{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:08:08Z","timestamp":1790755688075,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.cca.2016.12.017","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T09:04:32Z","timestamp":1482915872000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["Complement in autoimmune diseases"],"prefix":"10.1016","volume":"465","author":[{"given":"Pandiarajan","family":"Vignesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhubala","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0005","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ni0708-705","article-title":"Immunology's foundation: the 100-year anniversary of the Nobel prize to Paul Ehrlich and Elie Metchnikoff","volume":"9","author":"Kaufmann","year":"2008","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0010","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1556\/EuJMI.2.2012.2.2","article-title":"The complement system: history, pathways, cascade and inhibitors","volume":"2","author":"Nesargikar","year":"2012","journal-title":"Eur. J. Microbiol. Immunol."},{"issue":"2\u20133","key":"10.1016\/j.cca.2016.12.017_bb0015","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s12026-013-8422-y","article-title":"Complement and autoimmunity","volume":"56","author":"Ballanti","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.cca.2016.12.017_bb0020","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fimmu.2016.00036","article-title":"Early components of the complement classical activation pathway in human systemic autoimmune diseases","volume":"7","author":"Lintner","year":"2016","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.cca.2016.12.017_bb0025","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1016\/j.molimm.2009.04.026","article-title":"Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions","volume":"46","author":"G\u00e1l","year":"2009","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0030","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.138.6.1305","article-title":"Formation of a hemolytically active cellular intermediate by the interaction between properdin factors B and D and the activated third component of complement","volume":"138","author":"Fearon","year":"1973","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.cca.2016.12.017_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molimm.2005.06.028","article-title":"Complement and toll-like receptors: key regulators of adaptive immune responses","volume":"43","author":"Hawlisch","year":"2006","journal-title":"Mol. Immunol."},{"issue":"15","key":"10.1016\/j.cca.2016.12.017_bb0040","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","article-title":"Complement. Second of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0045","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.4049\/jimmunol.173.5.3044","article-title":"Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells","volume":"173","author":"Nauta","year":"2004","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molimm.2015.05.007","article-title":"Classical pathway deficiencies - a short analytical review","volume":"68","author":"Truedsson","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cca.2016.12.017_bb0055","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.immunol.22.012703.104549","article-title":"The role of complement in the development of systemic lupus erythematosus","volume":"22","author":"Manderson","year":"2004","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.cca.2016.12.017_bb0060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: a key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0753-3322(03)00084-2","article-title":"Complement and autoimmunity","volume":"57","author":"Boackle","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cca.2016.12.017_bb0070","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0065-2776(08)60908-6","article-title":"The role of complement in B cell activation and tolerance","volume":"74","author":"Carroll","year":"2000","journal-title":"Adv. Immunol."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0075","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S1074-7613(00)80669-X","article-title":"A critical role for complement in maintenance of self-tolerance","volume":"9","author":"Prodeus","year":"1998","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.cca.2016.12.017_bb0080","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1080\/08916930701510673","article-title":"Complement deficiencies and systemic lupus erythematosus","volume":"40","author":"Truedsson","year":"2007","journal-title":"Autoimmunity"},{"key":"10.1016\/j.cca.2016.12.017_bb0085","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fimmu.2016.00055","article-title":"Systemic lupus erythematosus and deficiencies of early components of the complement classical pathway","volume":"7","author":"Macedo","year":"2016","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0090","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1177\/0961203311411598","article-title":"Complement and antibody primary immunodeficiency in juvenile systemic lupus erythematosus patients","volume":"20","author":"Jesus","year":"2011","journal-title":"Lupus"},{"issue":"8","key":"10.1016\/j.cca.2016.12.017_bb0095","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10875-015-0212-y","article-title":"Early complement component deficiency in a single-Centre cohort of pediatric onset lupus","volume":"35","author":"Bhattad","year":"2015","journal-title":"J. Clin. Immunol."},{"issue":"6166","key":"10.1016\/j.cca.2016.12.017_bb0100","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/332738a0","article-title":"The binding site for C1q on IgG","volume":"332","author":"Duncan","year":"1988","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0105","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molimm.2015.03.007","article-title":"Clinical presentation of human C1q deficiency: how much of a lupus?","volume":"67","author":"Stegert","year":"2015","journal-title":"Mol. Immunol."