{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:17:10Z","timestamp":1765887430265,"version":"3.37.3"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.cca.2012.09.015","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T14:55:11Z","timestamp":1348584911000},"page":"266-272","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Third generation anti-citrullinated peptide antibody assay is a sensitive marker in rheumatoid factor negative rheumatoid arthritis"],"prefix":"10.1016","volume":"414","author":[{"given":"Andreas","family":"Swart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufus W.","family":"Burlingame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"G\u00fcrtler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mahler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2012.09.015_bb0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nrrheum.2011.76","article-title":"Anti-CCP antibodies: the past, the present and the future","volume":"7","author":"van Venrooij","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.cca.2012.09.015_bb0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.autrev.2010.08.009","article-title":"All you wanted to know about anti-CCP but were afraid to ask","volume":"10","author":"Wiik","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.cca.2012.09.015_bb0015","doi-asserted-by":"crossref","unstructured":"Trouw LA, Mahler M. Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis. Autoimmun Rev in press, http:\/\/dx.doi.org\/10.1016\/j.autrev.2012.05.007.","DOI":"10.1016\/j.autrev.2012.05.007"},{"key":"10.1016\/j.cca.2012.09.015_bb0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2012.09.015_bb0025","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2012.09.015_bb0030","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0035","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.2174\/092986707782360150","article-title":"Synthetic peptides: the future of patient management in systemic rheumatic diseases?","volume":"14","author":"Kessenbrock","year":"2007","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.cca.2012.09.015_bb0040","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/art.24720","article-title":"Anti-cyclic citrullinated peptide testing for the diagnosis of rheumatoid arthritis and the quest for improved sensitivity and predictive value","volume":"60","author":"Levesque","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2012.09.015_bb0045","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/ard.2007.071654","article-title":"Do all anti-citrullinated protein\/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein\/peptide antibody tests in patients with and without rheumatoid arthritis","volume":"67","author":"Vander","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0050","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1373\/clinchem.2007.087569","article-title":"Analytical and diagnostic characteristics of 11 2nd- and 3rd-generation immunoenzymatic methods for the detection of antibodies to citrullinated proteins","volume":"53","author":"Bizzaro","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2012.09.015_bb0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10067-007-0656-4","article-title":"A comparison of the frequency of antibodies to cyclic citrullinated peptides using a third generation anti-CCP assay (CCP3) in systemic sclerosis, primary biliary cirrhosis and rheumatoid arthritis","volume":"27","author":"Santiago","year":"2008","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.cca.2012.09.015_bb0060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12016-007-8030-5","article-title":"Comparison of three anti-CCP antibody tests and rheumatoid factor in RA and control patients","volume":"34","author":"Correia","year":"2008","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.cca.2012.09.015_bb0065","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1002\/art.24716","volume":"60","author":"van der Linden","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2012.09.015_bb0070","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3899\/jrheum.091236","article-title":"Relationship between rheumatoid factor isotypes and IgG anti-cyclic citrullinated peptide antibodies","volume":"37","author":"Jaskowski","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cca.2012.09.015_bb0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.autrev.2006.03.008","article-title":"Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis","volume":"6","author":"van Venrooij","year":"2006","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.cca.2012.09.015_bb0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/ar2903","article-title":"The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis","volume":"12","author":"Pruijn","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cca.2012.09.015_bb0085","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/ard.2007.085597","article-title":"Likelihood ratios as a function of antibody concentration for anti-cyclic citrullinated peptide antibodies and rheumatoid factor","volume":"68","author":"Bossuyt","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2249.2011.04378.x","article-title":"Antibodies to a new viral citrullinated peptide, VCP2: fine specificity and correlation with anti-cyclic citrullinated peptide (CCP) and anti-VCP1 antibodies","volume":"164","author":"Pratesi","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cca.2012.09.015_bb0095","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.autrev.2012.02.015","article-title":"Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: an Italian multicentric study and review of the