{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:49:32Z","timestamp":1783514972407,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY18H040012"],"award-info":[{"award-number":["LY18H040012"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY18H160052"],"award-info":[{"award-number":["LY18H160052"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.cca.2018.11.011","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T11:11:24Z","timestamp":1541589084000},"page":"215-220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Comparison of serum human epididymis protein 4 and CA125 on endometrial cancer detection: A meta-analysis"],"prefix":"10.1016","volume":"488","author":[{"given":"Jinping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanglei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Wen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cca.2018.11.011_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","article-title":"Cancer statistics, 2013","volume":"63","author":"Siegel","year":"2013","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.cca.2018.11.011_bb0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J. Clin."},{"issue":"15","key":"10.1016\/j.cca.2018.11.011_bb0015","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM198310133091503","article-title":"A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer","volume":"309","author":"Bast","year":"1983","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.cca.2018.11.011_bb0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ygyno.2008.04.002","article-title":"Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus","volume":"110","author":"Moore","year":"2008","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.cca.2018.11.011_bb0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.maturitas.2010.04.017","article-title":"Serum tumour markers in gynaecological cancers","volume":"67","author":"Aggarwal","year":"2010","journal-title":"Maturitas"},{"issue":"4","key":"10.1016\/j.cca.2018.11.011_bb0030","first-page":"315","article-title":"The value of serum CA 125 and association CA 125\/CA 19-9 in endometrial carcinoma","volume":"20","author":"Cherchi","year":"1999","journal-title":"Eur. J. Gynaecol. Oncol."},{"issue":"6B","key":"10.1016\/j.cca.2018.11.011_bb0035","first-page":"4635","article-title":"TATI (tumor associated trypsin inhibitor) and cancer antigen 125 (CA 125) in patients with early-stage endometrial cancer","volume":"18","author":"Peters-Engl","year":"1998","journal-title":"Anticancer Res."},{"issue":"4","key":"10.1016\/j.cca.2018.11.011_bb0040","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1097\/01.AOG.0000209463.53764.e7","article-title":"ACOG Practice Bulletin number 65: management of endometrial cancer","volume":"107","author":"Hernandez","year":"2006","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.cca.2018.11.011_bb0045","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1095\/biolreprod45.2.350","article-title":"A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors","volume":"45","author":"Kirchhoff","year":"1991","journal-title":"Biol. Reprod."},{"issue":"17","key":"10.1016\/j.cca.2018.11.011_bb0050","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1038\/sj.onc.1205363","article-title":"The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms","volume":"21","author":"Bingle","year":"2002","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.cca.2018.11.011_bb0055","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-04-3924","article-title":"Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas","volume":"65","author":"Drapkin","year":"2005","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.cca.2018.11.011_bb0060","first-page":"111","article-title":"HE4 and mesothelin: novel biomarkers of ovarian carcinoma in patients with pelvic masses","volume":"11","author":"Abdel-Azeez","year":"2010","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"12","key":"10.1016\/j.cca.2018.11.011_bb0065","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1515\/cclm-2011-0757","article-title":"Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome","volume":"50","author":"Zanotti","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2018.11.011_bb0070","series-title":"Midas: A Program for Meta-Analytical Integration of Diagnostic Accuracy Studies in Stata","author":"Dwamena","year":"2007"},{"issue":"1","key":"10.1016\/j.cca.2018.11.011_bb0075","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s13277-012-0583-0","article-title":"The role of novel biomarker HE4 in endometrial cancer: a case control prospective study","volume":"34","author":"Angioli","year":"2013","journal-title":"Tumour Biol."},{"issue":"9","key":"10.1016\/j.cca.2018.11.011_bb0080","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/bjc.2011.109","article-title":"Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients","volume":"104","author":"Bignotti","year":"2011","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.cca.2018.11.011_bb0085","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s13277-013-0814-z","article-title":"The diagnostic role of human epididymis protein 4 and serum amyloid-a in early-stage endometrial cancer patients","volume":"34","author":"Omer","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.cca.2018.11.011_bb0090","first-page":"1559","article-title":"Clinicial value of combined detection of CA125 and HE4 in diagnosis of endometrial cancer","volume":"10","author":"Wu","year":"2011","journal-title":"Zhong Guo Fu You Bao Jian"},{"issue":"11","key":"10.1016\/j.cca.2018.11.011_bb0095","first-page":"820","article-title":"Differential diagnostic value of combined detection of serum HE4 and CA125 in patients with endometrial cancer from benign uterus tumor","author":"Zhao","year":"2012","journal-title":"China Oncol."},{"key":"10.1016\/j.cca.2018.11.011_bb0100","first-page":"447","article-title":"Evaluation on the value of human epididymis protein 4 in the early diagnosis of endometrial and ovarian cancers","volume":"07","author":"Cong","year":"2011","journal-title":"Lab. Med."},{"issue":"05","key":"10.1016\/j.cca.2018.11.011_bb0105","first-page":"466","article-title":"Research of tumor markers for endometrial cancer risk evaluation","author":"Zhang","year":"2013","journal-title":"J. Int. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2018.11.011_bb0110","article-title":"The clinicial value of serum HE4 in diagnosis of ovarian tumor and endometrial carcinoma","volume":"02","author":"Yu","year":"2013","journal-title":"Chin. J. Health Lab. Technol."},{"key":"10.1016\/j.cca.2018.11.011_bb0115","first-page":"377","article-title":"Expression and significance of serum HE4 and YKL-40 in patients with endometrial cancer","volume":"5","author":"Zhang","year":"2011","journal-title":"Prog. Obstet. Gynecol."},{"key":"10.1016\/j.cca.2018.11.011_bb0120","first-page":"10","article-title":"The clinicial values of serum human epididymis secretory protein 4 in the diagnosis of endometrial cancer","author":"Liang","year":"2011","journal-title":"Zhong Guo Lao Nian Bao Jian Xue (03)"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118305837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898118305837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T09:06:37Z","timestamp":1544519197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898118305837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":24,"alternative-id":["S0009898118305837"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2018.11.011","relation":{},"ISSN":["0009-8981"],"issn-type":[{"value":"0009-8981","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of serum human epididymis protein 4 and CA125 on endometrial cancer detection: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2018.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}