{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:38:52Z","timestamp":1790660332216,"version":"4.1.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670265"],"award-info":[{"award-number":["81670265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470434"],"award-info":[{"award-number":["81470434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study","award":["2014-405"],"award-info":[{"award-number":["2014-405"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.cca.2018.01.032","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:54:31Z","timestamp":1517406871000},"page":"196-207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases"],"prefix":"10.1016","volume":"479","author":[{"given":"Zhe","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0005","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-5193(76)90133-8","article-title":"Purinergic receptors","volume":"62","author":"Burnstock","year":"1976","journal-title":"J. Theor. Biol."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0031-6997(25)06930-3","article-title":"Purinergic nerves","volume":"24","author":"Burnstock","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.cca.2018.01.032_bb0015","series-title":"Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach","first-page":"107","article-title":"A basis for distinguishing two types of purinergic receptor","author":"Burnstock","year":"1978"},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0020","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0306-3623(85)90001-1","article-title":"Is there a basis for distinguishing two types of P2-purinoceptor?","volume":"16","author":"Burnstock","year":"1985","journal-title":"Gen. Pharmacol."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/bj2330309","article-title":"Extracellular ATP: effects, sources and fate","volume":"233","author":"Gordon","year":"1986","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0165-6147(91)90530-6","article-title":"Further subclassification of ATP receptors based on agonist studies","volume":"12","author":"O'Connor","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0035","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1124\/mol.107.042077","article-title":"Go it alone no more\u2014P2X7 joins the society of heteromeric ATP-gated receptor channels","volume":"72","author":"Dubyak","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.cca.2018.01.032_bb0040","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.neuro.23.1.649","article-title":"Synaptic plasticity and memory: an evaluation of the hypothesis","volume":"23","author":"Martin","year":"2000","journal-title":"Annu. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0045","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/cne.21013","article-title":"P2X2R purinergic receptor subunit mRNA and protein are expressed by all hypothalamic hypocretin\/orexin neurons","volume":"498","author":"Florenzano","year":"2006","journal-title":"J. Comp. Neurol."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00213-002-1386-6","article-title":"Enhanced P2Y1 receptor expression in the brain after sensitisation with d\u2011amphetamine","volume":"167","author":"Franke","year":"2003","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.pneurobio.2011.08.006","article-title":"Purinergic signalling: from normal behaviour to pathological brain function","volume":"95","author":"Burnstock","year":"2011","journal-title":"Prog. Neurobiol."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0060","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00210-009-0403-2","article-title":"P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions","volume":"379","author":"Musa","year":"2009","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"issue":"7","key":"10.1016\/j.cca.2018.01.032_bb0065","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1476-5381.2009.00287.x","article-title":"Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells","volume":"157","author":"Wareham","year":"2009","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.cca.2018.01.032_bb0070","doi-asserted-by":"crossref","first-page":"G1171","DOI":"10.1152\/ajpgi.00352.2011","article-title":"P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice","volume":"302","author":"Hoque","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00232-005-0742-y","article-title":"P2X7 receptor stimulation of membrane internalization in a thyrocyte cell line","volume":"204","author":"Kochukov","year":"2005","journal-title":"J. Membr. Biol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0080","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1159\/000086036","article-title":"The P2X7 ATP receptor in the kidney: a matter of life or death?","volume":"101","author":"Hillman","year":"2005","journal-title":"Nephron Exp. Nephrol."