{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:12:40Z","timestamp":1791303160141,"version":"4.1.0"},"reference-count":141,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.cca.2006.07.005","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T01:27:50Z","timestamp":1153186070000},"page":"20-35","source":"Crossref","is-referenced-by-count":206,"title":["Molecular mechanisms of insulin resistance and associated diseases"],"prefix":"10.1016","volume":"375","author":[{"given":"Barbara","family":"Mlinar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janja","family":"Marc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Jane\u017e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2006.07.005_bib1","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2006.07.005_bib2","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.2337\/diabetes.53.11.2735","article-title":"Molecular mechanisms of insulin resistance that impact cardiovascular biology","volume":"53","author":"Wang","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00007611-199901000-00002","article-title":"Insulin resistance syndrome: options for treatment","volume":"92","author":"Granberry","year":"1999","journal-title":"South Med J"},{"key":"10.1016\/j.cca.2006.07.005_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.clindermatol.2004.01.011","article-title":"Insulin resistance and obesity","volume":"22","author":"Greenfield","year":"2004","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.cca.2006.07.005_bib5","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1172\/JCI119628","article-title":"Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)","volume":"100","author":"Ferrannini","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib6","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2006.07.005_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib8","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jc.85.7.2402","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2337\/diacare.24.3.460","article-title":"Diagnosing insulin resistance in the general population","volume":"24","author":"McAuley","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2006.07.005_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.med.54.101601.152403","article-title":"Genetics and pathophysiology of human obesity","volume":"54","author":"Cummings","year":"2003","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.cca.2006.07.005_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute\/American Heart Association conference on scientific issues related to definition","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2006.07.005_bib12","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.mcna.2004.04.013","article-title":"Pathogenesis of type 2 diabetes mellitus","volume":"88","author":"DeFronzo","year":"2004","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.cca.2006.07.005_bib13","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1359-6101(03)00052-2","article-title":"Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha","volume":"14","author":"Ruan","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.cca.2006.07.005_bib15","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI117899","article-title":"The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase","volume":"95","author":"Kern","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib16","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.2337\/diabetes.51.5.1319","article-title":"Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory","volume":"51","author":"Ruan","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1749-6632.1965.tb34800.x","article-title":"The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus","volume":"131","author":"Randle","year":"1965","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cca.2006.07.005_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/er.23.2.201","article-title":"Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes","volume":"23","author":"Lewis","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.cca.2006.07.005_bib19","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.2337\/diabetes.51.11.3176","article-title":"Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance","volume":"51","author":"Ruan","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1538-7836.2003.00147.x","article-title":"Weak and non-independent association between plasma TAFI antigen levels and the insulin resistance syndrome","volume":"1","author":"Aubert","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.cca.2006.07.005_bib21","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1172\/JCI117252","article-title":"Mechanisms of fatty acid-induced inhibition of glucose uptake","volume":"93","author":"Boden","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1023\/B:BOLI.0000031097.31587.81","article-title":"The genetics and pathophysiology of diabetes mellitus type II","volume":"27","author":"Jenkins","year":"2004","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.cca.2006.07.005_bib23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1172\/JCI111938","article-title":"Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus","volume":"76","author":"DeFronzo","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib24","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1016\/S0021-9258(18)83748-6","article-title":"Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids","volume":"264","author":"Saxena","year":"1989","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"10.1016\/j.cca.2006.07.005_bib25","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/s00592-005-0175-1","article-title":"Obesity, hypertension and insulin resistance","volume":"42","author":"Sharma","year":"2005","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.cca.2006.07.005_bib26","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.2337\/diacare.26.8.2442","article-title":"Adiponectin: more than just another fat cell hormone?","volume":"26","author":"Chandran","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2006.07.005_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1210\/en.2003-1513","article-title":"Adiponectin and HIV-lipodystrophy: taking HAART","volume":"145","author":"Kinlaw","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2006.07.005_bib28","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1373\/clinchem.2004.032482","article-title":"Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin","volume":"50","author":"Meier","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2006.07.005_bib29","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1172\/JCI14120","article-title":"Endogenous glucose production is inhibited by the adipose-derived protein Acrp30","volume":"108","author":"Combs","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib30","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/oby.2002.138","article-title":"Plasma