{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T07:10:45Z","timestamp":1772262645849,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"crossref","award":["HHSN272201300023I"],"award-info":[{"award-number":["HHSN272201300023I"]}],"id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"crossref","award":["HHSN2722013000201"],"award-info":[{"award-number":["HHSN2722013000201"]}],"id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.cca.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:17:53Z","timestamp":1534285073000},"page":"265-268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Beta-lactam carryover in arterial and central venous catheters is negligible"],"prefix":"10.1016","volume":"486","author":[{"given":"Emily","family":"Marsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia M.","family":"Verhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Groszek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Fissell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratish","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddy","family":"Creech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Shotwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.cca.2018.08.008_bb0005","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1080\/07853890.2017.1332776","article-title":"Internal medicine Sepsis study group. Sepsis in internal medicine wards: current knowledge, uncertainties and new approaches for management optimization","volume":"49","author":"Zaccone","year":"2017","journal-title":"Ann. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.cca.2018.08.008_bb0010","article-title":"ICU Mortality Rates in Patients with Sepsis Compared with Patients without Sepsis","volume":"19","author":"Melville","year":"2015","journal-title":"Crit. Care"},{"issue":"3","key":"10.1016\/j.cca.2018.08.008_bb0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"issue":"7","key":"10.1016\/j.cca.2018.08.008_bb0020","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/bmc.800","article-title":"An improved high-performance liquid chromatographic method with a solid-phase extraction for the determination of piperacillin and tazobactam: application to pharmacokinetic study of different dosage in Chinese healthy volunteers","volume":"21","author":"Xia","year":"2007","journal-title":"Biomed. Chromatogr."},{"issue":"9","key":"10.1016\/j.cca.2018.08.008_bb0025","first-page":"475","article-title":"Predictive performance of physiologically based pharmacokinetic and population pharmacokinetic modeling of renally cleared drugs in children","volume":"5","author":"Zhou","year":"2016","journal-title":"CPT: Pharmacometrics & Systems Pharmacology"},{"issue":"1","key":"10.1016\/j.cca.2018.08.008_bb0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijantimicag.2010.08.016","article-title":"Steady-state pharmacokinetics and pharmacodynamics of cefepime administered by prolonged infusion in hospitalised patients","volume":"37","author":"Cheatham","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"Suppl. 2","key":"10.1016\/j.cca.2018.08.008_bb0035","first-page":"ii25","article-title":"Antibiotic dosing in critical illness","volume":"66","author":"McKenzie","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"issue":"3","key":"10.1016\/j.cca.2018.08.008_bb0040","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/cc10257","article-title":"Recommended beta-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy","volume":"15","author":"Seyler","year":"2011","journal-title":"Crit. Care"},{"issue":"4","key":"10.1016\/j.cca.2018.08.008_bb0045","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1186\/cc9091","article-title":"Insufficient \u03b2-lactam concentrations in the early phase of severe sepsis and septic shock","volume":"14","author":"Taccone","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.cca.2018.08.008_bb0050","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cca.2018.03.021","article-title":"Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens","volume":"482","author":"Verhoven","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2018.08.008_bb0055","article-title":"Quantification of cefepime, meropenem, piperacillin and tazobactam in human plasma using a sensitive and robust LC-MS\/MS method - Part I. Assay development and validation","author":"D'Cunha","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.cca.2018.08.008_bb0060","article-title":"Quantification of cefepime, meropenem, piperacillin and tazobactam in human plasma using a sensitive and robust LC-MS\/MS method- Part II. Stability evaluation","author":"D'Cunha","year":"2018","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.cca.2018.08.008_bb0065","series-title":"Regression Modeling Strategies","first-page":"413","article-title":"Parametric survival models","author":"Harrell","year":"2001"},{"key":"10.1016\/j.cca.2018.08.008_bb0070","series-title":"In all Likelihood: Statistical Modelling and Inference Using Likelihood","author":"Pawitan","year":"2001"},{"issue":"9","key":"10.1016\/j.cca.2018.08.008_bb0075","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1128\/AAC.42.9.2417","article-title":"Single-dose pharmacokinetics of meropenem during continuous venovenous hemofiltration","volume":"42","author":"Thalhammer","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.cca.2018.08.008_bb0080","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1128\/AAC.36.3.552","article-title":"Pharmacokinetics of cefepime after single and multiple intravenous administrations in healthy subjects","volume":"36","author":"Barbhaiya","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.cca.2018.08.008_bb0085","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2146\/ajhp080434","article-title":"Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists","volume":"66","author":"Rybak","year":"2009","journal-title":"American Journal of Health-system Pharmacy: AJHP: Official Journal of the American Society of Health-System Pharmacists"},{"key":"10.1016\/j.cca.2018.08.008_bb0090","series-title":"Goodman & Gilman's the Pharmacological Basis of Therapeutics","year":"2011"},{"key":"10.1016\/j.cca.2018.08.008_bb0095","series-title":"Antibiotic Essentials","first-page":"643","author":"Cunha","year":"2015"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118304017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118304017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:50:17Z","timestamp":1542675017000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898118304017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":19,"alternative-id":["S0009898118304017"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2018.08.008","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beta-lactam carryover in arterial and central venous catheters is negligible","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}