},{"issue":"13","key":"10.1016\/j.cca.2016.12.017_bb0110","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1016\/j.molimm.2007.02.014","article-title":"Complement protein C1q induces maturation of human dendritic cells","volume":"44","author":"Csomor","year":"2007","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0115","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.4049\/jimmunol.1103760","article-title":"Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells","volume":"188","author":"Benoit","year":"2012","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.cca.2016.12.017_bb0120","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1002\/art.24852","article-title":"C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis","volume":"60","author":"Lood","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cca.2016.12.017_bb0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0065-2776(01)76021-X","article-title":"Systemic lupus erythematosus, complement deficiency, and apoptosis","volume":"76","author":"Pickering","year":"2000","journal-title":"Adv. Immunol."},{"issue":"10","key":"10.1016\/j.cca.2016.12.017_bb0130","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1177\/0961203312443993","article-title":"Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency","volume":"21","author":"Namjou","year":"2012","journal-title":"Lupus"},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0135","first-page":"52","article-title":"Clinical and immunological studies in a case of selective complete C1q deficiency","volume":"38","author":"Berkel","year":"1979","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s004390050464","article-title":"Multiple identification of a particular type of hereditary C1q deficiency in the Turkish population: review of the cases and additional genetic and functional analysis","volume":"100","author":"Petry","year":"1997","journal-title":"Hum. Genet."},{"issue":"3\u20134","key":"10.1016\/j.cca.2016.12.017_bb0145","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0171-2985(00)80089-3","article-title":"Molecular, genetic and epidemiologic studies on selective complete C1q deficiency in Turkey","volume":"201","author":"Berkel","year":"2000","journal-title":"Immunobiology"},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0150","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ki.1996.359","article-title":"Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family","volume":"50","author":"Topaloglu","year":"1996","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0155","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/ard.2003.016592","article-title":"Hereditary C1q deficiency and secondary Sj\u00f6gren's syndrome","volume":"63","author":"Hoppenreijs","year":"2004","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.cca.2016.12.017_bb0160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/gene.2011.39","article-title":"Molecular basis of hereditary C1q deficiency - revisited: identification of several novel disease-causing mutations","volume":"12","author":"Schejbel","year":"2011","journal-title":"Genes Immun."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF00291737","article-title":"Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13","volume":"78","author":"Nguyen","year":"1988","journal-title":"Hum. Genet."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0170","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1084\/jem.131.4.803","article-title":"Deficiency of C1r in human serum. Effects on the structure and function of macromolecular C1","volume":"131","author":"Pickering","year":"1970","journal-title":"J. Exp. Med."},{"issue":"13","key":"10.1016\/j.cca.2016.12.017_bb0175","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJM197203302861304","article-title":"Lupus-erythematosus-like syndrome with a familial defect of complement","volume":"286","author":"Moncada","year":"1972","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0180","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1172\/JCI106902","article-title":"C1r deficiency: an inborn error associated with cutaneous and renal disease","volume":"51","author":"Day","year":"1972","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0185","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.molimm.2007.09.034","article-title":"Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene","volume":"45","author":"Amano","year":"2008","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0190","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s004390050843","article-title":"Selective complement C1s deficiency caused by homozygous four-base deletion in the C1s gene","volume":"103","author":"Inoue","year":"1998","journal-title":"Hum. Genet."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0195","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.4049\/jimmunol.162.4.2180","article-title":"Molecular basis of human complement C1s deficiency","volume":"162","author":"Endo","year":"1999","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0200","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.4049\/jimmunol.182.3.1681","article-title":"Unique phenotypes of C1s deficiency and abnormality caused by two compound heterozygosities in a Japanese family","volume":"182","author":"Abe","year":"2009","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0205","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.4049\/jimmunol.166.12.7612","article-title":"Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases","volume":"166","author":"Dragon-Durey","year":"2001","journal-title":"J. Immunol."},{"issue":"5948","key":"10.1016\/j.cca.2016.12.017_bb0210","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/307237a0","article-title":"A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B","volume":"307","author":"Carroll","year":"1984","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0215","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.4049\/jimmunol.179.5.3012","volume":"179","author":"Wu","year":"2007","journal-title":"J. Immunol."