{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:39:07Z","timestamp":1761597547786,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["ENMed\/0001\/2013","Pest-OE\/EQB\/LA0004\/2011"],"award-info":[{"award-number":["ENMed\/0001\/2013","Pest-OE\/EQB\/LA0004\/2011"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["JPND\/0002\/2011","JPND\/0003\/2011"],"award-info":[{"award-number":["JPND\/0002\/2011","JPND\/0003\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.cca.2014.09.011","type":"journal-article","created":{"date-parts":[[2014,9,28]],"date-time":"2014-09-28T14:51:15Z","timestamp":1411915875000},"page":"342-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Phosphoneurofilament heavy chain and N-glycomics from the cerebrospinal fluid in amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"438","author":[{"given":"Margarida","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Tillack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald S.","family":"Conradt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7782-6319","authenticated-orcid":false,"given":"J\u00falia","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2014.09.011_bb0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1172-4-3","article-title":"Amyotrophic lateral sclerosis","volume":"4","author":"Wijesekera","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.cca.2014.09.011_bb0010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1212\/01.wnl.0000343008.26874.d1","article-title":"Epidemiology of ALS in Italy: a 10-year prospective population-based study","volume":"72","author":"Chio","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.cca.2014.09.011_bb0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1212\/01.wnl.0000296811.19811.db","article-title":"Genetics of familial amyotrophic lateral sclerosis","volume":"70","author":"Valdmanis","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.cca.2014.09.011_bb0020","doi-asserted-by":"crossref","first-page":"764","DOI":"10.2174\/187152710793237502","article-title":"Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis","volume":"9","author":"Costa","year":"2010","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.cca.2014.09.011_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/17482968.2011.627589","article-title":"Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS","volume":"13","author":"Otto","year":"2012","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.cca.2014.09.011_bb0030","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/17482960801934239","article-title":"Proteomic analysis of plasma from Portuguese patients with familial amyotrophic lateral sclerosis","volume":"9","author":"Palma","year":"2008","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.cca.2014.09.011_bb0035","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/17482968.2011.584881","article-title":"Erythropoietin and amyotrophic lateral sclerosis: plasma level determination","volume":"12","author":"Carilho","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.cca.2014.09.011_bb0040","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/mus.23955","article-title":"Vascular endothelial growth factor and amyotrophic lateral sclerosis: the interplay with exercise and non-invasive ventilation","volume":"49","author":"Carilho","year":"2013","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.cca.2014.09.011_bb0045","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/21678421.2014.884592","article-title":"Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis","volume":"15","author":"Lehnert","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degeneration"},{"key":"10.1016\/j.cca.2014.09.011_bb0050","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1212\/01.wnl.0000203120.85850.54","article-title":"Axonal damage markers in cerebrospinal fluid are increased in ALS","volume":"66","author":"Brettschneider","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.cca.2014.09.011_bb0055","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1471-4159.2011.07224.x","article-title":"Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS","volume":"117","author":"Ganesalingam","year":"2011","journal-title":"J Neurochem"},{"key":"10.1016\/j.cca.2014.09.011_bb0060","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1471-4159.2009.06386.x","article-title":"Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker","volume":"111","author":"Boylan","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.cca.2014.09.011_bb0065","doi-asserted-by":"crossref","first-page":"e89065","DOI":"10.1371\/journal.pone.0089065","article-title":"MicroRNA-206: a potential circulating biomarker candidate for amyotrophic lateral sclerosis","volume":"9","author":"Toivonen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2014.09.011_bb0070","doi-asserted-by":"crossref","first-page":"e35772","DOI":"10.1371\/journal.pone.0035772","article-title":"Glycans in sera of amyotrophic lateral sclerosis patients and their role in killing neuronal cells","volume":"7","author":"Edri-Brami","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2014.09.011_bb0075","doi-asserted-by":"crossref","first-page":"e89596","DOI":"10.1371\/journal.pone.0089596","article-title":"Highly immunoreactive IgG antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array","volume":"9","author":"May","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2014.09.011_bb0080","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/21678421.2014.881499","article-title":"Transcranial brainstem sonography as a diagnostic tool for amyotrophic lateral sclerosis","volume":"15","author":"Prell","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degeneration"},{"key":"10.1016\/j.cca.2014.09.011_bb0085","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/jamaneurol.2013.6064","article-title":"Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis","volume":"71","author":"Prell","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.cca.2014.09.011_bb0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1474-4422(13)70036-X","article-title":"Controversies and priorities in amyotrophic lateral