},{"issue":"16","key":"10.1016\/j.cca.2018.01.032_bb0085","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1021\/acs.jmedchem.5b01690","article-title":"Potent suppressive effects of 1\u2011piperidinylimidazole based novel P2X7 receptor antagonists on cancer cell migration and invasion","volume":"59","author":"Park","year":"2016","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11302-007-9078-7","article-title":"P2 receptors in cardiovascular regulation and disease","volume":"4","author":"Erlinge","year":"2008","journal-title":"Purinergic Signal"},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0095","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpheart.00822.2010","article-title":"A new function for ATP: activating cardiac sympathetic afferents during myocardial ischemia","volume":"299","author":"Fu","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0100","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/physrev.2001.81.2.767","article-title":"Adenosine 5\u2032\u2011triphosphate: a P2-purinergic agonist in the myocardium","volume":"81","author":"Vassort","year":"2001","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0105","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00079.2004","article-title":"A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy","volume":"287","author":"Yang","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0110","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cardiores.2006.06.011","article-title":"Accumulation of extracellular ATP protects against acute reperfusion injury in rat heart endothelial cells","volume":"71","author":"Gunduz","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/eurheartj\/ehl410","article-title":"Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11","volume":"28","author":"Amisten","year":"2007","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/j.cca.2018.01.032_bb0120","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/13522","article-title":"Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice","volume":"5","author":"Fabre","year":"1999","journal-title":"Nat. Med."},{"issue":"5262","key":"10.1016\/j.cca.2018.01.032_bb0125","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.272.5262.735","article-title":"The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)","volume":"272","author":"Surprenant","year":"1996","journal-title":"Science"},{"issue":"2\u20133","key":"10.1016\/j.cca.2018.01.032_bb0130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-5793(96)00499-1","article-title":"Molecular cloning and functional expression of a novel rat heart P2X purinoceptor","volume":"388","author":"Garcia-Guzman","year":"1996","journal-title":"FEBS Lett."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0135","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1073\/pnas.93.8.3684","article-title":"P2X4: an ATP-activated ionotropic receptor cloned from rat brain","volume":"93","author":"Soto","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000025582","article-title":"Coexpression of mRNAs for P2X1, P2X2 and P2X4 receptors in rat vascular smooth muscle: an in situ hybridization and RT-PCR study","volume":"35","author":"Nori","year":"1998","journal-title":"J. Vasc. Res."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0145","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1124\/jpet.107.135350","article-title":"P2X7 receptor activation amplifies lipopolysaccharide-induced vascular hyporeactivity via interleukin-1 beta release","volume":"326","author":"Chiao","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0150","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.RES.83.2.196","article-title":"P2X7 receptor activation-induced contraction and lysis in human saphenous vein smooth muscle","volume":"83","author":"Cario-Toumaniantz","year":"1998","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0155","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1007\/s10753-015-0189-y","article-title":"P2X7 receptor expression in peripheral blood monocytes is correlated with plasma C-reactive protein and cytokine levels in patients with type 2 diabetes mellitus: a preliminary report","volume":"38","author":"Wu","year":"2015","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0160","first-page":"R2090","article-title":"Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes","volume":"293","author":"Sluyter","year":"2007","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"21","key":"10.1016\/j.cca.2018.01.032_bb0165","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.2174\/0929867324666170303161659","article-title":"P2X7 receptor orchestrates multiple signalling pathways triggering inflammation, autophagy and metabolic\/trophic responses","volume":"24","author":"Orioli","year":"2017","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037491","article-title":"A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events","volume":"7","author":"Gidlof","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0175","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/oxfordjournals.eurheartj.a060991","article-title":"Myocardial reperfusion injury: experimental evidence and clinical relevance","volume":"16","author":"Hansen","year":"1995","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cca.2018.01.032_bb0180","first-page":"47","article-title":"Myocardial ischemia and reperfusion","volume":"37","author":"Jennings","year":"1995","journal-title":"Monogr. Pathol."},{"key":"10.1016\/j.cca.2018.01.032_bb0185","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.autneu.2014.12.001","article-title":"Study of baicalin on sympathoexcitation induced by myocardial ischemia via P2X3 receptor in superior cervical ganglia","volume":"189","author":"Zhang","year":"2015","journal-title":"Auton. Neurosci."