{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:34Z","timestamp":1790232574682,"version":"4.1.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.cca.2007.02.026","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T14:27:24Z","timestamp":1172154444000},"page":"32-38","source":"Crossref","is-referenced-by-count":22,"title":["VacA and HP-NAP, Ying and Yang of Helicobacter pylori-associated gastric inflammation"],"prefix":"10.1016","volume":"381","author":[{"given":"Mario Milco","family":"D'Elios","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Montecucco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2007.02.026_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0966-842X(93)90047-U","article-title":"Helicobacter pylori: microbiology of a \u201cslow\u201d bacterial infection","volume":"1","author":"Blaser","year":"1993","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib2","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","volume":"1","author":"Warren","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2007.02.026_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.272.1.65","article-title":"NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. Helicobacter pylori in peptic ulcer disease","volume":"272","year":"1994","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.cca.2007.02.026_bib4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.cca.2007.02.026_bib5","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.158.2.962","article-title":"T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease","volume":"158","author":"D'Elios","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00365529409096832","article-title":"Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa","volume":"29","author":"Davies","year":"1994","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cca.2007.02.026_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0016-5085(99)70121-6","article-title":"Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers","volume":"116","author":"Hamlet","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cca.2007.02.026_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1099\/00222615-26-2-93","article-title":"Cytotoxin activity in broth-culture filtrates of Campylobacter pylori","volume":"26","author":"Leunk","year":"1988","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib9","doi-asserted-by":"crossref","first-page":"10570","DOI":"10.1016\/S0021-9258(19)50054-0","article-title":"Purification and characterization of the vacuolating toxin from Helicobacter pylori","volume":"267","author":"Cover","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1365-2958.1994.tb01019.x","article-title":"Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein","volume":"12","author":"Schmitt","year":"1994","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib11","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.179.5.1653","article-title":"Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease","volume":"179","author":"Telford","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.cca.2007.02.026_bib12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.133.4.801","article-title":"Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin","volume":"133","author":"Lupetti","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cca.2007.02.026_bib13","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/jmbi.1999.2877","article-title":"3D imaging of the 58\u00a0kDa cell binding subunit of the Helicobacter pylori cytotoxin","volume":"290","author":"Reyrat","year":"1999","journal-title":"J Mol Biol"},{"key":"10.1016\/j.cca.2007.02.026_bib14","doi-asserted-by":"crossref","first-page":"23937","DOI":"10.1074\/jbc.270.41.23937","article-title":"Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant","volume":"270","author":"de Bernard","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib15","doi-asserted-by":"crossref","first-page":"36693","DOI":"10.1074\/jbc.274.51.36693","article-title":"Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta","volume":"274","author":"Yahiro","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib16","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1083\/jcb.138.4.759","article-title":"Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating toxin, reveals its pattern of assembly","volume":"138","author":"Cover","year":"1997","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cca.2007.02.026_bib17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/bbrc.1998.8808","article-title":"The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies","volume":"24","author":"Molinari","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cca.2007.02.026_bib18","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1093\/emboj\/18.20.5517","article-title":"Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity","volume":"18","author":"Szab\u00f2","year":"1999","journal-title":"EMBO J"},{"key":"10.1016\/j.cca.2007.02.026_bib19","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.270.30.17771","article-title":"Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration","volume":"270","author":"Atherton","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2958.1996.tb02612.x","article-title":"The vacuolating cytotoxin of Helicobacter pylori","volume":"20","author":"Cover","year":"1996","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-4274(98)00140-4","article-title":"Cell vacuolization induced by Helicobacter pylori VacA toxin: cell line sensitivity and quantitative estimation","volume":"99","author":"de Bernard","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.cca.2007.02.026_bib22","doi-asserted-by":"crossref","first-page":"10212","DOI":"10.1073\/pnas.95.17.10212","article-title":"The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity","volume":"95","author":"Pagliaccia","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2007.02.026_bib23","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/0046-8177(92)90261-Z","article-title":"Characterization of HeLa cell vacuoles induced by Helicobacter pylori broth culture supernatant","volume":"23","author":"Cover","year":"1992","journal-title":"Human Pathol"},{"key":"10.1016\/j.cca.2007.02.026_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/(SICI)1096-9896(199712)183:4<453::AID-PATH950>3.0.CO;2-2","article-title":"Helicobacter pylori vacuolating toxin accumulates within the endosomal\u2013vacuolar compartment of cultured gastric cells and potentiates the vacuolating activity of ammonia","volume":"183","author":"Ricci","year":"1997","journal-title":"J Pathol"},{"key":"10.1016\/j.cca.2007.02.026_bib25","doi-asserted-by":"crossref","first-page":"9720","DOI":"10.1073\/pnas.91.21.9720","article-title":"Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments","volume":"91","author":"Papini","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2007.02.026_bib26","doi-asserted-by":"crossref","first-page":"25339","DOI":"10.1074\/jbc.272.40.25339","article-title":"Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers","volume":"272","author":"Molinari","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/emboj\/16.1.15","article-title":"The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin","volume":"16","author":"Papini","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.cca.2007.02.026_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1462-5822.2002.00163.x","article-title":"Cell vacuolization induced by Helicobacter pylori VacA cytotoxin does not depend on late endosomal SNAREs","volume":"4","author":"de Bernard","year":"2002","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib29","doi-asserted-by":"crossref","first-page":"25022","DOI":"10.1074\/jbc.272.40.25022","article-title":"Effect of Helicobacter pylori vacuolating toxin on maturation and extracellular release of procathepsin D and on epidermal growth factor