adiponectin levels are not associated with fat oxidation in humans","volume":"10","author":"Stefan","year":"2002","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2006.07.005_bib31","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1210\/jc.86.8.3815","article-title":"Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin","volume":"86","author":"Yang","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib32","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.2337\/diacare.26.9.2493","article-title":"Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect","volume":"26","author":"Satoh","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2006.07.005_bib33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/oby.2004.24","article-title":"A novel pathway to the manifestations of metabolic syndrome","volume":"12","author":"Sonnenberg","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2006.07.005_bib34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11892-003-0020-2","article-title":"Adipokines, inflammation, and the endothelium in diabetes","volume":"3","author":"Aldhahi","year":"2003","journal-title":"Curr Diab Rep"},{"key":"10.1016\/j.cca.2006.07.005_bib35","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMoa012437","article-title":"Leptin-replacement therapy for lipodystrophy","volume":"346","author":"Oral","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cca.2006.07.005_bib36","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.cca.2006.07.005_bib37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1079\/PNS2003256","article-title":"Energy balance in obesity","volume":"62","author":"Webber","year":"2003","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.cca.2006.07.005_bib38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1210\/rp.59.1.305","article-title":"Leptin signaling in the central nervous system and the periphery","volume":"59","author":"Bjorbaek","year":"2004","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.cca.2006.07.005_bib39","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","article-title":"Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy","volume":"12","author":"Shimomura","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.cca.2006.07.005_bib40","doi-asserted-by":"crossref","unstructured":"Chehab FF, Qiu J, Mounzih K, Ewart-Toland A, Ogus S. Leptin and reproduction. Nutr Rev 2002;60:S39-46; discussion S68-84, 85-37.","DOI":"10.1301\/002966402320634823"},{"key":"10.1016\/j.cca.2006.07.005_bib41","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1210\/jc.2003-030371","article-title":"Bound leptin and sympathetic outflow in nonobese men","volume":"88","author":"Tank","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cca.2006.07.005_bib43","doi-asserted-by":"crossref","first-page":"25651","DOI":"10.1074\/jbc.C100189200","article-title":"Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists","volume":"276","author":"Way","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2006.07.005_bib44","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00109-003-0428-9","article-title":"Resistin: molecular history and prognosis","volume":"81","author":"Banerjee","year":"2003","journal-title":"J Mol Med"},{"key":"10.1016\/j.cca.2006.07.005_bib45","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1007\/s00125-005-1932-y","article-title":"Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans","volume":"48","author":"Utzschneider","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib46","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1007\/s00125-005-1956-3","article-title":"Resistin: yet another adipokine tells us that men are not mice","volume":"48","author":"Arner","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib47","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1073\/pnas.1133870100","article-title":"Monocyte chemoattractant protein 1 in obesity and insulin resistance","volume":"100","author":"Sartipy","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2006.07.005_bib48","doi-asserted-by":"crossref","first-page":"46654","DOI":"10.1074\/jbc.M309895200","article-title":"Adiposity elevates plasma MCP-1 levels leading to the increased CD11b-positive monocytes in mice","volume":"278","author":"Takahashi","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2006.07.005_bib49","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1210\/en.2003-1336","article-title":"Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans","volume":"145","author":"Fain","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2006.07.005_bib50","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1046\/j.1365-2796.2001.00898.x","article-title":"Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism","volume":"250","author":"Vestergaard","year":"2001","journal-title":"J Intern Med"},{"key":"10.1016\/j.cca.2006.07.005_bib51","doi-asserted-by":"crossref","first-page":"13740","DOI":"10.1074\/jbc.M210689200","article-title":"Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes","volume":"278","author":"Senn","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2006.07.005_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1155\/2004\/945073","article-title":"Update on diabetes mellitus","volume":"20","author":"Korc","year":"2004","journal-title":"Dis Markers"},{"key":"10.1016\/j.cca.2006.07.005_bib53","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI119207","article-title":"Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation","volume":"99","author":"De Benedetti","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib54","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1210\/jc.2002-021437","article-title":"Association of low interleukin-10 levels with the metabolic syndrome in obese women","volume":"88","author":"Esposito","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib55","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI116567","article-title":"Glucocorticoid induction of epinephrine synthesizing enzyme in rat skeletal muscle and insulin resistance","volume":"92","author":"Kennedy","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib56","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0022-2275(20)41151-4","article-title":"Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes","volume":"35","author":"Slavin","year":"1994","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cca.2006.07.005_bib57","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1210\/en.130.4.2310","article-title":"The regulation of lipoprotein lipase gene expression by dexamethasone in isolated rat adipocytes","volume":"130","author":"Ong","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2006.07.005_bib58","first-page":"E643","article-title":"In vivo effects of dexamethasone and sucrose on glucose transport (GLUT-4) protein tissue