{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:45:13Z","timestamp":1760550313292},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171655"],"award-info":[{"award-number":["81171655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui Province","award":["1403062023"],"award-info":[{"award-number":["1403062023"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.cca.2017.06.024","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T16:32:29Z","timestamp":1498926749000},"page":"13-19","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A biochip-based combined immunoassay for detection of serological status of Borrelia burgdorferi in Lyme borreliosis"],"prefix":"10.1016","volume":"472","author":[{"given":"Na-Li","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Xin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Bin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/infdis\/170.1.115","article-title":"Seroprotective groups of Lyme borreliosis spirochetes from North America and Europe","volume":"170","author":"Lovrich","year":"1994","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.cca.2017.06.024_bb0010","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1210\/en.2009-1501","article-title":"Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44","volume":"151","author":"Long","year":"2010","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.cca.2017.06.024_bb0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.idc.2015.02.010","article-title":"Epidemiology of Lyme disease","volume":"29","author":"Mead","year":"2015","journal-title":"Infect. Dis. Clin. N. Am."},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0020","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/CMR.12.4.633","article-title":"Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological, and clinical implications","volume":"12","author":"Wang","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0025","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1099\/00207713-44-4-743","article-title":"Diversity of Borrelia burgdorferi sensu lato evidenced by restriction fragment length polymorphism of rrf (5S)-rrl (23S) intergenic spacer amplicons","volume":"44","author":"Postic","year":"1994","journal-title":"Int. J. Syst. Bacteriol."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0030","first-page":"8","article-title":"Studies on epidemiology and etiology of Lyme disease in China","volume":"18","author":"Zhang","year":"1997","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0923-2508(94)90187-2","article-title":"Evidence for the involvement of different genospecies of Borrelia in the clinical outcome of Lyme disease in Belgium","volume":"145","author":"Anthonissen","year":"1994","journal-title":"Res. Microbiol."},{"issue":"8","key":"10.1016\/j.cca.2017.06.024_bb0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1473-3099(03)00722-9","article-title":"Lyme borreliosis","volume":"3","author":"Hengge","year":"2003","journal-title":"Lancet Infect. Dis."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s15010-004-3042-z","article-title":"Comparison of erythema migrans caused by Borrelia afzelii and Borrelia garinii","volume":"32","author":"Logar","year":"2004","journal-title":"Infection"},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0050","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/clinids\/17.4.708","article-title":"Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis","volume":"17","author":"van Dam","year":"1993","journal-title":"Clin. Infect. Dis."},{"issue":"9396","key":"10.1016\/j.cca.2017.06.024_bb0055","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0140-6736(03)14798-8","article-title":"Lyme borreliosis","volume":"362","author":"Stanek","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.cca.2017.06.024_bb0060","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1086\/315862","article-title":"Antigenic conservation of an immunodominant invariable region of the VlsE lipoprotein among European pathogenic genospecies of Borrelia burgdorferi SL","volume":"182","author":"Liang","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cca.2017.06.024_bb0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.1988.tb31834.x","article-title":"Chronic neurologic manifestations of erythema migrans borreliosis","volume":"539","author":"Ackermann","year":"1988","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0070","first-page":"463","article-title":"European erythema migrans disease and related disorders","volume":"57","author":"Weber","year":"1984","journal-title":"Yale J. Biol. Med."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0075","doi-asserted-by":"crossref","first-page":"76","DOI":"10.7326\/0003-4819-99-1-76","article-title":"The early clinical manifestations of Lyme disease","volume":"99","author":"Steere","year":"1983","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0080","first-page":"485","article-title":"Tick-borne meningopolyneuritis (Garin-Bujadoux, Bannwarth)","volume":"57","author":"Ackermann","year":"1984","journal-title":"Yale J. Biol. Med."},{"issue":"Pt 3","key":"10.1016\/j.cca.2017.06.024_bb0085","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1099\/jmm.0.000009","article-title":"Multiplex assay (Mikrogen recomBead) for detection of serum IgG and IgM antibodies to 13 recombinant antigens of Borrelia burgdorferi sensu lato in patients with neuroborreliosis: the more the better?","volume":"64","author":"Dessau","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.cca.2017.06.024_bb0090","doi-asserted-by":"crossref","first-page":"294587","DOI":"10.1155\/2012\/294587","article-title":"Adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed asymptomatic children and children with previous clinical Lyme borreliosis","volume":"2012","author":"Skogman","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.cca.2017.06.024_bb0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/1471-2334-10-352","article-title":"Erythema caused by a localised skin infection with Arthrobacter mysorens","volume":"10","author":"Imirzalioglu","year":"2010","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijmm.2006.09.001","article-title":"Immune responses to borrelial VlsE IR6 peptide variants","volume":"297","author":"Sillanpaa","year":"2007","journal-title":"Int. J. Med. Microbiol."