{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:08:50Z","timestamp":1770217730542,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.cca.2013.11.024","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T03:31:03Z","timestamp":1385609463000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["High throughput identification and quantification of 16 antipsychotics and 8 major metabolites in serum using ultra-high performance liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1016","volume":"429","author":[{"given":"Lisbeth","family":"Patteet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristof E.","family":"Maudens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Sabbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Morrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"De Doncker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9034-168X","authenticated-orcid":false,"given":"Hugo","family":"Neels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2013.11.024_bb0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/FTD.0b013e3182708ec5.","article-title":"Therapeutic drug monitoring of common antipsychotics","volume":"34","author":"Patteet","year":"2012","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2013.11.024_bb0010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2004-832687","article-title":"The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry","volume":"37","author":"Baumann","year":"2004","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.cca.2013.11.024_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0031-1286287","article-title":"AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011","volume":"44","author":"Hiemke","year":"2011","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.cca.2013.11.024_bb0020","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/dta.1337","article-title":"The analysis of antipsychotic drugs in human matrices using LC\u2013MS(\/MS)","volume":"4","author":"Saar","year":"2012","journal-title":"Drug Test Anal"},{"key":"10.1016\/j.cca.2013.11.024_bb0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.forsciint.2013.02.010","article-title":"LC\u2013MS\/MS of some atypical antipsychotics in human plasma, serum, oral fluid and haemolysed whole blood","volume":"229","author":"Fisher","year":"2013","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.cca.2013.11.024_bb0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.cca.2013.04.014","article-title":"Simultaneous UPLC\u2013MS\/MS assay for the detection of the traditional antipsychotics haloperidol, fluphenazine, perphenazine, and thiothixene in serum and plasma","volume":"423C","author":"Juenke","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2013.11.024_bb0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chroma.2012.12.071","article-title":"Fast quantification of ten psychotropic drugs and metabolites in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry for therapeutic drug monitoring","volume":"1292","author":"Ansermot","year":"2013","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.cca.2013.11.024_bb0040","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jms.1783","article-title":"Identification and quantification of 30 antipsychotics in blood using LC\u2013MS\/MS","volume":"45","author":"Saar","year":"2010","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.cca.2013.11.024_bb0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1570-0232(03)00207-1","article-title":"Evaluation of electrospray ionisation liquid chromatography\u2013tandem mass spectrometry for rational determination of a number of neuroleptics and their major metabolites in human body fluids and tissues","volume":"789","author":"Josefsson","year":"2003","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.cca.2013.11.024_bb0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jchromb.2006.05.031","article-title":"Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC\u2013tandem mass spectrometry: a multi-level, single-sample approach","volume":"843","author":"Kirchherr","year":"2006","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.cca.2013.11.024_bb0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jms.440","article-title":"Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography\/mass spectrometry with atmospheric pressure chemical ionization","volume":"38","author":"Kratzsch","year":"2003","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.cca.2013.11.024_bb0060","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00216-011-5187-9","article-title":"Ultra high performance liquid chromatographic\u2013tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs","volume":"401","author":"Remane","year":"2011","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jchromb.2010.11.024","article-title":"Quantification of antidepressants and antipsychotics in human serum by precipitation and ultra high pressure liquid chromatography\u2013tandem mass spectrometry","volume":"879","author":"Hasselstrom","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.cca.2013.11.024_bb0070","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jpba.2009.07.007","article-title":"Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC\u2013MS","volume":"50","author":"Choong","year":"2009","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.cca.2013.11.024_bb0075","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/rcm.718","article-title":"Direct-injection high performance liquid chromatography ion trap mass spectrometry for the quantitative determination of olanzapine, clozapine and N-desmethylclozapine in human plasma","volume":"16","author":"Kollroser","year":"2002","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.cca.2013.11.024_bb0080","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jat\/32.2.147","article-title":"Quantitation