{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T13:59:07Z","timestamp":1774360747046,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.cca.2007.03.015","type":"journal-article","created":{"date-parts":[[2007,3,25]],"date-time":"2007-03-25T06:51:00Z","timestamp":1174805460000},"page":"20-24","source":"Crossref","is-referenced-by-count":22,"title":["Simultaneous determination and pharmacokinetic study of roxithromycin and ambroxol hydrochloride in human plasma by LC-MS\/MS"],"prefix":"10.1016","volume":"382","author":[{"given":"Tai-jun","family":"Hang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-ping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2007.03.015_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0014-2999(03)01998-8","article-title":"Roxithromycin promotes lymphocyte apoptosis in Dermatophagoides-sensitive asthma patients","volume":"474","author":"Ogawa","year":"2003","journal-title":"Eur J Pharm"},{"issue":"Suppl A","key":"10.1016\/j.cca.2007.03.015_bib2","first-page":"76","article-title":"Effects of roxithromycin on a guinea pig model for chronic asthma","volume":"57","author":"Tada","year":"2004","journal-title":"Jpn J Antibiot"},{"key":"10.1016\/j.cca.2007.03.015_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5414\/CPP44409","article-title":"Safety and usage pattern of an over-the-counter ambroxol cough syrup: a community pharmacy-based cohort study","volume":"44","author":"Schulz","year":"2006","journal-title":"Int J Clin Pharmacol Ther"},{"key":"10.1016\/j.cca.2007.03.015_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.phrs.2003.07.011","article-title":"Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers","volume":"49","author":"Lee","year":"2004","journal-title":"Pharm Res"},{"key":"10.1016\/j.cca.2007.03.015_bib5","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jpba.2004.04.001","article-title":"Simultaneous determination of roxithromycin and ambroxol HCl in a new tablet formation by liquid chromatography","volume":"35","author":"Qi","year":"2004","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.cca.2007.03.015_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/0253-7613.25802","article-title":"Irrational drug combinations: need to sensitize undergraduates","volume":"38","author":"Gautam","year":"2006","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.cca.2007.03.015_bib7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0378-4347(98)00533-7","article-title":"Determination of roxithromycin in human plasma by high-performance liquid chromatography with spectrophotometric detection","volume":"723","author":"Macek","year":"1999","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.cca.2007.03.015_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-4347(00)00614-9","article-title":"Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography","volume":"755","author":"Pappa-Louisi","year":"2001","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"2","key":"10.1016\/j.cca.2007.03.015_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-4347(00)00334-0","article-title":"Determination of roxithromycin residues in the flounder muscle with electrospray liquid chromatography mass spectrometry","volume":"746","author":"Lim","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"4","key":"10.1016\/j.cca.2007.03.015_bib10","first-page":"233","article-title":"Bioequivalence evaluation of two roxithromycin formulations in healthy human volunteers by high performance liquid chromatography coupled to tandem mass spectrometry","volume":"49","author":"Motta","year":"1999","journal-title":"Acta Physiol Pharmacol Ther Latinoam"},{"key":"10.1016\/j.cca.2007.03.015_bib11","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jpba.2005.04.006","article-title":"Determination of roxithromycin in rat lung tissue by liquid chromatography-mass spectrometry","volume":"39","author":"Wang","year":"2005","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.cca.2007.03.015_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0731-7085(03)00059-1","article-title":"Determination of ambroxol in human plasma using LC-MS\/MS","volume":"32","author":"Kim","year":"2003","journal-title":"J Pharm Biomed Anal"},{"issue":"1","key":"10.1016\/j.cca.2007.03.015_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0378-4347(00)00150-X","article-title":"Sensitive method for the determination of ambroxol in body fluids by capillary electrophoresis and fluorescence detection","volume":"742","author":"Perez-Ruiz","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"issue":"8","key":"10.1016\/j.cca.2007.03.015_bib14","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/S0149-2918(03)80215-1","article-title":"Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men","volume":"25","author":"Villacampa","year":"2003","journal-title":"Clin Ther"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107001520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107001520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T11:28:30Z","timestamp":1546946910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898107001520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":14,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0009898107001520"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2007.03.015","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}