{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T09:47:11Z","timestamp":1767260831931,"version":"build-2065373602"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinica Chimica Acta"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.cca.2019.11.037","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T20:04:28Z","timestamp":1576008268000},"page":"53-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Magnesium: An old player revisited in the context of CKD-MBD"],"prefix":"10.1016","volume":"501","author":[{"given":"M.V.","family":"Pend\u00f3n-Ruiz de Mier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rodelo-Haad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"D\u00edaz-Tocados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Mu\u00f1oz-Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2017","key":"10.1016\/j.cca.2019.11.037_b0005","first-page":"1151","article-title":"Causes of Death Collaborators, Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD","year":"2016","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.cca.2019.11.037_b0010","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cca.2019.11.037_b0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S2213-8587(14)70059-2","article-title":"Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders","volume":"2","author":"Vervloet","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.cca.2019.11.037_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/ki.2012.370","article-title":"Circulating Klotho levels: clinical relevance and relationship with tissue Klotho expression","volume":"83","author":"Dr\u00fceke","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0025","first-page":"3858","article-title":"Differential regulation of renal Klotho and FGFR1 in normal and uremic rats, FASEB","volume":"31","author":"Mu\u00f1oz-Casta\u00f1eda","year":"2017","journal-title":"J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.cca.2019.11.037_b0030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1053\/j.ajkd.2010.12.027","article-title":"Role of Klotho in aging, phosphate metabolism, and CKD","volume":"58","author":"John","year":"2011","journal-title":"Am. J. Kidney Dis. Off. J. Natl. Kidney Found."},{"key":"10.1016\/j.cca.2019.11.037_b0035","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Kidney Disease: improving global outcomes (KDIGO), definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0040","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(02)37965-0","article-title":"On a form of late rickets associated with albuminuria, rickets of adolescents","volume":"121","author":"Clement Lucas","year":"1883","journal-title":"The Lancet."},{"key":"10.1016\/j.cca.2019.11.037_b0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/0003-4819-64-2-293","article-title":"Hemodialysis: a successful therapy for chronic uremia","volume":"64","author":"Pendras","year":"1966","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cca.2019.11.037_b0050","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1681\/ASN.2006070771","article-title":"Metabolic bone disease in chronic kidney disease","volume":"18","author":"Martin","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0055","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1210\/en.2005-0480","article-title":"Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts","volume":"146","author":"Lotinun","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2019.11.037_b0060","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s40620-017-0397-7","article-title":"Adynamic bone disease is a predominant bone pattern in early stages of chronic kidney disease","volume":"30","author":"Massy","year":"2017","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0065","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5301\/jn.5000212","article-title":"Osteoporosis and adynamic bone in chronic kidney disease","volume":"26","author":"Cannata-And\u00eda","year":"2013","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0070","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1046\/j.1523-1755.2000.00306.x","article-title":"Down-regulation of human osteoblast PTH\/PTHrP receptor mRNA in end-stage renal failure","volume":"58","author":"Picton","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0075","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1172\/JCI107500","article-title":"Bone magnesium pools in uremia","volume":"52","author":"Alfrey","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cca.2019.11.037_b0080","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1177\/00220345810600041301","article-title":"Magnesium inhibition of apatite nucleation by proteolipid","volume":"60","author":"Ennever","year":"1981","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.cca.2019.11.037_b0085","first-page":"2383","article-title":"A comparison of calcium acetate\/magnesium carbonate and sevelamer-hydrochloride effects on fibroblast growth factor-23 and bone markers: post hoc evaluation from a controlled, randomized study","volume":"28","author":"Covic","year":"2013","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0090","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s00198-006-0104-3","article-title":"Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism","volume":"17","author":"Rude","year":"2006","journal-title":"Osteoporos. Int. J. Establ. Result Coop. Eur. Found. Osteoporos. Natl. Osteoporos. Found. USA"},{"key":"10.1016\/j.cca.2019.11.037_b0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/69.4.727","article-title":"Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women","volume":"69","author":"Tucker","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2019.11.037_b0100","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(86)90987-6","article-title":"Substitution of aluminium salts by magnesium salts in control of dialysis hyperphosphataemia","volume":"1","author":"O\u2019Donovan","year":"1986","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.cca.2019.11.037_b0105","first-page":"416","article-title":"Magnesium carbonate is an effective phosphate binder for chronic hemodialysis patients: a pilot study","volume":"17","author":"Spiegel","year":"2007","journal-title":"J. Ren. Nutr. Off. J. Counc. Ren. Nutr. Natl. Kidney Found."