{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:19:48Z","timestamp":1790839188765,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"9-10","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.cca.2010.02.058","type":"journal-article","created":{"date-parts":[[2010,2,23]],"date-time":"2010-02-23T15:03:35Z","timestamp":1266937415000},"page":"758-761","source":"Crossref","is-referenced-by-count":26,"title":["Development of an enzyme-linked immunosorbent assay for metallothionein-I and -II in plasma of humans and experimental animals"],"prefix":"10.1016","volume":"411","author":[{"given":"Katsuyuki","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Kodaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoumi","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Tokita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Nagamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2010.02.058_bib1","series-title":"Metallothionein II","first-page":"25","article-title":"Chemistry and biochemistry of metallothionein","author":"Kagi","year":"1987"},{"key":"10.1016\/j.cca.2010.02.058_bib2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.bi.55.070186.004405","article-title":"Metallothionein","volume":"55","author":"Hamer","year":"1986","journal-title":"Ann Rev Biochem"},{"key":"10.1016\/j.cca.2010.02.058_bib3","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1073\/pnas.89.14.6333","article-title":"MT-III, a brain-specific member of the metallothionein gene family","volume":"89","author":"Palmiter","year":"1992","journal-title":"Proc Natl Acad.Sci"},{"key":"10.1016\/j.cca.2010.02.058_bib4","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1021\/bi00189a029","article-title":"Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia","volume":"33","author":"Quaife","year":"1994","journal-title":"Biochem"},{"key":"10.1016\/j.cca.2010.02.058_bib5","series-title":"Metallothionein II","first-page":"507","article-title":"Metallothionein in blood, bile and urine","author":"Bremner","year":"1987"},{"key":"10.1016\/j.cca.2010.02.058_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1367-5931(00)00082-X","article-title":"Metallothioneins: new functional and structural insights","volume":"4","author":"Vasak","year":"2000","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.cca.2010.02.058_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0041-008X(91)90327-B","article-title":"The protective effect of metallothionein on the toxicity of various metals in rat primary hepatocyte culture","volume":"107","author":"Liu","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cca.2010.02.058_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1006\/taap.1995.1227","article-title":"Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity","volume":"135","author":"Liu","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.cca.2010.02.058_bib9","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/jn\/114.9.1683","article-title":"Measurement of plasma metallothionein-1 in the assessment of the zinc status of zinc-deficient and stressed rats","volume":"114","author":"Sato","year":"1984","journal-title":"J Nutr"},{"key":"10.1016\/j.cca.2010.02.058_bib10","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1128\/MCB.4.7.1221","article-title":"Regulation, linkage, and sequence of mouse metallothionein I and II genes","volume":"4","author":"Searle","year":"1984","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cca.2010.02.058_bib11","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/jn\/126.7.1782","article-title":"Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice","volume":"126","author":"Kelly","year":"1996","journal-title":"J Nutr"},{"key":"10.1016\/j.cca.2010.02.058_bib12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj2130459","article-title":"Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys","volume":"213","author":"Mehra","year":"1983","journal-title":"Biochem J"},{"key":"10.1016\/j.cca.2010.02.058_bib13","first-page":"1","article-title":"Metallothionein in plasma and urine of cadmium-exposed rats determined by a single antibody radioimmunoassay","volume":"1","author":"Toyama","year":"1981","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.cca.2010.02.058_bib14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0076-6879(82)84011-1","article-title":"Radioimmunoassay of metallothioneins","volume":"84","author":"Garvey","year":"1982","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cca.2010.02.058_bib15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0076-6879(91)05097-F","article-title":"Epitope mapping of metallothionein antibodies","volume":"205","author":"Nakajima","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cca.2010.02.058_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0076-6879(91)05120-K","article-title":"Detection of metallothionein in brain","volume":"205","author":"Nakajima","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cca.2010.02.058_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0076-6879(91)05095-D","article-title":"Measurement of human metallothionein by enzyme-linked immunosorbent assay","volume":"205","author":"Cousins","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.cca.2010.02.058_bib18","first-page":"119","article-title":"Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine","volume":"125","author":"Akintola","year":"1995","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.cca.2010.02.058_bib19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1073\/pnas.91.2.584","article-title":"Target disruption of metallothionein I and II genes increases sensitivity to cadmium","volume":"91","author":"Masters","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.cca.2010.02.058_bib20","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1523\/JNEUROSCI.17-04-01271.1997","article-title":"Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures","volume":"17","author":"Erickson","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.cca.2010.02.058_bib21","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1440-1827.2008.02308.x","article-title":"Immunohistochemical staining with newly developed metallothionein fragment antibodies against NH2-terminal, middle-regional and COOH-terminal peptides in rabbits","volume":"58","author":"Nakazato","year":"2008","journal-title":"Pathol Int"},{"key":"10.1016\/j.cca.2010.02.058_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0305-0491(91)90027-B","article-title":"Effect of the metal in the reaction between metallothionein and antimetallothionein antibody","volume":"99","author":"Mesna","year":"1991","journal-title":"Comp Biochem Physiol B"},{"key":"10.1016\/j.cca.2010.02.058_bib23","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1365-2249.2003.02074.x","article-title":"High positive frequency of antibodies to metallothionein and heat shock protein70 in sera of patients with metal allergy","volume":"131","author":"Jin","year":"2003","journal-title":"Clin Exp Immunol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898110001531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898110001531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T20:29:35Z","timestamp":1739910575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898110001531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":23,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0009898110001531"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2010.02.058","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}