literature","volume":"11","author":"Bartoloni","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.cca.2012.09.015_bb0100","doi-asserted-by":"crossref","first-page":"R119","DOI":"10.1186\/ar2008","article-title":"Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis","volume":"8","author":"Dejaco","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cca.2012.09.015_bb0105","first-page":"1658","article-title":"Clinical evaluation of anti-mutated citrullinated vimentin by ELISA in rheumatoid arthritis","volume":"34","author":"Soos","year":"2007","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cca.2012.09.015_bb0110","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/ard.2009.108456","article-title":"Diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis","volume":"69","author":"Damjanovska","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0115","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1136\/ard.2005.035691","article-title":"Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis","volume":"64","author":"Nell","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0120","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/ar3383","article-title":"Novel multiplex technology for diagnostic characterization of rheumatoid arthritis","volume":"13","author":"Chandra","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cca.2012.09.015_bb0125","doi-asserted-by":"crossref","first-page":"R191","DOI":"10.1186\/ar3520","article-title":"Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis","volume":"13","author":"Shoda","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cca.2012.09.015_bb0130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2012.09.015_bb0135","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/btr574","article-title":"BDTcomparator: a program for comparing binary classifiers","volume":"27","author":"Fijorek","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cca.2012.09.015_bb0140","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1002\/sim.2850","article-title":"Comparison of the likelihood ratios of two binary diagnostic tests in paired designs","volume":"26","author":"Nofuentes","year":"2007","journal-title":"Stat Med"},{"key":"10.1016\/j.cca.2012.09.015_bb0145","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1007\/s10067-007-0601-6","article-title":"Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RF","volume":"26","author":"Silveira","year":"2007","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.cca.2012.09.015_bb0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00365513.2010.493381","article-title":"Anti-CCP: challenges in quantifying auto-antibodies and creating international reference materials","volume":"242","author":"Rottmann","year":"2010","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"10.1016\/j.cca.2012.09.015_bb0155","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/annrheumdis-2011-200421","article-title":"The ACPA recognition profile and subgrouping of ACPA-positive RA patients","volume":"71","author":"Willemze","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0160","doi-asserted-by":"crossref","first-page":"e35296","DOI":"10.1371\/journal.pone.0035296","article-title":"Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis","volume":"7","author":"Sokolove","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2012.09.015_bb0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10875-011-9610-y","article-title":"Second Generation Automated Anti-CCP Test Better Predicts the Clinical Diagnosis of Rheumatoid Arthritis","volume":"32","author":"Elrefaei","year":"2012","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.cca.2012.09.015_bb0170","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar3237","article-title":"Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis","volume":"13","author":"Kokkonen","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.cca.2012.09.015_bb0175","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1136\/ard.2010.143560","article-title":"Performance of the 2010 ACR\/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort","volume":"70","author":"Cader","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0180","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/annrheumdis-2011-200259","article-title":"Level of agreement of the 1987 ACR and 2010 ACR\/EULAR rheumatoid arthritis classification criteria: an analysis based on ESPOIR cohort data","volume":"71","author":"Fautrel","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0185","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/ard.2003.015131","article-title":"Attitudes to early rheumatoid arthritis: changing patterns. Results of a survey","volume":"63","author":"Aletaha","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2012.09.015_bb0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaut.2010.10.003","article-title":"Novel autoantibody markers for early and seronegative rheumatoid arthritis","volume":"36","author":"Somers","year":"2011","journal-title":"J Autoimmun"},{"key":"10.1016\/j.cca.2012.09.015_bb0195","doi-asserted-by":"crossref","first-page":"17372","DOI":"10.1073\/pnas.1114465108","article-title":"Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage","volume":"108","author":"Shi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112004500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898112004500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:54:13Z","timestamp":1542707653000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898112004500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":39,"alternative-id":["S0009898112004500"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2012.09.015","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}