{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:57:26Z","timestamp":1791496646667,"version":"4.3.4"},"reference-count":176,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.cca.2015.01.031","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T17:40:39Z","timestamp":1423071639000},"page":"46-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"special_numbering":"PA","title":["Translational research and biomarkers in neonatal sepsis"],"prefix":"10.1016","volume":"451","author":[{"given":"Joris R.","family":"Delanghe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijn M.","family":"Speeckaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2015.01.031_bb0005","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0010","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.110.2.285","article-title":"Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network","volume":"110","author":"Stoll","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0015","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1542\/peds.2006-0440","article-title":"How reliable is a negative blood culture result? Volume of blood submitted for culture in routine practice in a children's hospital","volume":"119","author":"Connell","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1034\/j.1399-3038.2002.01064.x","article-title":"Expression of CD64 as a potential marker of neonatal sepsis","volume":"13","author":"Layseca-Espinosa","year":"2002","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0025","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.clp.2010.05.005","article-title":"Biomarkers for late-onset neonatal sepsis: cytokines and beyond","volume":"37","author":"Ng","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000336629","article-title":"An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks","volume":"102","author":"Hofer","year":"2012","journal-title":"Neonatology"},{"key":"10.1016\/j.cca.2015.01.031_bb0035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0161-5890(01)00042-6","article-title":"Human C-reactive protein: expression, structure, and function","volume":"38","author":"Volanakis","year":"2001","journal-title":"Mol Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0040","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2015.01.031_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/jcla.20464","article-title":"Serum amyloid-A levels in neonatal necrotizing enterocolitis","volume":"25","author":"Eras","year":"2011","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.cca.2015.01.031_bb0050","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/jp.2008.207","article-title":"Comparison of serum amyloid A concentrations with those of C-reactive protein and procalcitonin in diagnosis and follow-up of neonatal sepsis in premature infants","volume":"29","author":"Cetinkaya","year":"2009","journal-title":"J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0055","doi-asserted-by":"crossref","first-page":"520294","DOI":"10.1155\/2013\/520294","article-title":"Diagnosis value of the serum amyloid A test in neonatal sepsis: a meta-analysis","volume":"2013","author":"Yuan","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.cca.2015.01.031_bb0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2431-10-22","article-title":"A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection","volume":"10","author":"Edgar","year":"2010","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0065","doi-asserted-by":"crossref","first-page":"737141","DOI":"10.1155\/2008\/737141","article-title":"Serum amyloid A, procalcitonin, tumor necrosis factor-alpha, and interleukin-1beta levels in neonatal late-onset sepsis","volume":"2008","author":"Ucar","year":"2008","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.cca.2015.01.031_bb0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.jp.7211682","article-title":"Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis","volume":"27","author":"Arnon","year":"2007","journal-title":"J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0075","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1515\/JPM.2002.048","article-title":"Serum amyloid A protein in the early detection of late-onset bacterial sepsis in preterm infants","volume":"30","author":"Arnon","year":"2002","journal-title":"J Perinat Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0080","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s001340000709","article-title":"Comparison of procalcitonin with C-reactive protein and serum amyloid for the early diagnosis of bacterial sepsis in critically ill neonates and children","volume":"27","author":"Enguix","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0085","first-page":"271","article-title":"Serum amyloid A an early diagnostic marker for neonatal sepsis","volume":"8","author":"Mostafa","year":"2011","journal-title":"Life Sci J"},{"key":"10.1016\/j.cca.2015.01.031_bb0090","first-page":"530","article-title":"Study on diagnostic value of serum amyloid A protein during late- onset sepsis in pretermand full term neonates","volume":"6","author":"Mohsen","year":"2012","journal-title":"Aust J Basic Appl Sci"},{"key":"10.1016\/j.cca.2015.01.031_bb0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000081979","article-title":"Serum amyloid A protein is a useful inflammatory marker during late-onset sepsis in preterm infants","volume":"87","author":"Arnon","year":"2005","journal-title":"Biol Neonate"},{"key":"10.1016\/j.cca.2015.01.031_bb0100","doi-asserted-by":"crossref","first-page":"F283","DOI":"10.1136\/adc.2005.085449","article-title":"Procalcitonin in preterm infants during the first few days of life: introducing an age related nomogram","volume":"91","author":"Turner","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0105","doi-asserted-by":"crossref","first-page":"e854","DOI":"10.1016\/j.ijid.2011.09.007","article-title":"Procalcitonin measurement at 24hours of age may be helpful in the prompt diagnosis of early-onset neonatal sepsis","volume":"15","author":"Altunhan","year":"2011","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2431-10-89","article-title":"Neonatal Procalcitonin Intervention Study (NeoPInS): Effect of procalcitonin-guided decision making on duration of antibiotic therapy in suspected neonatal early-onset sepsis: a multi-centre randomized superiority and non-inferiority intervention