{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:01:21Z","timestamp":1781154081255,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"19-20","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.cca.2012.06.014","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T02:05:53Z","timestamp":1339725953000},"page":"1488-1492","source":"Crossref","is-referenced-by-count":52,"title":["A novel multiplex analysis of filaggrin polymorphisms: A universally applicable method for genotyping"],"prefix":"10.1016","volume":"413","author":[{"given":"Michael","family":"Meldgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal B.","family":"Szecsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit C.","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Stender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2012.06.014_bb0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/mp.52.5.295","article-title":"High throughput genotyping for the detection of a single nucleotide polymorphism in NAD(P)H quinone oxidoreductase (DT diaphorase) using TaqMan probes","volume":"52","author":"Shi","year":"1999","journal-title":"Mol Pathol"},{"key":"10.1016\/j.cca.2012.06.014_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-39978-2_11","article-title":"SNP and mutation analysis","volume":"593","author":"Wang","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.cca.2012.06.014_bb0015","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2144\/01303dd04","article-title":"Flow cytometric platform for high-throughput single nucleotide polymorphism analysis","volume":"30","author":"Taylor","year":"2001","journal-title":"Biotechniques"},{"key":"10.1016\/j.cca.2012.06.014_bb0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cccn.2005.06.023","article-title":"Applications of Luminex xMAP technology for rapid, high-throughput multiplexed nucleic acid detection","volume":"363","author":"Dunbar","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2012.06.014_bb0025","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin mutations associated with skin and allergic diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cca.2012.06.014_bb0030","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2012.06.014_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2133.2010.09822.x","article-title":"Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study","volume":"163","author":"Thyssen","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.cca.2012.06.014_bb0040","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jaci.2011.08.045","article-title":"Interaction between filaggrin null mutations and tobacco smoking in relation to asthma","volume":"129","author":"Berg","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.cca.2012.06.014_bb0045","doi-asserted-by":"crossref","first-page":"e000062","DOI":"10.1136\/bmjopen-2011-000062","article-title":"A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study","volume":"1","author":"Thyssen","year":"2011","journal-title":"BMJ Open"},{"key":"10.1016\/j.cca.2012.06.014_bb0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2230.2010.03994.x","article-title":"Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy","volume":"36","author":"Carlsen","year":"2011","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.cca.2012.06.014_bb0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0536.2010.01815.x","article-title":"Nickel reactivity and filaggrin null mutations\u2013evaluation of the filaggrin bypass theory in a general population","volume":"64","author":"Ross-Hansen","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.cca.2012.06.014_bb0060","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: filaggrin","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.cca.2012.06.014_bb0065","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1373\/clinchem.2004.035071","article-title":"Analytical validation of the tag-it high-throughput microsphere-based universal array genotyping platform: application to the multiplex detection of a panel of thrombophilia-associated single-nucleotide polymorphisms","volume":"50","author":"Bortolin","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2012.06.014_bb0070","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2144\/98254bm09","article-title":"Rapid, simple alkaline extraction of human genomic DNA from whole blood, buccal epithelial cells, semen and forensic stains for PCR","volume":"25","author":"Rudbeck","year":"1998","journal-title":"Biotechniques"},{"key":"10.1016\/j.cca.2012.06.014_bb0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1258\/0023677041958981","article-title":"Non-invasive method for sampling and extraction of mouse DNA for PCR","volume":"38","author":"Meldgaard","year":"2004","journal-title":"Lab Anim"},{"key":"10.1016\/j.cca.2012.06.014_bb0080","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2144\/000112960","article-title":"Improvements to bead-based oligonucleotide ligation SNP genotyping assays","volume":"45","author":"Bruse","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.cca.2012.06.014_bb0085","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1093\/nar\/16.10.4637","article-title":"The thermal stability of oligonucleotide duplexes is sequence independent in tetraalkylammonium salt solutions: application to identifying recombinant DNA clones","volume":"16","author":"Jacobs","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.cca.2012.06.014_bb0090","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/ng2020","article-title":"Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema","volume":"39","author":"Sandilands","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2012.06.014_bb0095","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1099\/jmm.0.46493-0","article-title":"Genotyping of human papillomavirus in cervical lesions by L1 consensus PCR and the Luminex xMAP system","volume":"55","author":"Jiang","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.cca.2012.06.014_bb0100","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000228834","article-title":"HLA genotyping and antibody characterization using the luminex multiplex technology","volume":"36","author":"Heinemann","year":"2009","journal-title":"Transfus Med Hemother"},{"key":"10.1016\/j.cca.2012.06.014_bb0105","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/JCM.44.2.504-512.2006","article-title":"Bead-based multiplex genotyping of human papillomaviruses","volume":"44","author":"Schmitt","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cca.2012.06.014_bb0110","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1525-1578(10)60531-4","article-title":"Microsphere bead arrays and sequence validation of 5\/7\/9T genotypes for multiplex screening of cystic fibrosis polymorphisms","volume":"6","author":"Hadd","year":"2004","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.cca.2012.06.014_bb0115","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1537-2995.2007.01555.x","article-title":"Blood group genotyping for Jk(a)\/Jk(b), Fy(a)\/Fy(b), S\/s, K\/k, Kp(a)\/Kp(b), Js(a)\/Js(b), Co(a)\/Co(b), and Lu(a)\/Lu(b) with microarray beads","volume":"48","author":"Karpasitou","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.cca.2012.06.014_bb0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.ejhg.5201742","article-title":"Filaggrinmutations p.R501X and c.2282del4 in ichthyosis vulgaris","volume":"15","author":"Gruber","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.cca.2012.06.014_bb0125","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.cca.2012.06.014_bb0130","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.jaci.2008.02.014","article-title":"Filaggrin mutations, atopic eczema, hay fever, and asthma in children","volume":"121","author":"Weidinger","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.cca.2012.06.014_bb0135","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/sj.jid.5700459","article-title":"Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis","volume":"126","author":"Sandilands","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.cca.2012.06.014_bb0140","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1468-3083.2011.04107.x","article-title":"The filaggrin null genotypes R501X and 2282del4 seem not to be associated with psoriasis: results from general population study and meta-analysis","volume":"26","author":"Thyssen","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.cca.2012.06.014_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1365-2133.2011.10530.x","article-title":"Filaggrin loss-of-function mutation R501X and 2282del4 carrier status is associated with fissured skin on the hands: results from a cross-sectional population study","volume":"166","author":"Thyssen","year":"2012","journal-title":"Br J Dermatol"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112003166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112003166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:05:08Z","timestamp":1642464308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898112003166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":29,"journal-issue":{"issue":"19-20","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0009898112003166"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2012.06.014","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}