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Lipid Res."},{"issue":"41","key":"10.1016\/j.cca.2020.01.015_b0425","doi-asserted-by":"crossref","first-page":"26388","DOI":"10.1074\/jbc.273.41.26388","article-title":"Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia","volume":"273","author":"Huang","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.cca.2020.01.015_b0430","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jhep.2003.12.011","article-title":"The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice","volume":"40","author":"Mensenkamp","year":"2004","journal-title":"J. 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