{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:38:38Z","timestamp":1760121518046},"reference-count":122,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.cca.2007.04.006","type":"journal-article","created":{"date-parts":[[2007,4,15]],"date-time":"2007-04-15T11:12:19Z","timestamp":1176635539000},"page":"1-20","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oxidative mechanisms at rest and during exercise"],"prefix":"10.1016","volume":"383","author":[{"given":"Edouard","family":"Ghanassia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fr\u00e9d\u00e9ric","family":"Brun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Raynaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2007.04.006_bib1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0007-9960(05)80482-1","article-title":"Hom\u00e9ostasie \u00e9nerg\u00e9tique et m\u00e9tabolisme glucido\u2013lipidique: pourquoi deux substrats diff\u00e9rents?","volume":"40","author":"Leverve","year":"2005","journal-title":"Cah Nutr Di\u00e9t"},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2007.04.006_bib2","first-page":"73","article-title":"Insulin secretion, insulin resistance, and obesity","volume":"6","author":"DeFronzo","year":"1982","journal-title":"Int J Obes"},{"key":"10.1016\/j.cca.2007.04.006_bib3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(63)91500-9","article-title":"The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus","volume":"13","author":"Randle","year":"1963","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2007.04.006_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1079\/PNS2004350","article-title":"Physiological regulation of NEFA availability: lipolysis pathway","volume":"63","author":"Stich","year":"2004","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.cca.2007.04.006_bib5","doi-asserted-by":"crossref","first-page":"49443","DOI":"10.1074\/jbc.M104095200","article-title":"Characterization of the functional interaction of adipocyte lipid-binding protein with hormone-sensitive lipase","volume":"276","author":"Shen","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib6","doi-asserted-by":"crossref","first-page":"20896","DOI":"10.1074\/jbc.M001119200","article-title":"Aquaporin adipose, a putative glycerol channel in adipocytes","volume":"275","author":"Kishida","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib7","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1096\/fasebj.14.10.1345","article-title":"Natriuretic peptides: a new lipolytic pathway in human adipocytes","volume":"14","author":"Sengenes","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.cca.2007.04.006_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbalip.2005.08.018","article-title":"Long-chain fatty acid uptake and FAT\/CD36 translocation in heart and skeletal muscle","volume":"1736","author":"Koonen","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2007.04.006_bib9","first-page":"685","article-title":"Insulin and adipose tissue lipoprotein lipase activity in humans","volume":"5","author":"Brunzell","year":"1981","journal-title":"Int J Obes"},{"key":"10.1016\/j.cca.2007.04.006_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-2001-12628","article-title":"Nutrient regulation of post-heparin lipoprotein lipase activity in obese subjects","volume":"33","author":"Ranganath","year":"2001","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.cca.2007.04.006_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev.nu.16.070196.002515","article-title":"Regulation of hepatic de novo lipogenesis in humans","volume":"16","author":"Hellerstein","year":"1996","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.cca.2007.04.006_bib12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1172\/JCI16253","article-title":"Energy expenditure, sex, and endogenous fuel availability in humans","volume":"111","author":"Nielsen","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib13","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.38.12.1595","article-title":"Insulin regulation of lipolysis in nondiabetic and IDDM subjects","volume":"38","author":"Jensen","year":"1989","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib14","doi-asserted-by":"crossref","first-page":"E599","DOI":"10.1152\/ajpendo.00502.2002","article-title":"Activation of alpha2-adrenergic receptors blunts epinephrine-induced lipolysis in subcutaneous adipose tissue during a hyperinsulinemic euglycemic clamp in men","volume":"285","author":"Stich","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.33549\/physiolres.930424","article-title":"Hyperglycemia downregulates total lipoprotein lipase activity in humans","volume":"53","author":"Kovar","year":"2004","journal-title":"Physiol Res"},{"issue":"279","key":"10.1016\/j.cca.2007.04.006_bib16","doi-asserted-by":"crossref","first-page":"40683","DOI":"10.1074\/jbc.M400541200","article-title":"Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase","volume":"24","author":"Soni","year":"2004","journal-title":"J Biol Chem"},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2007.04.006_bib17","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.2337\/diabetes.53.2007.S143","article-title":"Update on adipocyte hormones: regulation of energy balance and carbohydrate\/lipid metabolism","volume":"53","author":"Havel","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib18","first-page":"3503","article-title":"The distinction of android and gynoid obesities as the base for their prognosis","volume":"31","author":"Vague","year":"1955","journal-title":"Sem Hop"},{"key":"10.1016\/j.cca.2007.04.006_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome\u2014a new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet Med"},{"key":"10.1016\/j.cca.2007.04.006_bib20","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0022-2275(20)40090-2","article-title":"Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers","volume":"35","author":"Abate","year":"1994","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cca.2007.04.006_bib21","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/sj.ijo.0800467","article-title":"Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?","volume":"21","author":"Seidell","year":"1997","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.cca.2007.04.006_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2337\/diabetes.48.1.10","article-title":"Insulin regulation of regional free fatty acid