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0190","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11302-016-9518-3","article-title":"Long noncoding NONRATT021972 siRNA normalized abnormal sympathetic activity mediated by the upregulation of P2X7 receptor in superior cervical ganglia after myocardial ischemia","volume":"12","author":"Tu","year":"2016","journal-title":"Purinergic Signal"},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/1074248409360356","article-title":"Pannexin-I\/P2X 7 purinergic receptor channels mediate the release of cardioprotectants induced by ischemic pre- and postconditioning","volume":"15","author":"Vessey","year":"2010","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"issue":"1\u20132","key":"10.1016\/j.cca.2018.01.032_bb0200","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-011-0713-9","article-title":"Ischemic preconditioning requires opening of pannexin-1\/P2X(7) channels not only during preconditioning but again after index ischemia at full reperfusion","volume":"351","author":"Vessey","year":"2011","journal-title":"Mol. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0205","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00395-007-0671-2","article-title":"Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury","volume":"102","author":"Simpkin","year":"2007","journal-title":"Basic Res. Cardiol."},{"issue":"12","key":"10.1016\/j.cca.2018.01.032_bb0210","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1089\/dna.2016.3391","article-title":"Apelin\/APJ system: a novel therapeutic target for myocardial ischemia\/reperfusion injury","volume":"35","author":"Chen","year":"2016","journal-title":"DNA Cell Biol."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0215","doi-asserted-by":"crossref","first-page":"H881","DOI":"10.1152\/ajpheart.00305.2011","article-title":"P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1\/P2X(7) channels","volume":"301","author":"Vessey","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0220","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0225","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia\/reperfusion injury","volume":"123","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.cca.2018.01.032_bb0235","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3389\/fimmu.2017.00728","article-title":"Sestrin2 suppresses classically activated macrophages-mediated inflammatory response in myocardial infarction through inhibition of mTORC1 signaling","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Immunol."},{"issue":"6149","key":"10.1016\/j.cca.2018.01.032_bb0240","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/330658a0","article-title":"Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve","volume":"330","author":"Lindholm","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.cca.2018.01.032_bb0245","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijcard.2015.03.057","article-title":"Prevention of ventricular arrhythmia complicating acute myocardial infarction by local cardiac denervation","volume":"184","author":"Chen","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.cca.2018.01.032_bb0250","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archinte.162.10.1099","article-title":"Nonsteroidal anti-inflammatory drug use and acute myocardial infarction","volume":"162","author":"Solomon","year":"2002","journal-title":"Arch. Intern. Med."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0255","first-page":"244","article-title":"Effect of P2X7 receptor on inflammatory diseases and its mechanism","volume":"65","author":"Xu","year":"2013","journal-title":"Sheng Li Xue Bao"},{"issue":"11","key":"10.1016\/j.cca.2018.01.032_bb0260","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1111\/jcmm.13185","article-title":"P2X7 receptor inhibition attenuated sympathetic nerve sprouting after myocardial infarction via the NLRP3\/IL-1beta pathway","volume":"21","author":"Yin","year":"2017","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0265","doi-asserted-by":"crossref","DOI":"10.1111\/1755-5922.12245","article-title":"Targeted P2X7 R shRNA delivery attenuates sympathetic nerve sprouting and ameliorates cardiac dysfunction in rats with myocardial infarction","volume":"35","author":"Gao","year":"2017","journal-title":"Cardiovasc. Ther."},{"issue":"14","key":"10.1016\/j.cca.2018.01.032_bb0270","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jacc.2011.11.050","article-title":"Heart transplantation research in the next decade\u2014a goal to achieving evidence-based outcomes: National Heart, Lung, and Blood Institute Working Group","volume":"59","author":"Shah","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0275","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacc.2008.05.020","article-title":"The changing face of heart transplantation","volume":"52","author":"Hunt","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0280","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3324\/haematol.10810","article-title":"P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation","volume":"92","author":"Lee","year":"2007","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0285","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.4049\/jimmunol.176.4.2152","article-title":"P2X7 receptors regulate NKT cells in autoimmune