{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:33:15Z","timestamp":1781019195584,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Collaborative Innovation Center of Infectious Diseases","award":["PXM2015_014226_000058"],"award-info":[{"award-number":["PXM2015_014226_000058"]}]},{"name":"Collaborative Innovation Center of Infectious Diseases","award":["PXM2016_014226_000052"],"award-info":[{"award-number":["PXM2016_014226_000052"]}]},{"name":"National Science and Technology Major Project of China","award":["2008ZX10003006-011"],"award-info":[{"award-number":["2008ZX10003006-011"]}]},{"name":"National Science and Technology Major Project of China","award":["2012ZX10003002"],"award-info":[{"award-number":["2012ZX10003002"]}]},{"name":"National Science and Technology Major Project of China","award":["2013ZX10003003-004"],"award-info":[{"award-number":["2013ZX10003003-004"]}]},{"name":"National Science and Technology Major Project of China","award":["2015ZX10004801-003"],"award-info":[{"award-number":["2015ZX10004801-003"]}]},{"name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development Special Funding Support","award":["ZYLX201304"],"award-info":[{"award-number":["ZYLX201304"]}]},{"name":"Beijing Outstanding Talents Training Program","award":["20081D0301300095"],"award-info":[{"award-number":["20081D0301300095"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.cca.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:03:04Z","timestamp":1483646584000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis"],"prefix":"10.1016","volume":"466","author":[{"given":"Zihui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boping","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongde","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2017.01.002_bb0005","series-title":"Global Tuberculosis Report 2015","author":"WHO","year":"2015"},{"key":"10.1016\/j.cca.2017.01.002_bb0010","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S1474-4422(13)70168-6","article-title":"Tuberculous meningitis: more questions, still too few answers","volume":"12","author":"Thwaites","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cca.2017.01.002_bb0015","article-title":"Tuberculous meningitis in adults: a review of 160 cases","volume":"169028","author":"Pehlivanoglu","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.cca.2017.01.002_bb0020","first-page":"64","article-title":"Predictors of outcome in patients with tuberculous meningitis","volume":"6","author":"Hosoglu","year":"2002","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0025","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1128\/JCM.05756-11","article-title":"A highly efficient Ziehl-Neelsen stain: identifying de novo intracellular Mycobacterium tuberculosis and improving detection of extracellular M. tuberculosis in cerebrospinal fluid","volume":"50","author":"Chen","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cca.2017.01.002_bb0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/bmb\/ldv003","article-title":"Tuberculous meningitis: advances in diagnosis and treatment","volume":"113","author":"Torok","year":"2015","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.cca.2017.01.002_bb0035","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1164\/rccm.200912-1931OC","article-title":"Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population","volume":"182","author":"Patel","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cca.2017.01.002_bb0040","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1086\/652142","article-title":"Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells","volume":"50","author":"Kim","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0045","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jinf.2011.03.009","article-title":"Diagnostic and prognostic value of Mycobacterium tuberculosis complex specific interferon gamma release assay in patients with tuberculous meningitis","volume":"62","author":"Vidhate","year":"2011","journal-title":"J. Infect."},{"key":"10.1016\/j.cca.2017.01.002_bb0050","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1183\/09031936.00098111","article-title":"T-cell-based assays on cerebrospinal fluid and PBMCs for rapid diagnosis of TB meningitis in non-HIV patients","volume":"39","author":"Park","year":"2012","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cca.2017.01.002_bb0055","series-title":"Global Tuberculosis Report 2014","author":"WHO","year":"2014"},{"key":"10.1016\/j.cca.2017.01.002_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001536","article-title":"Diagnostic accuracy of quantitative PCR (Xpert MTB\/RIF) for tuberculous meningitis in a high burden setting: a prospective study","volume":"10","author":"Patel","year":"2013","journal-title":"PLoS Med."},{"key":"10.1016\/j.cca.2017.01.002_bb0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/JCM.01834-13","article-title":"Evaluation of GeneXpert MTB\/RIF for diagnosis of tuberculous meningitis","volume":"52","author":"Nhu","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cca.2017.01.002_bb0070","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.2217\/bmm.14.67","article-title":"Methods of rapid diagnosis for the etiology of meningitis in adults","volume":"8","author":"Bahr","year":"2014","journal-title":"Biomark. Med"},{"key":"10.1016\/j.cca.2017.01.002_bb0075","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5588\/ijtld.11.0687","article-title":"Clinical prediction rule for differentiating tuberculous from viral meningitis","volume":"16","author":"Hristea","year":"2012","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0080","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.2337\/db12-0707","article-title":"Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance","volume":"62","author":"Ferrannini","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.cca.2017.01.002_bb0085","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1053\/j.gastro.2013.01.054","article-title":"Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes","volume":"144","author":"Budhu","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cca.2017.01.