},{"key":"10.1016\/j.cca.2019.11.037_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089525","article-title":"Magnesium inhibits Wnt\/\u03b2-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells","volume":"9","author":"Montes de Oca","year":"2014","journal-title":"PloS One."},{"issue":"56","key":"10.1016\/j.cca.2019.11.037_b0115","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/HYPERTENSIONAHA.110.152058","article-title":"Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium","volume":"1979","author":"Montezano","year":"2010","journal-title":"Hypertens. Dallas Tex"},{"key":"10.1016\/j.cca.2019.11.037_b0120","first-page":"514","article-title":"Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner","volume":"27","author":"Kircelli","year":"2012","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0125","first-page":"869","article-title":"Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells","author":"Louvet","year":"2013","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc. 28"},{"key":"10.1016\/j.cca.2019.11.037_b0130","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.kint.2017.04.011","article-title":"Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats","volume":"92","author":"Diaz-Tocados","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0135","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0014-2999(02)01849-6","article-title":"Physiological and pharmacological agonists of the extracellular Ca2+-sensing receptor","volume":"447","author":"McLarnon","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cca.2019.11.037_b0140","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1681\/ASN.2017080849","article-title":"Magnesium and Risk of Hip Fracture among Patients Undergoing Hemodialysis","volume":"29","author":"Sakaguchi","year":"2018","journal-title":"J. Am. Soc. Nephrol. JASN."},{"key":"10.1016\/j.cca.2019.11.037_b0145","first-page":"651","article-title":"Magnesium hydroxide as a complementary aluminium-free phosphate binder to moderate doses of oral calcium in uraemic patients on chronic haemodialysis: lack of deleterious effect on bone mineralisation","volume":"3","author":"Morini\u00e8re","year":"1988","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0150","first-page":"240","article-title":"Improved bone morphology by normalizing serum magnesium in chronically hemodialyzed patients","volume":"14","author":"Gonella","year":"1988","journal-title":"Miner. Electrolyte Metab."},{"key":"10.1016\/j.cca.2019.11.037_b0155","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.1038\/s41598-017-08379-y","article-title":"Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells","volume":"7","author":"D\u00edaz-Tocados","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2019.11.037_b0160","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/HJH.0b013e3283190582","article-title":"Regulation of the novel Mg2+ transporter transient receptor potential melastatin 7 (TRPM7) cation channel by bradykinin in vascular smooth muscle cells","volume":"27","author":"Callera","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cca.2019.11.037_b0165","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/j.1582-4934.2008.00157.x","article-title":"Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels","volume":"12","author":"Hamaguchi","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cca.2019.11.037_b0170","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cub.2005.02.050","article-title":"Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7","volume":"15","author":"Elizondo","year":"2005","journal-title":"Curr. Biol. CB."},{"key":"10.1016\/j.cca.2019.11.037_b0175","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1210\/en.2008-0140","article-title":"Notch inhibits osteoblast differentiation and causes osteopenia","volume":"149","author":"Zanotti","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.cca.2019.11.037_b0180","doi-asserted-by":"crossref","first-page":"E171","DOI":"10.1152\/ajpendo.00395.2015","article-title":"Canonical Notch activation in osteocytes causes osteopetrosis","volume":"310","author":"Canalis","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cca.2019.11.037_b0185","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.cca.2019.11.037_b0190","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.actbio.2015.08.042","article-title":"Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture","volume":"27","author":"Wu","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cca.2019.11.037_b0195","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jnutbio.2012.12.008","article-title":"Magnesium deficiency results in an increased formation of