{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:52Z","timestamp":1777593652045,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.cca.2018.11.001","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:56:46Z","timestamp":1541167006000},"page":"98-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["LC-MS\/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization"],"prefix":"10.1016","volume":"488","author":[{"given":"Giulia","family":"Forni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Malvagia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Funghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Scolamiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Della Bona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Villanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Damiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"la Marca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2018.11.001_bb0005","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev.bi.60.070191.002303","article-title":"Proteoglycans: structures and interactions","volume":"60","author":"Kjell\u00e9n","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cca.2018.11.001_bb0010","series-title":"Metabolic and Molecular Basis of Inherited Disease","first-page":"3421","article-title":"The mucopolysaccharidoses","author":"Neufeld","year":"2001"},{"issue":"2012","key":"10.1016\/j.cca.2018.11.001_bb0015","first-page":"471325","article-title":"Glycosaminoglycan storage disorders: a review","author":"Coutinho","year":"2012","journal-title":"Biochem. Res. Int."},{"issue":"5 Suppl","key":"10.1016\/j.cca.2018.11.001_bb0020","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jpeds.2004.01.052","article-title":"The mucopolysaccharidoses: a heterogeneous group of disorders with variable pediatric presentations","volume":"144","author":"Muenzer","year":"2004","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cca.2018.11.001_bb0025","series-title":"Inherited Metabolic Disease in Adults A Clinical Guide","article-title":"Mucopolysaccharidosis in adults","author":"Hendriks","year":"2016"},{"issue":"4","key":"10.1016\/j.cca.2018.11.001_bb0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/diseases4040040","article-title":"Biomarkers in lysosomal storage diseases","volume":"4","author":"Bobillo Lobato","year":"2016","journal-title":"Diseases"},{"issue":"5","key":"10.1016\/j.cca.2018.11.001_bb0035","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10545-005-0069-y","article-title":"Heparan sulfate levels in mucopolysaccharidoses and mucolipidoses","volume":"28","author":"Tomatsu","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0040","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/abio.1999.4027","article-title":"K, Microanalysis of glycosaminoglycan-derived oligosaccharides labeled with a fluorophore 2-aminobenzamide by high-performance liquid chromatography: application to disaccharide composition analysis and exosequencing of oligosaccharides","volume":"269","author":"Kinoshita","year":"1999","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.cca.2018.11.001_bb0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0003-2697(82)90674-1","article-title":"High-resolution electrophoresis of urinary glycosaminoglycans: an improved screening test for the mucopolysaccharidoses","volume":"119","author":"Hopwood","year":"1982","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-4165(86)90306-5","article-title":"Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue","volume":"883","author":"Farndale","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0055","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj1310351","article-title":"The quantitative determination of glycosaminoglycans in urine with Alcian Blue 8GX","volume":"131","author":"Whiteman","year":"1973","journal-title":"Biochem. J."},{"issue":"1\u20132","key":"10.1016\/j.cca.2018.11.001_bb0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ymgme.2016.09.005","article-title":"Glycosaminoglycans detection methods: applications of mass spectrometry","volume":"120","author":"Kubaski","year":"2017","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.cca.2018.11.001_bb0065","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/157016411798220871","article-title":"Analysis of Glycosaminoglycans using Mass Spectrometry","volume":"8","author":"O. Staples","year":"2011","journal-title":"Curr. Proteomics"},{"key":"10.1016\/j.cca.2018.11.001_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2018.11.100","article-title":"Data in support for the measurement of heparan sulfate and dermatan sulfate by LC-MS\/MS analysis","author":"Forni","year":"2018","journal-title":"Data Brief"},{"key":"10.1016\/j.cca.2018.11.001_bb0075","first-page":"45","volume":"47","year":"2001","journal-title":"J. Postgrad. Med."},{"issue":"18","key":"10.1016\/j.cca.2018.11.001_bb0080","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1021\/acs.analchem.5b01743","article-title":"Butanolysis derivatization: improved sensitivity in LC-MS\/MS quantitation of heparan sulfate in urine from mucopolysaccharidosis patients","volume":"87","author":"Trim","year":"2015","journal-title":"Anal. Chem."