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1574-695X.2006.00139.x","article-title":"Microbiological and serological diagnosis of Lyme borreliosis","volume":"49","author":"Wilske","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"12","key":"10.1016\/j.cca.2017.06.024_bb0110","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1469-0691.2004.01019.x","article-title":"Guidelines for the diagnosis of tick-borne bacterial diseases in Europe","volume":"10","author":"Brouqui","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"issue":"3","key":"10.1016\/j.cca.2017.06.024_bb0115","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CMR.18.3.484-509.2005","article-title":"Diagnosis of lyme borreliosis","volume":"18","author":"Aguero-Rosenfeld","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.cca.2017.06.024_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130048","article-title":"C6 peptide-based multiplex phosphorescence analysis (PHOSPHAN) for serologic confirmation of Lyme borreliosis","volume":"10","author":"Pomelova","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.cca.2017.06.024_bb0125","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1469-0691.2006.01448.x","article-title":"Comparison of five different immunoassays for the detection of Borrelia burgdorferi IgM and IgG antibodies","volume":"12","author":"Smismans","year":"2006","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.cca.2017.06.024_bb0130","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/JCM.40.2.319-324.2002","article-title":"Laboratory testing for Lyme disease: possibilities and practicalities","volume":"40","author":"Reed","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.cca.2017.06.024_bb0135","doi-asserted-by":"crossref","first-page":"595427","DOI":"10.1155\/2012\/595427","article-title":"Evaluating frequency, diagnostic quality, and cost of Lyme borreliosis testing in Germany: a retrospective model analysis","volume":"2012","author":"Muller","year":"2012","journal-title":"Clin. Dev. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2017.06.024_bb0140","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1212\/01.wnl.0000171349.06645.79","article-title":"The chemokine CXCL13 (BLC): a putative diagnostic marker for neuroborreliosis","volume":"65","author":"Rupprecht","year":"2005","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.cca.2017.06.024_bb0145","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.diagmicrobio.2007.06.006","article-title":"Antigen biochips verify and extend the scope of antibody detection in Lyme borreliosis","volume":"59","author":"Du","year":"2007","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.cca.2017.06.024_bb0150","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bios.2015.11.050","article-title":"Establishment of N-succinimidyl 4-(maleimidomethyl) cyclohexanecarboxylate (SMCC) modified biochip enabling concurrent detection of serum infectious antibodies in neuroborreliosis","volume":"78","author":"Ye","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2017.06.024_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000213070","article-title":"Clinical manifestations and diagnosis of lyme borreliosis","volume":"37","author":"Strle","year":"2009","journal-title":"Curr. Probl. Dermatol."},{"issue":"8","key":"10.1016\/j.cca.2017.06.024_bb0160","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1099\/0022-1317-51-8-649","article-title":"Comparative reactivity of human sera to recombinant VlsE and other Borrelia burgdorferi antigens in class-specific enzyme-linked immunosorbent assays for Lyme borreliosis","volume":"51","author":"Magnarelli","year":"2002","journal-title":"J. Med. Microbiol."},{"issue":"6","key":"10.1016\/j.cca.2017.06.024_bb0165","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijmm.2008.10.006","article-title":"Antibody responses to borrelia IR(6) peptide variants and the C6 peptide in Swedish patients with erythema migrans","volume":"299","author":"Tjernberg","year":"2009","journal-title":"Int. J. Med. Microbiol."},{"issue":"2","key":"10.1016\/j.cca.2017.06.024_bb0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0092-8674(00)80206-8","article-title":"Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes","volume":"89","author":"Zhang","year":"1997","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.cca.2017.06.024_bb0175","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.4049\/jimmunol.163.10.5566","article-title":"An immunodominant conserved region within the variable domain of VlsE, the variable surface antigen of Borrelia burgdorferi","volume":"163","author":"Liang","year":"1999","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.cca.2017.06.024_bb0180","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1128\/JCM.37.12.3990-3996.1999","article-title":"Sensitive and specific serodiagnosis of Lyme disease by enzyme-linked immunosorbent assay with a peptide based on an immunodominant conserved region of Borrelia burgdorferi vlsE","volume":"37","author":"Liang","year":"1999","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.cca.2017.06.024_bb0185","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1086\/314477","article-title":"Analysis of antibody response to the outer surface protein family in lyme borreliosis patients","volume":"178","author":"Batsford","year":"1998","journal-title":"J Infect Dis"},{"issue":"2","key":"10.1016\/j.cca.2017.06.024_bb0190","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/JCM.36.2.427-436.1998","article-title":"Impact of strain heterogeneity on Lyme disease serology in Europe: comparison of enzyme-linked immunosorbent assays using different species of Borrelia burgdorferi sensu lato","volume":"36","author":"Hauser","year":"1998","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.cca.2017.06.024_bb0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0003-2697(03)00468-8","article-title":"Functionalized self-assembled monolayer on gold for detection of human mitochondrial tRNA gene mutations","volume":"322","author":"Du","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cca.2017.06.024_bb0200","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bios.2015.08.036","article-title":"Development of a novel protein biochip enabling validation of immunological assays and detection of serum IgG and IgM antibodies against Treponema pallidum pathogens in the patients with syphilis","volume":"75","author":"Huang","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.cca.2017.06.024_bb0205","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaut.2014.09.004","article-title":"Lyme disease: a rigorous review of diagnostic criteria and treatment","volume":"57","author":"Borchers","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.cca.2017.06.024_bb0210","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bios.2014.07.041","article-title":"Multiplexed gold nanorod array biochip for multi-sample analysis","volume":"67","author":"Wang","year":"2015","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.cca.2017.06.024_bb0215","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/adt.2009.0228","article-title":"Development of a protein biochip to identify 6 monoclonal antibodies against subtypes of recombinant human interferons","volume":"8","author":"Xu","year":"2010","journal-title":"Assay Drug Dev. Technol."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117302504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117302504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:53:03Z","timestamp":1692863583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898117302504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":43,"alternative-id":["S0009898117302504"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2017.06.024","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A biochip-based combined immunoassay for detection of serological status of Borrelia burgdorferi in Lyme borreliosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2017.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}