hepatitis","volume":"176","author":"Kawamura","year":"2006","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0290","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/CIRCULATIONAHA.112.123653","article-title":"Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7","volume":"127","author":"Vergani","year":"2013","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0295","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4330\/wjc.v6.i6.478","article-title":"Cardiomyopathies: evolution of pathogenesis concepts and potential for new therapies","volume":"6","author":"Sisakian","year":"2014","journal-title":"World J. Cardiol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0300","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pcad.2014.03.003","article-title":"Myocardial mechanics in cardiomyopathies","volume":"57","author":"Modesto","year":"2014","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0305","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1096\/fj.04-3042com","article-title":"Effects on heart rate of an anti-M2 acetylcholine receptor immune response in mice","volume":"19","author":"Peter","year":"2005","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.cca.2018.01.032_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052161","article-title":"Loss of P2X7 receptor plasma membrane expression and function in pathogenic B220+ double-negative T lymphocytes of autoimmune MRL\/lpr mice","volume":"7","author":"Le Gall","year":"2012","journal-title":"PLoS One"},{"issue":"14","key":"10.1016\/j.cca.2018.01.032_bb0315","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.micinf.2012.07.006","article-title":"P2 receptors and immunity","volume":"14","author":"Rayah","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/j.cca.2018.01.032_bb0320","doi-asserted-by":"crossref","first-page":"16940","DOI":"10.1038\/srep16940","article-title":"P2x7 purinergic signaling in dilated cardiomyopathy induced by auto-immunity against muscarinic M2 receptors: autoantibody levels, heart functionality and cytokine expression","volume":"5","author":"Martinez","year":"2015","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0325","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.CIR.99.8.1091","article-title":"From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future","volume":"99","author":"Kawai","year":"1999","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0330","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejheart.2006.05.007","article-title":"Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis","volume":"9","author":"Suzuki","year":"2007","journal-title":"Eur. J. Heart Fail."},{"issue":"40","key":"10.1016\/j.cca.2018.01.032_bb0335","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1074\/jbc.M117.790741","article-title":"P2X7 receptor antagonism prevents IL-1beta release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy","volume":"292","author":"Khalafalla","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0340","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00380-014-0527-2","article-title":"A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4+ T and macrophage infiltration and NADPH oxidase 2\/4 expression in mice","volume":"30","author":"Zempo","year":"2015","journal-title":"Heart Vessel."},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2018.01.032_bb0345","first-page":"I19","article-title":"Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults","volume":"9","author":"Stary","year":"1989","journal-title":"Arteriosclerosis"},{"issue":"7293","key":"10.1016\/j.cca.2018.01.032_bb0350","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0355","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.ATV.0000064374.15232.C3","article-title":"Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice","volume":"23","author":"Kirii","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0360","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/sj.bjp.0704524","article-title":"P2 receptors: new potential players in atherosclerosis","volume":"135","author":"Di Virgilio","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0365","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/sj.bjp.0707417","article-title":"Agonist potency at P2X7 receptors is modulated by structurally diverse lipids","volume":"152","author":"Michel","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cca.2018.01.032_bb0370","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneuroim.2015.06.007","article-title":"Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL\/6J mice","volume":"285","author":"Asatryan","year":"2015","journal-title":"J. Neuroimmunol."