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001303","article-title":"Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis","volume":"5","author":"Al-Mubarak","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0095","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1039\/C4MB00700J","article-title":"An integrated metabolomics approach for the research of new cerebrospinal fluid biomarkers of multiple sclerosis","volume":"11","author":"Pieragostino","year":"2015","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.cca.2017.01.002_bb0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: metabolomics: the apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cca.2017.01.002_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/2213235X02666140301002510","article-title":"Recent advances in metabolic profiling and imaging of prostate cancer","volume":"2","author":"Thapar","year":"2014","journal-title":"Curr. Metabolomics"},{"key":"10.1016\/j.cca.2017.01.002_bb0110","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1039\/c4mb00090k","article-title":"NMR- and MS-based metabolomics: various organ responses following naphthalene intervention","volume":"10","author":"Ling","year":"2014","journal-title":"Mol. BioSyst."},{"key":"10.1016\/j.cca.2017.01.002_bb0115","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s11306-014-0741-z","article-title":"A hypothetical astrocyte-microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis","volume":"11","author":"Mason","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.cca.2017.01.002_bb0120","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/497836","article-title":"Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis","volume":"41","author":"Coen","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/nbm.944","article-title":"Proton MR CSF analysis and a new software as predictors for the differentiation of meningitis in children","volume":"18","author":"Subramanian","year":"2005","journal-title":"NMR Biomed."},{"key":"10.1016\/j.cca.2017.01.002_bb0130","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1473-3099(10)70138-9","article-title":"Tuberculous meningitis: a uniform case definition for use in clinical research","volume":"10","author":"Marais","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0135","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2014making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cca.2017.01.002_bb0140","doi-asserted-by":"crossref","first-page":"W71","DOI":"10.1093\/nar\/gkq329","article-title":"MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data","volume":"38","author":"Xia","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cca.2017.01.002_bb0145","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.3390\/ijms12117635","article-title":"A HNMR-based metabonomics study of postmenopausal osteoporosis and intervention effects of Er-Xian Decoction in ovariectomized rats","volume":"12","author":"Xue","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2017.01.002_bb0150","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00415-013-7060-6","article-title":"A 43-year systematic review and meta-analysis: case-fatality and risk of death among adults with tuberculous meningitis in Africa","volume":"261","author":"Woldeamanuel","year":"2014","journal-title":"J. Neurol."},{"key":"10.1016\/j.cca.2017.01.002_bb0155","first-page":"DC15","article-title":"Prospective analysis of 55 cases of tuberculosis meningitis (TBM) in North India","volume":"9","author":"Kaur","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.cca.2017.01.002_bb0160","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000368894","article-title":"Adult tuberculous meningitis in Qatar: a descriptive retrospective study from its referral center","volume":"73","author":"Imam","year":"2015","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.cca.2017.01.002_bb0165","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1590\/0037-8682-0122-2014","article-title":"Incidence of tuberculous meningitis in the State of Santa Catarina, Brazil","volume":"47","author":"Souza","year":"2014","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.cca.2017.01.002_bb0170","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S1473-3099(14)70872-2","article-title":"Death and disability: the outcomes of tuberculous meningitis","volume":"14","author":"Graham","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0175","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1473-3099(14)70852-7","article-title":"Treatment outcomes of childhood tuberculous meningitis: a systematic review and meta-analysis","volume":"14","author":"Chiang","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133477","article-title":"Tuberculous meningitis in children and adults: a 