},{"issue":"38","key":"10.1016\/j.cca.2016.12.017_bb0220","doi-asserted-by":"crossref","first-page":"15425","DOI":"10.1073\/pnas.1208031109","article-title":"Structural basis for activation of the complement system by component C4 cleavage","volume":"109","author":"Kidmose","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0225","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/gene.2009.10","article-title":"Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosus","volume":"10","author":"Wu","year":"2009","journal-title":"Genes Immun."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0230","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.4049\/jimmunol.173.4.2803","article-title":"Complete complement components C4A and C4B deficiencies in human kidney diseases and systemic lupus erythematosus","volume":"173","author":"Yang","year":"2004","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0235","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.4049\/jimmunol.162.6.3687","article-title":"Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes","volume":"162","author":"Lokki","year":"1999","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0240","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4049\/jimmunol.169.3.1570","article-title":"The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes","volume":"169","author":"Rupert","year":"2002","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0245","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1086\/518257","volume":"80","author":"Yang","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"10","key":"10.1016\/j.cca.2016.12.017_bb0250","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s00296-011-2023-7","article-title":"Confirmation of C4 gene copy number variation and the association with systemic lupus erythematosus in Chinese Han population","volume":"32","author":"Lv","year":"2012","journal-title":"Rheumatol. Int."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0255","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/art.37854","article-title":"Deletion variants of RABGAP1L, 10q21.3, and C4 are associated with the risk of systemic lupus erythematosus in Korean women","volume":"65","author":"Kim","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0260","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/art.39589","article-title":"Effects of complement C4 gene copy number variations, size dichotomy, and C4A deficiency on genetic risk and clinical presentation of systemic lupus erythematosus in east Asian populations","volume":"68","author":"Yih Chen","year":"2016","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0265","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2012.01.012","article-title":"Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations","volume":"90","author":"Boteva","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cca.2016.12.017_bb0270","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12969-015-0050-8","article-title":"Primary complement and antibody deficiencies in autoimmune rheumatologic diseases with juvenile onset: a prospective study at two centers","volume":"13","author":"Sp\u00e2rchez","year":"2015","journal-title":"Pediatr. Rheumatol. Online J."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0275","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.clim.2010.06.003","article-title":"Familial C4B deficiency and immune complex glomerulonephritis","volume":"137","author":"Soto","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.cca.2016.12.017_bb0280","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-1-4757-9182-2_72","article-title":"Wegener's granulomatosis and Henoch-Sch\u00f6nlein purpura in a family with hereditary C4 deficiency","volume":"336","author":"Lhotta","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"issue":"13","key":"10.1016\/j.cca.2016.12.017_bb0285","doi-asserted-by":"crossref","first-page":"9347","DOI":"10.1016\/S0021-9258(19)50430-6","article-title":"Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing","volume":"267","author":"Johnson","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0290","doi-asserted-by":"crossref","first-page":"578","DOI":"10.4049\/jimmunol.161.2.578","article-title":"A novel type II complement C2 deficiency allele in an African-American family","volume":"161","author":"Zhu","year":"1998","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0295","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/rheumatology\/kem023","article-title":"Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency","volume":"46","author":"J\u00f6nsson","year":"2007","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0300","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.4049\/jimmunol.143.7.2256","article-title":"Lysis of sensitized sheep erythrocytes in human sera deficient in the second component of complement","volume":"143","author":"Knutzen Steuer","year":"1989","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0305","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1024540917593","article-title":"Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency","volume":"23","author":"Alper","year":"2003","journal-title":"J. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0310","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10067-008-0838-8","article-title":"The role of mannose-binding lectin in systemic lupus erythematosus","volume":"27","author":"Monticielo","year":"2008","journal-title":"Clin. Rheumatol."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0315","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1002\/art.21484","article-title":"The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis","volume":"52","author":"Lee","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0320","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.humimm.2011.03.007","article-title":"Mannose binding lectin gene (MBL2) functional polymorphisms are associated with systemic lupus erythematosus in southern Brazilians","volume":"72","author":"Sandrin-Garcia","year":"2011","journal-title":"Hum. Immunol."