},{"issue":"21","key":"10.1016\/j.cca.2018.01.032_bb0375","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1038\/sj.emboj.7601378","article-title":"Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor","volume":"25","author":"Pelegrin","year":"2006","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0380","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1038\/s41598-017-05137-y","article-title":"P2X7 receptor antagonism modulates IL-1beta and MMP9 in human atherosclerotic vessels","volume":"7","author":"Lombardi","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0385","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1016\/j.ijcard.2013.03.084","article-title":"P2X7 receptor is expressed in human vessels and might play a role in atherosclerosis","volume":"168","author":"Piscopiello","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"25","key":"10.1016\/j.cca.2018.01.032_bb0390","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1161\/CIRCULATIONAHA.117.027400","article-title":"P2X7 deficiency blocks lesional inflammasome activity and ameliorates atherosclerosis in mice","volume":"135","author":"Stachon","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0395","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2011.09.031","article-title":"Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis","volume":"52","author":"Leonarduzzi","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0400","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0976-7800.201967","article-title":"Hormone replacement therapy reduces lipid oxidation directly at the arterial wall: a possible link to estrogens' cardioprotective effect through atherosclerosis prevention","volume":"8","author":"Escalante","year":"2017","journal-title":"J. Mid-life Health"},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0405","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11302-011-9255-6","article-title":"Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view","volume":"7","author":"Costa-Junior","year":"2011","journal-title":"Purinergic Signal"},{"issue":"11","key":"10.1016\/j.cca.2018.01.032_bb0410","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1096\/fj.13-236166","article-title":"Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor","volume":"27","author":"Guha","year":"2013","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0415","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2007.10.148","article-title":"Statins and ATP regulate nuclear pAkt via the P2X7 purinergic receptor in epithelial cells","volume":"365","author":"Mistafa","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125111","article-title":"The ATP receptors P2X7 and P2X4 modulate high glucose and palmitate-induced inflammatory responses in endothelial cells","volume":"10","author":"Sathanoori","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0425","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-201X.2004.01317.x","article-title":"Renal autoregulation in P2X1 knockout mice","volume":"181","author":"Inscho","year":"2004","journal-title":"Acta Physiol. Scand."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0430","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1161\/HYPERTENSIONAHA.108.113282","article-title":"Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes","volume":"52","author":"Palomino-Doza","year":"2008","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0435","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000051064","article-title":"P2X receptor immunoreactivity in different arteries from the femoral, pulmonary, cerebral, coronary and renal circulations","volume":"38","author":"Lewis","year":"2001","journal-title":"J. Vasc. Res."},{"issue":"Pt. 3","key":"10.1016\/j.cca.2018.01.032_bb0440","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1113\/jphysiol.2003.047977","article-title":"ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina","volume":"551","author":"Kawamura","year":"2003","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0445","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1523-1755.2004.00717.x","article-title":"Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models","volume":"66","author":"Vonend","year":"2004","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0450","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.RES.87.5.385","article-title":"Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors","volume":"87","author":"Yamamoto","year":"2000","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0455","doi-asserted-by":"crossref","first-page":"F9","DOI":"10.1152\/ajprenal.00663.2016","article-title":"Physiopathological implications of P2X1 and P2X7 receptors in regulation of glomerular hemodynamics in angiotensin II-induced hypertension","volume":"313","author":"Franco","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0460","doi-asserted-by":"crossref","first-page":"F1207","DOI":"10.1152\/ajprenal.00051.2012","article-title":"P2X7 deficiency attenuates hypertension and renal injury in deoxycorticosterone acetate-salt hypertension","volume":"303","author":"Ji","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0465","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/hr.2011.153","article-title":"P2X(7) receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats","volume":"35","author":"Ji","year":"2012","journal-title":"Hypertens. Res."},{"issue":"11","key":"10.1016\/j.cca.2018.01.032_bb0470","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1007\/s10439-017-1906-5","article-title":"Review of mechanical testing and modelling of thrombus material for vascular implant and device design","volume":"45","author":"Johnson","year":"2017","journal-title":"Ann. Biomed. Eng."