study","volume":"10","author":"Stocker","year":"2010","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0120","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00134-011-2174-8","article-title":"Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis","volume":"37","author":"Vouloumanou","year":"2011","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0125","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3109\/00365548.2010.489906","article-title":"The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis","volume":"42","author":"Yu","year":"2010","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0130","article-title":"The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants","author":"Leante-Castellanos","year":"2014","journal-title":"J Perinat Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0135","first-page":"440","article-title":"Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early- onset sepsis","volume":"9","author":"Berner","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0145","doi-asserted-by":"crossref","first-page":"F551","DOI":"10.1136\/adc.2003.030049","article-title":"Lipopolysaccharide binding protein in preterm infants","volume":"89","author":"Behrendt","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/sj.jp.7211422","article-title":"Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection","volume":"26","author":"Orlikowsky","year":"2006","journal-title":"J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0155","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1007\/s00134-004-2307-4","article-title":"Lipopolysaccharide-binding protein in critically ill neonates and children with suspected infection: comparison with procalcitonin, interleukin-6, and C-reactive protein","volume":"30","author":"Pavcnik-Arnol","year":"2004","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0160","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00134-007-0626-y","article-title":"Lipopolysaccharide-binding protein, lipopolysaccharide, and soluble CD14 in sepsis of critically ill neonates and children","volume":"33","author":"Pavcnik-Arnol","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0165","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1007\/s00134-009-1637-7","article-title":"Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children","volume":"35","author":"Groselj-Grenc","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0885","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1042\/bst0310745","article-title":"Introduction to mannan-binding lectin","volume":"31","author":"Kilpatrick","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.cca.2015.01.031_bb0890","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1242\/jcs.1988.Supplement_9.6","article-title":"The structure and function of vertebrate mannose lectin-like proteins","volume":"9","author":"Ezekowitz","year":"1988","journal-title":"J Cell Sci Suppl"},{"key":"10.1016\/j.cca.2015.01.031_bb0170","doi-asserted-by":"crossref","first-page":"625803","DOI":"10.1155\/2013\/625803","article-title":"The role of mannose-binding lectin in severe sepsis and septic shock","volume":"2013","author":"De Pascale","year":"2013","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.cca.2015.01.031_bb0175","doi-asserted-by":"crossref","first-page":"F452","DOI":"10.1136\/adc.2009.172122","article-title":"Mannose-binding lectin and infection risk in newborns: a systematic review","volume":"95","author":"Isra\u00ebls","year":"2010","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0180","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.molimm.2008.07.025","article-title":"Two factors of the lectin pathway of complement, I-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates","volume":"46","author":"Swierzko","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0185","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/jp.2011.79","article-title":"Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia","volume":"32","author":"\u00d6zkan","year":"2012","journal-title":"J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0190","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.mehy.2013.12.017","article-title":"Detection of cord blood hepcidin levels as a biomarker for early-onset neonatal sepsis","volume":"82","author":"Cizmeci","year":"2014","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.cca.2015.01.031_bb0195","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jpeds.2012.06.010","article-title":"The utility of serum hepcidin as a biomarker for late-onset neonatal sepsis","volume":"162","author":"Wu","year":"2013","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0200","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1365-2249.2004.02313.x","article-title":"Immature anti- inflammatory response in neonates","volume":"135","author":"Schultz","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0205","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1055\/s-0028-1090585","article-title":"Utility of interleukin-12 and interleukin-10 in comparison with other cytokines and acute-phase reactants in the diagnosis of neonatal sepsis","volume":"25","author":"Sherwin","year":"2008","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0210","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1182\/blood-2005-06-2259","article-title":"TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens","volume":"107","author":"Peyssonaux","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cca.2015.01.031_bb0215","doi-asserted-by":"crossref","first-page":"F208","DOI":"10.1136\/adc.2004.064188","article-title":"Newer approaches to the diagnosis of early onset neonatal sepsis","volume":"91","author":"Mishra","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0220","doi-asserted-by":"crossref","first-page":"F221","DOI":"10.1136\/fn.77.3.F221","article-title":"Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants","volume":"77","author":"Ng","year":"1997","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0225","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1097\/01.PCC.0000161946.73305.0A","article-title":"Definitions of bloodstream infection in the newborn","volume":"6","author":"Haque","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0230","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1515\/JPM.2003.009","article-title":"Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile","volume":"31","author":"Gonzalez","year":"2003","journal-title":"J