{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:42:31Z","timestamp":1787240551239,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.cca.2014.07.010","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T05:34:36Z","timestamp":1405488876000},"page":"93-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["A new simple and rapid LC\u2013ESI-MS\/MS method for quantification of plasma oxysterols as dimethylaminobutyrate esters. Its successful use for the diagnosis of Niemann\u2013Pick type C disease"],"prefix":"10.1016","volume":"437","author":[{"given":"Sara","family":"Boenzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Deodato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Taurisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Verrigni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Carrozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Dionisi-Vici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2014.07.010_bb0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann\u2013Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin Genet"},{"issue":"4\u20135","key":"10.1016\/j.cca.2014.07.010_bb0010","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000112178","article-title":"Type C Niemann\u2013Pick disease: biochemical aspects and phenotypic heterogeneity","volume":"13","author":"Vanier","year":"1991","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.cca.2014.07.010_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1001\/jama.281.3.249","article-title":"Prevalence of lysosomal storage disorders","volume":"281","author":"Meikle","year":"1999","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.cca.2014.07.010_bb0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ymgme.2012.03.012","article-title":"Recommendations for the diagnosis and management of Niemann\u2013Pick disease type C: an update","volume":"106","author":"Patterson","year":"2012","journal-title":"Mol Genet Metab"},{"issue":"8","key":"10.1016\/j.cca.2014.07.010_bb0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1023\/A:1005474803278","article-title":"Cholesterol and oxygenated cholesterol concentrations are markedly elevated in peripheral tissue but not in brain from mice with the Niemann\u2013Pick type C phenotype","volume":"21","author":"Tint","year":"1998","journal-title":"J Inherit Metab Dis"},{"issue":"56","key":"10.1016\/j.cca.2014.07.010_bb0030","doi-asserted-by":"crossref","first-page":"56ra81","DOI":"10.1126\/scitranslmed.3001417","article-title":"Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann\u2013Pick C1 disease","volume":"2","author":"Porter","year":"2010","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.cca.2014.07.010_bb0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1750-1172-8-35","article-title":"Niemann\u2013Pick disease type C clinical database: cognitive and coordination deficits are early disease indicators","volume":"8","author":"Stampfer","year":"2013","journal-title":"Orphanet J Rare Dis"},{"issue":"9B","key":"10.1016\/j.cca.2014.07.010_bb0040","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1111\/j.1582-4934.2008.00493.x","article-title":"Oxidative stress in NP-C1 deficient cells: protective effect of allopregnanolone","volume":"13","author":"Zampieri","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.cca.2014.07.010_bb0045","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1371\/journal.pone.0000019","article-title":"Clues to neuro-degeneration in Niemann\u2013Pick type C disease from global gene expression profiling","volume":"1","author":"Reddy","year":"2006","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.cca.2014.07.010_bb0050","doi-asserted-by":"crossref","first-page":"e28777","DOI":"10.1371\/journal.pone.0028777","article-title":"Alteration of gene expression profile in Niemann\u2013Pick type C mice correlates with tissue damage and oxidative stress","volume":"6","author":"V\u00e1zquez","year":"2011","journal-title":"PLoS One"},{"issue":"2\u20133","key":"10.1016\/j.cca.2014.07.010_bb0055","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ymgme.2010.06.018","article-title":"Oxidative stress in Niemann\u2013Pick disease, type C","volume":"101","author":"Fu","year":"2010","journal-title":"Mol Genet Metab"},{"issue":"1","key":"10.1016\/j.cca.2014.07.010_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bcp.2013.01.027","article-title":"Methods for oxysterol analysis: past, present and future","volume":"86","author":"Griffiths","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"10.1016\/j.cca.2014.07.010_bb0065","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1194\/jlr.D800040-JLR200","article-title":"Highly sensitive quantification of key regulatory oxysterols in biological samples by LC\u2013ESI-MS\/MS","volume":"50","author":"Honda","year":"2009","journal-title":"J Lipid Res"},{"issue":"11","key":"10.1016\/j.cca.2014.07.010_bb0070","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00535-012-0585-0","article-title":"Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease","volume":"47","author":"Ikegami","year":"2012","journal-title":"J Gastroenterol"},{"issue":"3","key":"10.1016\/j.cca.2014.07.010_bb0075","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jasms.2005.10.012","article-title":"Analysis of oxysterols by electrospray tandem mass spectrometry","volume":"17","author":"Griffiths","year":"2006","journal-title":"J Am Soc Mass Spectrom"},{"issue":"2","key":"10.1016\/j.cca.2014.07.010_bb0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/rcm.2820","article-title":"Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine","volume":"21","author":"Jiang","year":"2007","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.cca.2014.07.010_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cca.2013.06.022","article-title":"Fast LC\u2013MS\/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque","volume":"425","author":"Helmschrodt","year":"2013","journal-title":"Clin Chim Acta"},{"issue":"7","key":"10.1016\/j.cca.2014.07.010_bb0090","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1194\/jlr.D015735","article-title":"A sensitive and specific LC\u2013MS\/MS method for rapid diagnosis of Niemann\u2013Pick C1 disease from human plasma","volume":"52","author":"Jiang","year":"2011","journal-title":"J Lipid Res"},{"issue":"3","key":"10.1016\/j.cca.2014.07.010_bb0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ymgme.2013.07.019","article-title":"Efficacy of miglustat in Niemann\u2013Pick C disease: a single centre experience","volume":"110","author":"Ginocchio","year":"2013","journal-title":"Mol Genet Metab"},{"issue":"10","key":"10.1016\/j.cca.2014.07.010_bb0100","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/S0022-2275(20)32225-2","article-title":"A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry","volume":"42","author":"Johnson","year":"2001","journal-title":"J Lipid Res"},{"issue":"1","key":"10.1016\/j.cca.2014.07.010_bb0105","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abio.1995.1110","article-title":"Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry","volume":"225","author":"Dzeletovic","year":"1995","journal-title":"Anal Biochem"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898114002976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898114002976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T01:22:49Z","timestamp":1649640169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898114002976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":21,"alternative-id":["S0009898114002976"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2014.07.010","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new simple and rapid LC\u2013ESI-MS\/MS method for quantification of plasma oxysterols as dimethylaminobutyrate esters. Its successful use for the diagnosis of Niemann\u2013Pick type C disease","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2014.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}