventive therapies using gilthead seabream farming as a model system","volume":"13","author":"Sanches-Fernandes","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0230","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1432-1033.1995.tb20363.x","article-title":"A novel EF-hand Ca2+-binding protein from abdominal muscle of crustaceans with similarity to Calcyphosine from Dog Thyroidea","volume":"227","author":"Sauter","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cbpc.2026.110685_bb0235","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/raq.12900","article-title":"Salinity tolerance of fishes: experimental approaches and implications for aquaculture production","volume":"16","author":"Seale","year":"2024","journal-title":"Rev. Aquac."},{"key":"10.1016\/j.cbpc.2026.110685_bb0240","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrm3565","article-title":"Signals from the lysosome: a control centre for cellular clearance and energy metabolism","volume":"14","author":"Settembre","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0245","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3389\/fmars.2022.816932","article-title":"The mechanism of carbonate alkalinity exposure on juvenile Exopalaemon carinicauda with the transcriptome and microRNA analysis","volume":"9","author":"Shi","year":"2022","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0250","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aquatox.2005.09.006","article-title":"Differential protein expression profiles in anterior gills of Eriocheir sinensis during acclimation to cadmium","volume":"76","author":"Silvestre","year":"2006","journal-title":"Aquat. Toxicol. (Amsterdam, Neth.)"},{"key":"10.1016\/j.cbpc.2026.110685_bb0255","article-title":"Muribaculaceae genomes assembled from metagenomes suggest genetic drivers of differential response to acarbose treatment in mice","volume":"6","author":"Smith Byron","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.cbpc.2026.110685_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109420","article-title":"Integrated characterizations of intestinal bacteria and transcriptomics revealed the acute stress response to carbonate alkalinity in white shrimp Penaeus vannamei","volume":"146","author":"Song","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0265","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00244-004-3069-2","article-title":"Degradation of aromatic hydrocarbons by Sphingomonas paucimobilis strain EPA505","volume":"47","author":"Story","year":"2004","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164734","article-title":"Effects of different saline-alkaline conditions on the characteristics of phytoplankton communities in the lakes of Songnen plain, China","volume":"11","author":"Sui","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.cbpc.2026.110685_bb0275","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.aquaculture.2006.04.038","article-title":"Comparison of growth, osmoregulatory capacity, ionic regulation and organosomatic indices of black tiger prawn (Penaeus monodon Fabricius, 1798) juveniles reared in potassium fortified inland saline water and ocean water at different salinities","volume":"258","author":"Tantulo","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.cbpc.2026.110685_bb0280","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2583.2010.01001.x","article-title":"Molecular characterization and enzymatic analysis of juvenile hormone epoxide hydrolase genes in the red flour beetle Tribolium castaneum","volume":"19","author":"Tsubota","year":"2010","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0285","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41598-017-00907-0","article-title":"Juvenile hormone epoxide hydrolase: a promising target for hemipteran pest management","volume":"7","author":"Tusun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cbpc.2026.110685_bb0290","doi-asserted-by":"crossref","DOI":"10.1186\/2193-1801-3-280","article-title":"Microbiota from Litopenaeus vannamei: digestive tract microbial community of Pacific white shrimp (Litopenaeus vannamei)","volume":"3","author":"Tzuc","year":"2014","journal-title":"SpringerPlus"},{"key":"10.1016\/j.cbpc.2026.110685_bb0295","article-title":"Gene identification and characterization of correlations for DEPs_DEGs same trend responding to salinity adaptation in Scylla paramamosain","volume":"2019","author":"Wang","year":"2019","journal-title":"Int. J. Genom."