{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:39:55Z","timestamp":1791329995829,"version":"4.3.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"23-24","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"crossref","award":["KMU-Q098022"],"award-info":[{"award-number":["KMU-Q098022"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"crossref","award":["KMUH99-9M06"],"award-info":[{"award-number":["KMUH99-9M06"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Health, Executive Yuan, R.O.C. (Taiwan)","award":["DOH100-TD-C-111-002"],"award-info":[{"award-number":["DOH100-TD-C-111-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.cca.2011.07.015","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T13:26:03Z","timestamp":1312377963000},"page":"2089-2093","source":"Crossref","is-referenced-by-count":18,"title":["Polymorphism at the mucin-like protocadherin gene influences susceptibility to gallstone disease"],"prefix":"10.1016","volume":"412","author":[{"given":"Shih-Chang","family":"Chuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen-Nien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lung","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Teh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suh-Hang Hank","family":"Juo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2011.07.015_bb0005","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncpgasthep0257","article-title":"Mechanisms of disease: the genetic epidemiology of gallbladder stones","volume":"2","author":"Lammert","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.cca.2011.07.015_bb0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00004836-199010000-00011","article-title":"Risk factors for gallstones among Chinese in Taiwan. A community sonographic survey","volume":"12","author":"Lu","year":"1990","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.cca.2011.07.015_bb0015","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.3748\/wjg.v12.i8.1281","article-title":"Clinical correlation of gallstone disease in a Chinese population in Taiwan: experience at Cheng Hsin General Hospital","volume":"12","author":"Liu","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"Suppl 2","key":"10.1016\/j.cca.2011.07.015_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-2036.2000.014s2039.x","article-title":"Review: pathogenesis of gallstones","volume":"14","author":"Dowling","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.cca.2011.07.015_bb0025","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bpg.2006.05.007","article-title":"Pathogenesis of gallstones: a genetic perspective","volume":"20","author":"Gr\u00fcnhage","year":"2006","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.cca.2011.07.015_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4439(02)00173-4","article-title":"Genetic background of cholesterol gallstone disease","volume":"1637","author":"Kosters","year":"2003","journal-title":"Biochim Biophys Acta (BBA)\u2014Mol. Basis Dis."},{"key":"10.1016\/j.cca.2011.07.015_bb0035","first-page":"149","article-title":"Genetics of gallstone disease","volume":"48","author":"Mittal","year":"2002","journal-title":"J Postgrad Med"},{"key":"10.1016\/j.cca.2011.07.015_bb0040","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3928\/0090-4481-19970901-06","article-title":"The epidemiology and genetic basis of common diseases","volume":"26","author":"Raffel","year":"1997","journal-title":"Pediatr Ann"},{"key":"10.1016\/j.cca.2011.07.015_bb0045","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.20654","article-title":"Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs","volume":"41","author":"Katsika","year":"2005","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.cca.2011.07.015_bb0050","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00439-003-0907-7","article-title":"Biallelic expression of HRAS and MUCDHL in human and mouse","volume":"112","author":"Goldberg","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.cca.2011.07.015_bb0055","doi-asserted-by":"crossref","first-page":"F454","DOI":"10.1152\/ajprenal.00012.2002","article-title":"Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys","volume":"283","author":"Goldberg","year":"2002","journal-title":"Am J Physiol-Renal"},{"issue":"Pt 11","key":"10.1016\/j.cca.2011.07.015_bb0060","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1242\/jcs.109.11.2609","article-title":"Protocadherins and diversity of the cadherin superfamily","volume":"109","author":"Suzuki","year":"1996","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0065","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1242\/jcs.114.4.629","article-title":"The cadherin superfamily: diversity in form and function","volume":"114","author":"Angst","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1620\/tjem.214.139","article-title":"Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients","volume":"214","author":"Kim","year":"2008","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.cca.2011.07.015_bb0075","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s10620-006-9162-9","article-title":"Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation","volume":"52","author":"Vilkin","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0080","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.2353\/ajpath.2006.060146","article-title":"MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder","volume":"169","author":"Finzi","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cca.2011.07.015_bb0085","first-page":"330","article-title":"Expression of MUC3, MUC5AC, MUC6 and epidermal growth factor receptor in gallbladder epithelium according to gallstone composition","volume":"42","author":"Kim","year":"2003","journal-title":"Korean J Gastroenterol=Taehan Sohwagi Hakhoe Chi"},{"key":"10.1016\/j.cca.2011.07.015_bb0090","first-page":"762","article-title":"Mucin gene expression in gallbladder epithelium","volume":"101","author":"Lee","year":"2002","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.cca.2011.07.015_bb0095","first-page":"517","article-title":"Mucin gene expression in gallbladder epithelium with black pigment stone ascertained by in situ hybridization","volume":"17","author":"Lee","year":"2001","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.cca.2010.12.008","article-title":"Multiple mucin genes polymorphisms are associated with gallstone disease in Chinese men","volume":"412","author":"Chuang","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2011.07.015_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcn\/80.1.1","article-title":"Cholesterol gallstones: a fellow traveler with metabolic syndrome?","volume":"80","author":"Grundy","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cca.2011.07.015_bb0110","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.3748\/wjg.v11.i11.1653","article-title":"Metabolic