sclerosis","volume":"12","author":"Turner","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.cca.2014.09.011_bb0095","doi-asserted-by":"crossref","first-page":"31648","DOI":"10.1074\/jbc.M504395200","article-title":"O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)","volume":"280","author":"Ludemann","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2014.09.011_bb0100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nchembio.797","article-title":"Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation","volume":"8","author":"Yuzwa","year":"2012","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.cca.2014.09.011_bb0105","doi-asserted-by":"crossref","first-page":"e48783","DOI":"10.1371\/journal.pone.0048783","article-title":"Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia","volume":"7","author":"Jesse","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2014.09.011_bb0110","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.neurobiolaging.2011.02.023","article-title":"A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH","volume":"33","author":"Futakawa","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.cca.2014.09.011_bb0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jns.2006.01.019","article-title":"Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death","volume":"246","author":"Gonatas","year":"2006","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.cca.2014.09.011_bb0120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10529-007-9595-z","article-title":"Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis","volume":"30","author":"Gomes","year":"2008","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.cca.2014.09.011_bb0125","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/j.cca.2014.09.011_bb0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-1-62703-547-7_22","article-title":"N-glycosylation analysis by HPAEC-PAD and mass spectrometry","volume":"1049","author":"Kandzia","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.cca.2014.09.011_bb0135","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1016\/j.bbagen.2012.09.004","article-title":"Expression of glycogenes in differentiating human NT2N neurons. Downregulation of fucosyltransferase 9 leads to decreased Lewis(x) levels and impaired neurite outgrowth","volume":"1820","author":"Gouveia","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2014.09.011_bb0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/abio.1995.1468","article-title":"Nonselective and efficient fluorescent labeling of glycans using 2-amino benzamide and anthranilic acid","volume":"230","author":"Bigge","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1016\/j.cca.2014.09.011_bb0145","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1515\/hsz-2012-0135","article-title":"The GlycanBuilder and GlycoWorkbench glycoinformatics tools: updates and new developments","volume":"393","author":"Damerell","year":"2012","journal-title":"Biol Chem"},{"key":"10.1016\/j.cca.2014.09.011_bb0150","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/glycob\/cwq051","article-title":"Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans","volume":"20","author":"Knezevic","year":"2010","journal-title":"Glycobiology"},{"key":"10.1016\/j.cca.2014.09.011_bb0155","doi-asserted-by":"crossref","first-page":"e42688","DOI":"10.1371\/journal.pone.0042688","article-title":"CSF N-glycan profiles to investigate biomarkers in brain developmental disorders: application to leukodystrophies related to eIF2B mutations","volume":"7","author":"Fogli","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2014.09.011_bb0160","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1046\/j.1471-4159.1994.63062185.x","article-title":"Carbohydrate structures of beta-trace protein from human cerebrospinal fluid: evidence for \"\u201cbrain-type\"\u201d N-glycosylation","volume":"63","author":"Hoffmann","year":"1994","journal-title":"J Neurochem"},{"key":"10.1016\/j.cca.2014.09.011_bb0165","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0014-5793(95)00034-7","article-title":"Brain-type N-glycosylation of asialo-transferrin from human cerebrospinal fluid","volume":"359","author":"Hoffmann","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.cca.2014.09.011_bb0170","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1021\/pr1002356","article-title":"Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia","volume":"9","author":"Stanta","year":"2010","journal-title":"J Proteome Res"},{"year":"2005","series-title":"Proteins of the cerebrospinal fluid","author":"Thompson","key":"10.1016\/j.cca.2014.09.011_bb0175"},{"key":"10.1016\/j.cca.2014.09.011_bb0180","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1016\/j.jprot.2012.07.007","article-title":"Glycomics of pediatric and adulthood diseases of the central nervous system","volume":"75","author":"Barone","year":"2012","journal-title":"J Proteomics"},{"key":"10.1016\/j.cca.2014.09.011_bb0185","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0009-8981(95)06025-6","article-title":"Changed transferrin sialylation in Parkinson's disease","volume":"235","author":"van Kamp","year":"1995","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.cca.2014.09.011_bb0190","first-page":"185","article-title":"A decrease in neural sialyltransferase activity in Alzheimer's disease","volume":"6","author":"Maguire","year":"1995","journal-title":"Dementia"},{"key":"10.1016\/j.cca.2014.09.011_bb0195","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1073\/pnas.1102664108","article-title":"Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein\/amyloid beta-peptides in human cerebrospinal fluid","volume":"108","author":"Halim","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898114004070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898114004070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:45:57Z","timestamp":1757861157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898114004070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":39,"alternative-id":["S0009898114004070"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2014.09.011","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphoneurofilament heavy chain and N-glycomics from the cerebrospinal fluid in amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2014.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}