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0325","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1177\/0961203314536478","article-title":"MBL2 gene variants coding for mannose-binding lectin deficiency are associated with increased risk of nephritis in Danish patients with systemic lupus erythematosus","volume":"23","author":"Tanha","year":"2014","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0330","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.rbr.2015.09.003","article-title":"Mild and moderate mannose binding lectin deficiency are associated with systemic lupus erythematosus and lupus nephritis in Brazilian patients","volume":"56","author":"Perazzio","year":"2016","journal-title":"Rev. Bras. Reumatol."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0335","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/10799893.2014.975247","article-title":"The association of mannose-binding lectin genetic polymorphisms with the risk of rheumatoid arthritis: a meta-analysis","volume":"35","author":"Zhang","year":"2015","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142287","article-title":"Formal comment on Schorr GS, Falcone EA, Moretti DJ, Andrews RD (2014) first long-term behavioral records from Cuvier's beaked whales (Ziphius Cavirostris) reveal record-breaking dives","volume":"10","author":"Tyack","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0345","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00467-015-3076-8","article-title":"An international consensus approach to the management of atypical hemolytic uremic syndrome in children","volume":"31","author":"Loirat","year":"2016","journal-title":"Pediatr. Nephrol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0350","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molimm.2015.03.012","article-title":"The role of complement in C3 glomerulopathy","volume":"67","author":"Zipfel","year":"2015","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0355","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4161\/viru.26515","article-title":"Meningococcal disease and the complement system","volume":"5","author":"Lewis","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.cca.2016.12.017_bb0360","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fimmu.2013.00117","article-title":"Anti-C1q autoantibodies, novel tests, and clinical consequences","volume":"4","author":"Mahler","year":"2013","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0365","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0961203314547791","article-title":"Anti-C1q antibodies in systemic lupus erythematosus","volume":"24","author":"Orbai","year":"2015","journal-title":"Lupus"},{"issue":"9","key":"10.1016\/j.cca.2016.12.017_bb0370","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.160.9.4641","article-title":"In vitro stimulation of C1s proteolytic activities by C1s-presenting autoantibodies from patients with systemic lupus erythematosus","volume":"160","author":"He","year":"1998","journal-title":"J. Immunol."},{"issue":"6090","key":"10.1016\/j.cca.2016.12.017_bb0375","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/323722a0","article-title":"An IgG autoantibody which inactivates C1-inhibitor","volume":"323","author":"Jackson","year":"1986","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0380","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0961203309357059","article-title":"C1-inhibitor autoantibodies in SLE","volume":"19","author":"M\u00e9sz\u00e1ros","year":"2010","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0385","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.imlet.2014.01.014","article-title":"Autoantibodies to complement components in C3 glomerulopathy and atypical hemolytic uremic syndrome","volume":"160","author":"J\u00f3zsi","year":"2014","journal-title":"Immunol. Lett."},{"issue":"10","key":"10.1016\/j.cca.2016.12.017_bb0390","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI105272","article-title":"Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus","volume":"44","author":"Paronetto","year":"1965","journal-title":"J. Clin. Invest."},{"issue":"5 Pt 1","key":"10.1016\/j.cca.2016.12.017_bb0395","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0190-9622(93)70093-9","article-title":"Deposition of membrane attack complex in cutaneous lesions of lupus erythematosus","volume":"28","author":"Helm","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0400","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4049\/jimmunol.135.3.2005","article-title":"Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and\/or complement activation","volume":"135","author":"Ross","year":"1985","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0405","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.semarthrit.2008.11.002","article-title":"The pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus: a reappraisal","volume":"39","author":"Katsiari","year":"2010","journal-title":"Semin. Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0410","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-2478(03)00066-X","article-title":"Deficiency of red cell bound CD55 and CD59 in patients with systemic lupus erythematosus","volume":"88","author":"Richaud-Patin","year":"2003","journal-title":"Immunol. Lett."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0415","doi-asserted-by":"crossref","first-page":"R218","DOI":"10.1186\/ar4057","article-title":"Mannose binding lectin: a biomarker of systemic lupus erythematosus disease activity","volume":"14","author":"Panda","year":"2012","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0420","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00296-012-2519-9","article-title":"A study on anti-mannose binding lectin (anti-MBL) antibodies and serum MBL levels in Indian systemic lupus erythematosus patients","volume":"33","author":"Pradhan","year":"2013","journal-title":"Rheumatol. Int."