{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:51:18Z","timestamp":1782604278948,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.cca.2015.10.024","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T21:16:21Z","timestamp":1445807781000},"page":"117-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"PB","title":["Revisiting HELLP syndrome"],"prefix":"10.1016","volume":"451","author":[{"given":"Luci Maria","family":"Dusse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Nessralla","family":"Alpoim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano Teixeira","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyelle Romana Alves","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto Henriques","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Carlos Vieira","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2015.10.024_bb0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9378(16)32330-4","article-title":"Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy","volume":"142","author":"Weinstein","year":"1982","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0010","first-page":"657","article-title":"Preeclampsia\/eclampsia with hemolysis, elevated liver enzymes, and thrombocytopenia","volume":"66","author":"Weinstein","year":"1985","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0015","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1515\/JPM.2002.076","article-title":"Clinical and biophysical aspects of HELLP-syndrome","volume":"30","author":"Ertan","year":"2002","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.cca.2015.10.024_bb0020","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0002-9378(93)90043-I","article-title":"Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome)","volume":"169","author":"Sibai","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0025","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00003081-200206000-00004","article-title":"Acute complications of preeclampsia","volume":"45","author":"Norwitz","year":"2002","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0030","first-page":"756","article-title":"Hepatic hemorrhage and the HELLP syndrome: a surgeon's perspective","volume":"61","author":"Stevenson","year":"1995","journal-title":"Am. Surg."},{"key":"10.1016\/j.cca.2015.10.024_bb0035","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.clp.2004.06.008","article-title":"Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome","volume":"31","author":"Barton","year":"2004","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.cca.2015.10.024_bb0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-385855-9.00004-7","article-title":"Biochemistry of HELLP syndrome","volume":"53","author":"Benedetto","year":"2011","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.cca.2015.10.024_bb0045","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.ajog.2005.06.058","article-title":"It has been a great ride: the history of HELLP syndrome","volume":"193","author":"Weinstein","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0050","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/0002-9378(93)90678-C","article-title":"Acute renal failure in pregnancies complicated by hemolysis, elevated liver enzymes, and low platelets","volume":"168","author":"Sibai","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0055","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1067\/mob.2002.120279","article-title":"Acute renal failure complicating severe preeclampsia requiring admission to an obstetric intensive care unit","volume":"186","author":"Drakeley","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0060","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/01.AOG.0000126245.35811.2a","article-title":"Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count","volume":"103","author":"Sibai","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0065","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0002-9378(90)90376-I","article-title":"The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing?","volume":"162","author":"Sibai","year":"1990","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0070","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ajog.2005.02.113","article-title":"Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. 1982","volume":"193","author":"Weinstein","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0075","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/00003081-199909000-00009","article-title":"Twelve steps to optimal management of HELLP syndrome","volume":"42","author":"Magann","year":"1999","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0080","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/01.ogx.0000146948.19308.c5","article-title":"HELLP syndrome: the state of the art","volume":"59","author":"Baxter","year":"2004","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.cca.2015.10.024_bb0085","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1001\/jama.1980.03300450023014","article-title":"The predictive value of serum haptoglobin in hemolytic disease","volume":"243","author":"Marchand","year":"1980","journal-title":"JAMA"},{"key":"10.1016\/j.cca.2015.10.024_bb0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0020-7292(92)90776-F","article-title":"Haptoglobin as a sensitive marker of hemolysis in HELLP-syndrome","volume":"39","author":"Wilke","year":"1992","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.cca.2015.10.024_bb0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1515\/JPM.2000.033","article-title":"HELLP syndrome","volume":"28","author":"Rath","year":"2000","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.cca.2015.10.024_bb0100","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0002-9378(98)70645-3","article-title":"Plasma glutathione S-transferase alpha 1\u20131: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy","volume":"178","author":"Knapen","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejogrb.2005.12.031","article-title":"Moderate to severe thrombocytopenia during pregnancy","volume":"128","author":"Parnas","year":"2006","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.cca.2015.10.024_bb0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cca.2010.09.030","article-title":"Pre-eclampsia: relationship between coagulation, fibrinolysis and