metabolism","volume":"48","author":"Meek","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib23","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1172\/JCI116821","article-title":"Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men","volume":"92","author":"Fried","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib24","first-page":"E815","article-title":"Regional specificity of ASP binding in human adipose tissue","volume":"276","author":"Saleh","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib25","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1210\/jc.2003-031157","article-title":"Glucocorticoids down-regulate glucose uptake capacity and insulin-signaling proteins in omental but not subcutaneous human adipocytes","volume":"89","author":"Lundgren","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib26","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1210\/jcem.87.8.8761","article-title":"Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans","volume":"87","author":"Virtanen","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-201X.2004.01385.x","article-title":"Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies","volume":"183","author":"Giorgino","year":"2005","journal-title":"Acta Physiol Scand"},{"issue":"2","key":"10.1016\/j.cca.2007.04.006_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2362.1987.tb02395.x","article-title":"Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences","volume":"17","author":"Mauriege","year":"1987","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/j.1550-8528.1993.tb00026.x","article-title":"Lipolysis in intraabdominal adipose tissues of obese women and men","volume":"1","author":"Fried","year":"1993","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2007.04.006_bib30","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.biocel.2005.09.013","article-title":"Rethinking leptin and insulin action: therapeutic opportunities for diabetes","volume":"38","author":"Yildiz","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cca.2007.04.006_bib31","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1172\/JCI119865","article-title":"Leptin selectively decreases visceral adiposity and enhances insulin action","volume":"100","author":"Barzilai","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib32","doi-asserted-by":"crossref","first-page":"27758","DOI":"10.1074\/jbc.272.44.27758","article-title":"Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action","volume":"272","author":"Rossetti","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/38717","article-title":"Acute stimulation of glucose metabolism in mice by leptin treatment","volume":"389","author":"Kamohara","year":"1997","journal-title":"Nature"},{"issue":"Suppl. 4","key":"10.1016\/j.cca.2007.04.006_bib34","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.ijo.0802861","article-title":"Substrate cycling between de novo lipogenesis and lipid oxidation: a thermogenic mechanism against skeletal muscle lipotoxicity and glucolipotoxicity","volume":"28","author":"Dulloo","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.cca.2007.04.006_bib35","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.2000.278.1.E1","article-title":"The adipoinsular axis: effects of leptin on pancreatic beta-cells","volume":"278","author":"Kieffer","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/oby.2000.66","article-title":"Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes","volume":"8","author":"Mueller","year":"2000","journal-title":"Obes Res"},{"key":"10.1016\/j.cca.2007.04.006_bib37","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/sj.ijo.0802142","article-title":"Leptin: a review of its peripheral actions and interactions","volume":"26","author":"Margetic","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.cca.2007.04.006_bib38","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1365-2265.2004.02101.x","article-title":"Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers","volume":"61","author":"Wolfe","year":"2004","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.cca.2007.04.006_bib39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1043-2760(01)00524-0","article-title":"ACRP30\/adiponectin. An adipokine regulating glucose and lipid metabolism","volume":"13","author":"Berg","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.cca.2007.04.006_bib41","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.cca.2007.04.006_bib42","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1073\/pnas.98.4.2005","article-title":"Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice","volume":"98","author":"Fruebis","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2007.04.006_bib43","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.cca.2007.04.006_bib44","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1055\/s-2002-38260","article-title":"Relationship between serum adiponectin concentration and intramyocellular lipid stores in humans","volume":"34","author":"Thamer","year":"2002","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.cca.2007.04.006_bib45","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.2337\/diacare.26.12.3315","article-title":"Plasma adiponectin and endogenous glucose production in humans","volume":"26","author":"Stefan","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2007.04.006_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/diab.47.1.98","article-title":"Depot-specific differences in adipose tissue gene expression in lean and obese subjects","volume":"47","author":"Lefebvre","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mce.2004.03.002","article-title":"Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects","volume":"219","author":"Lihn","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2007.04.006_bib48","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1017\/S0007114500000994","article-title":"Fatty acids and insulin secretion","volume":"83","author":"Grill","year":"2000","journal-title":"Br J Nutr"},{"key":"10.1016\/j.cca.2007.04.006_bib49","doi-asserted-by":"crossref","first-page":"E1156","DOI":"10.1152\/ajpendo.00427.2002","article-title":"Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT","volume":"284","author":"Stefan","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib50","first-page":"171","article-title":"GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion","volume":"33","author":"Itoh","year":"2005","journal-title":"Hepatol