{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:08:06Z","timestamp":1791130086470,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.cca.2013.02.028","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T08:23:39Z","timestamp":1362471819000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Analytical aspects of marinobufagenin"],"prefix":"10.1016","volume":"421","author":[{"given":"C.","family":"Lenaerts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Demeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gerbaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Blankert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2013.02.028_bb0005","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1046\/j.1432-1033.2002.02911.x","article-title":"Endogenous cardiac glycosides, a new class of steroid hormones","volume":"269","author":"Schoner","year":"2002","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.cca.2013.02.028_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.semnephrol.2005.03.010","article-title":"Endogenous cardiac glycosides: hormones using the sodium pump as signal transducer","volume":"25","author":"Schoner","year":"2005","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.cca.2013.02.028_bb0015","series-title":"Venomous animals and their venoms","first-page":"521","article-title":"Collection of toad venoms and chemistry of toad venom steroids","author":"Meyer","year":"1971"},{"key":"10.1016\/j.cca.2013.02.028_bb0020","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/10641969809053240","article-title":"Simultaneous measurement of marinobufagenin, ouabain, and hypertension-associated protein in various disease states","volume":"20","author":"Gonick","year":"1998","journal-title":"Clin Exp Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0025","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0014-2999(94)00735-P","article-title":"Effects of two endogenous Na+, K+-ATPase inhibitors, marinobufagenin and ouabain, on isolated rat aorta","volume":"274","author":"Bagrov","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.cca.2013.02.028_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-9422(97)00426-3","article-title":"Bufadienolides from animal and plant sources","volume":"48","author":"Krenn","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cca.2013.02.028_bb0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1039\/a815397y","article-title":"Bufadienolides of plant and animal origin","volume":"15","author":"Steyn","year":"1998","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.cca.2013.02.028_bb0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jchromb.2007.09.026","article-title":"Simultaneous determination of five main active bufadienolides of Chan Su in rat plasma by liquid chromatography tandem mass spectrometry","volume":"859","author":"Xu","year":"2007","journal-title":"J Chromatogr B Biomed Appl"},{"key":"10.1016\/j.cca.2013.02.028_bb0045","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.aca.2008.01.029","article-title":"Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry","volume":"610","author":"Zhang","year":"2008","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.cca.2013.02.028_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/pr.108.000711","article-title":"Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets","volume":"61","author":"Bagrov","year":"2009","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.cca.2013.02.028_bb0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-4165(91)90183-H","article-title":"Effect of salt acclimation on digitalis-like compounds in the toad","volume":"1073","author":"Lichtstein","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2013.02.028_bb0060","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/hc0902.104710","article-title":"Endogenous ligand of \u03b11 sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension","volume":"105","author":"Fedorova","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2013.02.028_bb0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.trsl.2012.01.005","article-title":"Pathogenesis of pre-eclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome","volume":"160","author":"Uddin","year":"2012","journal-title":"Transl Res"},{"key":"10.1016\/j.cca.2013.02.028_bb0070","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0895-7061(97)00096-4","article-title":"Inhibition of Na\/K ATPase from rat aorta by two Na\/K pump inhibitors, ouabain and marinobufagenin: evidence of interaction with different \u03b1-subunit isoforms","volume":"10","author":"Fedorova","year":"1997","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/CRD.0b013e31823c835c","article-title":"Systemic hypertension: the roles of salt, vascular Na+\/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin","volume":"20","author":"Hauck","year":"2012","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.cca.2013.02.028_bb0080","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.bbadis.2010.02.005","article-title":"Marinobufagenin, resibufogenin and preeclampsia","volume":"1802","author":"Puschett","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2013.02.028_bb0085","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/01.HYP.31.5.1097","article-title":"Characterization of a urinary bufodienolide Na+, K+-ATPase inhibitor in patients after acute myocardial infarction","volume":"31","author":"Bagrov","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.cca.2013.02.028_bb0090","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0008-6363(95)00208-1","article-title":"Plasma