{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:59:57Z","timestamp":1790765997948,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.cbpc.2026.110688","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:30:22Z","timestamp":1789745422000},"page":"110688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative toxicological responses of cancer and normal cells to silver nanoparticles: Roles of oxidative stress and DNA damage"],"prefix":"10.1016","volume":"311","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cbpc.2026.110688_bb0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cbpc.2026.110688_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2017.10.008","article-title":"A systematic review on silver nanoparticles-induced cytotoxicity: physicochemical properties and perspectives","volume":"9","author":"Akter","year":"2018","journal-title":"J. Adv. Res."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110688_bb0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/nn800596w","article-title":"Cytotoxicity and genotoxicity of silver nanoparticles in human cells","volume":"3","author":"AshaRani","year":"2009","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.cbpc.2026.110688_bb0020","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.0608582104","article-title":"Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.cbpc.2026.110688_bb0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrc883","article-title":"The Bcl2 family: regulators of the cellular life-or-death switch","volume":"2","author":"Cory","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.cbpc.2026.110688_bb0030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00204-010-0545-5","article-title":"Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line A549","volume":"85","author":"Foldbjerg","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.cbpc.2026.110688_bb0035","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.2147\/IJN.S37397","article-title":"Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa","volume":"7","author":"Gurunathan","year":"2012","journal-title":"Int. J. Nanomedicine"},{"issue":"11","key":"10.1016\/j.cbpc.2026.110688_bb0040","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/ac0702084","article-title":"Determination of size and concentration of gold nanoparticles from UV\/Vis spectra","volume":"79","author":"Haiss","year":"2007","journal-title":"Anal. Chem."},{"issue":"5","key":"10.1016\/j.cbpc.2026.110688_bb0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.cbpc.2026.110688_bb0050","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.tiv.2005.06.034","article-title":"In vitro toxicity of nanoparticles in BRL 3A rat liver cells","volume":"19","author":"Hussain","year":"2005","journal-title":"Toxicol. in Vitro"},{"issue":"7267","key":"10.1016\/j.cbpc.2026.110688_bb0055","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.cbpc.2026.110688_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020839","article-title":"Cancer therapy by silver nanoparticles: fiction or reality?","volume":"23","author":"Kovacs","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physrev.00013.2006","article-title":"Mitochondrial membrane permeabilization in cell death","volume":"87","author":"Kroemer","year":"2007","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.cbpc.2026.110688_bb0070","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/17435390.2010.483745","article-title":"Impact of silver nanoparticles on human cells: effect of particle size","volume":"4","author":"Liu","year":"2010","journal-title":"Nanotoxicology"},{"issue":"1\u20132","key":"10.1016\/j.cbpc.2026.110688_bb0075","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.cbpc.2026.110688_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinform."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0090","first-page":"6","article-title":"Differential cytotoxicity: cancer versus normal cells in nanomedicine","volume":"7","author":"Nair","year":"2011","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.cbpc.2026.110688_bb0095","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nprot.2006.5","article-title":"The comet assay: a method to measure DNA damage in individual cells","volume":"1","author":"Olive","year":"2006","journal-title":"Nat. Protoc."},{"issue":"14","key":"10.1016\/j.cbpc.2026.110688_bb0105","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/jnci\/81.14.1088","article-title":"Display and analysis of patterns of differential activity of drugs against human tumor cell lines","volume":"81","author":"Paull","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol. Adv."},{"issue":"18","key":"10.1016\/j.cbpc.2026.110688_bb0120","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","article-title":"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential","volume":"30","author":"Reers","year":"1991","journal-title":"Biochemistry"},{"issue":"Pt 1","key":"10.1016\/j.cbpc.2026.110688_bb0125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","article-title":"Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis","volume":"377","author":"Rejman","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.cbpc.2026.110688_bb0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.biortech.2011.11.092","article-title":"Synthesis and characterization of agar-based silver nanoparticles and nanocomposite film with antibacterial applications","volume":"107","author":"Shukla","year":"2012","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"issue":"18","key":"10.1016\/j.cbpc.2026.110688_bb0140","first-page":"6075","article-title":"Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10","volume":"50","author":"Soule","year":"1990","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.cbpc.2026.110688_bb0145","first-page":"1439","article-title":"Size-based cytotoxicity of silver nanoparticles in bovine retinal endothelial cells","volume":"5","author":"Sriram","year":"2010","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.cbpc.2026.110688_bb0150","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cbpc.2026.110688_bb0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(95)00072-I","article-title":"A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V","volume":"184","author":"Vermes","year":"1995","journal-title":"J. Immunol. Methods"},{"issue":"3","key":"10.1016\/j.cbpc.2026.110688_bb0160","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","article-title":"Sulforhodamine B colorimetric assay for cytotoxicity screening","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"issue":"5\u20136","key":"10.1016\/j.cbpc.2026.110688_bb0165","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0891-5849(99)00107-0","article-title":"Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader","volume":"27","author":"Wang","year":"1999","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.cbpc.2026.110688_bb0170","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1073\/pnas.94.2.514","article-title":"Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress","volume":"94","author":"Yakes","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1532045626002462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:16:06Z","timestamp":1790763366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1532045626002462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":33,"alternative-id":["S1532045626002462"],"URL":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110688","relation":{},"ISSN":["1532-0456"],"issn-type":[{"value":"1532-0456","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative toxicological responses of cancer and normal cells to silver nanoparticles: Roles of oxidative stress and DNA damage","name":"articletitle","label":"Article Title"},{"value":"Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cbpc.2026.110688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110688"}}