{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:21:11Z","timestamp":1762507271872},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Sci-Tech Plan in Sichuan Province","award":["No. 2014SZ0050"],"award-info":[{"award-number":["No. 2014SZ0050"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.cca.2017.12.046","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T03:26:24Z","timestamp":1514517984000},"page":"188-193","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption"],"prefix":"10.1016","volume":"478","author":[{"given":"Jinglin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renhuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2017.12.046_bb0005","first-page":"175","article-title":"Orthodontically induced inflammatory root resorption. Part I: the basic science aspects","volume":"72","author":"Brezniak","year":"2002","journal-title":"Angle Orthod."},{"issue":"3A","key":"10.1016\/j.cca.2017.12.046_bb0010","article-title":"Root resorption during orthodontic treatment","volume":"19","author":"Bau","year":"2003","journal-title":"Aust. Orthod. J."},{"key":"10.1016\/j.cca.2017.12.046_bb0015","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ajodo.2008.10.014","article-title":"Detection of apical root resorption after orthodontic treatment by using panoramic radiography and cone-beam computed tomography of super-high resolution","volume":"135","author":"Dudic","year":"2009","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"10.1016\/j.cca.2017.12.046_bb0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40510-014-0048-7","article-title":"Radiologically determined orthodontically induced external apical root resorption in incisors after non-surgical orthodontic treatment of class II division 1 malocclusion: a systematic review","volume":"15","author":"Tieu","year":"2014","journal-title":"Prog. Orthod."},{"key":"10.1016\/j.cca.2017.12.046_bb0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1746-160X-9-21","article-title":"Apical root resorption during orthodontic treatment with aligners? A retrospective radiometric study","volume":"9","author":"Krieger","year":"2013","journal-title":"Head Face Med"},{"key":"10.1016\/j.cca.2017.12.046_bb0030","first-page":"161","article-title":"Hyalinization and root resorption during early orthodontic tooth movement in adolescents","volume":"68","author":"Kurol","year":"1998","journal-title":"Angle Orthod."},{"key":"10.1016\/j.cca.2017.12.046_bb0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ejo\/cji090","article-title":"Root resorption associated with orthodontic force in inbred mice: genetic contributions","volume":"28","author":"Al-Qawasmi","year":"2006","journal-title":"Eur. J. Orthod."},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2017.12.046_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/ocr.12078","article-title":"Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia","volume":"18","author":"Sharab","year":"2015","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0045","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1590\/2176-9451.20.1.052-058.oar","article-title":"Severe root resorption resulting from orthodontic treatment: prevalence and risk factors","volume":"20","author":"Maues","year":"2015","journal-title":"Dent. Press J. Orthod."},{"key":"10.1016\/j.cca.2017.12.046_bb0050","first-page":"236","article-title":"Pathways in external apical root resorption associated with orthodontia","author":"Jr","year":"2009","journal-title":"Orthod. Craniofacial Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0055","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/617032","article-title":"Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane","volume":"2014","author":"Kitaura","year":"2014","journal-title":"TheScientificWorldJOURNAL"},{"key":"10.1016\/j.cca.2017.12.046_bb0060","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajodo.2014.05.027","article-title":"Downregulation of Wnt causes root resorption","volume":"146","author":"Lim","year":"2014","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"10.1016\/j.cca.2017.12.046_bb0065","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0022034514555364","article-title":"Notch signaling induces root resorption via RANKL and IL-6 from hPDL cells","volume":"94","author":"Kikuta","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/ejo\/20.1.57","article-title":"Early radiographic diagnosis of apical root resorption during orthodontic treatment: a study of maxillary incisors","volume":"20","author":"Levander","year":"1998","journal-title":"Eur. J. Orthod."},{"key":"10.1016\/j.cca.2017.12.046_bb0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.bdj.4800870","article-title":"Radiographic diagnosis of root resorption in relation to orthodontics","volume":"190","author":"Leach","year":"2001","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.cca.2017.12.046_bb0080","first-page":"194","article-title":"Enzyme activity profiles and ELISA analysis of biomarkers from human saliva and gingival crevicular fluid during orthodontic tooth movement using self-ligating brackets","volume":"13","author":"Abdul Wahab","year":"2014","journal-title":"Oral health Dent. Manage."},{"key":"10.1016\/j.cca.2017.12.046_bb0085","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/597892","article-title":"Evaluation of oxidative stress biomarkers in patients with fixed orthodontic appliances","volume":"2014","author":"Atug Ozcan","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cca.2017.12.046_bb0090","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1177\/154405910208100613","article-title":"1H and 13C NMR spectroscopic analysis of human saliva","volume":"81","author":"Silwood","year":"2002","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0095","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1016\/j.jacc.2011.09.083","article-title":"Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models","volume":"59","author":"Bodi","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cca.2017.12.046_bb0100","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1177\/0022034511416240","article-title":"Metabolomics reveals elevated macromolecular degradation in periodontal disease","volume":"90","author":"Barnes","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.meegid.2013.09.020","article-title":"Exploring the effect of dentition, dental decay and familiality on oral health using metabolomics","volume":"22","author":"Foxman","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.cca.2017.12.046_bb0110","first-page":"1015","article-title":"Pilot study of changes in salivary metabolic profiles induced by template therapy","volume":"26","author":"Tanaka","year":"2012","journal-title":"In Vivo"},{"key":"10.1016\/j.cca.2017.12.046_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/509043","article-title":"A metabonomic approach to analyze the dexamethasone-induced cleft palate in mice","volume":"2011","author":"Zhou","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.cca.2017.12.046_bb0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.freeradbiomed.2014.02.024","article-title":"Mass spectrometry-based metabolomic profiling identifies alterations in salivary redox status and fatty acid metabolism in response to inflammation and oxidative stress in periodontal disease","volume":"70","author":"Huang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cca.2017.12.046_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.autneu.2015.04.011","article-title":"Purinergic signaling in the immune system","volume":"191","author":"Di Virgilio","year":"2015","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.cca.2017.12.046_bb0130","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/0022034509341967","article-title":"Acceleration of purine degradation by periodontal diseases","volume":"88","author":"Barnes","year":"2009","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cca.2017.12.046_bb0135","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.acra.2014.04.009","article-title":"Higher glutamate+glutamine and reduction of N-acetylaspartate in posterior cingulate according to age range in patients with cognitive impairment and\/or pain","volume":"21","author":"Fayed","year":"2014","journal-title":"Acad. Radiol."},{"issue":"1","key":"10.1016\/j.cca.2017.12.046_bb0140","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10753-015-0271-5","article-title":"Rebamipide suppresses monosodium urate crystal-induced interleukin-1beta production through regulation of oxidative stress and caspase-1 in THP-1 cells","volume":"39","author":"Kim","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.cca.2017.12.046_bb0145","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.odw.2007.04.001","article-title":"ALP activity decreased in compressed PDL cells obtained from severe orthodontically root resorption","volume":"66","author":"Kariya","year":"2007","journal-title":"Orthod. Waves"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117305454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898117305454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T16:52:24Z","timestamp":1570553544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898117305454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":29,"alternative-id":["S0009898117305454"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2017.12.046","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2017.12.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}