marinobufagenin-like and ouabain-like immunoreactivity during saline volume expansion in anesthetized dogs","volume":"31","author":"Bagrov","year":"1996","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.cca.2013.02.028_bb0095","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3109\/10641969809053236","article-title":"Endogenous marinobufagenin-like factor in acute plasma volume expansion","volume":"20","author":"Fedorova","year":"1998","journal-title":"Clin Exp Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0100","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/00004872-199917080-00018","article-title":"Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia","volume":"17","author":"Lopatin","year":"1999","journal-title":"J Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0105","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/01.HYP.37.2.462","article-title":"Marinobufagenin, an endogenous \u03b1-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats","volume":"37","author":"Fedorova","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.cca.2013.02.028_bb0110","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1161\/01.CIR.102.24.3009","article-title":"Endogenous Na, K pump ligands are differentially regulated during acute NaCl loading of Dahl rats","volume":"102","author":"Fedorova","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.cca.2013.02.028_bb0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/01.HYP.27.2.219","article-title":"Pathophysiological consequences of changes in the coupling ratio of Na, K-ATPase for renal sodium reabsorption and its implications for hypertension","volume":"27","author":"Orosz","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.cca.2013.02.028_bb0120","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1055\/s-0031-1272965","article-title":"Marinobufagenin levels in preeclamptic patients: a preliminary report","volume":"28","author":"Agunanne","year":"2011","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cca.2013.02.028_bb0125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1159\/000088461","article-title":"Involvement of marinobufagenin in a rat model of human preeclampsia","volume":"25","author":"Vu","year":"2005","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.cca.2013.02.028_bb0130","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1097\/HJH.0b013e328312c86a","article-title":"Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na\/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension","volume":"26","author":"Fedorova","year":"2008","journal-title":"J Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0140-6736(96)02257-X","article-title":"An inhibitor of the sodium pump obtained from human placenta","volume":"348","author":"Hilton","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2013.02.028_bb0140","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/01.HYP.36.3.442","article-title":"Mammalian bufadienolide is synthesized from cholesterol in the adrenal cortex by a pathway that is independent of cholesterol side-chain cleavage","volume":"36","author":"Dmitrieva","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.cca.2013.02.028_bb0145","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.toxicon.2005.01.017","article-title":"Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens","volume":"45","author":"Cunha Filho","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.cca.2013.02.028_bb0150","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1017\/S0006323197005045","article-title":"The natural history of amphibian skin secretions, their normal functioning and potential medical applications","volume":"72","author":"Clarke","year":"1997","journal-title":"Biol Rev"},{"key":"10.1016\/j.cca.2013.02.028_bb0155","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1248\/cpb.27.1881","article-title":"Isolation and characterization of cardiotonic steroid conjugates from the skin of Bufo marinus (L.) Schneider","volume":"27","author":"Shimada","year":"1979","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.cca.2013.02.028_bb0160","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1248\/cpb.45.249","article-title":"A novel bufadienolide, marinosin, in the skin of the giant toad, Bufo marinus","volume":"45","author":"Matsukawa","year":"1997","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.cca.2013.02.028_bb0165","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0041-0101(96)00131-6","article-title":"Effects of Bufo marinus skin toxins on human fetal extracorporeal blood vessels","volume":"35","author":"Lim","year":"1997","journal-title":"Toxicon"},{"key":"10.1016\/j.cca.2013.02.028_bb0170","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1002\/rcm.1989","article-title":"Analysis of bufadienolides in the Chinese drug ChanSu by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry","volume":"19","author":"Ye","year":"2005","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.cca.2013.02.028_bb0175","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jpba.2011.05.014","article-title":"Comprehensive chemical analysis of Venenum Bufonis by using liquid chromatography\/electrospray ionization tandem mass spectrometry","volume":"56","author":"Hu","year":"2011","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.cca.2013.02.028_bb0180","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jchromb.2006.04.042","article-title":"Simultaneous determination of cytotoxic bufadienolides in the Chinese medicine ChanSu by high-performance liquid