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ymgme.2014.09.009","article-title":"A straightforward, quantitative ultra-performance liquid chromatography-tandem mass spectrometric method for heparan sulfate, dermatan sulfate and chondroitin sulfate in urine: an improved clinical screening test for the mucopolysaccharidoses","volume":"114","author":"Zhang","year":"2015","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.cca.2018.11.001_bb0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ab.2007.05.016","article-title":"Analytical method for the determination of disaccharides derived from keratan, heparan, and dermatan sulfates in human serum and plasma by high-performance liquid chromatography\/turbo ionspray ionization tandem mass spectrometry","volume":"368","author":"Oguma","year":"2007","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ymgme.2009.10.001","article-title":"Validation of disaccharide compositions derived from dermatan sulfate and heparan sulfate in mucopolysaccharidoses and mucolipidoses II and III by tandem mass spectrometry","volume":"99","author":"Tomatsu","year":"2010","journal-title":"Mol. Genet. Metab."},{"issue":"530","key":"10.1016\/j.cca.2018.11.001_bb0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ab.2017.04.019","article-title":"Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring","author":"Antia","year":"2017","journal-title":"Anal. Biochem."},{"issue":"9","key":"10.1016\/j.cca.2018.11.001_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138622","article-title":"A multiplex assay for the diagnosis of mucopolysaccharidoses and mucolipidoses","volume":"10","author":"Langereis","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0110","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/ac3030448","article-title":"Disaccharide analysis of glycosaminoglycans using hydrophilic interaction chromatography and mass spectrometry","volume":"85","author":"Gill","year":"2013","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.cca.2018.11.001_bb0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ymgme.2010.09.003","article-title":"Efficient analysis of urinary glycosaminoglycans by LC-MS\/MS in mucopolysaccharidoses type I, II and VI","volume":"102","author":"Auray-Blais","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"7\u20138","key":"10.1016\/j.cca.2018.11.001_bb0120","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cca.2012.01.012","article-title":"An improved method for glycosaminoglycan analysis by LC-MS\/MS of urine samples collected on filter paper","volume":"413","author":"Auray-Blais","year":"2012","journal-title":"Clin. Chim. Acta"},{"issue":"7","key":"10.1016\/j.cca.2018.11.001_bb0125","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1373\/clinchem.2010.161141","article-title":"Analysis of glycosaminoglycans in cerebrospinal fluid from patients with mucopolysaccharidoses by isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry","volume":"57","author":"Zhang","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2018.11.001_bb0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13023-014-0135-3","article-title":"A modified liquid chromatography\/ tandem mass spectrometry method for predominant disaccharide units of urinary glycosaminoglycans in patients with mucopolysaccharidoses","volume":"9","author":"Chuang","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"issue":"8","key":"10.1016\/j.cca.2018.11.001_bb0135","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/rcm.6861","article-title":"A simple method for early age phenotype confirmation using toe tissue from a mouse model of MPS IIIA","volume":"28","author":"Trim","year":"2014","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"3","key":"10.1016\/j.cca.2018.11.001_bb0140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1096-7192(03)00018-0","article-title":"Determination of monosaccharides and disaccharides in mucopolysaccharidoses patients by electrospray ionisation mass spectrometry","volume":"78","author":"Ramsay","year":"2003","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ab.2010.04.002","article-title":"Determination of urinary oligosaccharides by high-performance liquid chromatography\/electrospray ionization-tandem mass spectrometry: application to Hunter syndrome","volume":"402","author":"Nielsen","year":"2010","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10545-009-9036-3","article-title":"Dermatan sulfate and heparan sulfate as a biomarker for mucopolysaccharidosis I","volume":"33","author":"Tomatsu","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.cca.2018.11.001_bb0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10545-012-9538-2","article-title":"Plasma and urinary levels of dermatan sulfate and heparan sulfate derived disaccharides after long-term enzyme replacement therapy (ERT) in MPS I: correlation with the timing of ERT and with total urinary excretion of glycosaminoglycans","volume":"36","author":"de Ru","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"issue":"1\u20132","key":"10.1016\/j.cca.2018.11.001_bb0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ymgme.2014.07.008","article-title":"Novel heparan sulfate assay by using automated high-throughput mass spectrometry: application to monitoring and screening for mucopolysaccharidoses","volume":"113","author":"Shimada","year":"2014","journal-title":"Mol. Genet. Metab."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118305746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118305746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T09:06:29Z","timestamp":1544519189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898118305746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":32,"alternative-id":["S0009898118305746"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2018.11.001","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LC-MS\/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2018.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}