distribution","volume":"271","author":"Coderre","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2006.07.005_bib59","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/CS19980388","article-title":"Glucocorticoids and insulin resistance: old hormones, new targets","volume":"96","author":"Andrews","year":"1999","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.cca.2006.07.005_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0039-128X(94)90044-2","article-title":"In vivo effect of free fatty acids on the specific binding of glucocorticosteroids to corticosteroid binding globulin and liver receptors in immature rats","volume":"59","author":"Haourigui","year":"1994","journal-title":"Steroids"},{"key":"10.1016\/j.cca.2006.07.005_bib61","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00125-003-1313-3","article-title":"Modulation of insulin action","volume":"47","author":"Pirola","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib62","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cca.2006.07.005_bib63","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0968-0004(01)01958-2","article-title":"Ten years of protein kinase B signalling: a hard Akt to follow","volume":"26","author":"Brazil","year":"2001","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.cca.2006.07.005_bib64","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1073\/pnas.121145898","article-title":"The target of rapamycin (TOR) proteins","volume":"98","author":"Raught","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2006.07.005_bib65","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1242\/jcs.114.8.1429","article-title":"Insulin signalling","volume":"114","author":"Bevan","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cca.2006.07.005_bib66","first-page":"174","article-title":"Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes","volume":"39","author":"Sharma","year":"1991","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.cca.2006.07.005_bib67","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1365-2265.2002.01610.x","article-title":"Genetics of type 2 diabetes and insulin resistance: knowledge from human studies","volume":"57","author":"McIntyre","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.cca.2006.07.005_bib68","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1530\/eje.0.1470435","article-title":"Insights into obesity and insulin resistance from the study of extreme human phenotypes","volume":"147","author":"O'Rahilly","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.cca.2006.07.005_bib69","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","author":"Barroso","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.cca.2006.07.005_bib70","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1210\/jcem-54-5-919","article-title":"Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance","volume":"54","author":"Taylor","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib71","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2337\/diabetes.49.6.889","article-title":"Serine residues 1177\/78\/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation","volume":"49","author":"Bossenmaier","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib72","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1172\/JCI116060","article-title":"Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance","volume":"90","author":"Saad","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib73","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0968-0004(02)02085-6","article-title":"The SOCS box: a tale of destruction and degradation","volume":"27","author":"Kile","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.cca.2006.07.005_bib74","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1194\/jlr.M300003-JLR200","article-title":"Increased expression of the SNARE accessory protein Munc18c in lipid-mediated insulin resistance","volume":"44","author":"Schlaepfer","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cca.2006.07.005_bib75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1464-5491.2005.01566.x","article-title":"Molecular mechanisms of insulin resistance","volume":"22","author":"Schinner","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.cca.2006.07.005_bib76","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrg1556","article-title":"The genetics of human obesity","volume":"6","author":"Bell","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib77","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1056\/NEJMp038114","article-title":"To eat or not to eat- how the gut talks to the brain","volume":"349","author":"Korner","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cca.2006.07.005_bib78","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1126\/science.1121214","article-title":"Biomedicine. Separation of conjoined hormones yields appetite rivals","volume":"310","author":"Nogueiras","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cca.2006.07.005_bib79","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2174\/1389450053174587","article-title":"The hypothalamus and obesity","volume":"6","author":"King","year":"2005","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.cca.2006.07.005_bib80","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cca.2006.07.005_bib81","first-page":"353","article-title":"Diabetes mellitus: a \u201cthrifty\u201d genotype rendered detrimental by \u201cprogress\u201d?","volume":"14","author":"Neel","year":"1962","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib82","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/35019082","article-title":"Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean","volume":"406","author":"Clapham","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cca.2006.07.005_bib83","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/oby.2005.50","article-title":"The human obesity gene map: the 2004 update","volume":"13","author":"Perusse","year":"2005","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2006.07.005_bib84","series-title":"Workshop and Symposium Gastric Surgery-Standards and Novelties Proceedings of the symposium Klini\u010dni oddelek za abdominalno kirurgijo Kirur\u0161ka klinika Klini\u010dni center Ljubljana: Ljubljana","first-page":"11","article-title":"Morbid obesity","author":"Pfeifer","year":"2005"},{"key":"10.1016\/j.cca.2006.07.005_bib85","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1001\/jama.287.11.1382","article-title":"Epidemic of obesity expands its spread to developing countries","volume":"287","author":"Friedrich","year":"2002","journal-title":"Jama"},{"key":"10.1016\/j.cca.2006.07.005_bib86","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/oby.2004.153","article-title":"A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men","volume":"12","author":"Vohl","year":"2004","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2006.07.005_bib87","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/07853899709002451","article-title":"Differences in lipolysis between