Perinat Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0235","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0140-6736(05)77250-0","article-title":"Interleukin-6 concentrations in neonatal sepsis","volume":"353","author":"Onal","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2015.01.031_bb0240","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s004310050041","article-title":"Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms","volume":"159","author":"Kantar","year":"2000","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0245","first-page":"411","article-title":"The role of IL-6 for predicting neonatal sepsis: a systematic review and meta-analysis","volume":"21","author":"Shahkar","year":"2011","journal-title":"Iran J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0250","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1651-2227.2003.tb00530.x","article-title":"Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis","volume":"92","author":"Santana Reyes","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0255","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1203\/00006450-199810000-00002","article-title":"Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)- 1beta, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis","volume":"44","author":"Berner","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0260","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1055\/s-2003-45382","article-title":"Diagnostic value of cytokines and C-reactive protein in the first 24hours of neonatal sepsis","volume":"20","author":"Laborada","year":"2003","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0265","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1542\/peds.108.4.e61","article-title":"Reactive hyperemia and interleukin 6, interleukin 8, and tumor necrosis factor-alpha in the diagnosis of early-onset neonatal sepsis","volume":"108","author":"Martin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0270","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1542\/peds.93.1.54","article-title":"Interleukin-6: a sensitive parameter for the early diagnosis of neonatal bacterial infection","volume":"93","author":"Buck","year":"1994","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0275","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0140-6736(98)08148-3","article-title":"Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2days before clinical manifestation","volume":"352","author":"K\u00fcster","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2015.01.031_bb0280","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000047118","article-title":"Inflammatory mediators in umbilical plasma from neonates who develop early-onset sepsis","volume":"80","author":"D\u00f8llner","year":"2001","journal-title":"Biol Neonate"},{"key":"10.1016\/j.cca.2015.01.031_bb0285","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000047130","article-title":"Cord blood levels of interleukin-6 and interleukin-8 for the immediate diagnosis of early-onset infection in premature infants","volume":"80","author":"Krueger","year":"2001","journal-title":"Biol Neonate"},{"key":"10.1016\/j.cca.2015.01.031_bb0290","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/S0021-75572008000700011","article-title":"Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis","volume":"84","author":"Caldas","year":"2008","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.cca.2015.01.031_bb0295","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.anpedi.2009.07.027","article-title":"Usefulness of a rapid serum interleukin-6 test combined with C-reactive protein to predict sepsis in newborns with suspicion of infection","volume":"71","author":"Beceiro Mosquera","year":"2009","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.cca.2015.01.031_bb0300","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1203\/01.pdr.0000200808.35368.57","article-title":"Inflammatory mediators for the diagnosis and treatment of sepsis in early infancy","volume":"59","author":"Verboon-Maciolek","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0305","first-page":"219","article-title":"Early and late markers for the detection of early-onset neonatal sepsis","volume":"55","author":"Bender","year":"2008","journal-title":"Dan Med Bull"},{"key":"10.1016\/j.cca.2015.01.031_bb0310","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s004310050051","article-title":"Elevated gene expression of interleukin-8 in cord blood is a sensitive marker for neonatal infection","volume":"159","author":"Berner","year":"2000","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0315","first-page":"201","article-title":"Biomarkers for diagnosis of neonatal infections: a systematic analysis of their potential as a point-of-care diagnostics","volume":"1","author":"Meem","year":"2011","journal-title":"J Glob Health"},{"key":"10.1016\/j.cca.2015.01.031_bb0320","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/0009922813482751","article-title":"Usefulness of urinary immune biomarkers in the evaluation of neonatal sepsis: a pilot project","volume":"52","author":"Suguna Narasimhulu","year":"2013","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1016\/j.cca.2015.01.031_bb0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/00365540903449832","article-title":"Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early- and late-onset neonatal sepsis","volume":"42","author":"Zeitoun","year":"2010","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0330","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1074\/mcp.M800175-MCP200","article-title":"Identification of diagnostic biomarkers for infection in premature neonates","volume":"7","author":"Kingsmore","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.cca.2015.01.031_bb0335","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0022-3476(95)70228-8","article-title":"Soluble interleukin-2 receptor as a predictor of neonatal sepsis","volume":"126","author":"Spear","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0340","doi-asserted-by":"crossref","first-page":"e806","DOI":"10.1016\/j.ijid.2010.03.015","article-title":"Circulating concentrations of \u03b1- and \u03b2-chemokines in neonatal sepsis","volume":"14","author":"Manoura","year":"2010","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0345","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1373\/clinchem.2005.062075","article-title":"Early