osteoclasts","volume":"24","author":"Belluci","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.cca.2019.11.037_b0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/jn\/134.1.79","article-title":"Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha","volume":"134","author":"Rude","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.cca.2019.11.037_b0205","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nrneph.2015.74","article-title":"Magnesium and cardiovascular complications of chronic kidney disease","volume":"11","author":"Massy","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0210","doi-asserted-by":"crossref","first-page":"i39","DOI":"10.1093\/ndtplus\/sfr166","article-title":"Magnesium in chronic kidney disease Stages 3 and 4 and in dialysis patients","volume":"5","author":"Cunningham","year":"2012","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.cca.2019.11.037_b0215","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1271\/bbb.66.192","article-title":"Changes in N-acetyl-beta-D-glucosaminidase activity in the urine and urinary albumin excretion in magnesium deficient rats","volume":"66","author":"Matsuzaki","year":"2002","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.cca.2019.11.037_b0220","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1681\/ASN.2004100832","article-title":"Magnesium supplementation combined with N-acetylcysteine protects against postischemic acute renal failure","volume":"16","author":"de Araujo","year":"2005","journal-title":"J. Am. Soc. Nephrol. JASN."},{"key":"10.1016\/j.cca.2019.11.037_b0225","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2337\/dc12-0226","article-title":"Hypomagnesemia in type 2 diabetic nephropathy: a novel predictor of end-stage renal disease","volume":"35","author":"Sakaguchi","year":"2012","journal-title":"Diabetes Care."},{"key":"10.1016\/j.cca.2019.11.037_b0230","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/j.ackd.2017.11.001","article-title":"Magnesium and Progression of Chronic Kidney Disease: Benefits Beyond Cardiovascular Protection?","volume":"25","author":"Sakaguchi","year":"2018","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.cca.2019.11.037_b0235","doi-asserted-by":"crossref","first-page":"13701","DOI":"10.1038\/s41598-018-32065-2","article-title":"Increased phosphaturia accelerates the decline in renal function A Search for Mechanisms","volume":"8","author":"Santamar\u00eda","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cca.2019.11.037_b0240","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ki.2015.165","article-title":"Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease","volume":"88","author":"Sakaguchi","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0245","article-title":"Low magnesium diet aggravates phosphate-induced kidney injury","author":"Sakaguchi","year":"2018","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0250","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1046\/j.1523-1755.2000.00429.x","article-title":"Dietary potassium and magnesium supplementation in cyclosporine-induced hypertension and nephrotoxicity","volume":"58","author":"Pere","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0255","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/sj.ki.5002786","article-title":"Cisplatin nephrotoxicity: mechanisms and renoprotective strategies","volume":"73","author":"Pabla","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0260","first-page":"481","article-title":"Premedication with intravenous magnesium has a protective effect against cisplatin-induced nephrotoxicity","volume":"25","author":"Saito","year":"2017","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer."},{"key":"10.1016\/j.cca.2019.11.037_b0265","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.amjmed.2013.02.036","article-title":"Hypomagnesemia and the risk of death and GFR decline in chronic kidney disease","volume":"126","author":"Van Laecke","year":"2013","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cca.2019.11.037_b0270","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5414\/CNP63429","article-title":"Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2","volume":"63","author":"Pham","year":"2005","journal-title":"Clin. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0275","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ki.2014.331","article-title":"Results from the atherosclerosis risk in communities study suggest that low serum magnesium is associated with incident kidney disease","volume":"87","author":"Tin","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0280","article-title":"Proteinuria-associated renal magnesium wasting leads to hypomagnesemia: a common electrolyte abnormality in chronic kidney disease","author":"Oka","year":"2018","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc. - Eur. Ren. Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0285","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/ki.2015.33","article-title":"PREVEND Study Group, Low plasma magnesium and risk of developing chronic kidney disease: results from the PREVEND Study","volume":"87","author":"Joosten","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0290","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbadis.2010.06.016","article-title":"Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB","volume":"1802","author":"Ferr\u00e8","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.cca.2019.11.037_b0295","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000450861","article-title":"Dietary magnesium and kidney function decline: the healthy aging in neighborhoods of diversity across the life span study","volume":"44","author":"Rebholz","year":"2016","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0300","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/nu8040217","article-title":"Micronutrient intakes and incidence of chronic kidney disease in adults: tehran lipid and glucose study","volume":"8","author":"Farhadnejad","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.cca.2019.11.037_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030664","article-title":"Magnesium replacement to protect cardiovascular and kidney damage? lack of prospective clinical trials","volume":"19","author":"Mu\u00f1oz-Casta\u00f1eda","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cca.2019.11.037_b0310","doi-asserted-by":"crossref","DOI":"10.3390\/nu10020168","article-title":"Dietary magnesium and cardiovascular disease: A review with emphasis in epidemiological studies","volume":"10","author":"Rosique-Esteban","year":"2018","journal-title":"Nutrients."