{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:42:27Z","timestamp":1771256547841,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ratchadaphiseksomphot Endowment Fund 2013 of Chulalongkorn University","award":["CU-56-341-AS"],"award-info":[{"award-number":["CU-56-341-AS"]}]},{"name":"Ratchadapiseksompotch Fund","award":["RA55\/22"],"award-info":[{"award-number":["RA55\/22"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.cca.2015.01.032","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T14:17:12Z","timestamp":1423318632000},"page":"72-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Plasma and synovial fluid autotaxin correlate with severity in knee osteoarthritis"],"prefix":"10.1016","volume":"444","author":[{"given":"Thomas","family":"Mabey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pimpisa","family":"Taleongpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanvisa","family":"Udomsinprasert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napaphat","family":"Jirathanathornnukul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sittisak","family":"Honsawek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2015.01.032_bb0005","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J Orthop Res"},{"key":"10.1016\/j.cca.2015.01.032_bb0010","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/art.38300","article-title":"Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies","volume":"66","author":"Rodriguez-Fontenla","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.cca.2015.01.032_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2005.09.007","article-title":"Osteoarthritis: epidemiology","volume":"20","author":"Arden","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.cca.2015.01.032_bb0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10354-012-0168-y","article-title":"Osteoarthritis: histology and pathogenesis","volume":"163","author":"Sulzbacher","year":"2013","journal-title":"Wien Med Wochenschr"},{"key":"10.1016\/j.cca.2015.01.032_bb0025","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.cca.2015.01.032_bb0030","first-page":"279","article-title":"Radiographic assessment of osteoarthritis","volume":"64","author":"Swagerty","year":"2001","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.cca.2015.01.032_bb0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbalip.2008.04.009","article-title":"Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysopld activity and matricellular properties","volume":"1781","author":"Yuelling","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2015.01.032_bb0040","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1194\/jlr.R046391","article-title":"Autotaxin: structure-function and signaling","volume":"55","author":"Perrakis","year":"2014","journal-title":"J Lipid Res"},{"key":"10.1016\/j.cca.2015.01.032_bb0045","first-page":"42","article-title":"Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)\/lPC and ATX\/lPA axes","volume":"2013","author":"Sevastou","year":"1831","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cca.2015.01.032_bb0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ydbio.2010.01.007","article-title":"ATX expression and LPA signalling are vital for the development of the nervous system","volume":"339","author":"Fotopoulou","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.cca.2015.01.032_bb0055","doi-asserted-by":"crossref","first-page":"25822","DOI":"10.1074\/jbc.M605142200","article-title":"Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid","volume":"281","author":"Tanaka","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2015.01.032_bb0060","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.02419-05","article-title":"Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development","volume":"26","author":"van Meeteren","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.cca.2015.01.032_bb0065","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1124\/jpet.110.165845","article-title":"A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation","volume":"334","author":"Gierse","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.cca.2015.01.032_bb0070","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrm3188","article-title":"Insights into autotaxin: how to produce and present a lipid mediator","volume":"12","author":"Moolenaar","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.cca.2015.01.032_bb0075","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.20112012","article-title":"Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis","volume":"209","author":"Nikitopoulou","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.cca.2015.01.032_bb0080","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1124\/mol.107.038216","article-title":"Regulation of lysophosphatidic acid receptor expression and function in human synoviocytes: implications for rheumatoid arthritis?","volume":"73","author":"Zhao","year":"2008","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.cca.2015.01.032_bb0085","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2015.01.032_bb0090","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2015.01.032_bb0095","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1016\/j.cca.2015.01.032_bb0100","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bone.2011.12.002","article-title":"The emerging role of lysophosphatidic acid (LPA) in skeletal biology","volume":"50","author":"Blackburn","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.cca.2015.01.032_bb0105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2249.2001.01432.x","article-title":"IL-1 beta- and IL-4-induced down-regulation of autotaxin mRNA and pc-1 in fibroblast-like synoviocytes of patients with rheumatoid arthritis (ra)","volume":"123","author":"Kehlen","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cca.2015.01.032_bb0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/bbrc.1996.1819","article-title":"Treatment of fibroblast-like synoviocytes with IFN-gamma results in the down-regulation of autotaxin mrna","volume":"229","author":"Santos","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cca.2015.01.032_bb0115","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1093\/ndt\/gfl437","article-title":"Lysophospholipase D activity exists in the urine to catalyse the formation of lysophosphatidic acid","volume":"21","author":"Ohkawa","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cca.2015.01.032_bb0120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2141.2008.07325.x","article-title":"Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma","volume":"143","author":"Masuda","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cca.2015.01.032_bb0125","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/art.37991","article-title":"Necessity of lysophosphatidic acid receptor 1 for development of arthritis","volume":"65","author":"Miyabe","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.cca.2015.01.032_bb0130","doi-asserted-by":"crossref","first-page":"6551","DOI":"10.1074\/jbc.M113.533232","article-title":"Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity","volume":"289","author":"David","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.cca.2015.01.032_bb0135","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.bcp.2005.09.015","article-title":"Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes","volume":"70","author":"Kim","year":"2005","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.cca.2015.01.032_bb0140","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbamcr.2009.01.020","article-title":"Lysophosphatidic acid signaling promotes proliferation, differentiation, and cell survival in rat growth plate chondrocytes","volume":"1793","author":"Hurst-Kennedy","year":"2009","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.cca.2015.01.032_bb0145","doi-asserted-by":"crossref","first-page":"e95180","DOI":"10.1371\/journal.pone.0095180","article-title":"Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating gi\/nf-kb-dependent angiogenic factor expression","volume":"9","author":"Chuang","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cca.2015.01.032_bb0150","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.archoralbio.2007.08.006","article-title":"Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through lpa1 receptors on human osteoblasts","volume":"53","author":"Aki","year":"2008","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.cca.2015.01.032_bb0155","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00264-013-2192-y","article-title":"Relationship of plasma and synovial fluid vascular endothelial growth factor with radiographic severity in primary knee osteoarthritis","volume":"38","author":"Saetan","year":"2014","journal-title":"Int Orthop"},{"key":"10.1016\/j.cca.2015.01.032_bb0160","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s00264-014-2406-y","article-title":"Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis","volume":"38","author":"Mabey","year":"2014","journal-title":"Int Orthop"},{"key":"10.1016\/j.cca.2015.01.032_bb0165","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","article-title":"Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis","volume":"49","author":"Walsh","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cca.2015.01.032_bb0170","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1136\/annrheumdis-2012-202832","article-title":"Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis","volume":"73","author":"Orosa","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.cca.2015.01.032_bb0175","article-title":"Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice","author":"Orosa","year":"2014","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.cca.2015.01.032_bb0180","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.joca.2013.08.012","article-title":"Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time","volume":"21","author":"Lafeber","year":"2013","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115000546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115000546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T11:58:24Z","timestamp":1537876704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898115000546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":36,"alternative-id":["S0009898115000546"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2015.01.032","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma and synovial fluid autotaxin correlate with severity in knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2015.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}