prediction of sepsis-induced disseminated intravascular coagulation with interleukin-10, interleukin-6, and RANTES in preterm infants","volume":"52","author":"Ng","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2015.01.031_bb0350","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.molmed.2004.12.007","article-title":"The \u201ccytokine profile\u201d: a code for sepsis","volume":"11","author":"Ulloa","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0355","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000342333","article-title":"Tumor necrosis factor receptors: biology and therapeutic potential in kidney diseases","volume":"36","author":"Speeckaert","year":"2012","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.cca.2015.01.031_bb0360","doi-asserted-by":"crossref","first-page":"471463","DOI":"10.1155\/2014\/471463","article-title":"Tumor necrosis factor-\u03b1 as a diagnostic marker for neonatal sepsis: a meta-analysis","volume":"2014","author":"Lv","year":"2014","journal-title":"Scientific World Journal"},{"key":"10.1016\/j.cca.2015.01.031_bb0365","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/PCC.0b013e31826e726d","article-title":"Diagnostic performance of triggering receptor expressed on myeloid cells-1 and CD64 index as markers of sepsis in preterm newborns","volume":"14","author":"Mazzucchelli","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0370","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3345\/kjp.2012.55.1.11","article-title":"Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis","volume":"55","author":"Choo","year":"2012","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0375","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jim.2007.09.002","article-title":"Simultaneous quantitative analysis of FcgammaRI (CD64) expression on neutrophils and monocytes: a new, improved way to detect infections","volume":"328","author":"Nuutila","year":"2007","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.cca.2015.01.031_bb0380","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2257.2004.00599.x","article-title":"A standardized procedure for quantitation of CD11b on polymorphonuclear neutrophil by flow cytometry: potential application in infectious diseases","volume":"26","author":"Latger-Cannard","year":"2004","journal-title":"Clin Lab Haematol"},{"key":"10.1016\/j.cca.2015.01.031_bb0385","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/cc10333","article-title":"Clinical review: flow cytometry perspectives in the ICU \u2014 from diagnosis of infection to monitoring of injury-induced immune dysfunctions","volume":"15","author":"Venet","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.cca.2015.01.031_bb0390","doi-asserted-by":"crossref","first-page":"F229","DOI":"10.1136\/adc.2002.023838","article-title":"Diagnostic markers of infection in neonates","volume":"89","author":"Ng","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0395","series-title":"Inflammation: Basic Principles and Clinical Correlates","author":"Gallin","year":"1999"},{"key":"10.1016\/j.cca.2015.01.031_bb0400","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1203\/00006450-199906000-00016","article-title":"Neutrophils from term and preterm newborn infants express the high affinity Fcgamma-receptor I (CD64) during bacterial infections","volume":"45","author":"Fjaertoft","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0405","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/00365540601113693","article-title":"Neutrophil CD64 (FcgammaRI) expression is a specific marker of bacterial infection: a study on the kinetics and the impact of major surgery","volume":"39","author":"Fjaertoft","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0410","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1365-2567.1997.00249.x","article-title":"Neutrophils from the synovial fluid of patients with rheumatoid arthritis express the high affinity immunoglobulin G receptor, Fc gamma RI (CD64): role of immune complexes and cytokines in induction of receptor expression","volume":"91","author":"Quayle","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.cca.2015.01.031_bb0415","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jlb.57.3.455","article-title":"Mature polymorphonuclear leukocytes express high-affinity receptors for IgG (Fc gamma RI) after stimulation with granulocyte colony-stimulating factor (G-CSF)","volume":"57","author":"Gericke","year":"1995","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.cca.2015.01.031_bb0420","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1542\/peds.2007-1308","article-title":"Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker","volume":"121","author":"Bhandari","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0425","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1128\/JCM.00628-09","article-title":"CD64 index provides simple and predictive testing for detection and monitoring of sepsis and bacterial infection in hospital patients","volume":"47","author":"Icardi","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cca.2015.01.031_bb0430","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1203\/01.PDR.0000142586.47798.5E","article-title":"Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection","volume":"56","author":"Ng","year":"2004","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0435","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1203\/00006450-200203000-00006","article-title":"Neutrophil CD64 expression: a sensitive diagnostic marker for late-onset nosocomial infection in very low birthweight infants","volume":"51","author":"Ng","year":"2002","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0440","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000311289","article-title":"Early diagnosis of intra-abdominal inflammation and sepsis by neutrophil CD64 expression in newborns","volume":"99","author":"Lam","year":"2011","journal-title":"Neonatology"},{"key":"10.1016\/j.cca.2015.01.031_bb0445","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/0968051907079101","article-title":"Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia","volume":"13","author":"van der Meer","year":"2007","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0450","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1651-2227.2005.tb03072.x","article-title":"CD64 (Fc gamma receptor I) cell surface expression on maturing neutrophils from