{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:06:18Z","timestamp":1762113978323,"version":"build-2065373602"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003510","name":"Haridus- ja Teadusministeerium","doi-asserted-by":"publisher","award":["IUT20-43","SF 0180035s08"],"award-info":[{"award-number":["IUT20-43","SF 0180035s08"]}],"id":[{"id":"10.13039\/501100003510","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.cca.2019.03.1614","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T05:26:57Z","timestamp":1552714017000},"page":"40-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Patients with down syndrome have increased prevalence of rheumatoid factor but not autoantibodies to anti-cyclic citrullinated peptide"],"prefix":"10.1016","volume":"495","author":[{"given":"Erik","family":"Orro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristi","family":"Alnek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiia","family":"Reimand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koit","family":"Reimand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oivi","family":"Uibo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina","family":"Talvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadri","family":"Haller-Kikkatalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalle","family":"Kisand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raivo","family":"Uibo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cca.2019.03.1614_bb0005","first-page":"602","article-title":"Les chromosomes humains en culture de tissus","volume":"248","author":"Lejeune","year":"1959","journal-title":"Comptes Rendus Hebd S\u00e9ances Acad\u00e9mie Sci."},{"issue":"3","key":"10.1016\/j.cca.2019.03.1614_bb0010","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2249.2012.04610.x","article-title":"Down syndrome, autoimmunity and T regulatory cells","volume":"169","author":"Pellegrini","year":"2012","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.cca.2019.03.1614_bb0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1542\/peds.85.3.450","article-title":"Intellectual and adaptive functioning in individuals with down syndrome in relation to age and environmental placement","volume":"85","author":"Brown","year":"1990","journal-title":"Pediatrics."},{"issue":"3","key":"10.1016\/j.cca.2019.03.1614_bb0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1352\/0047-6765(1998)036<0175:OPIPWD>2.0.CO;2","article-title":"Overweight prevalence in persons with down syndrome","volume":"36","author":"Rubin","year":"1998","journal-title":"Ment. Retard."},{"issue":"3","key":"10.1016\/j.cca.2019.03.1614_bb0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-8628(19981116)80:3<213::AID-AJMG6>3.0.CO;2-8","article-title":"Population-based study of congenital heart defects in down syndrome","volume":"80","author":"Freeman","year":"1998","journal-title":"Am. J. Med. Genet."},{"issue":"4","key":"10.1016\/j.cca.2019.03.1614_bb0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1469-8749.1999.tb00599.x","article-title":"Significance of oral health in persons with down syndrome: a literature review","volume":"41","author":"Hennequin","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"issue":"4","key":"10.1016\/j.cca.2019.03.1614_bb0035","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jpeds.2013.11.032","article-title":"A community cross-sectional survey of medical problems in 440 children with down syndrome in New York state","volume":"164","author":"Roizen","year":"2014","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.cca.2019.03.1614_bb0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/000992280104000502","article-title":"Frequency of celiac disease in individuals with down syndrome in the United States","volume":"40","author":"Mackey","year":"2001","journal-title":"Clin. Pediatr. (Phila)"},{"issue":"10","key":"10.1016\/j.cca.2019.03.1614_bb0045","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/rheumatology\/41.10.1191","article-title":"Is arthritis more common in children with down syndrome?","volume":"41","author":"Padmakumar","year":"2002","journal-title":"Rheumatology."},{"issue":"11","key":"10.1016\/j.cca.2019.03.1614_bb0050","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.2337\/db06-0856","article-title":"Islet autoimmunity in children with Down's syndrome","volume":"55","author":"Gillespie","year":"2006","journal-title":"Diabetes."},{"issue":"9","key":"10.1016\/j.cca.2019.03.1614_bb0055","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3748\/wjg.v12.i9.1430","article-title":"Screening for celiac disease in Down's syndrome patients revealed cases of subtotal villous atrophy without typical for celiac disease HLA-DQ and tissue transglutaminase antibodies","volume":"12","author":"Uibo","year":"2006","journal-title":"World J Gastroenterol WJG."},{"issue":"9","key":"10.1016\/j.cca.2019.03.1614_bb0060","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis."},{"issue":"4","key":"10.1016\/j.cca.2019.03.1614_bb0065","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.semarthrit.2013.08.005","article-title":"Diagnostic accuracy of a clinical prediction rule (CPR) for identifying patients with recent-onset undifferentiated arthritis who are at a high risk of developing rheumatoid arthritis: a systematic review and meta-analysis","volume":"43","author":"McNally","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"year":"2016","series-title":"An International System for Human Cytogenetic Nomenclature","author":"ISCN","key":"10.1016\/j.cca.2019.03.1614_bb0070"},{"key":"10.1016\/j.cca.2019.03.1614_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/srep44846","article-title":"Demographic associations for autoantibodies in disease-free individuals of a Estonian population","volume":"7","author":"Haller-Kikkatalo","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.cca.2019.03.1614_bb0080","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s10067-007-0606-1","article-title":"High positivity of anti-CCP antibodies in patients with down syndrome","volume":"26","author":"Nisihara","year":"2007","journal-title":"Clin. Rheumatol."},{"issue":"5","key":"10.1016\/j.cca.2019.03.1614_bb0085","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jbspin.2012.03.002","article-title":"Lack of anti-citrullinated fibrinogen and anti-CCP antibodies in adult patients with down syndrome","volume":"79","author":"Berthelot","year":"2012","journal-title":"Joint Bone Spine."},{"issue":"5","key":"10.1016\/j.cca.2019.03.1614_bb0090","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/ard.2009.112458","article-title":"Organ-specific autoantibodies but not anti-cyclic citrullinated peptides are a feature of autoimmunity in Down's syndrome","volume":"69","author":"Fisher","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.cca.2019.03.1614_bb0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12016-007-8030-5","article-title":"Comparison of three anti-CCP tests and rheumatoid factor in RA and control patients","volume":"34","author":"Correia","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.cca.2019.03.1614_bb0100","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1440-1754.2007.01229.x","article-title":"Autoantibodies in patients with down syndrome: early senescence of the immune system or precocious markers for immunological diseases?","volume":"44","author":"Utiyama","year":"2008","journal-title":"J. Paediatr. Child Health"},{"key":"10.1016\/j.cca.2019.03.1614_bb0105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cca.2014.07.032","article-title":"Clinical evaluation of a novel chemiluminescent immunoassay for the detection of anti-citrullinated peptide antibodies","volume":"437","author":"Webb","year":"2014","journal-title":"Clin. Chim. Acta"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811931719X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811931719X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:02:18Z","timestamp":1762113738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989811931719X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":21,"alternative-id":["S000989811931719X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2019.03.1614","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients with down syndrome have increased prevalence of rheumatoid factor but not autoantibodies to anti-cyclic citrullinated peptide","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2019.03.1614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}