},{"key":"10.1016\/j.cca.2019.11.037_b0315","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ki.2013.327","article-title":"Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis","volume":"85","author":"Sakaguchi","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.cca.2019.11.037_b0320","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MNH.0000000000000509","article-title":"Magnesium and calciprotein particles in vascular calcification: the good cop and the bad cop","volume":"28","author":"Zeper","year":"2019","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.cca.2019.11.037_b0325","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1542-4758.2009.00364.x","article-title":"Long-term effects of magnesium carbonate on coronary artery calcification and bone mineral density in hemodialysis patients: a pilot study","volume":"13","author":"Spiegel","year":"2009","journal-title":"Hemodial. Int. Int. Symp. Home Hemodial."},{"key":"10.1016\/j.cca.2019.11.037_b0330","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/eci.12517","article-title":"Angiotensin II prevents calcification in vascular smooth muscle cells by enhancing magnesium influx","volume":"45","author":"Herencia","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.cca.2019.11.037_b0335","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1681\/ASN.2018111150","article-title":"A Randomized trial of magnesium oxide and oral carbon adsorbent for coronary artery calcification in predialysis CKD","volume":"30","author":"Sakaguchi","year":"2019","journal-title":"J. Am. Soc. Nephrol. JASN."},{"key":"10.1016\/j.cca.2019.11.037_b0340","doi-asserted-by":"crossref","DOI":"10.1007\/s40620-019-00601-6","article-title":"Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis","author":"Xiong","year":"2019","journal-title":"J. Nephrol."},{"key":"10.1016\/j.cca.2019.11.037_b0345","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/j.ackd.2018.02.010","article-title":"Magnesium and cardiovascular disease","volume":"25","author":"Tangvoraphonkchai","year":"2018","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.cca.2019.11.037_b0350","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2018-000775","article-title":"Magnesium for the prevention and treatment of cardiovascular disease","volume":"5","author":"DiNicolantonio","year":"2018","journal-title":"Open Heart."},{"key":"10.1016\/j.cca.2019.11.037_b0355","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3945\/ajcn.112.053132","article-title":"Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies","author":"Del Gobbo","year":"2013","journal-title":"Am. J. Clin. Nutr. 98"},{"key":"10.1016\/j.cca.2019.11.037_b0360","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.3945\/ajcn.112.054114","article-title":"PREVEND Study Group, Urinary and plasma magnesium and risk of ischemic heart disease","volume":"97","author":"Joosten","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cca.2019.11.037_b0365","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005406","article-title":"The association of serum magnesium and mortality outcomes in heart failure patients: A systematic review and meta-analysis","volume":"95","author":"Angkananard","year":"2016","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.cca.2019.11.037_b0370","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002707","article-title":"Serum magnesium and the risk of death from coronary heart disease and sudden cardiac death","volume":"5","author":"Kieboom","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.cca.2019.11.037_b0375","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jtemb.2016.03.014","article-title":"Dose-response relationship between dietary magnesium intake and cardiovascular mortality: A systematic review and dose-based meta-regression analysis of prospective studies","volume":"38","author":"Fang","year":"2016","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem. GMS."}],"container-title":["Clinica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811932159X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000989811932159X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:02:39Z","timestamp":1762113759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000989811932159X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":75,"alternative-id":["S000989811932159X"],"URL":"https:\/\/doi.org\/10.1016\/j.cca.2019.11.037","relation":{},"ISSN":["0009-8981"],"issn-type":[{"type":"print","value":"0009-8981"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnesium: An old player revisited in the context of CKD-MBD","name":"articletitle","label":"Article Title"},{"value":"Clinica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cca.2019.11.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}