preterm and term newborn infants","volume":"94","author":"Fjaertoft","year":"2005","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0455","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1182\/blood.V90.8.3187","article-title":"Increased phagocyte Fc\u03b3 RI expression and improved Fc\u03b3-receptor-mediated phagocytosis after in vivo recombinant human interferon-\u03b3 treatment of normal human subjects","volume":"90","author":"Schiff","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.cca.2015.01.031_bb0460","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/INF.0b013e31826faede","article-title":"Evaluation of CD64 expression on neutrophils as an early indicator of neonatal sepsis","volume":"32","author":"Soni","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.cca.2015.01.031_bb0465","doi-asserted-by":"crossref","first-page":"e102647","DOI":"10.1371\/journal.pone.0102647","article-title":"Diagnostic utility of neutrophil CD64 as a marker for early-onset sepsis in preterm neonates","volume":"9","author":"Du","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2015.01.031_bb0470","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365548.2014.896028","article-title":"Diagnostic accuracy and prognostic value of the CD64 index in very low birth weight neonates as a marker of early-onset sepsis","volume":"46","author":"Motta","year":"2014","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0475","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2310\/JIM.0000000000000060","article-title":"Neutrophil CD64 as a diagnostic marker of sepsis in neonates","volume":"62","author":"Elawady","year":"2014","journal-title":"J Investig Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0480","doi-asserted-by":"crossref","first-page":"e82700","DOI":"10.1371\/journal.pone.0082700","article-title":"Which biomarkers reveal neonatal sepsis?","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2015.01.031_bb0485","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/0300060513489799","article-title":"Diagnostic accuracy of neutrophil CD64 expression in neonatal infection: a meta-analysis","volume":"41","author":"Jia","year":"2013","journal-title":"J Int Med Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0490","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-0033-1334453","article-title":"Neutrophil CD64 with hematologic criteria for diagnosis of neonatal sepsis","volume":"31","author":"Streimish","year":"2014","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0495","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/INF.0b013e318256fb07","article-title":"Neutrophil CD64 as a diagnostic marker in neonatal sepsis","volume":"31","author":"Streimish","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.cca.2015.01.031_bb0500","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12519-011-0304-6","article-title":"Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection","volume":"8","author":"Genel","year":"2012","journal-title":"World J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0505","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jcla.20370","article-title":"Predictive values of neutrophil CD64 expression compared with interleukin-6 and C-reactive protein in early diagnosis of neonatal sepsis","volume":"24","author":"Dilli","year":"2010","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.cca.2015.01.031_bb0510","first-page":"53","article-title":"CD64 cell surface expression on neutrophils for diagnosis of neonatal sepsis","volume":"15","author":"Morsy","year":"2008","journal-title":"Egypt J Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0515","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000088288","article-title":"Quantitative measurement of monocyte HLA-DR expression in the identification of early-onset neonatal infection","volume":"89","author":"Ng","year":"2006","journal-title":"Biol Neonate"},{"key":"10.1016\/j.cca.2015.01.031_bb0520","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15513815.2013.842270","article-title":"Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement","volume":"33","author":"Berrington","year":"2014","journal-title":"Fetal Pediatr Pathol"},{"key":"10.1016\/j.cca.2015.01.031_bb0525","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1532\/LH96.04077","article-title":"Comparison of neutrophil cd64 expression, manual myeloid immaturity counts, and automated hematology analyzer flags as indicators of infection or sepsis","volume":"11","author":"Davis","year":"2005","journal-title":"Lab Hematol"},{"key":"10.1016\/j.cca.2015.01.031_bb0530","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0022-3476(98)70018-6","article-title":"Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection","volume":"132","author":"Weirich","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0535","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1542\/peds.108.1.e12","article-title":"Neutrophil CD11b expression and circulating interleukin-8 as diagnostic markers for early-onset neonatal sepsis","volume":"108","author":"Nupponen","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0540","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12519-011-0304-6","article-title":"Evaluation of adhesion molecules CD64, CD11b and CD62L in neutrophils and monocytes of peripheral blood for early diagnosis of neonatal infection","volume":"8","author":"Genel","year":"2012","journal-title":"World J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0545","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1203\/01.PDR.0000148717.59861.2C","article-title":"Increased CD11b-density on circulating phagocytes as an early sign of late-onset sepsis in extremely low-birth-weight infants","volume":"57","author":"Turunen","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0550","first-page":"348","article-title":"Expression of neutrophil adhesion molecule CD11b as an early diagnostic marker for neonatal sepsis","volume":"41","author":"Cui","year":"2003","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"10.1016\/j.cca.2015.01.031_bb0555","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1067\/mpd.2000.107846","article-title":"Premature infants respond to early-onset and late-onset sepsis with leukocyte