{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:28Z","timestamp":1788872428413,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30572044"],"award-info":[{"award-number":["30572044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.cca.2007.04.014","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T07:13:15Z","timestamp":1177917195000},"page":"51-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The role of epithelial\u2013mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis"],"prefix":"10.1016","volume":"383","author":[{"given":"Hu","family":"Yanjia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xinchun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2007.04.014_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0714.2005.00366.x","article-title":"Cytokeratin expression in oral submucous fibrosis\u2014an immunohistochemical study","volume":"35","author":"Ranganathan","year":"2006","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.oraloncology.2005.08.005","article-title":"Oral submucous fibrosis: review on aetiology and pathogenesis","volume":"42","author":"Tilakaratne","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib3","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1034\/j.1600-0714.2002.00117.x","article-title":"High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis","volume":"31","author":"Chiang","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib4","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.mod.2003.06.005","article-title":"Mechanisms, mechanics and function of epithelial\u2013mesenchymal transitions in early development","volume":"120","author":"Shook","year":"2003","journal-title":"Mech Dev"},{"key":"10.1016\/j.cca.2007.04.014_bib5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.014_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/cbir.1995.1090","article-title":"Factors influencing myofibroblast differentiation during wound healing and fibrosis","volume":"19","author":"Desmouliere","year":"1995","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.cca.2007.04.014_bib7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.LAB.0000059927.97515.FD","article-title":"Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells","volume":"83","author":"Ackland","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.cca.2007.04.014_bib8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cca.2007.04.014_bib9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrm1175","article-title":"Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis","volume":"4","author":"Grunert","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib10","first-page":"563","article-title":"Early role of Fsp1 in epithelial\u2013mesenchymal transformation","volume":"273","author":"Okada","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.cca.2007.04.014_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.95.1.333","article-title":"Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells","volume":"95","author":"Greenburg","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000147748","article-title":"An overview of epithelio-mesenchymal transformation","volume":"154","author":"Hay","year":"1995","journal-title":"Acta Anat (Basel)"},{"key":"10.1016\/j.cca.2007.04.014_bib13","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)63153-7","article-title":"Smad3 signaling is required for epithelial\u2013mesenchymal transition of lens epithelium after injury","volume":"164","author":"Saika","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cca.2007.04.014_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1465-9921-8-1","article-title":"Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse","volume":"8","author":"Wu","year":"2007","journal-title":"Respir Res"},{"key":"10.1016\/j.cca.2007.04.014_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1053\/jhep.2002.30083","article-title":"Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury","volume":"35","author":"Tahashi","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2007.04.014_bib16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nm0405-373","article-title":"Setting a trap for tissue fibrosis","volume":"11","author":"Neilson","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.cca.2007.04.014_bib17","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial\u2013mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.014_bib18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nrc822","article-title":"Epithelial\u2013mesenchymal transitions in tumour progression","volume":"2","author":"Thiery","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.cca.2007.04.014_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1387\/ijdb.041794hp","article-title":"Transcriptional regulation of cadherins during development and carcinogenesis","volume":"48","author":"Peinado","year":"2004","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib20","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.cca.2007.04.014_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ccr.2005.07.009","article-title":"The transcriptional repressor Snail promotes mammary tumor recurrence","volume":"8","author":"Moody","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cca.2007.04.014_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0002-9440(10)63834-5","article-title":"Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma","volume":"162","author":"Petersen","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cca.2007.04.014_bib23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI200421358","article-title":"NF-kappaB is essential for epithelial\u2013mesenchymal transition and metastasis in a model of breast cancer progression","volume":"114","author":"Huber","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2007.04.014_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1357-2725(03)00215-2","article-title":"Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor beta1","volume":"36","author":"Yang","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.10066","article-title":"Regulation of cell proliferation by Smad proteins","volume":"191","author":"Ten","year":"2002","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cca.2007.04.014_bib26","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/emboj\/19.8.1745","article-title":"Transcriptional control by the TGF-beta\/Smad signaling system","volume":"19","author":"Massague","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.cca.2007.04.014_bib27","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/labinvest.3700151","article-title":"Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial\u2013mesenchymal