{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:50:06Z","timestamp":1773424206133,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"15-16","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.cca.2012.04.023","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T21:15:55Z","timestamp":1335388555000},"page":"1288-1294","source":"Crossref","is-referenced-by-count":26,"title":["Plasma myostatin measured by a competitive ELISA using a highly specific antiserum"],"prefix":"10.1016","volume":"413","author":[{"given":"Karl Florian","family":"Wintgens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Dschietzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanka","family":"Stoeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Paulsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz Paul","family":"Armbruster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2012.04.023_bb0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/387083a0","article-title":"Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member","volume":"387","author":"McPherron","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cca.2012.04.023_bb0010","doi-asserted-by":"crossref","first-page":"12457","DOI":"10.1073\/pnas.94.23.12457","article-title":"Double muscling in cattle due to mutations in the myostatin gene","volume":"94","author":"McPherron","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2012.04.023_bb0015","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nature01154","article-title":"Functional improvement of dystrophic muscle by myostatin blockade","volume":"420","author":"Bogdanovich","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cca.2012.04.023_bb0020","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/ana.10385","article-title":"Loss of myostatin attenuates severity of muscular dystrophy in mdx mice","volume":"52","author":"Wagner","year":"2002","journal-title":"Ann Neurol"},{"key":"10.1016\/j.cca.2012.04.023_bb0025","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/bjp.2008.144","article-title":"Gene doping: the hype and the reality","volume":"154","author":"Wells","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cca.2012.04.023_bb0030","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbiotec.2005.04.023","article-title":"Myostatin gene silenced by RNAi show a zebrafish giant phenotype","volume":"119","author":"Acosta","year":"2005","journal-title":"J Biotechnol"},{"key":"10.1016\/j.cca.2012.04.023_bb0035","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/eurjhf\/hfq039","article-title":"Myostatin activation in patients with advanced heart failure and after mechanical unloading","volume":"12","author":"George","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cca.2012.04.023_bb0040","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurjhf\/hfr024","article-title":"Increased plasma myostatin in heart failure","volume":"13","author":"Gruson","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cca.2012.04.023_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000231290.45676.d4","article-title":"Myostatin regulates cardiomyocyte growth through modulation of Akt signaling","volume":"99","author":"Morissette","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.cca.2012.04.023_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4652(199907)180:1<1::AID-JCP1>3.0.CO;2-V","article-title":"Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct","volume":"180","author":"Sharma","year":"1999","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.cca.2012.04.023_bb0055","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1249\/MSS.0b013e3181e0b9a8","article-title":"Myostatin decreases with aerobic exercise and associates with insulin resistance","volume":"42","author":"Hittel","year":"2010","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cca.2012.04.023_bb0060","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1210\/er.2008-0003","article-title":"Clinical, agricultural, and evolutionary biology of myostatin: a comparative review","volume":"29","author":"Rodgers","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.cca.2012.04.023_bb0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.cellbio.20.012103.135836","article-title":"Regulation of muscle mass by myostatin","volume":"20","author":"Lee","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.cca.2012.04.023_bb0070","doi-asserted-by":"crossref","first-page":"15842","DOI":"10.1073\/pnas.2534946100","article-title":"Activation of latent myostatin by the BMP-1\/tolloid family of metalloproteinases","volume":"100","author":"Wolfman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cca.2012.04.023_bb0075","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ki.2008.150","article-title":"Modulation of melanocortin signaling ameliorates uremic cachexia","volume":"74","author":"Cheung","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.cca.2012.04.023_bb0080","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0030-1267964","article-title":"Investigation of myostatin serum levels before and after a 6-month lifestyle intervention program in obese children","volume":"119","author":"Ehehalt","year":"2011","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.cca.2012.04.023_bb0085","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0300-8932(10)70212-8","article-title":"Serum myostatin levels in chronic heart failure","volume":"63","author":"Zamora","year":"2010","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.cca.2012.04.023_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2010.08.015","article-title":"Analysis of the effects of androgens and training on myostatin propeptide and follistatin concentrations in blood and skeletal muscle using highly sensitive immuno PCR","volume":"330","author":"Diel","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.cca.2012.04.023_bb0095","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2362.2006.01718.x","article-title":"Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure","volume":"36","author":"Shyu","year":"2006","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.cca.2012.04.023_bb0100","doi-asserted-by":"crossref","first-page":"40735","DOI":"10.1074\/jbc.M206379200","article-title":"The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum","volume":"277","author":"Hill","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2012.04.023_bb0105","doi-asserted-by":"crossref","first-page":"e1628","DOI":"10.1371\/journal.pone.0001628","article-title":"Genetic analysis of the role of proteolysis in the activation of latent myostatin","volume":"3","author":"Lee","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2012.04.023_bb0110","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/eurjhf\/hfp020","article-title":"Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model","volume":"11","author":"Lenk","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.cca.2012.04.023_bb0115","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cardiores.2005.06.028","article-title":"Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes","volume":"68","author":"Shyu","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cca.2012.04.023_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1677\/JOE-07-0596","article-title":"Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and myocyte enhance factor 2 pathway","volume":"197","author":"Wang","year":"2008","journal-title":"J Endocrinol"},{"key":"10.1016\/j.cca.2012.04.023_bb0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/CIRCULATIONAHA.109.882068","article-title":"Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure","volume":"121","author":"Heineke","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2012.04.023_bb0130","article-title":"Exercise training leads to a reduction of elevated myostatin levels in patients with chronic heart failure","author":"Lenk","year":"2011","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.cca.2012.04.023_bb0135","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s13539-010-0007-1","article-title":"Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training","volume":"1","author":"Lenk","year":"2010","journal-title":"J Cachex Sarcopenia Muscle"},{"key":"10.1016\/j.cca.2012.04.023_bb0140","first-page":"97","article-title":"Biosynthesis of cardiac natriuretic peptides","volume":"50","author":"Goetze","year":"2010","journal-title":"Results Probl Cell Differ"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112001957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112001957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T21:26:58Z","timestamp":1543008418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898112001957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":28,"journal-issue":{"issue":"15-16","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0009898112001957"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2012.04.023","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}