activation","volume":"137","author":"Weinschenk","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0560","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/14767058.2012.717462","article-title":"Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges","volume":"25","author":"Mussap","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0565","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/j.1651-2227.1996.tb14135.x","article-title":"Serum levels of CD14 in neonatal sepsis by Gram-positive and Gram-negative bacteria","volume":"85","author":"Blanco","year":"1996","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0570","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3109\/14767058.2011.601923","article-title":"Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers","volume":"242","author":"Mussap","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0575","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.4049\/jimmunol.170.7.3812","article-title":"A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response","volume":"170","author":"Bleharski","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0580","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1177\/039463201002300439","article-title":"Preterm newborns are provided with triggering receptor expressed on myeloid cells-1","volume":"23","author":"Garofoli","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.cca.2015.01.031_bb0585","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7883\/yoken.JJID.2008.31","article-title":"Soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1) as a diagnostic marker of serious bacterial infection in febrile infants less than three months of age","volume":"61","author":"Chen","year":"2008","journal-title":"Jpn J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0590","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7326\/0003-4819-141-1-200407060-00009","article-title":"Plasma level of a triggering receptor expressed on myeloid cells-1: Its diagnostic accuracy in patients with suspected sepsis","volume":"141","author":"Gibot","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0595","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.4049\/jimmunol.173.12.7131","article-title":"Cutting edge: Expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia","volume":"173","author":"Knapp","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0600","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cyto.2013.11.004","article-title":"Circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) as diagnostic and prognostic marker in neonatal sepsis","volume":"65","author":"Adly","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.cca.2015.01.031_bb0605","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s00134-010-1819-3","article-title":"Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates","volume":"36","author":"Sarafidis","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0610","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1651-2227.1997.tb08889.x","article-title":"Infections in neonates delivered at term are associated with increased serum levels of ICAM-1 and E-selectin","volume":"86","author":"Austgulen","year":"1997","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0615","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0895-4356(01)00400-0","article-title":"Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules","volume":"54","author":"D\u00f8llner","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.cca.2015.01.031_bb0620","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1089\/108729001750171353","article-title":"ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes","volume":"11","author":"Condon","year":"2001","journal-title":"Antisense Nucleic Acid Drug Dev"},{"key":"10.1016\/j.cca.2015.01.031_bb0625","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1055\/s-2007-981851","article-title":"Serum soluble ICAM-1, VCAM-1, L-selectin, and P-selectin levels as markers of infection and their relation to clinical severity in neonatal sepsis","volume":"24","author":"Figueras-Aloy","year":"2007","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0630","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1203\/00006450-199412000-00020","article-title":"L-selectin is down-regulated in umbilical cord blood granulocytes and monocytes of newborn infants with acute bacterial infection","volume":"36","author":"B\u00fchrer","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0635","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/09629350220131944","article-title":"Levels of soluble ICAM-1 in premature and full-term neonates with infection","volume":"11","author":"Apostolou","year":"2002","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.cca.2015.01.031_bb0640","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0378-3782(00)00115-8","article-title":"Serum soluble E- and L-selectin in the very early neonatal period","volume":"60","author":"Giannaki","year":"2000","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.cca.2015.01.031_bb0645","first-page":"83","article-title":"Soluble intercellular adhesion molecule-1 (slCAM-1) for early diagnosis of neonatal infections","volume":"16","author":"Mahmoud","year":"2009","journal-title":"Egypt J Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0650","doi-asserted-by":"crossref","first-page":"375702","DOI":"10.1155\/2014\/375702","article-title":"Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study","volume":"2014","author":"Siahanidou","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.cca.2015.01.031_bb0655","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/00365540902767056","article-title":"Diagnostic values of lipid and lipoprotein levels in late onset neonatal sepsis","volume":"41","author":"Yildiz","year":"2009","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0660","doi-asserted-by":"crossref","first-page":"291085","DOI":"10.1155\/2011\/291085","article-title":"Serum calprotectin: an antimicrobial peptide as a new marker for the diagnosis of sepsis in very low birth weight newborns","volume":"2011","author":"Terrin","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0665","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/pr.2012.106","article-title":"Proadrenomedullin as a prognostic marker in neonatal sepsis","volume":"72","author":"Oncel","year":"2012","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0670","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1357-2725(99)00125-9","article-title":"Bikunin\u2014not just a plasma proteinase