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0425","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molimm.2014.07.003","article-title":"Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus","volume":"63","author":"Hein","year":"2015","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0430","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.200116116","article-title":"Complement C3 activation is required for antiphospholipid antibody-induced fetal loss","volume":"195","author":"Holers","year":"2002","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0435","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/ard.2008.090670","article-title":"Complement activation in patients with primary antiphospholipid syndrome","volume":"68","author":"Oku","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0440","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12026-011-8239-5","article-title":"Membrane attack by complement: the assembly and biology of terminal complement complexes","volume":"51","author":"Tegla","year":"2011","journal-title":"Immunol. Res."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0445","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI200318817","article-title":"Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome","volume":"112","author":"Girardi","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0450","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.181.1.151","article-title":"Mouse complement regulatory protein Crry\/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein","volume":"181","author":"Kim","year":"1995","journal-title":"J. Exp. Med."},{"issue":"5452","key":"10.1016\/j.cca.2016.12.017_bb0455","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.287.5452.498","article-title":"A critical role for murine complement regulator Crry in fetomaternal tolerance","volume":"287","author":"Xu","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0460","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.200116116","article-title":"Complement C3 activation is required for antiphospholipid antibody-induced fetal loss","volume":"195","author":"Holers","year":"2002","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0465","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1002\/art.21157","article-title":"Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia","volume":"52","author":"Pierangeli","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0470","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2007.02.007","article-title":"Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation","volume":"77","author":"Salmon","year":"2008","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0475","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2215\/CJN.06710810","article-title":"Henoch-Schonlein purpura nephritis: pathophysiology, treatment, and future strategy","volume":"6","author":"Davin","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2016.12.017_bb0480","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40620-015-0245-6","article-title":"Role of complement in IgA nephropathy","volume":"29","author":"Daha","year":"2016","journal-title":"J Nephrol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0485","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/cei.12154","article-title":"Glomerular mannose-binding lectin deposition is a useful prognostic predictor in immunoglobulin a nephropathy","volume":"174","author":"Liu","year":"2013","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0490","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.amjmed.2004.02.030","article-title":"The antineutrophil cytoplasmic antibody-associated vasculitides","volume":"117","author":"Seo","year":"2004","journal-title":"Am. J. Med."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0495","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1681\/ASN.2008050497","article-title":"C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis","volume":"20","author":"Schreiber","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0500","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.autrev.2016.03.007","article-title":"Pathogenesis of ANCA-associated vasculitis: an update","volume":"15","author":"Jarrot","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.cca.2016.12.017_bb0505","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13075-015-0656-8","article-title":"Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis","volume":"17","author":"Chen","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0510","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.autrev.2011.05.013","article-title":"Pathogenesis and therapies of immune-mediated myopathies","volume":"11","author":"Dalakas","year":"2012","journal-title":"Autoimmun. Rev."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0515","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM198602063140601","article-title":"Microvascular deposition of complement membrane attack complex in dermatomyositis","volume":"314","author":"Kissel","year":"1986","journal-title":"N. Engl. J. Med."},{"issue":"9388","key":"10.1016\/j.cca.2016.12.017_bb0520","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(03)14368-1","article-title":"Polymyositis and dermatomyositis","volume":"362","author":"Dalakas","year":"2003","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0525","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1001\/archderm.1995.01690240040007","article-title":"Membrane attack complex deposits in cutaneous lesions of dermatomyositis","volume":"131","author":"Mascar\u00f3","year":"1995","journal-title":"Arch. Dermatol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0530","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0002-9343(75)90537-9","article-title":"Hereditary complement (C2) deficiency with dermatomyositis","volume":"58","author":"Leddy","year":"1975","journal-title":"Am. J. Med."