of seven low-dosage antipsychotic drugs in human postmortem blood using LC\u2013MS-MS","volume":"32","author":"Roman","year":"2008","journal-title":"J Anal Toxicol"},{"key":"10.1016\/j.cca.2013.11.024_bb0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jchromb.2003.11.037","article-title":"Simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in plasma by high-performance liquid chromatography\u2013electrospray ionization mass spectrometry","volume":"802","author":"Zhou","year":"2004","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.cca.2013.11.024_bb0090","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1373\/clinchem.2008.105478","article-title":"Pitfalls and prevention strategies for liquid chromatography\u2013tandem mass spectrometry in the selected reaction-monitoring mode for drug analysis","volume":"54","author":"Sauvage","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0095","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.forsciint.2006.05.021","article-title":"Validation of new methods","volume":"165","author":"Peters","year":"2007","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.cca.2013.11.024_bb0100","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00216-007-1248-5","article-title":"Current role of liquid chromatography\u2013mass spectrometry in clinical and forensic toxicology","volume":"388","author":"Maurer","year":"2007","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0105","series-title":"Guidance for industry: bioanalytical method validation","author":"U. S. Department of Health and Human Services FDA","year":"2001"},{"key":"10.1016\/j.cca.2013.11.024_bb0110","series-title":"Guideline on bioanalytical method validation","author":"European medicines agency: Comittee for medicinal products for human use","year":"2011"},{"key":"10.1016\/j.cca.2013.11.024_bb0115","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/ac020361s","article-title":"Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC\u2013MS\/MS","volume":"75","author":"Matuszewski","year":"2003","journal-title":"Anal Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0120","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00769-011-0775-0","article-title":"Practical aspects concerning validation and quality control for forensic and clinical bioanalytical quantitative methods","volume":"16","author":"Wille","year":"2011","journal-title":"Accred Qual Assur"},{"key":"10.1016\/j.cca.2013.11.024_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.forsciint.2013.03.021","article-title":"Stability of some atypical antipsychotics in human plasma, haemolysed whole blood, oral fluid, human serum and calf serum","volume":"229","author":"Fisher","year":"2013","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.cca.2013.11.024_bb0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0378-4347(01)00548-5","article-title":"Determination of olanzapine in human blood by liquid chromatography\u2013tandem mass spectrometry","volume":"767","author":"Berna","year":"2002","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.cca.2013.11.024_bb0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0378-4347(98)00205-9","article-title":"Determination of olanzapine in serum by high-performance liquid chromatography using ultraviolet detection considering the easy oxidability of the compound and the presence of other psychotropic drugs","volume":"714","author":"Olesen","year":"1998","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.cca.2013.11.024_bb0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.forsciint.2011.02.022","article-title":"Assessment of the stability of 30 antipsychotic drugs in stored blood specimens","volume":"215","author":"Saar","year":"2012","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.cca.2013.11.024_bb0145","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00007691-200408000-00019","article-title":"Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service","volume":"26","author":"Heller","year":"2004","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.cca.2013.11.024_bb0150","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1373\/49.7.1041","article-title":"Ion suppression in mass spectrometry","volume":"49","author":"Annesley","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0155","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1007\/s00216-012-6035-2","article-title":"Aspects of matrix effects in applications of liquid chromatography-mass spectrometry to forensic and clinical toxicology\u2014a review","volume":"403","author":"Peters","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.cca.2013.11.024_bb0160","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/bmc.1640","article-title":"Quantification of asenapine and three metabolites in human plasma using liquid chromatography\u2013tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects","volume":"26","author":"de Boer","year":"2012","journal-title":"Biomed Chromatogr"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898113004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898113004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T12:58:12Z","timestamp":1539003492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898113004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":32,"alternative-id":["S0009898113004713"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2013.11.024","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High throughput identification and quantification of 16 antipsychotics and 8 major metabolites in serum using ultra-high performance liquid chromatography\u2013tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2013.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}