},{"issue":"43","key":"10.1016\/j.cca.2018.01.032_bb0475","doi-asserted-by":"crossref","first-page":"44749","DOI":"10.1074\/jbc.M405631200","article-title":"Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X7 receptor","volume":"279","author":"Sluyter","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0480","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ceca.2011.05.002","article-title":"Stimulation of human red blood cells leads to Ca2+-mediated intercellular adhesion","volume":"50","author":"Steffen","year":"2011","journal-title":"Cell Calcium"},{"issue":"9","key":"10.1016\/j.cca.2018.01.032_bb0485","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1161\/CIRCRESAHA.115.306824","article-title":"Systems analysis of thrombus formation","volume":"118","author":"Diamond","year":"2016","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb0490","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cellsig.2006.10.010","article-title":"Murine macrophage P2X7 receptors support rapid prothrombotic responses","volume":"19","author":"Moore","year":"2007","journal-title":"Cell. Signal."},{"issue":"7","key":"10.1016\/j.cca.2018.01.032_bb0495","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1172\/JCI46129","article-title":"P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice","volume":"121","author":"Furlan-Freguia","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0500","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005280","article-title":"Selection of stent type in patients with atrial fibrillation presenting with acute myocardial infarction: an analysis from the ACTION (acute coronary treatment and intervention outcomes network) registry-get with the guidelines","volume":"6","author":"Vora","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"12","key":"10.1016\/j.cca.2018.01.032_bb0505","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1172\/JCI118746","article-title":"Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy","volume":"97","author":"Mizutani","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.cca.2018.01.032_bb0510","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1167\/iovs.16-20301","article-title":"Ligation of CD40 in human Muller cells induces P2X7 receptor-dependent death of retinal endothelial cells","volume":"57","author":"Portillo","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0515","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/cne.20045","article-title":"Synaptic localization of P2X7 receptors in the rat retina","volume":"472","author":"Puthussery","year":"2004","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.cca.2018.01.032_bb0520","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/978-1-4614-0631-0_104","article-title":"The role of the P2X7 receptor in the retina: cell signalling and dysfunction","volume":"723","author":"Vessey","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7","key":"10.1016\/j.cca.2018.01.032_bb0525","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1161\/01.ATV.0000133193.11078.c0","article-title":"Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes","volume":"24","author":"Solini","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0530","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20120479","article-title":"P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction","volume":"125","author":"Chiao","year":"2013","journal-title":"Clin. Sci."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0535","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1001\/archopht.124.8.1143","article-title":"Effect of P2X7 receptor activation on the retinal blood velocity of diabetic rabbits","volume":"124","author":"Sugiyama","year":"2006","journal-title":"Arch. Ophthalmol."},{"issue":"39","key":"10.1016\/j.cca.2018.01.032_bb0540","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1523\/JNEUROSCI.2812-04.2004","article-title":"ATP-induced non-neuronal cell permeabilization in the rat inner retina","volume":"24","author":"Innocenti","year":"2004","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0545","doi-asserted-by":"crossref","first-page":"C568","DOI":"10.1152\/ajpcell.00380.2004","article-title":"Regulation of P2X7-induced pore formation and cell death in pericyte-containing retinal microvessels","volume":"288","author":"Sugiyama","year":"2005","journal-title":"Am. J. Phys. Cell Phys."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0550","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1167\/iovs.03-1062","article-title":"Enhancement of P2X(7)-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature","volume":"45","author":"Sugiyama","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0555","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2337\/db16-0051","article-title":"CD40 in retinal Muller cells induces P2X7-dependent cytokine expression in macrophages\/microglia in diabetic mice and development of early experimental diabetic retinopathy","volume":"66","author":"Portillo","year":"2017","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb0560","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4239\/wjd.v5.i2.141","article-title":"Role of P2X7 receptors in the development of diabetic retinopathy","volume":"5","author":"Sugiyama","year":"2014","journal-title":"World J. Diabetes"},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0565","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4239\/wjd.v1.i1.12","article-title":"Diabetic retinopathy: role of inflammation and potential therapies for anti-inflammation","volume":"1","author":"Liou","year":"2010","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.cca.2018.01.032_bb0570","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bcp.2017.05.001","article-title":"P2X7 