Res"},{"key":"10.1016\/j.cca.2007.04.006_bib51","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nm1168","article-title":"Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120","volume":"11","author":"Hirasawa","year":"2005","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.cca.2007.04.006_bib52","first-page":"402","article-title":"The potential role of glucagon-like peptide 1 in diabetes","volume":"5","author":"Meier","year":"2004","journal-title":"Curr Opin Investig Drugs"},{"key":"10.1016\/j.cca.2007.04.006_bib53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-201X.2003.01167.x","article-title":"Fate of fatty acids at rest and during exercise: regulatory mechanisms","volume":"178","author":"Jensen","year":"2003","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.cca.2007.04.006_bib54","doi-asserted-by":"crossref","first-page":"E455","DOI":"10.1152\/ajpendo.2000.279.2.E455","article-title":"Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans","volume":"279","author":"Romanski","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib55","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.2337\/diabetes.54.9.2694","article-title":"Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men","volume":"54","author":"Timlin","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib56","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1172\/JCI111133","article-title":"Effect of fatty acids on glucose production and utilization in man","volume":"72","author":"Ferrannini","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib57","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1152\/ajpendo.00429.2001","article-title":"FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis","volume":"283","author":"Boden","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib58","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s001250051579","article-title":"Stingl lipid-dependent control of hepatic glycogen stores in healthy humans","volume":"44","author":"Stingl","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2007.04.006_bib59","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s001250051474","article-title":"Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein?","volume":"43","author":"Bergman","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.cca.2007.04.006_bib60","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1172\/JCI16426","article-title":"Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production","volume":"111","author":"Fisher","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib61","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1172\/JCI114735","article-title":"Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration","volume":"86","author":"Jenssen","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib62","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1172\/JCI118243","article-title":"Loss of hepatic autoregulation after carbohydrate overfeeding in normal man","volume":"96","author":"Clore","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib63","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1210\/en.2005-0731","article-title":"Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo","volume":"147","author":"Huang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2007.04.006_bib64","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1210\/en.2005-0898","article-title":"Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin","volume":"147","author":"Andreelli","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2007.04.006_bib65","series-title":"Handbook of physiology. Section 10: skeletal muscle","first-page":"555","article-title":"Skeletal muscle adaptability : significance for metabolism and performance","author":"Saltin","year":"1983"},{"key":"10.1016\/j.cca.2007.04.006_bib66","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1172\/JCI108764","article-title":"A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis","volume":"60","author":"McGarry","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib67","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1152\/jappl.1998.84.5.1788","article-title":"Contraction-induced increase in Vmax of palmitate uptake and oxidation in perfused skeletal muscle","volume":"84","author":"Turcotte","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib68","doi-asserted-by":"crossref","first-page":"E789","DOI":"10.1152\/ajpendo.2001.281.4.E789","article-title":"Lipid metabolism during fasting","volume":"281","author":"Jensen","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib69","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1113\/jphysiol.2004.075135","article-title":"High triacylglycerol turnover rate in human skeletal muscle","volume":"561","author":"Sacchetti","year":"2004","journal-title":"J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib70","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0026-0495(91)90100-B","article-title":"Effect of glucose and insulin on triacylglycerol metabolism in isolated normal and diabetic skeletal muscle","volume":"40","author":"Hopp","year":"1991","journal-title":"Metabolism"},{"key":"10.1016\/j.cca.2007.04.006_bib71","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-201X.2003.01155.x","article-title":"Hormone-sensitive lipase in skeletal muscle: regulatory mechanisms","volume":"178","author":"Langfort","year":"2003","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.cca.2007.04.006_bib72","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s00424-005-1509-0","article-title":"Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state","volume":"451","author":"Van Loon","year":"2006","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.cca.2007.04.006_bib73","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1042\/bst0311115","article-title":"The glucose\u2013fatty acid cycle: a physiological perspective","volume":"31","author":"Frayn","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.cca.2007.04.006_bib74","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2337\/diacare.27.9.2253","article-title":"Lipids and glucose in type 2 diabetes: what is the cause and effect?","volume":"27","author":"Boden","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cca.2007.04.006_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis","volume":"244","author":"McGarry","year":"1997","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.cca.2007.04.006_bib76","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1073\/pnas.93.21.11466","article-title":"Cloning