transition of lens epithelium in mice","volume":"84","author":"Saika","year":"2004","journal-title":"Lab Invest"},{"key":"10.1016\/j.cca.2007.04.014_bib28","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/carcin\/bgi110","article-title":"Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines","volume":"26","author":"Kloth","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cca.2007.04.014_bib29","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.cca.2007.04.014_bib30","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1152\/ajprenal.00191.2002","article-title":"Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models","volume":"285","author":"Zeisberg","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.cca.2007.04.014_bib31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1681\/ASN.2005111187","article-title":"Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells","volume":"18","author":"Yoshikawa","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.cca.2007.04.014_bib32","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1158\/0008-5472.CAN-06-1842","article-title":"In vivo and in vitro evidence for transforming growth factor-{beta}1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma","volume":"66","author":"Rees","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.cca.2007.04.014_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jsbmb.2006.11.011","article-title":"Therapeutic role and potential mechanisms of active vitamin D in renal interstitial fibrosis","volume":"103","author":"Tan","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib34","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.M309798200","article-title":"Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone","volume":"279","author":"Xavier","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.014_bib35","first-page":"393","article-title":"Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion","volume":"9","author":"Portella","year":"1998","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.cca.2007.04.014_bib36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000147848","article-title":"Epithelial\u2013mesenchymal transitions in cancer progression","volume":"156","author":"Birchmeier","year":"1996","journal-title":"Acta Anat (Basel)"},{"key":"10.1016\/j.cca.2007.04.014_bib37","first-page":"4222","article-title":"Transforming growth factor beta1 treatment leads to an epithelial\u2013mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation","volume":"61","author":"Ellenrieder","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.cca.2007.04.014_bib38","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1158\/0008-5472.CAN-03-1855","article-title":"Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity","volume":"64","author":"Miyazawa","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.cca.2007.04.014_bib39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/MCB.21.2.575-594.2001","article-title":"Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells","volume":"21","author":"Reeves","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cca.2007.04.014_bib40","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/ijc.2910550411","article-title":"E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome","volume":"55","author":"Mattijssen","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cca.2007.04.014_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1368-8375(00)00059-2","article-title":"Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro","volume":"37","author":"Yokoyama","year":"2001","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib42","first-page":"1535","article-title":"Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression","volume":"27","author":"Maeda","year":"2005","journal-title":"Int J Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib43","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(01)00260-X","article-title":"The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion","volume":"7","author":"Comijn","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.cca.2007.04.014_bib44","doi-asserted-by":"crossref","first-page":"39209","DOI":"10.1074\/jbc.M206400200","article-title":"Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression","volume":"277","author":"Guaita","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.014_bib45","doi-asserted-by":"crossref","first-page":"21113","DOI":"10.1074\/jbc.M211304200","article-title":"Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions","volume":"278","author":"Peinado","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2007.04.014_bib46","first-page":"487","article-title":"Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial\u2013mesenchymal transition in human squamous carcinoma cells","volume":"28","author":"Taki","year":"2006","journal-title":"Int J Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib47","first-page":"891","article-title":"Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas","volume":"22","author":"Yokoyama","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1349-7006.2003.tb01488.x","article-title":"Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial\u2013mesenchymal transition in human squamous carcinoma cells","volume":"94","author":"Taki","year":"2003","journal-title":"Cancer Sci"},{"key":"10.1016\/j.cca.2007.04.014_bib49","first-page":"1133","article-title":"Epithelial\u2013mesenchymal transition induced by the stromal cell-derived factor-1\/CXCR4 system in oral squamous cell carcinoma cells","volume":"29","author":"Onoue","year":"2006","journal-title":"Int J Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib50","first-page":"2172","article-title":"The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines","volume":"63","author":"Grille","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.cca.2007.04.014_bib51","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1158\/0008-5472.CAN-06-1213","article-title":"Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-{kappa}B signaling as characteristics of a high-risk head and neck squamous cell carcinoma","volume":"66","author":"Chung","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.cca.2007.04.014_bib52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0140-6736(91)92168-2","article-title":"Keratinocytes as initiators of inflammation","volume":"337","author":"Barker","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2007.04.014_bib53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1600-0714.1999.tb01998.x","article-title":"Effects