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0535","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/art.38137","article-title":"Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders","volume":"65","author":"Miller","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0540","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1046\/j.1365-2133.2001.04204.x","article-title":"Hereditary complement (C9) deficiency associated with dermatomyositis","volume":"144","author":"Ichikawa","year":"2001","journal-title":"Br. J. Dermatol."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0545","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/039463201102400209","article-title":"Complement system and rheumatoid arthritis: relationships with autoantibodies, serological, clinical features, and anti-TNF treatment","volume":"24","author":"Di Muzio","year":"2011","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.cca.2016.12.017_bb0550","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/ard.47.3.190","article-title":"Relation between synovial fluid C3 degradation products and local joint inflammation in rheumatoid arthritis, osteoarthritis, and crystal associated arthropathy","volume":"47","author":"Doherty","year":"1988","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.cca.2016.12.017_bb0555","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1136\/ard.55.12.888","article-title":"Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane","volume":"55","author":"Konttinen","year":"1996","journal-title":"Ann. Rheum. Dis."},{"issue":"14","key":"10.1016\/j.cca.2016.12.017_bb0560","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2174\/092986706777441959","article-title":"A review of current knowledge of the complement system and the therapeutic opportunities in inflammatory arthritis","volume":"13","author":"Mizuno","year":"2006","journal-title":"Curr. Med. Chem."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0565","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/ard.51.11.1254","article-title":"Complement factor 2 deficiency: a clinical and serological family study","volume":"51","author":"D'Cruz","year":"1992","journal-title":"Ann. Rheum. Dis."},{"issue":"5","key":"10.1016\/j.cca.2016.12.017_bb0570","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/art.33472","article-title":"Increased frequency of complement C4B deficiency in rheumatoid arthritis","volume":"64","author":"Rigby","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.cca.2016.12.017_bb0575","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-1759(90)90358-3","article-title":"Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays","volume":"133","author":"Oppermann","year":"1990","journal-title":"J. Immunol. Methods"},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0580","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/art.20561","article-title":"Measurement of erythrocyte C4d and complement receptor 1 in systemic lupus erythematosus","volume":"50","author":"Manzi","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0585","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2014-000056","article-title":"Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements","volume":"1","author":"Putterman","year":"2014","journal-title":"Lupus Sci. Med."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0590","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molimm.2012.10.044","article-title":"Monitoring and modeling treatment of atypical hemolytic uremic syndrome","volume":"54","author":"Heinen","year":"2013","journal-title":"Mol. Immunol."},{"issue":"11","key":"10.1016\/j.cca.2016.12.017_bb0595","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1681\/ASN.2013010045","article-title":"Soluble CR1 therapy improves complement regulation in C3 glomerulopathy","volume":"24","author":"Zhang","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"7","key":"10.1016\/j.cca.2016.12.017_bb0600","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/j.2326-5205.1989.tb00023.x","article-title":"Successful plasma infusion treatment of a patient with C2 deficiency and systemic lupus erythematosus: clinical experience over forty-five months","volume":"32","author":"Steinsson","year":"1989","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.cca.2016.12.017_bb0605","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/rheumatology\/kep387","article-title":"SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience","volume":"49","author":"Mehta","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.cca.2016.12.017_bb0610","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2172-11-43","article-title":"Recombinant human complement component C2 produced in a human cell line restores the classical complement pathway activity in-vitro: an alternative treatment for C2 deficiency diseases","volume":"11","author":"Martini","year":"2010","journal-title":"BMC Immunol."},{"issue":"1","key":"10.1016\/j.cca.2016.12.017_bb0615","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jaci.2013.07.035","article-title":"Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation","volume":"133","author":"Arkwright","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.cca.2016.12.017_bb0620","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1097\/TP.0000000000000975","article-title":"Allogeneic hematopoietic stem cell transplantation in the treatment of human C1q deficiency: the Karolinska experience","volume":"100","author":"Olsson","year":"2016","journal-title":"Transplantation"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898116305198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898116305198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T13:14:54Z","timestamp":1718975694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898116305198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":124,"alternative-id":["S0009898116305198"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2016.12.017","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement in autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2016.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}