inflammation","volume":"412","author":"Dusse","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2015.10.024_bb0115","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.ajog.2005.08.044","article-title":"Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child","volume":"195","author":"Martin","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0120","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/0002-9378(91)91429-Z","article-title":"The natural history of HELLP syndrome: patterns of disease progression and regression","volume":"164","author":"Martin","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0125","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0002-9378(99)70022-0","article-title":"The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification","volume":"180","author":"Martin","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0130","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0002-9378(96)70162-X","article-title":"Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome","volume":"175","author":"Audibert","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1471-0528.1986.tb07879.x","article-title":"A syndrome of liver damage and intravascular coagulation in the last trimester of normotensive pregnancy. A clinical and histopathological study","volume":"93","author":"Aarnoudse","year":"1986","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0140","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1471-0528.1995.tb09062.x","article-title":"Temporising management of severe pre-eclampsia with and without the HELLP syndrome","volume":"102","author":"Visser","year":"1995","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ajog.2006.01.016","article-title":"Characteristics and treatment of hepatic rupture caused by HELLP syndrome","volume":"195","author":"Araujo","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ajog.2003.08.029","article-title":"Subcapsular liver hematoma in HELLP syndrome: evaluation of diagnostic and therapeutic options\u2013a unicenter study","volume":"190","author":"Wicke","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0155","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/00006254-199903000-00024","article-title":"Preeclampsia-associated hepatic hemorrhage and rupture: mode of management related to maternal and perinatal outcome","volume":"54","author":"Rinehart","year":"1999","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.cca.2015.10.024_bb0160","first-page":"219","article-title":"Postpartum hepatic rupture and retroperitoneal hematoma associated with HELLP syndrome","volume":"8","author":"Gilboa","year":"2006","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.cca.2015.10.024_bb0165","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.clp.2004.06.007","article-title":"Imitators of severe pre-eclampsia\/eclampsia","volume":"31","author":"Sibai","year":"2004","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.cca.2015.10.024_bb0170","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1056\/NEJM199608223350807","article-title":"Liver disease in pregnancy","volume":"335","author":"Knox","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2015.10.024_bb0175","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MOH.0b013e3280dce531","article-title":"The presence of active von Willebrand factor under various pathological conditions","volume":"14","author":"Groot","year":"2007","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.cca.2015.10.024_bb0180","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJM199906033402204","article-title":"A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women","volume":"340","author":"Ibdah","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2015.10.024_bb0185","unstructured":"MP A, Relapse of thrombotic thrombocytopenic purpura associated with decreased VWF cleaving activity."},{"key":"10.1016\/j.cca.2015.10.024_bb0190","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12185-009-0481-4","article-title":"Pivotal role of ADAMTS13 function in liver diseases","volume":"91","author":"Uemura","year":"2010","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.cca.2015.10.024_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmrv.2014.08.004","article-title":"A mechanistic approach to the diagnosis and management of atypical hemolytic uremic syndrome","author":"Tsai","year":"2014","journal-title":"Transfus. Med. Rev."},{"key":"10.1016\/j.cca.2015.10.024_bb0200","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1538-7836.2009.03555.x","article-title":"Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Crommittee of the International Society on Thrombosis and Haemostasis","volume":"7","author":"Pengo","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.cca.2015.10.024_bb0205","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ijgo.2013.02.001","article-title":"Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia)","volume":"121","author":"Martin","year":"2013","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.cca.2015.10.024_bb0210","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ogc.2012.11.008","article-title":"Hypertensive emergencies of pregnancy","volume":"40","author":"Alexander","year":"2013","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.cca.2015.10.024_bb0215","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/01443615.2013.775231","article-title":"HELLP syndrome: understanding and management of a pregnancy-specific disease","volume":"33","author":"Aloizos","year":"2013","journal-title":"J. Obstet. Gynaecol."},{"key":"10.1016\/j.cca.2015.10.024_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008148.pub2","article-title":"Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy","author":"Woudstra","year":"2010","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115300267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898115300267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T04:24:02Z","timestamp":1537244642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898115300267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":44,"alternative-id":["S0009898115300267"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2015.10.024","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revisiting HELLP syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2015.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}