inhibitor","volume":"32","author":"Fries","year":"2000","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.cca.2015.01.031_bb0675","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-3476(03)00190-2","article-title":"Inter-alpha inhibitor proteins in infants and decreased levels in neonatal sepsis","volume":"143","author":"Baek","year":"2003","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0680","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jpeds.2008.10.008","article-title":"The role of inter-alpha inhibitor proteins in the diagnosis of neonatal sepsis","volume":"154","author":"Chaaban","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0685","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1371\/journal.pmed.0040018","article-title":"Proteomic profiling of the amniotic fluid to detect inflammation, infection and neonatal sepsis","volume":"4","author":"Buhimschi","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0690","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1172\/JCI40196","article-title":"Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants","volume":"120","author":"Ng","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cca.2015.01.031_bb0695","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.clp.2010.03.002","article-title":"The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis","volume":"37","author":"Buhimschi","year":"2010","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0700","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1203\/01.pdr.0000252439.48564.37","article-title":"Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate","volume":"61","author":"Buhimschi","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0705","doi-asserted-by":"crossref","first-page":"e26111","DOI":"10.1371\/journal.pone.0026111","article-title":"Proteomics mapping of cord blood identifies haptoglobin \u201cswitch-on\u201d pattern as biomarker of early-onset neonatal sepsis in preterm newborns","volume":"6","author":"Buhimschi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2015.01.031_bb0710","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1179\/1973947813Y.0000000149","article-title":"Is 1H NMR metabolomics becoming the promising early biomarker for neonatal sepsis and for monitoring the antibiotic toxicity?","volume":"26","author":"Noto","year":"2014","journal-title":"J Chemother"},{"key":"10.1016\/j.cca.2015.01.031_bb0715","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1164\/rccm.201209-1726OC","article-title":"Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality","volume":"187","author":"Mickiewicz","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0720","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0378-3782(14)70024-6","article-title":"Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis","volume":"90","author":"Fanos","year":"2014","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.cca.2015.01.031_bb0725","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1194\/jlr.P023309","article-title":"Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients","volume":"53","author":"Schmerler","year":"2012","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cca.2015.01.031_bb0730","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0378-3782(14)70007-6","article-title":"New diagnostic possibilities in systemic neonatal infections: metabolomics","volume":"90","author":"Dess\u00ec","year":"2014","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.cca.2015.01.031_bb0735","doi-asserted-by":"crossref","first-page":"e68426","DOI":"10.1371\/journal.pone.0068426","article-title":"Comparative assessment of cytokines and other inflammatory markers for the early diagnosis of neonatal sepsis-a case control study","volume":"8","author":"Prashant","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2015.01.031_bb0740","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1007\/s10753-011-9416-3","article-title":"Pre-inflammatory mediators and lymphocyte subpopulations in preterm neonates with sepsis","volume":"35","author":"Hotoura","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.cca.2015.01.031_bb0745","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0022-3476(98)70448-2","article-title":"Interleukin-6 concentrations in neonates evaluated for sepsis","volume":"132","author":"Doellner","year":"1998","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0750","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.114.1.1","article-title":"Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter, randomized, controlled trial","volume":"114","author":"Franz","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.cca.2015.01.031_bb0755","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1651-2227.2001.tb01359.x","article-title":"Interleukin-8: a valuable tool to restrict antibiotic therapy in newborn infants","volume":"90","author":"Franz","year":"2001","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0760","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1651-2227.2003.tb00534.x","article-title":"Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonate","volume":"92","author":"Resch","year":"2003","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0765","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/00006454-199908000-00003","article-title":"Comparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants","volume":"18","author":"Franz","year":"1999","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.cca.2015.01.031_bb0770","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1373\/49.1.60","article-title":"C-reactive protein, interleukin-6, and procalcitonin in the immediate postnatal period: influence of illness severity, risk status, antenatal and perinatal complications, and infection","volume":"49","author":"Chiesa","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.cca.2015.01.031_bb0775","first-page":"7","article-title":"Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis","volume":"49","author":"Kocaba\u015f","year":"2007","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0780","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-3083.2010.02499.x","article-title":"Tracking changes of lymphocyte subsets and pre-inflammatory mediators in full-term neonates with suspected or documented infection","volume":"73","author":"Hotoura","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.cca.2015.01.031_bb0785","doi-asserted-by":"crossref","first-page":"F345","DOI":"10.1136\/adc.2008.155754","article-title":"Rapid