},{"key":"10.1016\/j.cbpc.2026.110685_bb0300","doi-asserted-by":"crossref","first-page":"13456","DOI":"10.3390\/cimb46120803","article-title":"Regulation roles of juvenile hormone epoxide hydrolase gene 2 in the Female River prawn Macrobrachium nipponense reproductive process","volume":"46","author":"Wang","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0305","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s40104-024-01100-w","article-title":"Proline metabolism is essential for alkaline adaptation of Nile tilapia (Oreochromis niloticus)","volume":"15","author":"Wang","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0310","article-title":"Molecular mechanisms underlying substance transport, signal transduction, and anti-stress regulation, as well as anti-alkaline regulation via Bursicon in the cerebral ganglion of Chinese mitten crab Eriocheir sinensis under alkaline stress","volume":"14","author":"Wang","year":"2025","journal-title":"Biology"},{"key":"10.1016\/j.cbpc.2026.110685_bb0315","article-title":"Ammonia excretion in aquatic invertebrates: new insights and questions","volume":"221","author":"Weihrauch","year":"2018","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0320","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbpb.2011.04.003","article-title":"Characterization of sarcoplasmic calcium binding protein (SCP) variants from freshwater crayfish Procambarus clarkii","volume":"160","author":"White","year":"2011","journal-title":"Compar. Biochem. Physiol. Part B, Biochem. Molec. Biol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0325","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ecoenv.2019.05.029","article-title":"Stress response and tolerance mechanisms of ammonia exposure based on transcriptomics and metabolomics in Litopenaeus vannamei","volume":"180","author":"Xiao","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.cbpc.2026.110685_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/fishes9110463","article-title":"Changes in physiological homeostasis in the gills of Litopenaeus vannamei under carbonate alkalinity stress and recovery conditions","volume":"9","author":"Xiao","year":"2024","journal-title":"Fishes"},{"key":"10.1016\/j.cbpc.2026.110685_bb0335","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fmars.2025.1559292","article-title":"Comparative mechanisms of acute high-alkalinity stress on the normal and hybrid populations of Pacific white shrimp (Litopenaeus vannamei)","volume":"12","author":"Ye","year":"2025","journal-title":"Front. Mar. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0340","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1186\/s12864-020-07254-x","article-title":"Identification of a quantitative trait loci (QTL) associated with ammonia tolerance in the Pacific white shrimp (Litopenaeus vannamei)","volume":"21","author":"Zeng","year":"2020","journal-title":"BMC Genomics"},{"key":"10.1016\/j.cbpc.2026.110685_bb0345","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00253-024-13213-3","article-title":"The intestine microbiota of shrimp and its impact on cultivation","volume":"108","author":"Zeng","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0360","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s10126-023-10228-1","article-title":"Histological, physiological and transcriptomic analysis reveal the acute alkalinity stress of the gill and hepatopancreas of Litopenaeus vannamei","volume":"25","author":"Zhang","year":"2023","journal-title":"Mar. Biotechnol. (New York, N.Y.)"},{"key":"10.1016\/j.cbpc.2026.110685_bb0365","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s10126-023-10228-1","article-title":"Histological, physiological and transcriptomic analysis reveal the acute alkalinity stress of the gill and hepatopancreas of Litopenaeus vannamei","volume":"25","author":"Zhang","year":"2023","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.cbpc.2026.110685_bb0350","article-title":"Core gut microbiota of shrimp function as a regulator to maintain immune homeostasis in response to WSSV infection","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectrum"},{"key":"10.1016\/j.cbpc.2026.110685_bb0370","article-title":"Chitin synthase is required for cuticle formation and molting in the Chinese mitten crab Eriocheir sinensis","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cbpc.2026.110685_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/md19030153","article-title":"Chitin synthesis and degradation in crustaceans: a genomic view and application","volume":"19","author":"Zhang","year":"2021","journal-title":"Mar. Drugs"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:31:52Z","timestamp":1791343912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626002437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":74,"alternative-id":["S1532045626002437"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110685","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute high carbonate alkalinity alters ion regulatory functions, chitin turnover, and intestinal microbial communities in Penaeus monodon","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110685","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110685"}}