of human acetyl-CoA carboxylase-beta and its unique features","volume":"93","author":"Ha","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2007.04.006_bib77","first-page":"E1107","article-title":"AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle","volume":"273","author":"Merrill","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib78","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1432-1033.1997.00259.x","article-title":"The AMP-activated protein kinase\u2014fuel gauge of the mammalian cell?","volume":"246","author":"Hardie","year":"1997","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.cca.2007.04.006_bib79","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1042\/bst0311157","article-title":"Bypassing the glucose\/fatty acid cycle: AMP-activated protein kinase","volume":"31","author":"Carling","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.cca.2007.04.006_bib80","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/415339a","article-title":"Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase","volume":"415","author":"Minokoshi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cca.2007.04.006_bib81","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-2007-1021254","article-title":"Plasma hormones and physical exercise","volume":"13","author":"Viru","year":"1992","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.cca.2007.04.006_bib82","first-page":"E300","article-title":"Effects of epinephrine on lipid metabolism in resting skeletal muscle","volume":"275","author":"Peters","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib83","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2337\/diab.36.8.932","article-title":"Alpha-adrenergic blockade improves glucose-potentiated insulin secretion in non-insulin-dependent diabetes mellitus","volume":"36","author":"Broadstone","year":"1987","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib84","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI109840","article-title":"Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man","volume":"66","author":"Clutter","year":"1980","journal-title":"J Clin Invest"},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2007.04.006_bib85","doi-asserted-by":"crossref","first-page":"S271","DOI":"10.2337\/diabetes.51.2007.S271","article-title":"Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes","volume":"51","author":"Marliss","year":"2002","journal-title":"Diabetes"},{"issue":"Suppl. 4","key":"10.1016\/j.cca.2007.04.006_bib86","first-page":"S22","article-title":"Role of the endocrine pancreas in control of fuel metabolism by the liver during exercise","volume":"19","author":"Wasserman","year":"1995","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.cca.2007.04.006_bib87","first-page":"39","article-title":"Carbohydrate nutrition before and during exercise","volume":"5","author":"Guezennec","year":"1988","journal-title":"Sci Mot"},{"key":"10.1016\/j.cca.2007.04.006_bib88","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1210\/jcem-68-1-9","article-title":"Regulation of counterregulatory hormone secretion in man during exercise and hypoglycemia","volume":"68","author":"Sotsky","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib89","first-page":"406","article-title":"Glucose turnover and its regulation during intense exercise and recovery in normal male subjects","volume":"15","author":"Marliss","year":"1992","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.cca.2007.04.006_bib90","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2337\/diab.45.2.148","article-title":"The roles of catecholamines in glucoregulation in intense exercise as defined by the islet cell clamp technique","volume":"45","author":"Sigal","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib91","first-page":"29","article-title":"Natriuretic peptides: a new lipolytic pathway in human fat cells","volume":"21","author":"Sengenes","year":"2005","journal-title":"Med Sci (Paris)"},{"key":"10.1016\/j.cca.2007.04.006_bib92","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/01.ATV.0000183728.14712.d8","article-title":"An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans","volume":"25","author":"Lafontan","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.cca.2007.04.006_bib93","first-page":"E382","article-title":"Role of triglyceride\u2013fatty acid cycle in controlling fat metabolism in humans during and after exercise","volume":"258","author":"Wolfe","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib94","first-page":"E380","article-title":"Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration","volume":"265","author":"Romijn","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib95","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1249\/00005768-198502000-00002","article-title":"Control of hepatic glucose production during exercise","volume":"17","author":"Winder","year":"1985","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cca.2007.04.006_bib96","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/diabetes.53.7.1643","article-title":"Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction","volume":"53","author":"Febbraio","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib97","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1152\/physrev.00023.2004","article-title":"Skeletal muscle lipid metabolism in exercise and insulin resistance","volume":"86","author":"Kiens","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cca.2007.04.006_bib98","doi-asserted-by":"crossref","first-page":"558S","DOI":"10.1093\/ajcn\/72.2.558S","article-title":"Lipid metabolism during endurance exercise","volume":"72","author":"Horowitz","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cca.2007.04.006_bib99","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2337\/diabetes.51.1.7","article-title":"Banting Lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes","volume":"51","author":"McGarry","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2007.04.006_bib100","first-page":"E541","article-title":"Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise","volume":"270","author":"Odland","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib101","doi-asserted-by":"crossref","first-page":"E592","DOI":"10.1152\/ajpendo.00301.2004","article-title":"AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction","volume":"288","author":"Raney","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib102","doi-asserted-by":"crossref","first-page":"E696","DOI":"10.1152\/ajpendo.00001.2004","article-title":"Regulation