quantitative procalcitonin measurement to diagnose nosocomial infections in newborn infants","volume":"94","author":"Jacquot","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.cca.2015.01.031_bb0790","first-page":"204","article-title":"Usefulness of a semiquantitative procalcitonin test kit for early diagnosis of neonatal sepsis","volume":"49","author":"Boo","year":"2008","journal-title":"Singapore Med J"},{"key":"10.1016\/j.cca.2015.01.031_bb0795","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.clinbiochem.2008.05.015","article-title":"Procalcitonin for the diagnosis of earlyonset neonatal sepsis: a multilevel probabilistic approach","volume":"41","author":"Santuz","year":"2008","journal-title":"Clin Biochem"},{"key":"10.1016\/j.cca.2015.01.031_bb0800","first-page":"292","article-title":"Interest of Procalcitonin in neonatal intensive care unit for patients suspected of nosocomial sepsis: retrospective study on 40 children","volume":"21","author":"Savagner","year":"2008","journal-title":"J Pediatr Pueric"},{"key":"10.1016\/j.cca.2015.01.031_bb0805","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1157\/13102522","article-title":"Procalcitonin, C-reactive protein and leukocyte count in very-low birth weight infants with late neonatal sepsis","volume":"66","author":"Bustos Betanzo","year":"2007","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.cca.2015.01.031_bb0810","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/00365540701466181","article-title":"The use of procalcitonin in the diagnosis of late onset infection in neonatal intensive care unit patients","volume":"39","author":"Isidor","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cca.2015.01.031_bb0815","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2431-7-9","article-title":"Evaluation of procalcitonin for diagnosis of neonatal sepsis of vertical transmission","volume":"7","author":"Lopez Sastre","year":"2007","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0820","first-page":"530","article-title":"Usefulness of procalcitonin as an early diagnostic test of neonatal sepsis in newborns with risk factors for infection","volume":"67","author":"Pastor Peidro","year":"2007","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.cca.2015.01.031_bb0825","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/sj.jp.7211296","article-title":"Procalcitonin as a screening test for late-onset sepsis in preterm very low birth weight infants","volume":"25","author":"Vazzalwar","year":"2005","journal-title":"J Perinatol"},{"key":"10.1016\/j.cca.2015.01.031_bb0830","first-page":"851","article-title":"Serum procalcitonin as an early marker of neonatal sepsis","volume":"94","author":"Ballot","year":"2004","journal-title":"S Afr Med J"},{"key":"10.1016\/j.cca.2015.01.031_bb0835","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(05)79165-0","article-title":"Lack of specificity of procalcitonin for sepsis diagnosis in premature infants","volume":"351","author":"Lapillonne","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2015.01.031_bb0840","first-page":"254","article-title":"Value of umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1 as predictors of neonatal hematologic indices and suspected early sepsis","volume":"6","author":"Smulian","year":"1997","journal-title":"J Matern Fetal Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0845","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0022-3476(96)70123-3","article-title":"Evaluation of interleukin-6 and soluble receptors of tumor necrosis factor for early diagnosis of neonatal infection","volume":"129","author":"Messer","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0850","first-page":"1508","article-title":"Serum concentrations of interleukin-1 alpha, interleukin-6 and tumor necrosis factor-alpha in neonatal sepsis and meningitis","volume":"27","author":"Fida","year":"2006","journal-title":"Saudi Med J"},{"key":"10.1016\/j.cca.2015.01.031_bb0855","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000078492","article-title":"Amniotic fluid tumor necrosis factor-alpha is a marker for the prediction of early-onset neonatal sepsis in preterm labor","volume":"58","author":"Park","year":"2004","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.cca.2015.01.031_bb0860","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1080\/08035259950169314","article-title":"Evaluation of interleukin-6, tumour necrosis factor-alpha and interleukin-1beta for early diagnosis of neonatal sepsis","volume":"88","author":"Silveira","year":"1999","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.cca.2015.01.031_bb0865","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-3782(01)00245-6","article-title":"Monocyte phagocytosis as a reliable parameter for predicting early-onset sepsis in very low birthweight infants","volume":"67","author":"Hallwirth","year":"2002","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.cca.2015.01.031_bb0870","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/PCC.0b013e3182231074","article-title":"Association between high cytokine levels with white matter injury in preterm infants with sepsis","volume":"13","author":"Procianoy","year":"2012","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.cca.2015.01.031_bb0875","first-page":"45","article-title":"Role of tumor necrosis factor in neonatal sepsis","volume":"9","author":"Shi","year":"1994","journal-title":"Chin Med Sci J"},{"key":"10.1016\/j.cca.2015.01.031_bb0880","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1203\/01.pdr.0000250207.95723.96","article-title":"IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants","volume":"61","author":"Ng","year":"2007","journal-title":"Pediatr Res"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115000534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115000534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T06:39:51Z","timestamp":1691044791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898115000534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":176,"alternative-id":["S0009898115000534"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2015.01.031","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translational research and biomarkers in neonatal sepsis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2015.01.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}