receptor antagonism: implications in diabetic retinopathy","volume":"138","author":"Platania","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"16","key":"10.1016\/j.cca.2018.01.032_bb0575","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2174\/1568026043387223","article-title":"Agonists and antagonists acting at P2X7 receptor","volume":"4","author":"Baraldi","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"issue":"13","key":"10.1016\/j.cca.2018.01.032_bb0580","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1074\/jbc.M110.198879","article-title":"Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations","volume":"286","author":"Norenberg","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.cca.2018.01.032_bb0585","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1111\/bph.13123","article-title":"Selected ginsenosides of the protopanaxdiol series are novel positive allosteric modulators of P2X7 receptors","volume":"172","author":"Helliwell","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.cca.2018.01.032_bb0590","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1136\/annrheumdis-2011-143578","article-title":"Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine","volume":"71","author":"Keystone","year":"2012","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.cca.2018.01.032_bb0595","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.bmcl.2011.04.077","article-title":"Optimization of the physicochemical and pharmacokinetic attributes in a 6\u2011azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535","volume":"21","author":"Duplantier","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.cca.2018.01.032_bb0600","doi-asserted-by":"crossref","first-page":"983565","DOI":"10.1155\/2013\/983565","article-title":"Binding stoichiometry of a recombinant selenophosphate synthetase with one synonymic substitution E197D to a fluorescent nucleotide analog of ATP, TNP-ATP","volume":"2013","author":"Preobrazhenskaya","year":"2013","journal-title":"J. Amino Acids"},{"issue":"11","key":"10.1016\/j.cca.2018.01.032_bb0605","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1016\/S0021-9258(18)53082-9","article-title":"Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor","volume":"268","author":"Murgia","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.cca.2018.01.032_bb0610","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0005-2728(96)00110-7","article-title":"FSBA modifies both alpha- and beta-subunits of F1 specifically and can be bound together with AXP at the same alpha-subunit","volume":"1318","author":"Hartog","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0615","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1476-5381.1990.tb14134.x","article-title":"Suramin is a slowly-equilibrating but competitive antagonist at P2x-receptors in the rabbit isolated ear artery","volume":"101","author":"Leff","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.cca.2018.01.032_bb0620","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.bmcl.2015.03.021","article-title":"Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor","volume":"25","author":"Gao","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.cca.2018.01.032_bb0625","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1021\/jm051202e","article-title":"Structure-activity relationship studies on a series of novel, substituted 1\u2011benzyl\u20115\u2011phenyltetrazole P2X7 antagonists","volume":"49","author":"Nelson","year":"2006","journal-title":"J. Med. Chem."},{"issue":"6","key":"10.1016\/j.cca.2018.01.032_bb0630","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.bmcl.2008.01.095","article-title":"Synthesis and in vitro activity of 1\u2011(2,3\u2011dichlorophenyl)\u2011N\u2011(pyridin\u20113\u2011ylmethyl)\u20111H\u20111,2,4\u2011triazol\u20115\u2011amine and 4\u2011(2,3\u2011dichlorophenyl)\u2011N\u2011(pyridin\u20113\u2011ylmethyl)\u20114H\u20111,2,4\u2011triazol\u20113\u2011amine P2X7 antagonists","volume":"18","author":"Florjancic","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0635","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuropharm.2008.06.012","article-title":"[3H]A-804598 ([3H]2\u2011cyano\u20111\u2011[(1S)\u20111\u2011phenylethyl]\u20113\u2011quinolin\u20115\u2011ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors","volume":"56","author":"Donnelly-Roberts","year":"2009","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.cca.2018.01.032_bb0640","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.bjp.0706933","article-title":"Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373","volume":"149","author":"Stokes","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0645","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.bjp.0707196","article-title":"Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding","volume":"151","author":"Michel","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.cca.2018.01.032_bb0650","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1021\/acs.jmedchem.6b00989","article-title":"Identification of (R)\u2011(2\u2011chloro\u20113\u2011(trifluoromethyl)phenyl)(1\u2011(5\u2011fluoropyridin\u20112\u2011yl)\u20114\u2011methyl\u20116,7\u2011di hydro\u20111H\u2011imidazo[4,5\u2011c]pyridin\u20115(4H)\u2011yl)methanone (JNJ 54166060), a small molecule antagonist of the P2X7 receptor","volume":"59","author":"Swanson","year":"2016","journal-title":"J. Med. Chem."