10-year retrospective comparative analysis","volume":"10","author":"Miftode","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2017.01.002_bb0185","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.jprot.2011.06.020","article-title":"Two dimensional difference gel electrophoresis analysis of cerebrospinal fluid in tuberculous meningitis patients","volume":"74","author":"Kataria","year":"2011","journal-title":"J. Proteome"},{"key":"10.1016\/j.cca.2017.01.002_bb0190","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/ijmm.2015.2131","article-title":"iTRAQ-based quantitative proteomic analysis of cerebrospinal fluid reveals NELL2 as a potential diagnostic biomarker of tuberculous meningitis","volume":"35","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.cca.2017.01.002_bb0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.clineuro.2015.11.008","article-title":"Evaluation of host Hsp(s) as potential biomarkers for the diagnosis of tuberculous meningitis","volume":"140","author":"Shekhawat","year":"2016","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.cca.2017.01.002_bb0200","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/jnnp.44.9.791","article-title":"Cerebrospinal fluid amino acid concentrations in patients with viral and tuberculous meningitis","volume":"44","author":"Corston","year":"1981","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cca.2017.01.002_bb0205","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1086\/378642","article-title":"Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis","volume":"188","author":"Thwaites","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-2007-1001985","article-title":"Significance of lactate level, lysozyme concentration and phosphohexose isomerase activity in the cerebrospinal fluid in the differential diagnosis of meningitis","volume":"53","author":"Hornig","year":"1985","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"10.1016\/j.cca.2017.01.002_bb0215","first-page":"5","article-title":"The pathogenesis of tuberculous meningitis","volume":"52","author":"Rich","year":"1933","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"10.1016\/j.cca.2017.01.002_bb0220","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0140-6736(83)91676-8","article-title":"Tuberculostearic acid as a diagnostic marker in tuberculous meningitis","volume":"1","author":"Mardh","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2017.01.002_bb0225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(87)92328-2","article-title":"Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid","volume":"2","author":"French","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.cca.2017.01.002_bb0230","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0009-9120(89)80099-2","article-title":"The rapid and sensitive diagnosis of tuberculous meningitis by the detection of tuberculostearic acid in cerebrospinal fluid using gas chromatography\u2013mass spectrometry with selective ion monitoring","volume":"22","author":"Elias","year":"1989","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.cca.2017.01.002_bb0235","first-page":"322","article-title":"Diagnosis of tuberculous meningitis by detection of tuberculostearic acid in cerebrospinal fluid","volume":"104","author":"Luef","year":"1992","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.cca.2017.01.002_bb0240","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.bbrc.2015.08.036","article-title":"Elevated host lipid metabolism revealed by iTRAQ-based quantitative proteomic analysis of cerebrospinal fluid of tuberculous meningitis patients","volume":"466","author":"Mu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cca.2017.01.002_bb0245","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s15010-015-0777-7","article-title":"Rational application of adenosine deaminase activity in cerebrospinal fluid for the diagnosis of tuberculous meningitis","volume":"43","author":"Parra-Ruiz","year":"2015","journal-title":"Infection"},{"key":"10.1016\/j.cca.2017.01.002_bb0250","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.clineuro.2013.05.017","article-title":"Adenosine deaminase activity in cerebrospinal fluid and serum for the diagnosis of tuberculous meningitis","volume":"115","author":"Cho","year":"2013","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.cca.2017.01.002_bb0255","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/00365540903428158","article-title":"Adenosine deaminase and tuberculous meningitis\u2013a systematic review with meta-analysis","volume":"42","author":"Tuon","year":"2010","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.cca.2017.01.002_bb0260","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0387-7604(02)00160-2","article-title":"Neuron-specific enolase, nucleotides, nucleosides, purine bases, oxypurines and uric acid concentrations in cerebrospinal fluid of children with meningitis","volume":"25","author":"Rodriguez-Nunez","year":"2003","journal-title":"Brain Dev."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117300025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117300025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T05:52:42Z","timestamp":1568699562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898117300025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":52,"alternative-id":["S0009898117300025"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2017.01.002","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}