of plasma long-chain fatty acid oxidation in relation to uptake in human skeletal muscle during exercise","volume":"287","author":"Roepstorff","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.cca.2007.04.006_bib103","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-7793.2001.00295.x","article-title":"The effects of increasing exercise intensity on muscle fuel utilisation in humans","volume":"536","author":"Van Loon","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib104","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00421-005-0118-0","article-title":"Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males","volume":"96","author":"Koopman","year":"2006","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib105","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1113\/jphysiol.2001.012933","article-title":"Fat utilization during exercise: adaptation to a fat-rich diet increases utilization of plasma fatty acids and very low density lipoprotein\u2013triacylglycerol in humans","volume":"537","author":"Helge","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib106","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1172\/JCI114275","article-title":"Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action","volume":"84","author":"Kiens","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib107","first-page":"E332","article-title":"Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans","volume":"275","author":"Kiens","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib108","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1016\/S0021-9258(18)77362-6","article-title":"Exercise induces recruitment of the \u201cinsulin-responsive glucose transporter\u201d. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle","volume":"265","author":"Douen","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib109","first-page":"4902","article-title":"Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation","volume":"14","author":"Cheatham","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cca.2007.04.006_bib110","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1016\/S0021-9258(17)41901-6","article-title":"Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin","volume":"269","author":"Okada","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib111","series-title":"Human physiology: the basis of medicine","author":"Pocock","year":"1999"},{"key":"10.1016\/j.cca.2007.04.006_bib112","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1152\/jappl.1994.76.6.2253","article-title":"Balance of carbohydrate and lipid utilization during exercise: the \u201ccrossover\u201d concept","volume":"76","author":"Brooks","year":"1994","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1748-1716.1977.tb10356.x","article-title":"Time course of changes in human skeletal muscle succinate dehydrogenase and cytochrome oxidase activities and maximal oxygen uptake with physical activity and inactivity","volume":"99","author":"Henriksson","year":"1977","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.cca.2007.04.006_bib114","first-page":"2323","article-title":"Adaptation of muscle to exercise. Increase in levels of palmityl CoA synthetase, carnitine palmityltransferase, and palmityl CoA dehydrogenase, and in the capacity to oxidize fatty acids","volume":"50","author":"Mole","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.006_bib115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0026-0495(89)90253-9","article-title":"Hormonal and metabolic responses of untrained, moderately trained, and highly trained men to three exercise intensities","volume":"38","author":"Deuster","year":"1989","journal-title":"Metabolism"},{"key":"10.1016\/j.cca.2007.04.006_bib116","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1152\/jappl.1986.61.5.1693","article-title":"Increased epinephrine response and inaccurate glucoregulation in exercising athletes","volume":"61","author":"Kjaer","year":"1986","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib117","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1152\/jappl.1992.72.2.484","article-title":"Metabolic adaptations to training precede changes in muscle mitochondrial capacity","volume":"72","author":"Green","year":"1992","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib118","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0014-5793(90)80960-Q","article-title":"Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa\/fa) rats","volume":"268","author":"Friedman","year":"1990","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cca.2007.04.006_bib119","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/bj2700397","article-title":"Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level","volume":"270","author":"Kern","year":"1990","journal-title":"Biochem J"},{"key":"10.1016\/j.cca.2007.04.006_bib120","doi-asserted-by":"crossref","first-page":"14396","DOI":"10.1016\/S0021-9258(17)36636-X","article-title":"Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle","volume":"269","author":"Ren","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.006_bib121","first-page":"E72","article-title":"Influence of muscle glycogen content on metabolic regulation","volume":"274","author":"Weltan","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.006_bib122","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00421-003-0960-x","article-title":"New aspects of the hormone and cytokine response to training","volume":"91","author":"Steinacker","year":"2004","journal-title":"Eur J Appl Physiol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107002033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107002033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T22:25:53Z","timestamp":1720131953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898107002033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":122,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0009898107002033"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2007.04.006","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative mechanisms at rest and during exercise","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2007.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}