},{"issue":"9","key":"10.1016\/j.cca.2018.01.032_bb0655","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/boc.201200088","article-title":"MED1101: a new dialdehydic compound regulating P2x7 receptor cell surface expression in U937 cells","volume":"105","author":"Muzzachi","year":"2013","journal-title":"Biol. Cell."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb0660","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/sj.bjp.0701081","article-title":"The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes","volume":"120","author":"Gargett","year":"1997","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.cca.2018.01.032_bb0665","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0960-894X(00)00083-4","article-title":"Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor","volume":"10","author":"Baraldi","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.cca.2018.01.032_bb0670","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1021\/jm500324g","article-title":"Discovery of novel 2,5\u2011dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62","volume":"58","author":"Park","year":"2015","journal-title":"J. Med. Chem."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0675","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1124\/mol.54.1.22","article-title":"Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues","volume":"54","author":"Humphreys","year":"1998","journal-title":"Mol. Pharmacol."},{"issue":"22","key":"10.1016\/j.cca.2018.01.032_bb0680","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1016\/j.bmcl.2004.07.095","article-title":"Synthesis, radiolabeling, and preliminary biological evaluation of [3H]\u20111\u2011[(S)\u2011N,O\u2011bis\u2011(isoquinolinesulfonyl)\u2011N\u2011methyl\u2011tyrosyl]\u20114\u2011(o\u2011tolyl)\u2011piperazi ne, a potent antagonist radioligand for the P2X7 receptor","volume":"14","author":"Romagnoli","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.cca.2018.01.032_bb0685","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2125.2012.04320.x","article-title":"Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects","volume":"75","author":"Ali","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"9","key":"10.1016\/j.cca.2018.01.032_bb0690","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0028-3908(97)00141-X","article-title":"Effects of divalent cations, protons and calmidazolium at the rat P2X7 receptor","volume":"36","author":"Virginio","year":"1997","journal-title":"Neuropharmacology"},{"issue":"22","key":"10.1016\/j.cca.2018.01.032_bb0695","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.bmcl.2003.08.034","article-title":"Hit-to-lead studies: the discovery of potent adamantane amide P2X7 receptor antagonists","volume":"13","author":"Baxter","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0700","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bmcl.2004.11.031","article-title":"Synthesis and SAR of 5,6\u2011diarylpyridines as human CB1 inverse agonists","volume":"15","author":"Meurer","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.cca.2018.01.032_bb0705","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00395-015-0490-9","article-title":"MicroRNA-155 aggravates ischemia-reperfusion injury by modulation of inflammatory cell recruitment and the respiratory oxidative burst","volume":"110","author":"Eisenhardt","year":"2015","journal-title":"Basic Res. Cardiol."},{"issue":"4","key":"10.1016\/j.cca.2018.01.032_bb2018","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.bjp.0703124","article-title":"Bromoenol lactone enhances the permeabilization of rat submandibular acinar cells by P2X7 agonists","volume":"129","author":"Chaib","year":"2000","journal-title":"Br. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.cca.2018.01.032_bb2019","doi-asserted-by":"crossref","first-page":"11067","DOI":"10.1074\/jbc.M110.198879","article-title":"Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations","volume":"286","author":"N\u00f6renberg","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.cca.2018.01.032_bb2020","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/jlcr.3206","article-title":"Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation","volume":"57","author":"Janssen","year":"2014","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"2","key":"10.1016\/j.cca.2018.01.032_bb2021","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bmcl.2004.10.052","article-title":"Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists","volume":"15","author":"Merriman","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118300408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118300408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:11:49Z","timestamp":1751274709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898118300408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":145,"alternative-id":["S0009898118300408"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2018.01.032","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The P2X7 purinergic receptor: An emerging therapeutic target in cardiovascular diseases","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2018.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}