{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:58:35Z","timestamp":1790135915145,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.cca.2018.03.029","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T16:12:27Z","timestamp":1522080747000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Lactase persistence genotyping on whole blood by loop-mediated isothermal amplification and melting curve analysis"],"prefix":"10.1016","volume":"482","author":[{"given":"Anders","family":"Abildgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Tovbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Giltay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liselot","family":"Detemmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2018.03.029_bb0005","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00439-008-0593-6","article-title":"Lactose digestion and the evolutionary genetics of lactase persistence","volume":"124","author":"Ingram","year":"2009","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cca.2018.03.029_bb0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.genet.37.110801.143820","article-title":"Genetics of lactase persistence and lactose intolerance","volume":"37","author":"Swallow","year":"2003","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.cca.2018.03.029_bb0015","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ejcn.2016.80","article-title":"Perception of lactose intolerance impairs health-related quality of life","volume":"70","author":"Casellas","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2018.03.029_bb0020","doi-asserted-by":"crossref","first-page":"174","DOI":"10.20524\/aog.2016.0009","article-title":"Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices","volume":"29","author":"Schiffner","year":"2016","journal-title":"Ann. Gastroenterol."},{"key":"10.1016\/j.cca.2018.03.029_bb0025","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1053\/j.gastro.2003.09.031","article-title":"An upstream polymorphism associated with lactase persistence has increased enhancer activity","volume":"125","author":"Troelsen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cca.2018.03.029_bb0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng826","article-title":"Identification of a variant associated with adult-type hypolactasia","volume":"30","author":"Enattah","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cca.2018.03.029_bb0035","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00439-006-0291-1","article-title":"A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?","volume":"120","author":"Ingram","year":"2007","journal-title":"Hum. Genet."},{"key":"10.1016\/j.cca.2018.03.029_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1946","article-title":"Convergent adaptation of human lactase persistence in Africa and Europe","volume":"39","author":"Tishkoff","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cca.2018.03.029_bb0045","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1373\/clinchem.2005.057240","article-title":"Genotyping of the lactase-phlorizin hydrolase \u221213910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance","volume":"52","author":"Bodlaj","year":"2006","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2018.03.029_bb0050","doi-asserted-by":"crossref","first-page":"727","DOI":"10.7754\/Clin.Lab.2015.150923","article-title":"Lactase non-persistence genotyping: comparison of two real-time PCR assays and assessment of concomitant fructose\/sorbitol malabsorption rates","volume":"62","author":"Enko","year":"2016","journal-title":"Clin. Lab."},{"key":"10.1016\/j.cca.2018.03.029_bb0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cca.2007.06.008","article-title":"Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia","volume":"384","author":"Weiskirchen","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2018.03.029_bb0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/00365513.2016.1261408","article-title":"Combination of real-time PCR and sequencing to detect multiple clinically relevant genetic variations in the lactase gene","volume":"77","author":"Brasen","year":"2017","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cca.2018.03.029_bb0065","doi-asserted-by":"crossref","unstructured":"Nilsson TK, Olsson LA. Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT \u221213907C>G, LCT \u221213910C>T and LCT \u221213915T>G with Pyrosequencing technology. Clin. Chem. Lab. Med. 2008; 46:80\u201384.","DOI":"10.1515\/CCLM.2008.015"},{"key":"10.1016\/j.cca.2018.03.029_bb0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cca.2008.03.006","article-title":"Evaluation of a novel reverse-hybridization StripAssay for typing DNA variants useful in diagnosis of adult-type hypolactasia","volume":"392","author":"Tag","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2018.03.029_bb0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/00365513.2010.522251","article-title":"High-resolution melting analysis using unlabeled probe and amplicon scanning simultaneously detects several lactase persistence variants","volume":"70","author":"Janukonyte","year":"2010","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.cca.2018.03.029_bb0080","doi-asserted-by":"crossref","first-page":"E63","DOI":"10.1093\/nar\/28.12.e63","article-title":"Loop-mediated isothermal amplification of DNA","volume":"28","author":"Notomi","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cca.2018.03.029_bb0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1574-695X.2011.00785.x","article-title":"Robustness of a loop-mediated isothermal amplification reaction for diagnostic applications","volume":"62","author":"Francois","year":"2011","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.cca.2018.03.029_bb0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/mcpr.2002.0415","article-title":"Accelerated reaction by loop-mediated isothermal amplification using loop primers","volume":"16","author":"Nagamine","year":"2002","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.cca.2018.03.029_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112316","article-title":"High resolution melting (HRM) for high-throughput genotyping-limitations and caveats in practical case studies","volume":"18","author":"Slomka","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2018.03.029_bb0100","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ajhg.2014.02.009","article-title":"Genetic origins of lactase persistence and the spread of pastoralism in Africa","volume":"94","author":"Ranciaro","year":"2014","journal-title":"Am. J. Hum. Genet."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118301451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118301451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:55:15Z","timestamp":1534985715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898118301451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":20,"alternative-id":["S0009898118301451"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2018.03.029","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactase persistence genotyping on whole blood by loop-mediated isothermal amplification and melting curve analysis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2018.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}