degradation","volume":"272","author":"Satin","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.187.1.135","article-title":"Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA","volume":"187","author":"Molinari","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.cca.2007.02.026_bib31","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1172\/JCI2764","article-title":"Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin","volume":"102","author":"Papini","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.02.026_bib32","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI13045","article-title":"The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia","volume":"108","author":"Tombola","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.02.026_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/mpat.1998.0241","article-title":"Vacuolating cytotoxin purified from Helicobacter pylori causes mitochondrial damage in human gastric cells","volume":"26","author":"Kimura","year":"1999","journal-title":"Microb Pathog"},{"key":"10.1016\/j.cca.2007.02.026_bib34","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1093\/emboj\/19.23.6361","article-title":"The N-terminal 34\u00a0kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release","volume":"19","author":"Galmiche","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.cca.2007.02.026_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1462-5822.2003.00347.x","article-title":"Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity","volume":"6","author":"Willhite","year":"2004","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib36","doi-asserted-by":"crossref","first-page":"48204","DOI":"10.1074\/jbc.M304131200","article-title":"Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation","volume":"278","author":"Willhite","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib37","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1128\/IAI.69.8.5080-5087.2001","article-title":"Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS","volume":"69","author":"Kuck","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cca.2007.02.026_bib38","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1074\/jbc.M509404200","article-title":"Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation","volume":"281","author":"Yamasaki","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.02.026_bib39","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.15.1.821","article-title":"Capture and processing of exogenous antigens for presentation on MHC molecules","volume":"15","author":"Watts","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib40","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1084\/jem.20030621","article-title":"The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms","volume":"198","author":"Boncristiano","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.cca.2007.02.026_bib41","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1126\/science.1086871","article-title":"Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation","volume":"301","author":"Gebert","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cca.2007.02.026_bib42","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1101\/gad.1102703","article-title":"Transcriptional regulation by calcium, calcineurin, and NFAT","volume":"17","author":"Hogan","year":"2003","journal-title":"Genes Dev"},{"key":"10.1016\/j.cca.2007.02.026_bib43","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.4049\/jimmunol.168.6.2603","article-title":"Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines","volume":"168","author":"Supajatura","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1462-5822.2004.00446.x","article-title":"The Helicobacter pylori VacA cytotoxin activates RBL-2H3 cells by inducing cytosolic calcium oscillations","volume":"7","author":"de Bernard","year":"2005","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib45","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.cca.2007.02.026_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00365529409096832","article-title":"Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa","volume":"29","author":"Davies","year":"1994","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.cca.2007.02.026_bib47","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1286-4579(03)00124-2","article-title":"Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori","volume":"5","author":"Montecucco","year":"2003","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cca.2007.02.026_bib48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1365-2958.1999.01584.x","article-title":"The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure","volume":"34","author":"Tonello","year":"1999","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.cca.2007.02.026_bib49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-2836(02)00879-3","article-title":"Structure of the neutrophil-activating protein from Helicobacter pylori","volume":"323","author":"Zanotti","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1016\/j.cca.2007.02.026_bib50","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1128\/IAI.63.6.2213-2220.1995","article-title":"Characterization of a Helicobacter pylori neutrophil-activating protein","volume":"63","author":"Evans","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.cca.2007.02.026_bib51","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/1521-4141(200203)32:3<671::AID-IMMU671>3.3.CO;2-X","article-title":"The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a potent stimulant of mast cells","volume":"32","author":"Montemurro","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib52","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1086\/319280","article-title":"Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells","volume":"183","author":"Montemurro","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cca.2007.02.026_bib53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.femsle.2005.06.008","article-title":"Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP","volume":"249","author":"Brisslert","year":"2005","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cca.2007.02.026_bib54","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.4049\/jimmunol.178.3.1312","article-title":"The neutrophil-activating protein of Helicobacter pylori crosses endothelia to promote neutrophil adhesion in vivo","volume":"178","author":"Polenghi","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib55","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0016-5085(98)70531-1","article-title":"Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype","volume":"114","author":"Bamford","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cca.2007.02.026_bib56","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.4049\/jimmunol.165.9.5332","article-title":"Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa","volume":"165","author":"Luzza","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2007.02.026_bib57","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1086\/318541","article-title":"Expression of Interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection","volume":"183","author":"Tomita","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cca.2007.02.026_bib58","doi-asserted-by":"crossref","first-page":"G481","DOI":"10.1152\/ajpgi.00422.2001","article-title":"In situ correlation of cytokine secretion and apoptosis in Helicobacter pylori-associated gastritis","volume":"283","author":"Lehmann","year":"2002","journal-title":"Am J Physiol Gasterointest Liver Physiol"},{"key":"10.1016\/j.cca.2007.02.026_bib59","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1172\/JCI27177","article-title":"The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses","volume":"116","author":"Amedei","year":"2006","journal-title":"J Clin Invest"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107000940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107000940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T04:38:56Z","timestamp":1707626336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898107000940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0009898107000940"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2007.02.026","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}