{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T15:27:30Z","timestamp":1773847650967,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.cca.2015.09.009","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T13:30:25Z","timestamp":1447507825000},"page":"95-99","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Rapid quantitative analysis of human serum sphingomyelin species using MALDI-TOF mass spectrometry with lipid hydrolase treatment"],"prefix":"10.1016","volume":"453","author":[{"given":"Atsushi","family":"Hori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yamaura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Honda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2015.09.009_bb0005","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.plipres.2013.05.001","article-title":"Biological functions of sphingomyelins","volume":"52","author":"Slotte","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"Simons","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cca.2015.09.009_bb0015","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1126\/science.274.5294.1855","article-title":"Functions of ceramide in coordinating cellular responses to stress","volume":"274","author":"Hannun","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cca.2015.09.009_bb0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12017-010-8120-z","article-title":"Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses","volume":"12","author":"Wu","year":"2010","journal-title":"Neruomol. Med."},{"key":"10.1016\/j.cca.2015.09.009_bb0025","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/S0021-9258(17)41834-5","article-title":"The sphingomyelin cycle and the second messenger function of ceramide","volume":"269","author":"Hannun","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cca.2015.09.009_bb0030","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1161\/01.ATV.20.12.2614","article-title":"Plasma sphingomyelin level as a risk factor for coronary artery disease","volume":"20","author":"Jiang","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cca.2015.09.009_bb0035","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1194\/jlr.D800028-JLR200","article-title":"Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry","volume":"50","author":"Wiesner","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0040","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0005-2760(68)90187-2","article-title":"Metabolism of sphingomyelin in the intestinal tract of the rat","volume":"164","author":"Nilsson","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt 3","key":"10.1016\/j.cca.2015.09.009_bb0045","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/bj3500747","article-title":"The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide","volume":"350","author":"Higuchi","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.cca.2015.09.009_bb0050","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/biot.200800322","article-title":"Molecular facets of sphingolipids: mediators of diseases","volume":"4","author":"Ozbayraktar","year":"2009","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.cca.2015.09.009_bb0055","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.plipres.2012.12.001","article-title":"Molecular properties of various structurally defined sphingomyelins\u2014correlation of structure with function","volume":"52","author":"Peter Slotte","year":"2013","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0060","doi-asserted-by":"crossref","first-page":"17221","DOI":"10.1074\/jbc.R000005200","article-title":"Structure and function of sphingolipid- and cholesterol-rich membrane rafts","volume":"75","author":"Brown","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cca.2015.09.009_bb0065","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/oxfordjournals.jbchem.a128713","article-title":"Sphingomyelins in human erythrocytes and plasma","volume":"62","author":"Minai","year":"1967","journal-title":"J. Biochem."},{"key":"10.1016\/j.cca.2015.09.009_bb0070","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0022-2275(20)40579-6","article-title":"Separation of molecular species of sphingomyelin by reversed-phase high-performance liquid chromatography","volume":"20","author":"Jungalwala","year":"1979","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0075","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-2275(20)42648-3","article-title":"Separation and identification of ceramides derived from human plasma sphingomyelins","volume":"10","author":"Samuelsson","year":"1969","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0080","first-page":"213","article-title":"Analysis of human serum lipoprotein lipid composition using MALDI-TOF mass spectrometry","volume":"37","author":"Hidaka","year":"2007","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.cca.2015.09.009_bb0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ymeth.2005.01.009","article-title":"Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry","volume":"36","author":"Merrill","year":"2005","journal-title":"Methods"},{"key":"10.1016\/j.cca.2015.09.009_bb0090","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.clinbiochem.2008.06.010","article-title":"Specific, rapid, and sensitive enzymatic measurement of sphingomyelin, phosphatidylcholine and lysophosphatidylcholine in serum and lipid extracts","volume":"41","author":"Hidaka","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2015.09.009_bb0095","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)39620-6","article-title":"Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin","volume":"6","author":"O'Brien","year":"1965","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0100","first-page":"655","article-title":"Mass spectrometric analysis of lipid species of human circulating blood cells","volume":"2008","author":"Leidl","year":"1781","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cca.2015.09.009_bb0105","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1194\/jlr.M500011-JLR200","article-title":"ESI-MS quantitation of increased sphingomyelin in Niemann\u2013Pick disease type B HDL","volume":"46","author":"Lee","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/clinchem\/42.3.454","article-title":"Plasma phospholipid fatty acids in X-linked adrenoleukodystrophy","volume":"42","author":"Avelda\u00f1o","year":"1996","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2015.09.009_bb0115","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10096-014-2123-x","article-title":"Elevated plasma sphingomyelin (d18:1\/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection","volume":"33","author":"Li","year":"2014","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.cca.2015.09.009_bb0120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0022-2275(20)40282-2","article-title":"Purification and partial characterization of sphingomyelin from human plasma","volume":"4","author":"Sweeley","year":"1963","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cca.2015.09.009_bb0125","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/00021369.1966.10858625","article-title":"Fatty acid composition of hydrocarbon-assimilating yeast","volume":"30","author":"Mizuno","year":"1966","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.cca.2015.09.009_bb0130","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1079\/BJN19940111","article-title":"Cobalt-vitamin B12 deficiency causes accumulation of odd-numbered, branched-chain fatty acids in the tissues of sheep","volume":"71","author":"Kennedy","year":"1994","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.cca.2015.09.009_bb0135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/CIRCGENETICS.110.959098","article-title":"Comparative lipidomics profiling of human atherosclerotic plaques","volume":"4","author":"Stegemann","year":"2011","journal-title":"Circ. Cardiovasc. Genet."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115004180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115004180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T19:30:30Z","timestamp":1655926230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898115004180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":27,"alternative-id":["S0009898115004180"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2015.09.009","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid quantitative analysis of human serum sphingomyelin species using MALDI-TOF mass spectrometry with lipid hydrolase treatment","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2015.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}