of areca nut, inflorescence piper betel extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes","volume":"28","author":"Jeng","year":"1999","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib54","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/carcin\/bgg083","article-title":"Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline","volume":"24","author":"Jeng","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cca.2007.04.014_bib55","first-page":"239","article-title":"Expression of transforming growth factor beta 1 in keratinocytes of oral submucous fibrosis tissue","volume":"32","author":"Gao","year":"1997","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.cca.2007.04.014_bib56","first-page":"215","article-title":"Localization of endothelin-1 in biopsies from oral submucous fibrosis: immunoelectron microscopic study","volume":"35","author":"Xu","year":"2000","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.cca.2007.04.014_bib57","first-page":"23","article-title":"Changes of cytokines secreted by human oral mucosa keratinocytes from oral submucous fibrosis in vitro","volume":"18","author":"Feng","year":"2000","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.cca.2007.04.014_bib58","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-0714.2005.00325.x","article-title":"Molecular pathogenesis of oral submucous fibrosis\u2014a collagen metabolic disorder","volume":"34","author":"Rajalalitha","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib59","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/carcin\/22.9.1527","article-title":"Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential","volume":"22","author":"Chang","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cca.2007.04.014_bib60","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ijc.2910520225","article-title":"Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells","volume":"52","author":"Sundqvist","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cca.2007.04.014_bib61","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1368-8375(01)00083-5","article-title":"Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis","volume":"38","author":"Chang","year":"2002","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0714.2005.00366.x","article-title":"Cytokeratin expression in oral submucous fibrosis\u2014an immunohistochemical study","volume":"35","author":"Ranganathan","year":"2006","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib63","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1600-0714.2005.00339.x","article-title":"Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization","volume":"34","author":"Utsunomiya","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib64","first-page":"390","article-title":"Increased expression of matrix metalloproteinase-2 in oral cells after short-term stimulation and long-term usage of areca quid","volume":"104","author":"Liu","year":"2005","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.cca.2007.04.014_bib65","first-page":"113","article-title":"Areca quid chewing enhances the expression of salivary matrix metalloproteinase-9","volume":"104","author":"Liu","year":"2005","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.cca.2007.04.014_bib66","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1601-0825.2006.01272.x","article-title":"Increased plasminogen activator inhibitor-1\/tissue type plasminogen activator ratio in oral submucous fibrosis","volume":"13","author":"Yang","year":"2007","journal-title":"Oral Dis"},{"key":"10.1016\/j.cca.2007.04.014_bib67","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1006\/cyto.1997.0342","article-title":"Immunolocalization of cytokines and growth factors in oral submucous fibrosis","volume":"10","author":"Haque","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.cca.2007.04.014_bib68","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.oraloncology.2005.05.006","article-title":"The upregulation of insulin-like growth factor-1 in oral submucous fibrosis","volume":"41","author":"Tsai","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib69","article-title":"Elevated expression of NF-kappaB in oral submucous fibrosis \u2014 evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts","author":"Ni","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.cca.2007.04.014_bib70","first-page":"43","article-title":"Study on the expression of Smad2\/3 protein in oral submucous fibrosis","volume":"22","author":"Chen","year":"2006","journal-title":"J Clin Stomatol"},{"key":"10.1016\/j.cca.2007.04.014_bib71","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/ijc.21104","article-title":"Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes","volume":"116","author":"Lin","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.cca.2007.04.014_bib72","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1038\/sj.onc.1209712","article-title":"Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism","author":"Yang","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.cca.2007.04.014_bib73","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/carcin\/bgi357","article-title":"Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte","volume":"27","author":"Lu","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cca.2007.04.014_bib74","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1034\/j.1600-0714.2003.00199.x","article-title":"Areca nut extract treatment elicits the fibroblastoid morphological changes, actin re-organization and signaling activation in oral keratinocytes","volume":"32","author":"Yang","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.cca.2007.04.014_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","article-title":"Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention","volume":"15","author":"Liu","year":"2004","journal-title":"J Am Soc Nephrol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107002161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898107002161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T18:25:44Z","timestamp":1720117544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898107002161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":75,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0009898107002161"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2007.04.014","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of epithelial\u2013mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2007.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2007 Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}