human subcutaneous and omental adipose tissues","volume":"27","author":"Arner","year":"1995","journal-title":"Ann Med"},{"key":"10.1016\/j.cca.2006.07.005_bib88","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJMra041001","article-title":"Thiazolidinediones","volume":"351","author":"Yki-Jarvinen","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cca.2006.07.005_bib89","series-title":"The IDF consensus worldwide definition of the metabolic syndrome","year":"2001"},{"key":"10.1016\/j.cca.2006.07.005_bib90","series-title":"Endocrinology","first-page":"954","article-title":"Syndrome X","author":"Reaven","year":"2001"},{"key":"10.1016\/j.cca.2006.07.005_bib91","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1043-2760(01)00425-8","article-title":"Endothelial dysfunction in endocrine disease","volume":"12","author":"Abdu","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib92","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1172\/JCI115260","article-title":"Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans","volume":"87","author":"Anderson","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib93","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ejogrb.2004.06.024","article-title":"PCOS: an ovarian disorder that leads to dysregulation in the hypothalamic-pituitary-adrenal axis?","volume":"118","author":"Doi","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.cca.2006.07.005_bib94","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMra025261","article-title":"Acquired and inherited lipodystrophies","volume":"350","author":"Garg","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cca.2006.07.005_bib95","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magre","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib96","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nrm879","article-title":"Life at the edge: the nuclear envelope and human disease","volume":"3","author":"Burke","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cca.2006.07.005_bib97","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1210\/jc.2002-020794","article-title":"Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients","volume":"87","author":"Chen","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib98","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0140-6736(02)08094-7","article-title":"Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance","volume":"359","author":"Bastard","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2006.07.005_bib99","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00508-004-0268-9","article-title":"Lipodystrophy and metabolic abnormalities in Slovenian HIV-infected patients","volume":"116","author":"Tomazic","year":"2004","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.cca.2006.07.005_bib100","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1084\/jem.177.6.1827","article-title":"Complement-mediated adipocyte lysis by nephritic factor sera","volume":"177","author":"Mathieson","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.cca.2006.07.005_bib101","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s00125-003-1207-4","article-title":"Fatty acid metabolism and insulin secretion in pancreatic beta cells","volume":"46","author":"Yaney","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib102","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/diabetes.39.11.1315","article-title":"Mapping genes in diabetes. Genetic epidemiological perspective","volume":"39","author":"Rich","year":"1990","journal-title":"Diabetes"},{"issue":"Spec No 1","key":"10.1016\/j.cca.2006.07.005_bib103","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1093\/hmg\/ddh057","article-title":"Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification","volume":"13","author":"McCarthy","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib104","first-page":"E635","article-title":"Effect of fatty acids on insulin release: role of chain length and degree of unsaturation","volume":"266","author":"Opara","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2006.07.005_bib105","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/BF00401761","article-title":"Opposite effects of short-and long-term fatty acid infusion on insulin secretion in healthy subjects","volume":"38","author":"Paolisso","year":"1995","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib106","first-page":"E1055","article-title":"Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation","volume":"276","author":"Carpentier","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2006.07.005_bib107","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.2337\/diabetes.47.7.1086","article-title":"Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression","volume":"47","author":"Roche","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib108","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1677\/jme.0.0300271","article-title":"Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1)","volume":"30","author":"Wrede","year":"2003","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.cca.2006.07.005_bib109","first-page":"210","article-title":"Common non-coding SNPs near the hepatocyte nuclear factor-4 alpha gene are associated with type 2 diabetes","volume":"73","author":"Mohlke","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib110","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1073\/pnas.062059799","article-title":"HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community","volume":"99","author":"Triggs-Raine","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2006.07.005_bib111","first-page":"A44","article-title":"A common variant in the glucokinase beta-cell gene promoter increases fasting glucose levels and is associated with altered birth weight","volume":"20","author":"Weedon","year":"2003","journal-title":"Diabet Med"},{"key":"10.1016\/j.cca.2006.07.005_bib112","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2337\/diabetes.49.1.126","article-title":"Analysis of parent\u2013offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles","volume":"49","author":"Huxtable","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib113","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/79839","article-title":"The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes","volume":"26","author":"Altshuler","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib114","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2337\/diabetes.52.2.568","article-title":"Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes","volume":"52","author":"Gloyn","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2006.07.005_bib115","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1086\/379285","article-title":"Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility","volume":"73","author":"Weedon","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng0696-161","article-title":"A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2","volume":"13","author":"Hanis","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2006.07.005_bib117","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.AOG.0000104485.44999.C6","article-title":"Polycystic