chromatography coupled with photodiode array and mass spectrometry detections","volume":"838","author":"Ye","year":"2006","journal-title":"J Chromatogr B Biomed Appl"},{"key":"10.1016\/j.cca.2013.02.028_bb0185","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1248\/cpb.53.1582","article-title":"Quality evaluation of traditional Chinese drug toad venom from different origins through a simultaneous determination of bufogenins and indole alkaloids by HPLC","volume":"53","author":"Zhang","year":"2005","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.cca.2013.02.028_bb0190","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1007\/BF01923116","article-title":"Synthesis of marinobufagin and marinobufotoxin from telecinobufagin","volume":"28","author":"Kamano","year":"1972","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.cca.2013.02.028_bb0195","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1021\/jo00934a012","article-title":"Steroids and related natural products. 87. Bufadienolides. 28. Marinobufotoxin","volume":"39","author":"Pettit","year":"1974","journal-title":"J Org Chem"},{"key":"10.1016\/j.cca.2013.02.028_bb0200","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1472-8206.2009.00696.x","article-title":"The effects of telocinobufagin isolated from Chan Su on the activation and cytokine secretion of immunocytes in vitro","volume":"23","author":"Cao","year":"2009","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/j.cca.2013.02.028_bb0205","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.clinbiochem.2004.08.005","article-title":"A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure","volume":"38","author":"Komiyama","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.cca.2013.02.028_bb0210","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0079-6565(87)80001-8","article-title":"Carbon-13 NMR spectroscopy of cardenolides and bufadienolides","volume":"19","author":"Robien","year":"1987","journal-title":"Prog Nucl Magn Reson Spectrosc"},{"key":"10.1016\/j.cca.2013.02.028_bb0215","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/oms.1210060603","article-title":"High resolution mass spectrometry. Bufadienolides\u2014II","volume":"6","author":"Brown","year":"1972","journal-title":"Org Mass Spectrom"},{"key":"10.1016\/j.cca.2013.02.028_bb0220","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jep.2010.07.017","article-title":"Comparison of toad venoms from different Bufo species by HPLC and LC\u2013DAD\u2013MS\/MS","volume":"131","author":"Gao","year":"2010","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.cca.2013.02.028_bb0225","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.bmcl.2009.01.064","article-title":"Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins","volume":"19","author":"Hayes","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.cca.2013.02.028_bb0230","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/bmc.699","article-title":"Characterization of in vitro metabolites of toad venom using high-performance liquid chromatography and liquid chromatography\u2013mass spectrometry","volume":"20","author":"Shimada","year":"2006","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.cca.2013.02.028_bb0235","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jpba.2010.05.009","article-title":"Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection","volume":"53","author":"Xia","year":"2010","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.cca.2013.02.028_bb0240","doi-asserted-by":"crossref","first-page":"11A","DOI":"10.1016\/S0895-7061(97)88679-7","article-title":"Effects of Fab digoxin-specific antibody (Fab) on mean arterial pressure (MAP) in severe preeclampsia (PE)","volume":"10","author":"Adair","year":"1997","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.cca.2013.02.028_bb0245","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1124\/jpet.104.065250","article-title":"Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids","volume":"310","author":"Pullen","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cca.2013.02.028_bb0250","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/15321819.2010.538107","article-title":"A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids","volume":"32","author":"Abi-Ghanem","year":"2011","journal-title":"J Immunoassay Immunochem"},{"key":"10.1016\/j.cca.2013.02.028_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10641950802629709","article-title":"Resibufogenin prevents the manifestations of preeclampsia in an animal model of the syndrome","volume":"29","author":"Horvat","year":"2010","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.cca.2013.02.028_bb0260","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/01.hjh.0000163153.27954.33","article-title":"Antibody to marinobufagenin lowers blood pressure in pregnant rats on a high NaCl intake","volume":"23","author":"Fedorova","year":"2005","journal-title":"J Hypertens"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898113000831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898113000831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T08:27:02Z","timestamp":1539851222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898113000831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":52,"alternative-id":["S0009898113000831"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2013.02.028","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analytical aspects of marinobufagenin","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2013.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}