{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:40:01Z","timestamp":1764603601486,"version":"3.44.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cca.2019.11.009","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T11:16:31Z","timestamp":1573557391000},"page":"255-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Serum human epididymis protein 4 concentrations are associated with severity of patients with pulmonary tuberculosis"],"prefix":"10.1016","volume":"502","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-8397","authenticated-orcid":false,"given":"Laisheng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingsheng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caifeng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-2505","authenticated-orcid":false,"given":"Ben-Quan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-4410","authenticated-orcid":false,"given":"Shengfeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinmei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cca.2019.11.009_b0005","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJMoa1803484","article-title":"Phase 2b controlled trial of m72\/as01e vaccine to prevent tuberculosis","volume":"379","author":"Van Der Meeren","year":"2018","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.cca.2019.11.009_b0010","doi-asserted-by":"crossref","first-page":"e485","DOI":"10.1016\/S2214-109X(16)30074-2","article-title":"Prevalence of pulmonary tuberculosis in western china in 2010\u201311: a population-based, cross-sectional survey","volume":"4","author":"Mijiti","year":"2016","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.cca.2019.11.009_b0015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12916-014-0216-0","article-title":"How much is tuberculosis screening worth? Estimating the value of active case finding for tuberculosis in South Africa, China, and India","volume":"12","author":"Azman","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.cca.2019.11.009_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032976","article-title":"Spoligotyping and drug resistance analysis of mycobacterium tuberculosis strains from national survey in china","volume":"7","author":"Pang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cca.2019.11.009_b0025","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/imr.12252","article-title":"Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses","volume":"264","author":"Lenaerts","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.cca.2019.11.009_b0030","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/139127","article-title":"The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?","volume":"2012","author":"Silva Miranda","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.cca.2019.11.009_b0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cca.2017.05.029","article-title":"Performance of roma based on architect ca 125 ii and he4 values in chinese women presenting with a pelvic mass: a multicenter prospective study","volume":"471","author":"Shen","year":"2017","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2019.11.009_b0040","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cca.2016.06.010","article-title":"Value of serum human epididymis secretory protein 4 as a marker for differential diagnosis of malignant and benign gynecological diseases of patients in southern china","volume":"459","author":"Li","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2019.11.009_b0045","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cca.2018.03.040","article-title":"Human epididymis protein 4 in endometrial cancer: a meta-analysis","volume":"482","author":"Li","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.cca.2019.11.009_b0050","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/bjc.2011.109","article-title":"Diagnostic and prognostic impact of serum he4 detection in endometrial carcinoma patients","volume":"104","author":"Bignotti","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cca.2019.11.009_b0055","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1515\/cclm-2014-0041","article-title":"Serum human epididymis protein 4 (he4) as a tumor marker in men with lung cancer","volume":"52","author":"Nagy","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2019.11.009_b0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1258\/acb.2011.011258","article-title":"Elevated human epididymis protein 4 concentrations in chronic kidney disease","volume":"49","author":"Nagy","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.cca.2019.11.009_b0065","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.chest.2016.04.006","article-title":"Human epididymis protein 4: a novel serum inflammatory biomarker in cystic fibrosis","volume":"150","author":"Nagy","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.cca.2019.11.009_b0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardfail.2016.05.002","article-title":"He4 serum levels are associated with heart failure severity in patients with chronic heart failure","volume":"23","author":"Piek","year":"2017","journal-title":"J. Card Fail."},{"key":"10.1016\/j.cca.2019.11.009_b0075","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.it.2008.07.001","article-title":"Novel innate immune functions of the whey acidic protein family","volume":"29","author":"Bingle","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cca.2019.11.009_b0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm.2989","article-title":"Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cca.2019.11.009_b0085","doi-asserted-by":"crossref","first-page":"67748","DOI":"10.18632\/oncotarget.11682","article-title":"Elevated serum concentrations of he4 as a novel biomarker of disease severity and renal fibrosis in kidney disease","volume":"7","author":"Wan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cca.2019.11.009_b0090","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s10753-014-9978-y","article-title":"The relationship between inflammatory marker levels and pulmonary tuberculosis severity","volume":"38","author":"Abakay","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.cca.2019.11.009_b0095","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1158\/0008-5472.CAN-04-3924","article-title":"Human epididymis protein 4 (he4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas","volume":"65","author":"Drapkin","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.cca.2019.11.009_b0100","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1373\/clinchem.2010.157073","article-title":"Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases","volume":"57","author":"Escudero","year":"2011","journal-title":"Clin. Chem."},{"key":"10.1016\/j.cca.2019.11.009_b0105","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1515\/cclm-2012-0097","article-title":"Human epididymis protein 4 (he4) in benign and malignant diseases","volume":"50","author":"Hertlein","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.cca.2019.11.009_b0110","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.5588\/ijtld.13.0058","article-title":"Evaluating the clinical significance of serum he4 levels in lung cancer and pulmonary tuberculosis","volume":"17","author":"Liu","year":"2013","journal-title":"Int. J. Tuberc. Lung Dis"},{"key":"10.1016\/j.cca.2019.11.009_b0115","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/1354750X.2015.1118552","article-title":"Evaluating the clinical significances of serum he4 with ca125 in peritoneal tuberculosis and epithelial ovarian cancer","volume":"21","author":"Zhang","year":"2016","journal-title":"Biomarkers"},{"key":"10.1016\/j.cca.2019.11.009_b0120","doi-asserted-by":"crossref","first-page":"270","DOI":"10.5152\/balkanmedj.2014.13326","article-title":"Serum human epididymis protein 4 (he4) in the differential diagnosis of peritoneal tuberculosis: a report of two cases","volume":"31","author":"Kabaca","year":"2014","journal-title":"Balkan Med. J."},{"key":"10.1016\/j.cca.2019.11.009_b0125","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.cca.2018.05.006","article-title":"Serum human epididymis secretory protein 4 as a potential biomarker of renal fibrosis in kidney transplantation recipients","volume":"483","author":"Luo","year":"2018","journal-title":"Clin. Chim. Acta"}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898119321229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009898119321229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T14:53:03Z","timestamp":1757861583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009898119321229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":25,"alternative-id":["S0009898119321229"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2019.11.009","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum human epididymis protein 4 concentrations are associated with severity of patients with pulmonary tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2019.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}