{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T18:08:15Z","timestamp":1771610895831,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Sarstedt, Numbrecht Germany"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.cca.2011.08.037","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T12:10:35Z","timestamp":1316088635000},"page":"100-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Influence of separator gel in Sarstedt S-Monovette\u00ae serum tubes on various therapeutic drugs, hormones, and proteins"],"prefix":"10.1016","volume":"413","author":[{"given":"Sofie","family":"Schouwers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Willemse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Van Regenmortel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Uyttenbroeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Neels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2011.08.037_bb0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.clinbiochem.2009.10.001","article-title":"Impact of blood collection devices on clinical chemistry assays","volume":"43","author":"Bowen","year":"2010","journal-title":"Clin Biochem"},{"key":"10.1016\/j.cca.2011.08.037_bb0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/jcla.20277","article-title":"Different collection tubes in cardiac biomarkers detection","volume":"22","author":"Daves","year":"2008","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.cca.2011.08.037_bb0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00007691-200106000-00013","article-title":"Stability of therapeutic drugs in serum collected in vacutainer serum separator tubes containing a new gel (SST II)","volume":"23","author":"Bush","year":"2001","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2011.08.037_bb0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0009-8981(01)00396-5","article-title":"Comparison of BD Vacutainer\u2122 Plus tubes for common analytes","volume":"306","author":"Bush","year":"2001","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2011.08.037_bb0025","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00007691-200008000-00011","article-title":"Time-dependent adsorption of therapeutic drugs by the gel of the Greiner Vacuette blood collection tube","volume":"22","author":"Dasgupta","year":"2000","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2011.08.037_bb0030","unstructured":"A. Dasgupta, C. Hammett-Stabler. Serum separator tubes are still controversial for TDM. Clinical and Forensic Toxicology News, December 2007."},{"key":"10.1016\/j.cca.2011.08.037_bb0035","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/clinchem\/39.8.1712","article-title":"Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug-monitoring specimens","volume":"39","author":"Landt","year":"1993","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0040","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/clinchem\/30.3.465","article-title":"Effect of use of gel-barrier sampling tubes on determination of some antiepileptic drugs in serum","volume":"30","author":"Bergqvist","year":"1984","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0045","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/clinchem\/31.7.1239","article-title":"Effect of serum-separating gels on progesterone assays [Letter]","volume":"31","author":"Smith","year":"1985","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/clinchem\/22.2.235","article-title":"Assessment of a serum separator device for obtaining serum specimens suitable for clinical analyses","volume":"22","author":"Laessig","year":"1976","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0055","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1515\/CCLM.2006.099","article-title":"Evaluation of three different specimen types (serum, plasma lithium heparin and serum gel separator) for analysis of certain analytes: clinical significance of differences in results and efficiency in use","volume":"44","author":"O'Keane","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.cca.2011.08.037_bb0060","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/CCLM.2000.045","article-title":"Suitability of collection tubes with separator gels for collecting and storing blood samples for therapeutic drug monitoring (TDM)","volume":"38","author":"Karppi","year":"2000","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.cca.2011.08.037_bb0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0009-9120(98)00026-5","article-title":"Stability of digoxin and digitoxin in specimens collected in blood collection tubes containing serum separator gels","volume":"31","author":"Datta","year":"1998","journal-title":"Clin Biochem"},{"key":"10.1016\/j.cca.2011.08.037_bb0070","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00007691-199606000-00016","article-title":"Stability of therapeutic drug measurement in specimens collected in, VACUTAINER plastic blood-collection tubes","volume":"18","author":"Dasgupta","year":"1996","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2011.08.037_bb0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cca.2006.11.020","article-title":"Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents","volume":"378","author":"Bowen","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2011.08.037_bb0080","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/clinchem\/45.9.1574","article-title":"Effect of serum volume and time of exposure to gel barrier tubes on results for progesterone by Roche Diagnostics Elecsys 2010 [Letter]","volume":"45","author":"Ferry","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0085","doi-asserted-by":"crossref","unstructured":"J.J. Reinartz, M.L. Ramey, M.C. Fowler, A.A. Killeen. Plastic vs glass SST evacuated serum-separator blood drawing tubes for endocrinologic analytes [Letter]. Clin Chem;39:2535\u20132536.","DOI":"10.1093\/clinchem\/39.12.2535"},{"key":"10.1016\/j.cca.2011.08.037_bb0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/clinchem\/31.1.169","article-title":"Effect of silicone-separator tubes and storage time on ionized calcium in serum [Letter]","volume":"31","author":"Larsson","year":"1985","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/00007691-198309000-00020","article-title":"effect of serum separator blood collection tubes on drug concentrations","volume":"5","author":"Quattrochi","year":"1983","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2011.08.037_bb0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/clinchem\/33.1.203","article-title":"Effect of time of exposure of serum to gel-barrier tubes on results for progesterone and some other endocrine tests [Letter]","volume":"33","author":"Hilborn","year":"1987","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/clinchem\/30.4.553","article-title":"Effects of storage temperature and time before centrifugation on ionized calcium in blood collected in plain vacutainer tubes and silicone-separator (SST) tubes","volume":"30","author":"Toffaletti","year":"1984","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0110","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1093\/clinchem\/48.12.2242","article-title":"Stability studies of twenty-four analytes in human plasma and serum","volume":"48","author":"Boyanton","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0115","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/clinchem\/44.6.1325","article-title":"Effect of serum-clot contact time on clinical chemistry laboratory results","volume":"44","author":"Zhang","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0120","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/clinchem\/38.8.1474","article-title":"Comparison of plastic vs. glass evacuated serum-separator (SST\u2122) blood-drawing tubes for common clinical chemistry determinations","volume":"38","author":"Hill","year":"1992","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0125","series-title":"Disposition of toxic drugs and chemicals in man","author":"Baselt","year":"2008"},{"key":"10.1016\/j.cca.2011.08.037_bb0130","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/00365519950185229","article-title":"Current database on biologic variation: pros, cons and progress","volume":"59","author":"Ricos","year":"1999","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.cca.2011.08.037_bb0135","series-title":"Biological variation database specifications","author":"Westgard","year":"2010"},{"key":"10.1016\/j.cca.2011.08.037_bb0140","unstructured":"Westgard Q.C. Quality requirements of the Royal College of pathologists of Australasia. www.westgard.com\/rcpa.htm. Update 2010"},{"key":"10.1016\/j.cca.2011.08.037_bb0145","series-title":"Tietz clinical guide to laboratory tests","author":"Wu","year":"2006"},{"key":"10.1016\/j.cca.2011.08.037_bb0150","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/clinchem\/21.13.1907","article-title":"Factors influencing evaporation from sample cups, and assessment of their effect on analytical error","volume":"21","author":"Burtis","year":"1975","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2011.08.037_bb0155","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/clinchem\/38.5.768","article-title":"Design and evaluation of an anti-evaporative cover for use with liquid containers [Abstract]","volume":"38","author":"Burtis","year":"1992","journal-title":"Clin Chem"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898111004864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898111004864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:43:21Z","timestamp":1757861001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898111004864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0009898111004864"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2011.08.037","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of separator gel in Sarstedt S-Monovette\u00ae serum tubes on various therapeutic drugs, hormones, and proteins","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2011.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}