ovary syndrome","volume":"103","author":"Guzick","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.cca.2006.07.005_bib118","doi-asserted-by":"crossref","first-page":"132","DOI":"10.5694\/j.1326-5377.2004.tb05838.x","article-title":"4: Polycystic ovary syndrome","volume":"180","author":"Norman","year":"2004","journal-title":"Med J Aust"},{"key":"10.1016\/j.cca.2006.07.005_bib119","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.cca.2006.07.005_bib120","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/jc.2004-0229","article-title":"Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome","volume":"90","author":"Ehrmann","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib121","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2006.07.005_bib122","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.atherosclerosis.2005.10.007","article-title":"Cardiovascular disease in the polycystic ovary syndrome: new insights and perspectives","volume":"185","author":"Cussons","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cca.2006.07.005_bib123","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3109\/00016349209006227","article-title":"Polycystic ovary syndrome and risk for myocardial infarction. Evaluated from a risk factor model based on a prospective population study of women","volume":"71","author":"Dahlgren","year":"1992","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.cca.2006.07.005_bib124","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/S0140-6736(03)13409-5","article-title":"Polycystic ovary syndrome and endometrial carcinoma","volume":"361","author":"Hardiman","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2006.07.005_bib125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/0002-9378(83)90324-1","article-title":"Psychological stress and increases in urinary norepinephrine metabolites, platelet serotonin, and adrenal androgens in women with polycystic ovary syndrome","volume":"145","author":"Lobo","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.cca.2006.07.005_bib126","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1210\/jc.75.2.577","article-title":"Cellular mechanisms of insulin resistance in polycystic ovarian syndrome","volume":"75","author":"Ciaraldi","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib127","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1172\/JCI118126","article-title":"Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome","volume":"96","author":"Dunaif","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib128","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/en.2003-0329","article-title":"Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1\/2 in human ovarian theca cells","volume":"145","author":"Munir","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2006.07.005_bib129","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/jc.84.9.3110","article-title":"Selective insulin resistance in the polycystic ovary syndrome","volume":"84","author":"Book","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib130","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1210\/jc.83.6.2001","article-title":"Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system","volume":"83","author":"Nestler","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib131","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/me.2004-0178","article-title":"lterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome","volume":"19","author":"Nelson-Degrave","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.cca.2006.07.005_bib132","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1073\/pnas.92.23.10619","article-title":"Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome","volume":"92","author":"Zhang","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2006.07.005_bib133","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0301-0082(91)90015-S","article-title":"Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects","volume":"36","author":"Unger","year":"1991","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.cca.2006.07.005_bib134","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-2007-1016294","article-title":"Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications","volume":"15","author":"Nestler","year":"1997","journal-title":"Semin Reprod Endocrinol"},{"key":"10.1016\/j.cca.2006.07.005_bib135","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1472-6483(10)62053-6","article-title":"The polycystic ovary syndrome: what does insulin resistance have to do with it?","volume":"6","author":"Ben-Shlomo","year":"2003","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.cca.2006.07.005_bib136","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1210\/jc.2003-031378","article-title":"Insulin sensitivity in women with polycystic ovary syndrome","volume":"89","author":"Vrbikova","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2006.07.005_bib137","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1196\/annals.1290.005","article-title":"Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome","volume":"997","author":"Strauss","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.cca.2006.07.005_bib138","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.cca.2006.07.005_bib139","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/BF03347535","article-title":"Presence of metabolic risk factors in non-obese PCOS sisters: evidence of heritability of insulin resistance","volume":"27","author":"Diamanti-Kandarakis","year":"2004","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.cca.2006.07.005_bib140","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00125-005-1876-2","article-title":"The metabolic syndrome: time for a critical appraisal. Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes","volume":"48","author":"Kahn","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2006.07.005_bib141","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diacare.29.01.06.dc05-0862","article-title":"A single factor underlies the metabolic syndrome: a confirmatory factor analysis","volume":"29","author":"Pladevall","year":"2006","journal-title":"Diabetes Care"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898106004475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898106004475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T20:15:11Z","timestamp":1627589711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898106004475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":141,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0009898106004475"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2006.07.005","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}