syndrome as a risk factor for gallstone disease","volume":"11","author":"Mendez-Sanchez","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.cca.2011.07.015_bb0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1086\/500025","article-title":"Regression-based association analysis with clustered haplotypes through use of genotypes","volume":"78","author":"Tzeng","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cca.2011.07.015_bb0120","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/ng2101","article-title":"A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease","volume":"39","author":"Buch","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2011.07.015_bb0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2741\/2688","article-title":"Molecular pathophysiology and physical chemistry of cholesterol gallstones","volume":"13","author":"Wang","year":"2008","journal-title":"Front Biosci: J Virtual Libr"},{"key":"10.1016\/j.cca.2011.07.015_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2156-7-29","article-title":"Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene","volume":"7","author":"Nakamoto","year":"2006","journal-title":"BMC Genet"},{"key":"10.1016\/j.cca.2011.07.015_bb0135","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1440-1746.2007.05170.x","article-title":"Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer","volume":"23","author":"Srivastava","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.cca.2011.07.015_bb0140","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/bjs.6178","article-title":"Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease","volume":"95","author":"Kuo","year":"2008","journal-title":"Br J Surg"},{"key":"10.1016\/j.cca.2011.07.015_bb0145","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1111\/j.1572-0241.2007.01430.x","article-title":"Arg64 variant of the beta3-adrenergic receptor is associated with gallstone formation","volume":"102","author":"Klass","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.cca.2011.07.015_bb0150","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00535-007-2036-x","article-title":"Age-associated gallstone formation in male and female CCK-1(A) receptor-deficient mice","volume":"42","author":"Miyasaka","year":"2007","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.cca.2011.07.015_bb0155","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/hep.510270110","article-title":"Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction","volume":"27","author":"Sasaki","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2011.07.015_bb0160","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0002-9440(10)64423-9","article-title":"Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis","volume":"161","author":"Zen","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.cca.2011.07.015_bb0165","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/geno.2000.6339","article-title":"Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5","volume":"69","author":"Paris","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.cca.2011.07.015_bb0170","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/0016-5085(95)90656-8","article-title":"Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation","volume":"109","author":"Afdhal","year":"1995","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.cca.2011.07.015_bb0175","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1167\/iovs.10-5859","article-title":"A functional polymorphism at 3\u2032 UTR of the PAX6 gene may confer risk for extreme myopia in Chinese","volume":"52","author":"Liang","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0180","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cca.2011.07.015_bb0185","doi-asserted-by":"crossref","first-page":"13513","DOI":"10.1073\/pnas.0706217104","article-title":"A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance","volume":"104","author":"Mishra","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cca.2011.07.015_bb0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11373-006-9077-7","article-title":"A comparison of major histocompatibility complex SNPs in Han Chinese residing in Taiwan and Caucasians","volume":"13","author":"Yang","year":"2006","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0195","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng.326","article-title":"SNPs in BRAP associated with risk of myocardial infarction in Asian populations","volume":"41","author":"Ozaki","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2011.07.015_bb0200","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1365-2893.2009.01141.x","article-title":"Hepatitis C virus infection is a risk factor for gallstone disease: a prospective hospital-based study of patients with chronic viral C hepatitis","volume":"16","author":"Acalovschi","year":"2009","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.cca.2011.07.015_bb0205","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/hep.20647","article-title":"Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States","volume":"41","author":"Bini","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.cca.2011.07.015_bb0210","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/BF02071404","article-title":"Prevalence of gallbladder disease in diabetes mellitus","volume":"41","author":"Chapman","year":"1996","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.cca.2011.07.015_bb0215","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.gassur.2004.09.041","article-title":"Gallstones in chronic liver disease","volume":"9","author":"Silva","year":"2005","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.cca.2011.07.015_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1047-2797(01)00260-5","article-title":"Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease: a prospective study","volume":"12","author":"Boland","year":"2002","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.cca.2011.07.015_bb0225","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/ng1670","article-title":"An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets","volume":"37","author":"Zeggini","year":"2005","journal-title":"Nat Genet"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811100413X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811100413X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T12:41:38Z","timestamp":1638189698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989811100413X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":45,"journal-issue":{"issue":"23-24","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S000989811100413X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2011.07.015","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}